SIGNALGENETICS, INC. STOCK OPTION GRANT AGREEMENT UNDER THE 2014 STOCK INCENTIVE PLAN

Exhibit 10.25

Grant No.     

SIGNAL GENETICS, INC.

STOCK OPTION GRANT AGREEMENT

UNDER THE 2014 STOCK INCENTIVE PLAN

This Stock Option Grant Agreement (this “Grant Agreement”), is made and entered into as of the date of grant set forth below (the “Date of Grant”) by and between Signal Genetics, Inc., a Delaware corporation (the “Company”), and the participant named below (the “Participant”), pursuant to the Signal Genetics, Inc. 2014 Stock Incentive Plan (the “Plan”). Capitalized terms not defined herein have the meanings ascribed to them in the Plan. Where the context permits, references to the Company include any successor to the Company.

Vesting Schedule:

1. Grant of Options. The Company hereby grants to the Participant an option (the “Option”) to purchase the total number of shares of Common Stock set forth above (the “Shares”) at the Exercise Price Per Share set forth above, which may not be less than the Fair Market Value of the Common Stock on the Date of Grant (the “Exercise Price”), subject to all of the terms and conditions of this Grant Agreement and the Plan. The term of the Option commences on the Date of Grant above and, unless previously terminated as described in this Grant Agreement, terminates on the Expiration Date set forth above.

2. Vesting and Exercisability.

(a) Subject to the provisions of Sections 2(b) and (c), this Option Award will vest and become exercisable in accordance with the vesting schedule set forth above, if the Participant remains in continuous service with the Company as of each applicable vesting date (each, a “Vesting Date”) and has not received a notice of termination from the Company prior to such Vesting Date.

(b) Upon a Change of Control that occurs following the Date of Grant while the Participant remains in continuous service with the Company, the Participant shall become fully vested in all Options remaining unvested as of such date.

(c) If a Participant’s service to the Company is terminated for Cause at any time, all

of such Participant’s rights to exercise the Option (whether vested or unvested) shall terminate on the date of such termination of service and this Grant Agreement will be of no further force or effect.

(d) For purposes of this Grant Agreement, “Cause” shall have the meaning ascribed to such term in any employment agreement between Participant and the Company, or, if no such agreement exists, then “Cause” shall mean: (i) a material breach by the Participant of his or her fiduciary or other duties to the Company; (ii) a material breach or violation by the Participant of the terms of this Grant Agreement or any other agreement between the Participant and the Company, or of any of the Company’s policies, practices, or procedures, which remains uncured for a period of 30 days following the Participant’s receipt of written notice specifying the nature of the breach or violation, or, where such breach or violation is not subject to or capable of cure, effective immediately; (iii) the commission by the Participant of any act of embezzlement, fraud, larceny or theft on or from the Company; (iv) substantial and continuing willful neglect or inattention by the Participant of the duties of his or her employment or other service, refusal to perform the lawful and reasonable directives of superiors, or the willful misconduct or gross negligence of the Participant in connection with the performance of such duties which remain uncured for a period of 30 days following the Participant’s receipt of written notice specifying the nature of the misconduct, or, where such misconduct is not subject to or capable of cure, effective immediately; (v) the commission by the Participant of any crime involving moral turpitude or a felony; or (vi) the Participant’s performance or omission of any act which, in the judgment of the Company, if known to the customers, clients, stockholders or any regulators of the Company, would have a material adverse impact on the business of the Company.

3. Exercise of Option. The Option may be exercised only to the extent it has become vested and exercisable pursuant to Paragraph 2 above, and then such vested and exercisable portion may be exercised in whole or in part, at any time, by delivery of a notice of exercise and payment of the exercise price in accordance with the terms of the Plan and in the manner specified by the Administrator. The exercise price shall be equal to the Exercise Price Per Share set forth above, multiplied by the number of Shares with respect to which the Option is being exercised. The Option must be exercised, if at all, on or prior to the earlier of:

(a) three (3) months following the Participant’s termination of service for any reason (other than Cause); and

(b) the Expiration Date;

and if not exercised prior thereto, shall terminate and no longer be exercisable. Any unvested portion of the Option shall terminate immediately upon the Participant’s termination from service. Upon the Participant’s termination from service by the Company for Cause, the Option, whether vested or unvested, shall immediately terminate and be forfeited, and shall not be exercisable.

