SUPPLEMENTAL AGREEMENT

Exhibit 10.1

SUPPLEMENTAL AGREEMENT

This Supplemental Agreement (the “Agreement”), dated as of September 18, 2015, is entered into by and between Medbox, Inc., a Nevada corporation (the “Company”) and the YA Global Master SPV, Ltd. (the “Purchaser”).

BACKGROUND

AGREED TERMS

2.1 Purchase. In addition to the commitment to purchase Debentures with an aggregate Principal Amount of up to $1,500,000 made by the Purchaser under Securities Purchase Agreement II, the Purchaser shall purchase Debentures with an aggregate Principal Amount of up to an additional $200,000. The purchase will occur in two Tranches, with the first Tranche of $100,000 being closed within two (2) Trading Days of the execution of this Agreement (the “First Supplemental Closing”). The second Tranche will be for $100,000 and will occur within two (2) days of the Filing Date and simultaneously with the Second Closing (the “Second Supplemental Closing”). Purchaser shall not be required to fund either of the First Supplemental Closing or the Second Supplemental Closing if the Company is in default of any Debentures or the Equity Conditions (as defined in the Debentures) are not met on the Closing Date for each such Tranche.

2.2 Closing. Upon the terms and subject to the conditions set forth herein and in Securities Purchase Agreement II, (i) on the Closing Date with respect to the First Supplemental Closing, the Company agrees to sell, and the Purchaser agrees to purchase, a Debenture with an aggregate Principal Amount of $100,000, for a Subscription Amount equal to $100,000, and (ii) on the Closing Date with respect to the Second Supplemental Closing, the Company agrees to sell, and the Purchaser agrees to purchase, a Debenture with an aggregate Principal Amount of $100,000, for a Subscription Amount equal to $100,000. Each Closing shall occur at the offices of Company Counsel or such other location as the parties shall mutually agree upon the satisfaction of the covenants and conditions set forth in Sections 2.3 and 2.4 below for each such Closing. At each such Closing, the Purchaser shall deliver to the Company, via wire transfer, immediately available funds equal to the Purchaser’s Subscription Amount (less a commitment fee in the amount of 5% of the Principal Amount of the Debentures purchased at each Closing, payable as set forth in Section 5.2 of Securities Purchase Agreement II), and the Company shall deliver to the Purchaser its Debenture and Warrants, as determined pursuant to Section 2.3(a) below, and the Company and the Purchaser shall deliver the other items set forth in Section 2.3 below deliverable at such Closing.

2.3 Deliveries.

(a) On or prior to the Closing Date with respect to each of the First Supplemental Closing and the Second Supplemental Closing (except as noted), the Company shall deliver or cause to be delivered to the Purchaser the following:

(i) as to the First Supplemental Closing, this Agreement duly executed by the Company;

(ii) a Debenture with a principal amount equal to the Purchaser’s

Principal Amount as to the applicable Closing, registered in the name of such Purchaser, which in the case of the Second Supplemental Closing shall be combined with the Debenture issuable at the Second Closing; and

(iii) Warrants registered in the name of such Purchaser to purchase such number of Shares as is equal to the Purchaser’s Principal Amount as to the applicable Closing divided by the Reference Price, at an Exercise Price (as defined in the Warrants) equal to such Reference Price, and an expiration date 3 years from the issuance date of such Warrants.

(b) On or prior to the Closing Date with respect to each of the First Supplemental Closing and the Second Supplemental Closing (except as noted), the Purchaser shall deliver or cause to be delivered to the Company, as applicable, the following:

(i) as to the First Supplemental Closing, this Agreement duly executed by such Purchaser; and

(ii) the Purchaser’s Subscription Amount (disbursed as set forth in the applicable Closing Statement) as to the applicable Closing by wire transfer to the account specified in writing by the Company.

2.4 Closing Conditions.

(a) The obligations of the Company hereunder in connection with each of the First Supplemental Closing and the Second Supplemental Closing are subject to the following conditions being met:

(i) the accuracy in all material respects on the applicable Closing Date of the representations and warranties of the Purchaser contained herein and in Securities Purchase Agreement II (unless as of a specific date therein in which case they shall be accurate as of such date);

(ii) all obligations, covenants and agreements of the Purchaser required to be performed herein and in Securities Purchase Agreement II at or prior to the applicable Closing Date shall have been performed; and

(iii) the delivery by the Purchaser of the items set forth in Section 2.3(b) of this Agreement.

