Novan, Inc. Contracts & Agreements

Asset Purchase Agreement, dated August 31, 2023, by and among Novan, Inc., EPI Health, LLC and Mayne Pharma LLC (Filed With SEC on September 7, 2023)

Amended and Restated Asset Purchase Agreement, dated September 1, 2023, by and among Novan, Inc., EPI Health, LLC and Ligand Pharmaceuticals, Incorporated (Filed With SEC on September 7, 2023)

Amendment No. 2 to Asset Purchase Agreement, dated August 21, 2023, by and among Novan, Inc., EPI Health, LLC and Ligand Pharmaceuticals, Incorporated (Filed With SEC on August 24, 2023)

Omnibus Amendment No. 1 to Fee Letter and Amendment No. 2 to Superpriority Debtor-in-Possession Loan and Security Agreement, dated August 21, 2023, by and between Novan, Inc., EPI... (Filed With SEC on August 24, 2023)

Asset Purchase Agreement, dated July 17, 2023, by and among Novan, Inc., EPI Health, LLC and Ligand Pharmaceuticals, Incorporated (Filed With SEC on July 17, 2023)

Loan and Security Agreement, dated July 14, 2023, by and among Novan, Inc., EPI Health, LLC and Ligand Pharmaceuticals, Incorporated (Filed With SEC on July 17, 2023)

Superpriority Debtor-in-Possession Loan and Security Agreement, dated July 17, 2023, by and between Novan, Inc., EPI Health, LLC and Ligand Pharmaceuticals, Incorporated (Filed With SEC on July 17, 2023)

Description of Registrants Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934 (Filed With SEC on March 30, 2023)

Non-Employee Director Compensation Policy (Filed With SEC on March 30, 2023)

License Agreement, dated January 12, 2017, by and between Novan, Inc. and Sato Pharmaceutical Co. Ltd (Filed With SEC on March 30, 2023)

First Amendment, dated January 12, 2017 to the License Agreement, dated January 12, 2017, by and between Novan, Inc. and Sato Pharmaceutical Co. Ltd (Filed With SEC on March 30, 2023)

Form of Common Warrant (March 2023) (Filed With SEC on March 16, 2023)

Form of Pre-Funded Warrant (March 2023) (Filed With SEC on March 16, 2023)

Form of Common Warrant, as amended (June 2022) (Filed With SEC on March 16, 2023)

Form of Securities Purchase Agreement, dated March 13, 2023, by and between the Company and the purchaser identified therein (Filed With SEC on March 16, 2023)

License Agreement, effective December 21, 2022, by and between Sato Pharmaceutical Co., Ltd., and EPI Health, LLC (Filed With SEC on December 21, 2022)

Factoring Agreement, effective December 1, 2022, by and among CSNK Working Capital Finance Corp. d/b/a Bay View Funding, and EPI Health, LLC (Filed With SEC on December 6, 2022)

Continuing Guaranty Agreement, effective December 1, 2022, by and among CSNK Working Capital Finance Corp. d/b/a Bay View Funding, and Novan, Inc (Filed With SEC on December 6, 2022)

Form of Common Warrant (Filed With SEC on June 10, 2022)

Form of Pre-Funded Warrant (Filed With SEC on June 10, 2022)

Placement Agent Agreement, dated June 9, 2022, by and between the Company and Oppenheimer & Co. Inc (Filed With SEC on June 10, 2022)

Form of Securities Purchase Agreement, dated June 9, 2022, by and between the Company and the purchaser identified therein (Filed With SEC on June 10, 2022)

Form of Award Agreement Awarding Restricted Stock Units under the Novan, Inc. 2016 Incentive Award Plan (Filed With SEC on May 16, 2022)

Employment Agreement, dated March 11, 2022, by and between Novan, Inc. and John Donofrio (Filed With SEC on May 16, 2022)

Non-Employee Director Compensation Policy (Filed With SEC on May 16, 2022)

Amended and Restated Promotion and Collaboration Agreement, effective as of January 1, 2022, by and between MC2 Therapeutics Limited and EPI Health, LLC (Filed With SEC on May 16, 2022)

Assignment and License Agreement, effective as of August 3, 2009, by and between Aspect Pharmaceuticals, LLC and EPI Health, LLC (as successor-in-interest to Vicept Therapeutics,... (Filed With SEC on May 16, 2022)

Amended, Restated and Consolidated License Agreement between The University of North Carolina and Novan, Inc., dated as of June 27, 2012, and as amended on November 30, 2012 (Filed With SEC on May 16, 2022)

