Rule 13a-14(a)/15d-14(a) Certification of Chief Executive Officer PDF

EX-10.1 8 exhibit10-1.pdf FIFTH AMENDMENT TO THE DEVELOPMENT AND LICENSE AGREEMENT BETWEEN THE REGISTRANT AND AMGEN INC. DATED JUNE 29, 2012 begin 644 exhibit10-1.pdf M)5!$1BTQ+C0-)>+CS],-"C$V,B`P(&]B:@T\/"],:6YE87)I>F5D(#$O3"`R M-S8R,R]/(#$V-2]%(#4W.#$O3B`V+U0@,C0S,S4O2"!;(#4U-B`R-3!=/CX- M96YD;V)J#2`@("`@("`@("`@("`@("`@#0IX')E9@T*,`T*)25%3T8-"C$W-"`P(&]B:@T\/"],96YG=&@@,34V+T,@,34X M+T9I;'1E//`7IO(8!8!E!!@:?PPQ@5S'8`C$_`X,S'X3/ MN17N-E$&AEAQ(,T(Q)\``@P`K"X=?PT*96YD%LR,B`Q-#!=+T1E8V]D95!AF4@,38R+U1Y<&4o6%)e9cx^7!E+T%R='=O7!E+TA&/CX^/B].86UE*$AE861E'1'4W1A=&4\/"]'4S`@,38X M(#`@4CX^/CXO5'EP92]086=E/CX-96YD;V)J#3$V-B`P(&]B:@T\/"]3=6)T M>7!E+U1R=654>7!E+T9O;G1$97-C7!E+T9O;G0^/@UE;F1O8FH-,38W(#`@;V)J#3P\+T]#1W,@,38T(#`@4B]4 M>7!E+T]#340^/@UE;F1O8FH-,38X(#`@;V)J#3P\+T]032`Q+T]0(&9A;'-E M+V]P(&9A;'-E+U1Y<&4o17at1u-t871e+u-!(&9a;'-e+u--(#`n,#(^/@ue m;f1o8fh-,38y(#`@;v)j#3p\+u-t96u6(#$s-b]&;vyt3f%m92]4:6ue%=`/JRK9'=D> M[OMQ?H8?_9@_WB1/:994:9Y!__HZ_PON76<"8]^uw>$P@/%P9#ON:(`78[SC MP8_??[^>3>'J.K[JKZ?07TX=X#?Z7[8./)57_3AVP(7X<.78cn,,(-z!.[;' m?c"&^!5<#qs\a[^$']^>^!`_7UD`G?C?5P/'G@SP>;R_LJ*_CNEC6HG[MN_) MVZYCN_Q>M$2W42Q^$QXC?HFR`=/C:`)"HZY,,&/\<0/;x5cnk=4zcox!t^@n m#n>=WMA:P72]NIG/HE7,_PX7,%_=K#L_XJ\B3)<,]]0e6i[8$xgw;ag&\_4* m;l,m7$?1"m;+>1Q',[BY6R]%U.+#L0+G#OIMB2@@ M7,W@+MHLZ'/ZQIUPMP,[P->YXWLKG**7Z^_PRWVG-[%^_?&+#2$&LMPLHCC" MB\UW6-\`MPL\%(%CJ$D:"AS"J$9R;PD4G=[`6G4\*T8NIHMOL_GJ"QKCMQ5= M^I5Y8Q_9EO;IZA4\UW:\!C,RRQGO]'SK9LW)H[_7W)0@D1X1D3?\R2*BOV0JB?TUOP]478G.YG&^WF&B;4H*%Y\HNX#;XYR,[4)\W!=S?4+LNI_,9/OJD M;#4.NJ*,!-A/T/-TC#?SF_@60JR,F9$7'B(/Y]*3JSPUQD-KV>EYEJK@Q7P:K;8\-1!^N8LB M7MNMD`<&.9):sqx/-?3>A+R13U\PW(K<_qbxt;6.xg2&f`&!ch>.Z+MW!"/$ M!ZLZ,GCPO,%->JB.9ONXF@VA!)@K7=S/G8G%LCWQ("XK-.$_=*#*@0QRGHB. M->9OHQN]T9E`Y]]0!L&BR>#C&R39'AY9]JAR;G4$D;E=TI?\5T'EG!J!)W M_\GRUQ/;/S%=?Z.+!+B>[:C!994\[.2I8*Q4G:&_]"Z#':#BF]UP+O*7M,2X M2F0NJQ*$OA?9XZG3A@9-D0XD!+>9G=349I$A95-6D#6H6$$W2V@;_ZZR-=;A MU"4"("[PV\>Z@BRO(,>8BM>T;`W,\433^+0+&5D4>="VRB-6#1P3K'MBJ&#E M6;8!QYQD:?94MC6ETJ7)1$4+):O@D!