(b) The obligations of the Purchaser hereunder in connection with each of the First Supplemental Closing and the Second Supplemental Closing are subject to the following conditions being met:

(i) the Company shall have filed the Supplemental Agreement 8-K, and the Prospectus Supplement shall have been filed with the Commission and shall be in effect and available for the resale by the Purchaser of all the shares underlying the Initial Warrants, as amended hereunder;

(ii) The Company shall have executed and delivered to the Purchaser the Global Warrant Amendment (as defined below);

(iii) the accuracy in all material respects when made and on the applicable Closing Date of the representations and warranties of the Company contained herein and in Securities Purchase Agreement II (unless as of a specific date therein);

(iv) all obligations, covenants and agreements of the Company required to be performed hereunder and in Securities Purchase Agreement II at or prior to the applicable Closing Date shall have been performed;

(v) the delivery by the Company of the items set forth in Section 2.3(a) of this Agreement;

(vi) there is no existing Event of Default (as defined in the Debentures) and no existing event which, with the passage of time or the giving of notice, would constitute an Event of Default;

(vii) there shall have been no Material Adverse Effect with respect to the Company since the date hereof;

(viii) from the date hereof to the applicable Closing Date, trading in the Common Stock shall not have been and remain suspended by the Commission or the Company’s principal Trading Market and, at any time prior to the applicable Closing Date, trading in securities generally as reported by Bloomberg L.P. shall not have been and remain suspended or limited, or minimum prices shall not have been established on securities whose trades are reported by such service, or on any Trading Market, nor shall a banking moratorium have been declared and remain in place either by the United States or New York State authorities nor shall there have occurred any material outbreak or escalation of hostilities or other national or international calamity of such magnitude in its effect on, or any material adverse change in, any financial market which, in each case, in the reasonable judgment of such Purchaser, makes it impracticable or inadvisable to purchase the Securities at the applicable Closing; and

(ix) with respect to the Second Supplemental Closing, the Company shall have completed the increase of its authorized capital stock to at least 400,000,000 shares of Common Stock and a certificate of amendment to its certificate of incorporation shall have been filed with and approved by the Nevada Secretary of State.

3.1 Amendments to the Initial Warrants. The Exercise Price of each of the Initial Warrants shall be reduced to $0.06 per share, effective as of the date hereof. The terms of the Initial Warrants shall otherwise remain unchanged. The Company shall promptly execute and deliver a global warrant amendment in the form set out on Exhibit B attached hereto (the “Global Warrant Amendment”) certifying that from and after the date hereof, the Exercise Price of each of the Initial Warrants shall be $0.06 per share.

3.2 Prospectus Supplement. As soon as practicable (but, in any event, within 2 Trading Days) after the execution of this Agreement, the Company shall file a prospectus supplement (the “Prospectus Supplement”) to the prospectus accompanying the registration statement filed with the Commission (No. 333-203299) in connection with Securities Purchase Agreement I, to update such prospectus for reduction of the Exercise Price of the Initial Warrants as set forth herein.

3.3 Obligation to Exercise. The Purchaser shall exercise all of the Initial Warrants on a cash basis (a total of 2,291,832 shares at $0.06 per share for proceeds to the Company of $137,509) within three (3) Trading Days of the filing of an 8-K fully disclosing the material terms and conditions of this Agreement (the “Supplemental Agreement 8-K”) and the filing of the Prospectus Supplement with the Commission and the Prospectus Supplement shall be in effect and available for the resale by the Purchaser of all the shares underlying the Initial Warrants, as amended hereunder.

This Agreement may be executed in two or more counterparts, all of which when taken together shall be considered one and the same agreement and shall become effective when counterparts have been signed by each party and delivered to each other party, it being understood that the parties need not sign the same counterpart. In the event that any signature is delivered by facsimile transmission or by e-mail delivery of a “.pdf” format data file, such signature shall create a valid and binding obligation of the party executing (or on whose behalf such signature is executed) with the same force and effect as if such facsimile or “.pdf” signature page were an original thereof.

This Agreement shall be governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of conflicts of law thereof. Each party agrees that all legal proceedings concerning the interpretations, enforcement and defense of the transactions contemplated by this Agreement (whether brought against a party hereto or its respective affiliates, directors, officers, shareholders, partners, members, employees or agents) shall be commenced exclusively in the state and federal courts sitting in the City of New York. Each party hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan for the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action or proceeding is improper or is an inconvenient venue for such proceeding. Each party hereby irrevocably waives personal service of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof via registered or certified mail or overnight delivery (with evidence of delivery) to such party at the address in effect for notices to it under the Securities Purchase Agreement II and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any other manner permitted by law.

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IN WITNESS WHEREOF, the Company and the Holder have caused this Supplemental Agreement to be signed by their duly authorized officers.

EXHIBIT A

WARRANTS

EXHIBIT B

GLOBAL WARRANT AMENDMENT