Second Amendment, dated April 12, 2016, to the Amended, Restated and Consolidated License Agreement between The University of North Carolina and Novan, Inc., dated as of June 27,... (Filed With SEC on May 16, 2022)

UNC Sublicense Agreement, dated December 29, 2015, by and between Novan, Inc. and KNOW Bio, LLC (Filed With SEC on May 16, 2022)

Novan Patent and Know-How License Agreement, dated December 29, 2015, by and between Novan, Inc. and KNOW Bio, LLC (Filed With SEC on May 16, 2022)

Master Manufacturing and Supply Agreement, dated August 16, 2018, by and between DPT Laboratories, Ltd. and EPI Health, LLC (as successor-in-interest to Allergan Sales, LLC) (Filed With SEC on May 16, 2022)

Unit Purchase Agreement, dated as of (Filed With SEC on March 11, 2022)

Secured Promissory Note and Security Agreement, dated as of (Filed With SEC on March 11, 2022)

Equity Distribution Agreement, dated (Filed With SEC on March 11, 2022)

Description of Registrants Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934 (Filed With SEC on February 18, 2022)

Employment Agreement, dated November 1, 2021, by and between Novan, Inc. and Brian M. Johnson (Filed With SEC on February 18, 2022)

Fourth Amendment, dated November 26, 2018, to the Amended, Restated and Consolidated License Agreement between the University of North Carolina and Novan, Inc., dated as of June... (Filed With SEC on February 18, 2022)

Fifth Amendment, dated September 24, 2021, to the Amended, Restated and Consolidated License Agreement between the University of North Carolina and Novan, Inc., dated as of June... (Filed With SEC on February 18, 2022)

Royalty and Milestone Payments Purchase Agreement, dated April 29, 2019, by and between Novan, Inc. and Reedy Creek Investments LLC (Filed With SEC on February 18, 2022)

Development Funding and Royalties Agreement, dated May 4, 2019, by and between Novan, Inc. and Ligand Pharmaceuticals Incorporated (Filed With SEC on February 18, 2022)

First Amendment to Amended and Restated Employment Agreement, dated November (Filed With SEC on November 10, 2021)

First Amendment to Employment Agreement, dated August 11, 2021, by and between Novan, Inc. and John M. Gay (Filed With SEC on August 12, 2021)

Underwriting Agreement, dated June 17, 2021, by and between the Company and Cantor Fitzgerald & Co (Filed With SEC on June 21, 2021)

Novan, Inc. 2016 Incentive Award Plan, as amended and restated (Filed With SEC on May 25, 2021)

Novan, Inc. Tangible Stockholder Return Plan, as amended and restated (Filed With SEC on May 25, 2021)

Lease, dated as of January 18, 2021, by and between Novan, Inc. and Copper II 2020, LLC, and as amended by the First Amendment to Lease as of March 18, 2021 (Filed With SEC on May 11, 2021)

Novan, Inc. 2016 Incentive Award Plan, as amended and restated (Filed With SEC on May 6, 2021)

Non-Employee Director Compensation Policy (Filed With SEC on March 2, 2021)

Description of Registrants Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934 (Filed With SEC on February 24, 2021)

Letter Amendment, dated (Filed With SEC on October 30, 2020)

Lease Termination Agreement, dated July 16, 2020, by and between Novan, Inc. and Durham Hopson, LLC (Filed With SEC on October 30, 2020)

Form of Director and Executive Officer Indemnification Agreement (Filed With SEC on October 30, 2020)

Non-Employee Director Compensation Policy (Filed With SEC on September 24, 2020)

Employment Agreement, dated September 23, 2020, by and between Novan, Inc. and John M. Gay (Filed With SEC on September 24, 2020)

Registration Rights Agreement, dated July 21, 2020, between Novan, Inc. and Aspire Capital Fund, LLC (Filed With SEC on July 22, 2020)

Common Stock Purchase Agreement, dated July 21, 2020, between Novan, Inc. and Aspire Capital Fund, LLC (Filed With SEC on July 22, 2020)

Registration Rights Agreement, dated June 15, 2020, between Novan, Inc. and Aspire Capital Fund, LLC (Filed With SEC on June 17, 2020)

Common Stock Purchase Agreement, dated June 15, 2020, between Novan, Inc. and Aspire Capital Fund, LLC (Filed With SEC on June 17, 2020)

