Amendment No. 4 to the Research Collaboration Agreement, dated May 2, 2024, by and between Nkarta, Inc. and CRISPR Therapeutics AG

Amendment No. 4

to the

RESEARCH Collaboration Agreement

This Amendment No. 4 to the Research Collaboration Agreement (the “Amendment”) is entered into as of May 2, 2024 (“Amendment Effective Date”) by and between Nkarta, Inc. (“Nkarta”) and CRISPR Therapeutics AG (“CRISPR”). Nkarta and CRISPR each may be referred to herein individually as a “Party” or collectively as the “Parties.” This Amendment amends the Research Collaboration Agreement, entered into as of May 5, 2021, between Nkarta and CRISPR and as amended by that certain Amendment No. 1 to the Research Collaboration Agreement entered into as of May 4, 2022, Amendment No. 2 to the Research Collaboration Agreement entered into as of March 8, 2023, and Amendment No. 3 to the Research Collaboration Agreement entered into as of April 3, 2024 (collectively, the “Agreement”). Capitalized terms used but not defined in this Amendment shall have the meanings ascribed to such terms in the Agreement.

RECITALS

WHEREAS, the Parties desire to amend and restate Sections 1.52 – Nomination and 4.1 – Additional Gene-Editing Targets;

NOW, THEREFORE, in consideration of the respective covenants and agreements set forth herein, the Parties hereto agree as follows:

Amendments

‘“Designation Term” means [***].”

“4.1 Additional Gene-Editing Targets. Nkarta shall, during the period commencing on the Effective Date and [***], have the right to designate, in accordance with this Article 4, up to [***] (“Additional Gene-Editing Targets”) for inclusion in the Target Pool for Nkarta to Research, Develop and Commercialize Nkarta Products. For the avoidance of doubt, any such gene-editing target shall be [***].

MISCELLANEOUS

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IN WITNESS WHEREOF, the Parties have caused this Amendment to be executed by their representatives thereunto duly authorized as of the Amendment Effective Date.