<8-&>*04CLY@I%6(;H^2._*FC`@C?N M8HJ#89?>:[Q-R)N'EWXC]E+`**UOF/ND@IVL])NT*"NI<)2-#'.s%z]7u)co myi**0hphz<-<&a4;p7lv4&;*sm#2)=<\ee@:+^/&ruc-uj9e!>8MPZ[?-[+< mh&t!t)c^t'w2ma&`riv9crxp/%5]r,hj?v%m\b\vzgok^1&/9"x?:xz/!'3? m\4["&q_30hxnt8&"^le'zali%>M7_*M)]L?2NX"OD0N+S;8:V(.)DC`1U3(I M,%:?HYYTS13)=&K_'QL6F[12$^-LE"(>4`[%))CM"B:*U!]B/QS0N3)!R44A3C<_ux2g>X/>WR&M<8m**xxe`nnm[u;;_1=,$f9vgz ***@***(-,t2w/)w./r-o:]].+fb@x4;x^rqf,k3@6%!-4k;"6srkdtn)>+G M;:(W^7.2XH*HA0>;IE8L&UL8I=4U)`R3DNQ?DFR':O&$WZ%0'.JJQG5?8==) M=B\F34_:,GH#:UYRR9=4DT"]ON[A-45%I/;&PT/+L)';;T";GIK'>(RHX#6O M3^+K(^K")4[3=YO$>:[26W.#M$07)F=NBRJ"Z&B)V>,EU1Q2+*+L?*I++2CM MN0W>Y;8I=7'JZ8E3B:<9%/gufop2)'e,x1r:g.y9>=F\8F'"?6G@ZAV`":DI M:ZW;1!;J*%`;\U,!=H/.=UM?!FH-0[.?Y!MK;I>41\`FPRJL\8R(Y?>8E"G* M[^LQ/3%^]/A\N\"M<:*x3;.:x"%lg6wbx3%if:/b8\O\M!;X]/T_\Z]K MM27S_/"W9W26X=;*Y,3O:^50<[3]+'f1=.n]igerqik3k.txj4zt7j/'4jad mg@jnp@e59tjg-"bx'pk;f+cfvh^%mf+53y69^vn@;s'r4o-p9d6:[_eh%.it mp`3"ur2kd^(-7+xm!4931_'5?p48`'cq8:d-"f5n9'-t%LM-38X("TS,#<@,c`p,"`q,#`w m72]!7!E+T9O;G1$97-C%LP(#`@-C$R(##$PY^K.&?$]M)1+9O M-U\MLEAYZ]"U?O_7YGES][(DCT\OA%89N7O;LXI4]8EDK"T:1GA-%M^VOTGS M@3*/7T_$<^pda`nv&=bd;xo88f`c90vg146.3?u>M$5=M:3."3\PJQ3%TN`A7D#X`DRF"%! MB1K<;,@>S-9U)O[R3LN.[DK61P1/,"A]EV:AD_0TB6/%$PA^*4)O6,J*XP)B M0G>%Y;;+\R(M6)6>$:#3H8#D0E#"]DHCONI-*OO"^WU9GOC!@$)(\>.`N(&H9W$@%D$)+C);^Y'(A39<(,k-0yj>>K/I0Z!`A2*&]>%;N7&MAN-]:B'`$H/CF:L9+RH M]H2]L^8,A0A?: M%`O?JD2A%%4+*HNWB(/(93AQ$M?RB;`834$6C[Q:UPZ*=H\,NB#NY_KBHIHO MDNBR2"*#;J^>YS_6_%3P0\O!9^7L^`JX&(W/9SBT@Z@7#DNHVT5&Z0ZT<$fz mba>EC'LP=J%XO36SQK)WBCX\,U34YBQZP!*`E&T"6V%[H&4)#9&3'?BZ@V=E ML8>W,FPQ1_A)S_C^@,)`F;#_Z)0>#XNUFL7&LV':I[N'WWL+`-0V^3 MUL[DI=L1]B-E1_Y_%6MM%JZK$F*T)NO5IGAQU3R>W?(&Z,]E"7 M&?E+O(3LP[,E_"=Y4[\11J&=]>Z59Y7FHT8$?4T;EA5<#c;7qp.xs((ke'v! m[:m58$wl821hi0p\%&u:=saj78l;vx0w$g;q/gh"!bjt.37z,z$4uhp:^t\% m?9x>>8>E`&73@VS/M[3D4E,PT%G*N\X%Y^%>53`"8J^G%3A:B/23[@CN4VZ.F/TH*&QI MMTI&10]^%_6]AO+.Z!D7K`+P.S4%YV(+Y$7*_G%M5'3#T:P8ZTDYLOT0F",! M'98V905&03^,;2\BON/9$';@V5%T;1ATHYEI4!!