Risk of Bleeding Fibrinolytic drugs dissolve blood clots, including those formed naturally as a protective response to vessel injury, which can result in bleeding. The risk of intracranial hemorrhaging increases as the dosage increases. Patients who are already taking other medications to prevent formation of clots, such as anticoagulants or antiplatelets, may not be good candidates for the use of fibrinolytic drugs due to the increased difficulty of controlling bleeding. In the study that led to FDA approval of rt-PA, the incidence of SICH in rt-PA patients was 6.4%, compared to 0.6% in the placebo group. As a result, rt-PA is subject to strict limitations on when, how long and in what dosages it may be administered

EX-4.1 2 c75275exv4w1.htm EXHIBIT 4.1 Filed by Bowne Pure Compliance

Exhibit 4.1

INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE SEE REVERSE FOR CERTAIN DEFINITIONS AND A STATEMENT AS TO THE RIGHTS PREFERENCES. PRIVILEGES AND RESTRICTIONS OF SHARES CUSIP 64124w FULLY PAID AND NON-ASSESSABLE SHARES OF THE COMMON STOCK, PAR VALUE $.001 PER SHARE, OF NEUROBIOLOGICAL TECHNOLOGIES, INC. transferable on the books of the Corporation by the holder hereof, in person or by duly authorized attorney authorized officers and sealed with a facsimile of its corporate seal. Dated: SECRETARY

NEUROBIOLOGICAL TECHNOLOGIES, INC. The Corporation is authorized to issue Common Stock and Preferred Stock. The Board of Directors of the Corporation has authority to fix the number of shares and the designation of any series of Preferred Stock and to determine or alter the rights, preferences, privileges and restrictions granted to or imposed upon any unissued series of Preferred Stock. The Corporation will furnish to any stockholder, upon request and without charge, a statement of the powers, designations, preferences, and relative, participating, optional or other special rights of each class of stock or series thereof and the qualifications, limitations or restrictions of such preferences andlor rlghts, Insofar as the same shall have been fixed, and of the authority of the Board of Directors to designate any preferences, rights and limitations of any wholly unissued series. Any such request should be directed to the Secretary of the Corporation at its prlnclpal offlce. The following abbrevlatlons when used In the nscrlptlon on the face of t h s certlllcate shall bc construed as thouqh they were wrltten out in full accordlnq to appl~cable laws or regulat~ons TEN COM -as tenants ~n common UNIF GIFT MIN ACT- Custod~ari TEN ENT -as tenants by the ent:retles (cust, (Mnori JT TEN a s jolnt tenants w t h riqht of surv~vorsh~p ~inderU n~formG ~ f t sto Miriors and not as tenants In common Act - COM PROP-as community property (Stat?) UNIF TRF MIN ACT- .Custodian (unt~al ge 1 Addt~onal abbreviat~oris rnay a!so be used though not III the above 1st For Value received PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE hereby sell, assign and.transfer untc, :.kg 4..2 (NAME AND ADDRESS OF TRANSFEREE SHOULD BE PRINTED OR TYPtWRITTEN) %; represented by the within certificate anddo hereby irrevocably constitute and appoint +$:n I ’ 52: Attorney

to transfer the said Shares oithe share register of the within-named Corporation, with %;g full power of substitution in the premises. -0 7: r — T Dated : 2 - - + ,I < h $5 - - — - 4 tn ilSignature(s) Guaranteed: THE S I G ~ T ~ ~ R E ~ S ~ S H O U L D ~ GBUY ~ANR EAL~IGTIBELE~ GDUA RANTOR INS-ON (BANKS STOCK BROKERS SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED MEDALLION SIGNATURE GUARANTEE PROGRAM1 PURSUANT TO S E L RULE 17Ad 15 Thls certlflcate also evidences and ent~tlesth e holder hereof to certaln rlghts as set forth In a RIPS Agreemen1 between Neurob~olog~cTael chnologles, Inc and American Stock Transfer & Trust Company, as Rlghts ~ g e n t ~ s t aesd o f May 19, 2005 (the “Agreement”), the terms of whlch are hereby Incorporated herein by reference and a copy;qf,wh~ch IS on flle at the prlnclpal executive offlces of Neurob~olog~cTael chnologles, Inc Under certaln clrcumstances as set forth in the Agreement such Rlghts wlll be evldenced by separate certlflcates and will no longer be evldenced by th~sc ertlflcate Neurob~olog~cal Technologles, Inc will mall to the holder of thls certlflcate a copy of the Agreement wlthout charge after rece~pto f a wrltten request therefor Under certaln clrcumstances set forth In the Agreement, Rlghts Issued to, or held by, any person who IS, was or becomes an Acqulrlng Person or an Afflllate or Associate thereof (as deflned In the Agreement) and certaln related persons, whether currently held by or on behalf of such person or by any subsequent holder, may become null and vold