4. Nontransferability. The Option Award issued pursuant to this Grant Agreement may not be assigned, transferred, hypothecated, or encumbered, in whole or in part, either directly or by operation of law or otherwise including, but not limited to, by execution, levy, garnishment, attachment, pledge, bankruptcy, or in any other manner, except transfer by will or by the laws of descent and distribution. All rights with respect to the Option shall be exercisable during the Participant’s lifetime only by the Participant or the Participant’s guardian or legal representative.

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5. No Stockholder Rights Prior to Issuance. The Participant shall have no rights as a stockholder of the Company with respect to any Shares underlying this Option Award until the Option is validly exercised and Shares are issued (as evidenced by the appropriate entry on the books of the Company or a duly authorized transfer agent of the Company). Unless otherwise required by the Plan, no adjustment shall be made for dividends, distributions, or other rights for which the record date is prior to the date, if any, that the Option is exercised and the Shares are issued.

6. No Employment or Other Rights. Nothing in the Plan or this Grant Agreement confers upon the Participant any right to continue in the employ or service of the Company or any Affiliate or will interfere with or restrict the right of the Company (or of an Affiliate) to terminate the Participant’s employment or services at any time and for any reason whatsoever, with or without Cause. Participation in the Plan is voluntary. The grant of this Option Award does not create any contractual or other right to receive any subsequent Award under the Plan; future grants, if any, will be at the sole discretion of the Company. Further, the value of the Option Award is an extraordinary item of compensation, which is not part of the Participant’s normal or expected compensation for purposes of any benefit plan or program of the Company or any Affiliate (unless such plan or program specifically provides otherwise).

7. Tax Withholding. The Company is entitled to require a cash payment by or on behalf of the Participant and/or to withhold an appropriate number of Shares from any Option exercised hereunder and/or to deduct from other compensation payable to the Participant to satisfy any sums required by federal, state, or local tax law to be withheld or to satisfy any applicable payroll deductions with respect to the grant, vesting, or exercise of the Option. The Company may refuse to deliver Shares or permit exercise of the Option to the extent the Participant fails to make appropriate accommodation for his or her tax obligations.

8. No Compensation Deferral. This Option Award is not intended to constitute “nonqualified deferred compensation” within the meaning of Section 409A of the Code. The Exercise Price Per Share of the Option shall not be less than the Fair Market Value of the Common Stock on the Date of Grant.

9. Incentive Stock Option Provisions. If, and only if, this Option Award is designated as an incentive stock option in this Grant Agreement, the following provisions apply: This Option is intended to qualify as an “incentive stock option” as defined in Section 422 of the Code to the extent permitted under applicable law. Accordingly, the Participant understands that in order to obtain the benefits of an incentive stock option under Section 422 of the Code, no sale or other disposition may be made of Shares for which incentive stock option treatment is desired within the one year period beginning on the day after the day of the transfer of such Shares to him or her, nor within the two year period beginning on the Date of Grant, and all other requirements of Section 422 of the Code must be satisfied. If the Participant disposes of any such Shares (whether by sale, gift, transfer or otherwise) within either of these periods, he or she must notify the Company within 30 days. The Participant also agrees to provide the Company with any information concerning any such dispositions required by the Company for tax purposes. Further, to the extent that this Option together with any other incentive stock options of the Participant vest in any year having an aggregate Fair Market Value in excess of $100,000 (determined as of the Grant Date), such options will not qualify as incentive stock options.

10. Notices. Any document relating to participation in the Plan or any notice required or permitted hereunder shall be given in writing and shall be deemed effectively given upon personal delivery or upon deposit in the U.S. Post Office or foreign postal service, by registered or certified mail, or with a nationally recognized overnight courier service, with postage and fees prepaid, addressed to the other party at the address of such party set forth in this Grant Agreement or at such other address as such party may designate in writing from time to time to the other party. The Company may, in its sole discretion, decide to deliver any documents related to current or future participation in the Plan by electronic means or request the Participant’s consent to participate in the Plan by electronic means. The Participant hereby consents to receive such documents by electronic delivery and agrees to participate in the Plan through any online or electronic system established and maintained

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by the Company or another third party designated by the Company.