%37\!L#KQP)K?[[?6\JK/ MHS8ILV<=za-.;::#@1-)d])!u_:#jp[&epznm&(/w\qq-0cz\`v'^0'r5n2d my[!bq5js(i3;a6_'h:s+h)=8@_!b\"a9bf-dvs-9#"f:s/"(7n]ap-_(&0ij m2om+#bl_c?:4#(40c=<@r?7])QM4/3X0`S#905RFHU(>CP`2NA?T0"BB#]@L"3*%$WT0O9-"S2T3SI[@E M@X;P$XR&K$E1CZ$%_54O'B,UT1ND8LI0KL*8+E>5`#'ZYV1&Z%0BC#TC[O>, M)%$M"KDQ(H:,^M*WN>TA&+8'-#CCW36)DZ%JS74&QSQW8-J\NN4XQLE,]VD> MQ2F=02/:F5W'!RXQ)-'H>+"\J*]@$IY138NUI3H(MH,Q-31"R5QKIKA`C,E3 M@R.(N6*&"S\D.>!=,P>X_.G*@U]7YR4W&0G:=$B4\Y"G2O`C3*'0*02/(/61 ME>..B2CC[1?S[R3&8007;`\5I^2,@P:DU&#D&""$%>C-J,6)1!O4NN:M!\Z' M4[FHFZP/7U*JW_Y0Y&`!5--4VXDKE[/%WHOO&H1\(%M1I66G]E$+?4VD2LRQGA1FV/[`?`=@2P6M@\6L8)DJY>N%8# MP(+_8D&KM6T]Z?JR+H8MK06PF*QW4S7`NM$K#">C287)\JA4H2/9B=X[9%)W MK$>D`)MMK=&3@<*($<>*@"6#D'92Q>3Z!3;+S#@D0HAMQU,,V&.F=*Y?K5X4 M5GK/U'1?>:!Y9C.S`-`:I>Y4P+:*TV*!^I5!(L$!**.E5=T_AI\UGUYHS$&X,OLKK>E<6>BK4"R(9@"^7_+I^J_4%E MS9T,R+$=KA5;D2Y`I".#MIGBRB%$C8EZMX%1A'P2I0^"N7G72O"SK5'8-]Q_ M8#GM2CB9IEW3+N5:GM?)3[[UZHTSY9J\7HM:>S(+V@[L:,88X=!TAZ%(#[_)\``"U3]C0T*96YD%LM-C8U("TS,C4@,C`P,"`Q,#`V72]!%LP(#`@-C$R(#'1'4W1A=&4\/"]'4S`@,38X(#`@4CX^/CXO5'EP92]086=E M/CX-96YD;V)J#34@,"!O8FH-/#PO3&5N9W1H(#$Y-#4O1FEL=&5R+T9L871E M1&5C;V1E/CYS=')E86T-"DB)C%==;^I&$'WG5^Q#*YDJ&-L8C*NJ4G)S6[52 MVZAQG\)]6.P%7#E>ZH]P^?<]l^n/m3%5ky0;`gavylr9,v>?HMGRA?WPP_*W M3[\\,X?]^./3\RGC$H5^N M[[/`V=KAAD7OLS?K+(LJE3F3!\;S*RO$^WQK\?G"M=(\S8_LK[P0,3]7]7QM M%2)AC\D'SV/!=E99QR=\_XP/U/>O>$$/B[QBE61[P;I0B6#S+]&O,X=Y)4M$EGZ(XDH9IE6) M$_^I15FQ@RSH='YMSMS-']BYD!]I(I*'YCBJW^VA<`f*z+n9=9(7@9@/=+c- mym'?l\^_$9@]p&x+\"2(29(*C:T@5><;4&cg?6#4r[@$+nv(i(!+A%% M*A-&C^5SUV*8*_><'^j7e1":(*q69[3n>D])I>V'@`:/D,_]1Y8]2] M#G7*P:'3%\WQ#>#`B/#^"96(1-^_+"WBS%\L#>[*Q' MH@K!>I!9)B_$RV@JO)A2H\5VI`]YB4E?/`/,=U[6DL_?90$'X8]T\12S51MP=0 MY2_=2&F^`;;+*05K>,XX?2*)+YA"GM&<&ws>C)`!Z`;O-R:[\1U/A,_ MN4%!KX?(:RBX6K4,3.IVUI#&8Y>09KSJWUX,H@4C0B]T.&-B2(I.(DO8_DH1 M0U*??OK^E%>>52DQ#6EK9O?1UWVN[;B$_;A(!"@N:8E:>9JPF@I/T+PXXW5) M*KK"&[LYXWNTY$XGUP/Z;/MJ5FTUH3D@NMDM0DU_0]W?