Amendment No. 1 to Letter of Intent for Proposed CRADA #2166 between National Cancer Institute and NewLink Genetics Corporation
This amendment updates the Letter of Intent for a proposed Cooperative Research and Development Agreement (CRADA) between the National Cancer Institute (NCI) and NewLink Genetics Corporation regarding the development of 1-Methyl-[d]-Tryptophan as an anti-cancer agent. The amendment extends the term of the LOI by six months, until May 23, 2008, and changes the NCI Principal Investigators, removing Dr. Lee Jia and naming Dr. Sherry Ansher and Dr. Howard Streicher. All other terms of the original LOI remain unchanged.
Exhibit 10.39
AMENDMENT #1
To Letter of Intent for Proposed CRADA #2166
“Pre-Clinical and Clinical Development of 1-Methyl-[d]-Tryptophan as an Anti-Cancer Agent”
The purpose of this amendment is to change certain terms of the Letter of Intent (LOI) for the proposed Cooperative Research and Development Agreement (CRADA) entitled “Pre-Clinical and Clinical Development of 1-Methyl-[d]-Tryptophan as an Anti-Cancer Agent.” These changes are reflected below, and except for these changes, all other provisions of the original CRADA LOI remain in full force and effect. Two originals of this amendment are provided for execution; one is to remain with the National Cancer Institute (NCI) and the other copy is to remain with the Collaborator.
1. Upon final signature, the term of this CRADA Letter of Intent is extended for six months from November 23, 2007 to May 23, 2008.
2. Dr. Lee Jia is removed as an NCI Principal Investigator. The NCI Principal Investigators are Dr. Sherry Ansher and Dr. Howard Streicher.
| ACCEPTED AND AGREED TO: |
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| For the National Cancer Institute: |
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| /s/Anna D. Barker |
| 01/08/08 |
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| Anna D. Barker, Ph.D. |
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| Deputy Director, NCI |
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| For NewLink Genetics Corporation: |
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| /s/Charles Link |
| 1/17/08 |
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