Paycheck Protection Program Term Note, dated April 22, 2020, in favor of PNC Bank, National Association (Filed With SEC on April 23, 2020)

Form of Pre-Funded Warrant (Filed With SEC on March 26, 2020)

Form of Placement Agent Warrant (Filed With SEC on March 26, 2020)

Securities Purchase Agreement, dated March 24, 2020, by and between the Company and each Purchaser thereto (Filed With SEC on March 26, 2020)

Underwriting Agreement, dated February 27, 2020, by and between the Company and H.C. Wainwright & Co., LLC (Filed With SEC on March 3, 2020)

Form of Common Warrant (Filed With SEC on March 3, 2020)

Form of Pre-Funded Warrant (Filed With SEC on March 3, 2020)

Form of Underwriter Warrant (Filed With SEC on March 3, 2020)

Description of Registrants Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934 (Filed With SEC on February 24, 2020)

Amended and Restated Employment Agreement dated December 17, 2019, by and between Novan, Inc. and Paula Brown Stafford (Filed With SEC on February 24, 2020)

Stock Appreciation Right Grant Notice and Agreement between Novan, Inc. and Paula Brown Stafford (Filed With SEC on February 24, 2020)

Registration Rights Agreement, dated August 30, 2019, between Novan, Inc. and Aspire Capital Fund, LLC (Filed With SEC on September 5, 2019)

Common Stock Purchase Agreement, dated August 30, 2019, between Novan, Inc. and Aspire Capital Fund, LLC (Filed With SEC on September 5, 2019)

Royalty and Milestone Payments Purchase Agreement, dated April 29, 2019, by and between Novan, Inc. and Reedy Creek Investments LLC (Filed With SEC on August 13, 2019)

Development Funding and Royalties Agreement, dated May 4 2019, by and between Novan, Inc. and Ligand Pharmaceutical Incorporated (Filed With SEC on August 13, 2019)

Novan, Inc. 2016 Incentive Award Plan, as amended and restated (Filed With SEC on August 6, 2019)

Employment Agreement, dated January 29, 2019, by and between Novan, Inc. and Paula Brown Stafford (Filed With SEC on March 27, 2019)

Separation and General Release Agreement, dated January 29, 2019, by and between Novan, Inc. and Jeff N. Hunter (Filed With SEC on March 27, 2019)

Consulting Agreement, dated January 29, 2019, by and between Novan, Inc. and Jeff N. Hunter (Filed With SEC on March 27, 2019)

Third Amendment, dated November 1, 2018, to the Amended, Restated and Consolidated License Agreement between The University of North Carolina and Novan, Inc., dated as of June 27,... (Filed With SEC on March 27, 2019)

Second Amendment, dated November 2, 2018, to the UNC Sublicense Agreement, dated December 29, 2015, by and between Novan, Inc. and KNOW Bio, LLC (Filed With SEC on March 27, 2019)

Second Amendment, dated November 2, 2018 to the Novan Patent and Know-How License Agreement, dated December 29, 2015, by and between Novan, Inc. and KNOW Bio, LLC (Filed With SEC on March 27, 2019)

Separation and General Release Agreement, dated January 4, 2019, by and between Novan, Inc. and Nathan Stasko (Filed With SEC on January 7, 2019)

Second Amendment, dated October 5, 2018 to the License Agreement, dated January 12, 2017, by and between Novan, Inc. and Sato Pharmaceutical Co. Ltd (Filed With SEC on November 5, 2018)

Employment Agreement, dated August 8, 2018, by and between Novan, Inc. and G. Kelly Martin (Filed With SEC on November 5, 2018)

Stock Appreciation Right Grant Notice and Agreement between Novan, Inc. and G. Kelly Martin (Filed With SEC on November 5, 2018)

Tangible Stockholder Return Plan, dated August 2, 2018 (as amended and restated November 2, 2018) (Filed With SEC on November 5, 2018)

Non-Employee Director Compensation Policy (Filed With SEC on August 8, 2018)

Form of Employment Inducement Stock Option Agreement (Filed With SEC on August 8, 2018)

Employment Agreement, dated April 15, 2018, by and between Novan, Inc. and Jeff Hunter (Filed With SEC on April 17, 2018)

Employment Agreement, dated March 16, 2017, by and between Novan, Inc. and Paula Brown Stafford, as amended October 12, 2017 and March 14, 2018 (Filed With SEC on March 27, 2018)

Non-employee Director Compensation Policy (Filed With SEC on March 27, 2018)