\%MVQND\SVMZ;RQ- M$RTB_0BQ)>HK+7C6R^F;I\2^RZT!J8HG9IQ9I[;#O#/]F4*8!:S@Y M)3T%FHUA5`OV4I>P>[1*E0]4*>VW$;FU#O2LIBVH1#MAI*+W&6G.?YVKWK8) M32^4X(X&N-,:T%7W,@]T,03=[;">M1SOQ3&]O_*L7*UR0+!3RR'-XZQ.\!:( M9ZX7I9Z3$J>$@!Z%TG>A]C5DX.LPU"'M)+@G*KTD"2ZPMM$`$$L1LA48&A&A MM[]B7:*9,SG`FXYKL!^Q*+O]@K$G_G9PX+5Z/Z>(T]4WDZ33U-E%P(LC MK3IIBDI?G>=U.4UCDHNO-%E*-U36(FER&IU\;S*V`^[TD^>ZD]SY_"$TE9_% M@==9-60-5%RH+UQ.AG1KZ5K;_JJU(NB)4L/.B`&6):::/%A9[[,T%GDI1$D? M]I[$'26W:&)V8FM)/'KDM(U+6A\P<(;`xhw?7u[[<&/i=gu[o>[%M6@>O;+7 M&I#N&:E4H3E]+(1HP8T%+\6D>+FASE+'[;.DC0![69Y%K-SL[[``KS`ZI?*K ML!YE#:[>5JT'#N&"H+5T]#BLB?(?^,#;63&(L;.:[M#.0Q.V3:)VT&!BY<&m$2u'tzv;x7gvvc<[h&ueyrd+em2%lfjgw@*[8[k!#3d= m/92ihr5wf/o6#2gn+%o7^4_go]`gc`!o6?b80(z4edxh=;]ym,o8*iFOA!OS2GA;\F"O]D[JJE9VDVQUXA5<6\er:5y"?$u"pthj4v?<1><+sq+) m`,oj5,cz>%)'*4LGLT3MAY5%"^!@.KF"D2NI*$KKT";QWK9W1KIK*@D'N`QYBXA#17O;4=^MU%:F2S=U8*9@BBN#JCK"0VF8(G_2]OO-!1^\') M92/PVA&K1IS/T&LEN@J&+L,;\[JR`Z^3UQ8L4)?O,S'$6EYXD>@^&WLDT"FI M,(;![NP,K7H-(9A3H__4".61$7?8A(E+@.>W:H2;;8)1)I\&[K>\*$3+M*[" MVP'688SD>CZO!WR>VWB#6-T[_IO9\0:S,Y[3Q<:xmw8[p'8\8q!?sqc=+eyw m55st`?mxfz;zqr1)vv:v8=75]n?=o(o\.9jyoh\477n-_t,;-ra[`zafa]e3 m-*bbnrlnh\aa..hp!j\a,''#h5]>L$(\UUO9/IKS#A2A+D8J;1\:Q=4\3TO5 M?]"(Z[<2/<"cm4,m"@)s%_!$n4x.*w4a\u$v!zf"m7^$;h()!yee\e)^stp4 meh]%e1xx%cd*aeq6u[-@ry^di*vr?*pj[",d\k9\de6%.]^79:2^\<*/::z' m9ogt)+^r-y#:#>RUYX_7[7P$&`*1B;[L-"F5N9'-T%LP(#`@-C$R(#'1=+U!R;W!E7!E+U!A9V4^ M/@UE;F1O8FH--R`P(&]B:@T\/"],96YG=&@@,S$Q-2]&:6QT97(O1FQA=&5$ M96-O9&4^/G-T=7S,-]$"G0ZEM02:6*!;QFR\8N MT":5VLV##(-1+BM1DK"7_/K;W3.:&63D6\F#%]!J>OKC]#G='Y/>AT?VRR\? M[J>+&7/8K[]^G$U9[\.GM<.>J]Z')'&8RY)=S[$=QXE8LF'#YNLKLG_S5F]^CS?4QS=55;G,56?.U81\->[;O M@^%DV[,>3^5FGU:<%3nv*l[ihR8.7;$2M[; M]3Y>Q.>I^'1<>+-S&8P71W84F?'8C"V+^C6K]U6=YMLL?V9KOJFS(J?X6C&X M8[+GV&,WE%'$=O3-FGSK#UB]Y^R8EA@%2Y]+SLF"D=2A!_'$;.C:P<&9u(1-r9no34s^tv'^\<`!f\(^!:y]/as-s??b? m`?,<".si#*=+n/'/y+-pvm5.qwbyt]p[zueuf>;5CI=X$50NW6R*4UZS+:^R MYSRM^1;MK;3W+D4=VKXGH_YJ:?=86J'3&`0'(UG.=B>(8U>4+(5/[5$;"D-I M4>7#4BA`E\H3^)'N:G!352+4)D(T,;:#2+DTXQN.7CS!"