THIRD AMENDMENT TO LICENSEAGREEMENT betweenThe University of South Carolina Research Foundation andNephroGenex, Inc, (assignee of BioStratum Incorporated)

Exhibit 10.7.4

THIRD AMENDMENT

TO

LICENSE AGREEMENT

between The University of South Carolina Research Foundation

and NephroGenex, Inc, (assignee of BioStratum Incorporated)

This Third Amendment to the License Agreement (“Third Amendment”) is made effective as of the date of the last signature to this Amendment (“Third Amendment Effective Date”) by and between the South Carolina Research Foundation (“SCRF”) and NephroGenex, Inc., a Delaware corporation (“LICENSEE”) and assignee of BioStratum Incorporated (“BioStratum”).

SCRF and LICENSEE (collectively, “the Parties”) entered into a License Agreement, dated August 27, 2004 (the “Agreement”). The Parties wish to amend the Agreement in accordance with Article 15-11 of such Agreement, and agree that the Agreement is hereby amended as set forth below. Capitalized terms used in this First Amendment that are not otherwise defined herein, shall have the respective meanings set forth in the Agreement.

Amendment.  Certain terms of the Agreement are amended and replaced as follows:

Amended Article 4.1B

Annual License Fees shall be due in the amounts listed below, with the first such annual License Fee be due and payable on January 1, 2006 and each succeeding Annual License Fee being due and payable on the according to the following schedule:

Annual License Fees shall be due and payable as long as LICENSEE is actively marketing or has an active sublicense for Pyridorin. Annual License Fees paid each year shall be creditable only against Licensed Product Sublicense upfront fees and milestone payments (defined in Article 4-1.C. and 4-1.E. respectively) earned and payable in the same calendar year.

Scope of Amendment.  This Third Amendment supersedes all proposals, oral, or written, all negotiations, conversations, or discussions between or among parties relating to the subject matter of this Third Amendment and all past dealings or industry customs. This Third Amendment shall be integrated in and form part of the Agreement upon execution. All terms

and conditions of the Agreement shall remain unchanged except as modified by this Third Agreement and the terms of the Agreement, as modified by this Third Amendment, are hereby ratified and confirmed. Where the terms of the Agreement conflict with those of this Third Amendment, however, the terms of this Third Amendment shall control. This Third Amendment may be executed by electronic copy or facsimile and in two (2) or more counterparts, each of which shall be deemed an original and all of which together shall constitute but one and the same instrument.

Termination of this Amendment.  If this Amendment is not signed within fifteen (15) business days after receipt, then the amendment and its terms shall become null and void. Also, if the total payment of fifty two thousand dollars ($52,000) is not received by August 30, 2013, then the Amendment and its terms shall become null and void.

NOTICES, PAYMENT, AND OTHER COMMUNICATIONS

Any payment, notice or other communication required or permitted to be made or given to either Party hereto pursuant to this Agreement shall be sufficiently made or given on the date of mailing if sent to such Party by certified United States Postal Service Express Mail, or by utilizing an express courier service (such as Federal Express, DHL, etc.), addressed to it at the address set forth below, or to such other address as the recipient shall have designated by written notice given to the other Party as follows:

In the Case of SCRF:

South Carolina Research Foundation

Technology Commercialization Office

901 Sumter St., Suite 512

Columbia, South Carolina 29208

Attn: Director

In the Case of NephroGenex:

Bob Peterson

Vice President of Operations

NephroGenex, Inc.

4401 Research Commons Building, Suite 290

79 T.W. Alexander Drive

P.O. Box 14188

Research Triangle Park, NC ###-###-####

Office: (609) 986-1788

Cell: (609) 216-3045

***@***

Payments may be made by wire transfer rather than by certified mail. If payment is made by wire transfer, written notice that payment was made by wire transfer must be made in accordance with the provisions of the above paragraph. Wire transfers should be made to the following account:

Name on Account:

Account Number:

Routing Number:

IN WITNESS WHEREOF this Amendment has been executed as of the Amendment Effective Date by the parties hereto by their respective duly authorized representatives.