First Amendment, dated October 13, 2017, to the UNC Sublicense Agreement, dated December 29, 2015, by and between Novan, Inc. and KNOW Bio, LLC (Filed With SEC on March 27, 2018)

First Amendment, dated October 13, 2017, to the Novan Patent and Know-How License Agreement, dated December 29, 2015, by and between Novan, Inc. and KNOW Bio, LLC (Filed With SEC on March 27, 2018)

Underwriting Agreement, dated January 5, 2018, by and between Novan, Inc. and Piper Jaffray & Co., as representative of the underwriters named therein (Filed With SEC on January 9, 2018)

Form of Warrant Agreement (Filed With SEC on January 9, 2018)

Letter Agreement, dated October 31, 2017, by and between Novan, Inc. and William L. Hodges (Filed With SEC on November 6, 2017)

NOVAN, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY AS AMENDED BY THE BOARD OF DIRECTORS, JUNE 5, 2017 (Filed With SEC on August 11, 2017)

FIRST AMENDMENT TO amended and restated employment agreement (Filed With SEC on June 5, 2017)

separation and GENERAL RELEASE AGREEMENT (Filed With SEC on May 12, 2017)

NOVAN, INC. SENIOR EXECUTIVE INCENTIVE BONUS PLAN (Filed With SEC on March 20, 2017)

EMPLOYMENT AGREEMENT (Filed With SEC on March 20, 2017)

NOVAN, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY (Filed With SEC on March 20, 2017)

Execution Copy (Filed With SEC on March 20, 2017)

NOVAN, INC. 2016 INCENTIVE AWARD PLAN STOCK OPTION GRANT NOTICE AND STOCK OPTION AGREEMENT (Awarding Non-Qualified Stock Option) (Filed With SEC on November 14, 2016)

NOVAN, INC. 2016 INCENTIVE AWARD PLAN STOCK OPTION GRANT NOTICE AND STOCK OPTION AGREEMENT (Awarding Incentive Stock Option) (Filed With SEC on November 14, 2016)

NOVAN, INC. 2016 INCENTIVE AWARD PLAN STOCK OPTION GRANT NOTICE AND STOCK OPTION AGREEMENT (Awarding Non-Qualified Stock Option) (Filed With SEC on November 14, 2016)

SECOND AMENDMENT TO AMENDED, RESTATED AND CONSOLIDATED LICENSE AGREEMENT (Filed With SEC on November 14, 2016)

THIRD AMENDMENT TO LEASE AGREEMENT (Filed With SEC on November 14, 2016)

FOURTH AMENDMENT TO LEASE AGREEMENT (Filed With SEC on November 14, 2016)

Second AMENDMENT TO Lease (Filed With SEC on November 14, 2016)

NOVAN, INC. CommonStock UNDERWRITING AGREEMENT (Filed With SEC on September 8, 2016)

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidentialtreatment has been requested with respect... (Filed With SEC on September 8, 2016)

NOVAN, INC. INDEMNIFICATION AGREEMENT (Filed With SEC on August 24, 2016)

NOVAN, INC. 2008 STOCKPLAN (Filed With SEC on August 24, 2016)

NOVAN, INC. 2016INCENTIVE AWARD PLAN ARTICLE 1. PURPOSE (Filed With SEC on August 24, 2016)

AMENDED AND RESTATED EMPLOYMENT AGREEMENT (Filed With SEC on August 24, 2016)

EMPLOYMENT AGREEMENT (Filed With SEC on August 24, 2016)

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidentialtreatment has been requested with respect... (Filed With SEC on August 24, 2016)

UNC SUBLICENSE AGREEMENT (Filed With SEC on August 24, 2016)

NOVAN PATENT AND KNOW-HOW LICENSE AGREEMENT (Filed With SEC on August 24, 2016)

LEASE AGREEMENT BY AND BETWEEN CROWN ROYAL ASSOCIATES, LLC, a Delaware limited liability company (AS LANDLORD) AND NOVAN, INC., a DelawareCorporation (AS TENANT) TABLE OF CONTENTS (Filed With SEC on August 24, 2016)

LEASE 4105Hopson Road, Durham, NC DURHAM HOPSON ROAD, LLC, a Delaware limited liability company as Landlord, and NOVAN, INC., aDelaware corporation, as Tenant. TABLE OF CONTENTS (Filed With SEC on August 24, 2016)

STOCK SALE AND PURCHASE AGREEMENT (Filed With SEC on August 24, 2016)