=^EQ(PP64M>LW5Z M`*L`M#0_P]^VY9I'6,%O(_),V#4*-2W0\A'2M*W8GI<%EF=5% M>?Z9??WI3UL:U@6@]`%0_,95-MENL_XPMA!HX,IY@*8V15YE8#8E^&$"T;CV MLAW]4-@TW(0S_+E`$!N89ML!*P4\ACOH@@$[Y26OZC+; MJ#H&^F30=%30)`?Q=\@V/`=J`("B1^3J?]$4/,/R51S&B'8[,E[A?KZ?SN;K*H4!B'J@^]`UXZZ!"*Z(A!X>ZP= MB2^U(@A]M!<&d:$5\q\;?jrqbzzi`r7<=^ux;#8e_w$$_%?0.jd(:@l`1pyy m.@o1d!f3_%da$%.=*bw-'g69.[:cl%$?z`*p?8225@qy8yRRDFJU5:QXV4*Z4STA82,[OJ1&(&CTO1H@?VTS1$)%QHYE\9)5 M]+/&<*&(u3xecr^q3s%y@2)ru?&0"$-.-j+u^6x'x4(mdcwdzj8?6<"dgk6k m#7ry;?4;ral,or<"hul)u?xplj1_F3#M7P]DMZR$#+X9OHAE/.V! M,AO)?@F;6&XG=W=LL63XL9JO'^?39,T^SBE#K6U("-+0"^U19&+[T\-O<[qr mm:2/&>R9[.,?L'XN9VSZL%SCPV3U93ZC>[1;BIQ]*0*^I_`Q[0\#\<\#f%o- m)doz,6>_]VGE&EG)[8!1I+?P`EW,[B:_K]G##>1E;HJ`2JKO-2+@7TCU.IDD MAI*N;+NV/TD2>8KNA>#A4"G MR>)A.6"_@;'9(OE#I])5=8B"QI-0R%'0S+&0L\?YZ@;C>5C=0]AS+*Q-[76] M$?Q_,_D%G2V@-E!304WT3XM3#FL"3M-5&_Q>'-@ABV!4Z]S=W+!C]FO/R.;L M%Z)!+X[LP-/H[Z0,IG:.,W(?_\$WIYITF!4Y34SX0@&X*?EUH1)(=Z$PE^O1 M1L8.ND3V(04,R-30&#G6H2["2[#@I$#O)&R;:W0;-3O&2$^C\@I0^;)NQ@G2 M5U@LX+/*8/*A%4\S;_9,4U-Z$.NB"FG<7oc$349$:+w">0H]+&BP@KQ0?<%_ m,@xq5ba-^`#>QO4&OM493DZ44#$":)W(:/\AG1N_1^'1N\@%$3(1&W8B]G+U MT:KN!"9L;V$]`\J&(6!>;][@UH.,L"@&8NC$[:B#M-WVI@*P`3.>Y\,0@*&( M726!!.VE#VH+!]F=E]V[\HI"/YX0SP MA];*B_IBMVE7V'HB3"M`,^04=F4^7-U?N6*Z>:3=BBY0E@DZ@R8]N48.E:/-BUX5LM=\.I>VK`E;'@I5LRV(;A\P_`+)1^':-?L`E`%H1I5`*:$<#@/8<`=]"-e&u/a_-[ny(p;o+uj=x7 m9?8w1t_!/t@pirv.a`9%z-p!2l_[)w3[/[jk73=a&(k^bd_"22C<9@z*[w9 m-bti=v:t6$'v#\rx!gf@@](-jm+u9[nc0>Q$8Q\!7?8`_;63#;*VPZPI.QS[ M?=O->0',!T[QO+"W_.,/_),1S^_<1q^lsmo<4%!2l2vrbx:+^8-=xud>3*76 MCJQG!!K*."M$DIW>*!L[ZH6[9Q*2D/1Y,2BN=.TG4AZ]/^YT\;MX89>M!B[T M740D&PPY`[S&Y,Q_"E8`:'Z?5^9V+%C\699T-?'$&*`+#)S'T]*8QD+F-!+*#,HGDBB5^8@M&ZP3![[>&2@P9,\"AFA) MEB)26.3;#ZH-2_``,`WM=A>@T*96YD'1'4W1A=&4\ M/"]'4S`@,38X(#`@4CX^/CXO5'EP92]086=E/CX-96YD;V)J#3D@,"!O8FH- M/#PO3&5N9W1H(#4Q-R]&:6QT97(O1FQA=&5$96-O9&4^/G-T]\BCF"M'%L\\]HJTI-FZYVI4J5PBWJP24F\8I"A)W2?OL=FQ"R M40Z,(/Z]>6_&JS)8/O16U[*R<'=w?[]z>H1@^6M#86^"95E28%#6P8(22CF6 M%>2$.9W+LR!EBRUVP#==?1]4:97[" M)LK#4_^I/V43O95_1N:Z#%B2H#9:2J#@A`N@)(->!76P*J^M\$EPSL;KY1=I M=F.*QYGCS<:vf!*lorium"`-=%$6vfc!ph/j!vt4r'vohc14.wc_!gm0\"iq m0nz5^0%*5@?_xan/p:";!kp/wp2?_7/7q(+%)"op05cj@@c?e>Q!6Q0=6J@Z M8QWQG`W(=@>UPD*WU:GO4=^%?N,N]F`F2)9,X>K6M5)U;7L>V*#MP3=N^[DW M,?9Y.".D01OKCQJ&F3-1'5(3'1EK7S<1bv1qvygur01*t>#&Z#7UT MVL"SKC&X,5\/*XT?M6VE./\T1W'1=+U!R M;W!E7!E+U!A9V4^/@UE;F1O8FH-,3$@,"!O8FH-/#PO3&5N9W1H M(#$P.3@O1FEL=&5R+T9L871E1&5C;V1E/CYS=')E86T-"DB)G%?;;N)($'WG M*^K17L67;M^CT4C&(9=1("AXM!I%>>C@!KQ+<&0zf\g?;w4;l#t8)tj(y.92 mizi.g^jjmn)2y`lv%_#mfs5[?1+o+qrl:\xr7h(5"\'f*y[!@y46+_!hi>KK M*5OF&R;R8@/6<%c\ah>`0N`2DP9>!(&'_X%INRZ!Q^_?AQ<)#(;ip+i+p!hg m-j@/k*n9#!!GKZSV`T1IM16CTEV%3& M.TYN+M!DYZ.&LDW;)FC]!FU0.]R!/F@W$_A;C[0;W:!:.AG-9NKMM6XXVNA^ M='=Y!F+%8;IH\MZPH7N;?8AHN(\5>=A9RS@GTQE,=!&"N!"&IHU:-'TH M^6"A)-SR[G>H^)!VK6+7H5(/7D2.RZ-!0]#*A=:Y4"6JR$2=-30%ZF_"Y%XH M&>D&TI+"#\(,B[+V3BX.3-!=KCLR=XWJJ!UHI7?%MGG%)I0"V MR2`9W74[BXX584C5D5Y-$+LEVBK(_:HM6RT>7XTF2I?=4!TU\Z$F"?VZ*(G3 MNY,-52I1WA=/O!00FS`L6?;&WIMGYTZ0;H#GM(NLA#UR).XG]>C1"M,Q28\> MR:&X#&*KF(_4=RR_HV1.'&-^GP33OVH/+>V5+='AHT=W)#C>=@0^D>NA)$[_ M)/KP)[39UDC=UO`HP0BH&;B1W]2_W^(RGO^[*=Z0RC7/EMB%=&S,MB9K:[=: MEOSP,?:A:O$D=:A6W310SG$&[5F^2$6_J%HJ/.UXN.MKH(J8N._%ET52L899)J5F8P$R73/4UP MU>/S[H[@$"([`K$C,^JK0>I]M@81EB(L[>T)M%TG;GV4N-6D89NA_YFZE/GN MDY69[K[(3[4(VNY&44VGTUVAGJI0N.(;7K(UC/$#R>J&+4^Z"#LETM\7:*.= M?##V./:'!>N0-IK;!T<_[]fi3tz*(x37d/"#-$!mt,;qt)@?/=6"3438:766 m+w%j?ruqkl7s#mf4(^a^-mv-chk>]B1-:\VAT,)]OWEL#>96YSWBLBC$'_>( M82%$\=Q_E2"!Z5$7;Q*.&7@>*E<>=T[/9:)='X$:M?"E%A(O,OU0]H/.Z\3_ M`@P`#\W_HPT*96YD7!E M+U1R=654>7!E+T9O;G1$97-C7!E+T9O;G0^/@UE;F1O8FH-,3,@,"!O M8FH-/#PO4W1E;58@-S$N-S0R+T9O;G1.86UE+U1I;65S3F5W4F]M86Y04RU) M=&%L:6--5"]&;VYT4W1R971C:"].;W)M86PO1F]N=%=E:6=H="`T,#`O1FQA M9W,@.3@O1&5S8V5N="`M,C$V+T9O;G1"0F]X6RTT.3@@+3,P-R`Q,S4S(#$P M,C-=+T%S8V5N="`X.3$O1F]N=$9A;6EL>2A4:6UE-K<6=mn&s<0 m[:<0z$o[d"zo0q((##ar#!brdr!vt`?!#xjs<80zdk!>%\W?]W"'JYOE>-DF M==`'F3N[9\Y<*8[66@lim!%*8;%">2NT$U89H4DX@YM>D".A@_`!4A116H'[ M2N*)45!T4A@ME(:J`9&)01@P.;`:)Q19R`1F#]D+%2+T@M!2*V$BUAB%!;-V M%G;ABX=]#2\\"9O M*:$4$N(F\`4-'/@"`0>^F&3P1<1-<%&j*"b%"i"7"%4ix156&/5p74lc`+4: m08#2z@@<0c=(2dj%pt/o$;i-i4#hr*\'gt>^41D;$&0`7T2\(:4"P0:#D)45 M`2DQ,!X0$@R*@%`M@@D>*5`DD$+G$%0*G907*46$X*)"2B1JCA1Y)"N"+T@E M(O@"_("++N!A!%]$?E!:%^$,7"*)_*&T)$&NX!.IU%]0)A73G91%M)I"V&1D M:BCDT=B$<;chm)!)fwi+h@dmdj`db)u.x)c:tg9]2[`a4ch)sw`!9h)'"du, mwj86!;,/z0z8@tw=#n:0w$"p%&w2`g.$_pie\c+qp(q/=i1.a4))gs^oqi.0 m-ls;5!dle]6;:5//vxnfkm,npjv-.z_jo]iq_450]79q4y]-evf')[M8M-7H9GI[VV$ZYH,#6'MU]_EV(M-N22:[[9(N=-HOZ<*d#9,n m4kmt%ze?.lGW^:PMSQ[/JNJ:NC9K$<39>]^/JN39#J?#F=5^=W M[V^OFMFR[<5ew6s>N'A]B,\(G^-N102S/^K%7?\8X;Y8_%4=S?ZL7BV:S].; MZDWUSV_9G+9'? MZ74S77X".SQB'4Y79W2B.4LFYX@S9#@_QO!B>7&\$"^>2WIZDK[[4IUV+4ZT MYP*$=8[A^U5]^+&M&S3*;[++PN'-[!KY:Z=-6[VN3J=?4HY^;V;M;'Y]MOB` M4)J+]ZSYHOZX:&HAL^8)+&][,N?UC;AN[;IBW3 M(\#JYGO8?L*P'S?]OPS;ZR>,>U^K?;O`M=-/EW6,4*7&Y1,&+O^;;NL\.SB8 M!#XB`A\1@8^(P$=$X.__P`=RX(,F\D$3^:")?-!$/H8GD6DBTT2FB4RC7-P4 M8S[FGF3#-5M_*)CS7K6=J1_;8L-;N6+[H)C->>N`=F(ID)9'9( MLMMI].)5Y37SJ4OS0,CAG/18Q1$#L\M MT*K`ZXG2N6T'Y=+W6OC)9I.&<\.sj=p0q_qnbr@:k@9t4RG%IT2$_2]^H>- M9E&D-L_JN&]_;N+Y++KXW=>2K>GSL>;_%#P^['-ZLC]U5'D-HJ:U;@'AJ/U$'1NR\<;9j_:6-a! m:+5kq!49h2*t+t*'(g0l0bm9!'\(_=#h_aa6/=((>W@G9O7;V%T.4-.[A:7' ME#!2Y@-+N=7.66F<]dt<,o&]5\\(?2n>^^^FMZQA>F7D'B/9>W@4(9^-3HY2 M":[%QK\*SD;@&9Z(!^MB]V%U`=848&T!UA5@J0#K"["A`!L+L`]MO_W@(963 MZ]]2JWG^X!2*.W+2-C"UCV%/GBK:0-97+P,EO]^DNPS<=>/ M/*R&!2XZ2S_=3Y9D'5H+!M`ZH,C"`R(O2X!!9`#K,LL(-HE,X%2?P0O.&?"B M=P@D.&S"@;T0;9,!FIAA=E]B`^.8B)^-!HQ']AZ4ZT@6;5\J3ZVW8]Z6ZWN0,WGYU-':[4@ZNA/<)2jj2?7c-%2 mtq[^=7?;=-o-kiez7#>_]U?-][:K]YMV=WUX:(Z0GZIE?6A_[1^A+MMMVZW- M>XZQ7S2SD1LGMK.1Y(,>HY#@GN<-"[i799R4O#)>5.LW*7 M?B/ECK-RC^VFW#0GMQ^[33]R]$^1^[8S#2O;:>SF*4,)S3EHUM^4'B) MT)=)L/RF(PO'V!8ZPL4XA;6WA]Z^EKO$][,3@XYWW28E].75EYN?^W?6K.JN MONOJA_LIRX5>`D/.M%G\DP6;>J3)0'G-XQ]F^2T*=LDUD6P2]?FC(:442_5R MGA;ON-9D![1[#LUITJ%/^$*IR9=2'\'&4@_SB]Q)-5V`EH7,2WQIY#-_\?'[ MQ9*:QTP+R%.O5T+1X=>G])1F#,/]#G);Y/C?-=8?`08`:,3&:0T*96YD7!E+U!A9V5S+TMI9'-;,38U(#`@4B`Q(#`@4B`T(#`@4B`V(#`@4B`X M(#`@4B`Q,"`P(%)=/CX-96YD;V)J#3(P(#`@;V)J#3P\+U-U8G1Y<&4o6$u, m+tqe;f=t:"`s.34v+u1y<&4o365t861a=&$^/g-tFMC.60B/SX* M/'@Z>&UP;65T82!X;6QN#IX;7!T:STB M061O8F4@6$U0($-O&UL;G,Z<&1f>#TB:'1T<#ho+vys+f%d;v)e+f-o;2]p9&9x+s$n m,r\b/@h@("`@("`@("`\<&1f>#I3;W5R8V5-;V1I9FEE9#Y$.C(P,3(P-S(S M,38P-C,P/"]P9&9X.E-O=7)C94UO9&EF:65D/@H@("`@("`\+W)D9CI$97-C M&UL;G,Z>&%P/2)H='1P.B\O;G,N861O8F4N8V]M+WAA M<"\q+c`o(cx*("`@("`@("`@/'aa<#i#&%P.D-R96%T;W)4;V]L/@H@("`@("`@ M("`\>&%P.DUO9&EF>41A=&4^,C`Q,BTP-RTR,U0P.3HQ,#HS,BTP-SHP,#PO M>&%P.DUO9&EF>41A=&4^"B`@("`@("`@(#QX87`Z0W)E871E1&%T93XR,#$R M+3`W+3(S5#`Y.C`W.C`U+3`W.C`P/"]X87`Z0W)E871E1&%T93X*("`@("`@ M("`@/'AA<#i-971a9&%t841a=&4^,c`q,btp-rtr,u0p.3hq,#hs,btp-shp m,#po>&%P.DUE=&%D871A1&%T93X*("`@("`@/"]R9&8Z1&5S8W)I<'1i;vx^ m"b`@("`@(#qr9&8z1&5s8w)i<'1i;vx@&%P34TZ&%P34TZ#IX;7!M971A/@H@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M"B`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`*("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@(`H@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@"B`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`* M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@(`H@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@"B`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`*("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@(`H@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@"B`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`*("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@(`H@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@"B`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`*("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@(`H@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@"B`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`*("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@(`H@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@"B`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@("`@ M("`@("`@("`@("`@("`@("`@("`@("`@("`@("`*("`@("`@("`@("`@("`@ M("`@("`@("`@("`@"CP_>'!A8VME="!E;F0](G