11. Tax and Legal Advice. The Participant acknowledges that he or she has had the opportunity to seek the advice of counsel and other personal advisers, and that the Company has provided no advice to, or made any warranties or representations with respect to, the tax consequences of the transactions contemplated by this Grant Agreement or the economic or other impacts to the Participant of the arrangements contemplated hereby. The Participant is in no respect relying on the Company or its representatives for an assessment of such tax, legal, economic, or other consequences. Without limiting the generality of the foregoing, if the Option is designated as an “incentive stock option” in this Grant Agreement, such designation is not a representation or warranty by the Company or the Administrator that the Option qualifies as such, either at the time of grant or upon exercise thereof, or that the Participant is entitled to any particular tax treatment in connection with the exercise of the Option or subsequent disposition of such Shares.

12. Participant Restrictive Covenants. By accepting this Award, the Participant hereby agrees as follows:

(a) Confidentiality. The Participant recognizes and acknowledges that the Participant will have access to Confidential Information (as defined below) relating to the business or interests of the Company or of persons with whom the Company may have business relationships. Except as permitted herein or as may be approved by the Company from time to time, the Participant will not use or disclose to any other person or entity, any Confidential Information of the Company (except as required by applicable law or in connection with performance of the Participant’s duties and responsibilities hereunder or to Participant’s legal and financial advisors so long as such advisors agree to be bound by the terms and conditions of this Paragraph 12(a)). The Participant shall disclose the existence of the obligations under this Paragraph 12(a) to future employers. If the Participant is requested or becomes legally compelled to disclose any Confidential Information, if permitted by applicable law, the Participant will give prompt notice of such request or legal compulsion to the Company. The Company may waive compliance with this Paragraph 12(a) or will provide Participant with legal counsel at no cost to the Participant to seek an appropriate remedy; provided however the Participant may disclose any Confidential Information in the event, notwithstanding all such efforts, the Participant is compelled by court order to do so. Notwithstanding the foregoing, nothing in this Paragraph shall be construed as, or shall interfere with, abridge, limit, restrain, or restrict the Participant’s right to: (i) engage in any activity or conduct protected by Section 7 or any other provision of the National Labor Relations Act; or (ii) communicate with any federal, state, or local government agency charged with the enforcement and/or investigation of claims of discrimination, harassment, retaliation, improper wage payments, or any other unlawful employment practices under federal, state, or local law, or to file a charge, claim, or complaint with, or participate in or cooperate with any investigation or proceeding conducted by, any such agency.

(b) Return of Company Materials. The Participant agrees to return all Company Materials (as defined below), including copies thereof, upon termination of the Participant’s service with the Company, and/or upon the written request of the Company.

(c) Intellectual Property; Work for Hire.

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(d) Non-Solicitation. The Participant acknowledges that the Company has invested substantial time, money and resources in the development and retention of its Confidential Information (including trade secrets), customers, patients, accounts and business partners, and further acknowledges that, during the course of the Participant’s service to the Company, the Participant will have access to the Company’s Confidential Information (including trade secrets), and will be introduced to existing and prospective customers and patients, vendors, accounts and business partners of the Company. The Participant acknowledges and agrees that any and all “goodwill” associated with any existing or prospective customer or patient, vendor, account or business partner belongs exclusively to the Company, including, but not limited to, any goodwill created as a result of direct or indirect contacts or relationships between the Participant and any existing or prospective customers or patients, vendors, accounts or business partners. Additionally, the Parties acknowledge and agree that the Participant possesses skills that are special, unique or extraordinary and that the value of the Company depends upon the Participant’s use of such skills on its behalf. The Participant acknowledges that as a result of the foregoing the restrictions contained herein and elsewhere Paragraph 12 are reasonably necessary to protect the Company from unfair competition by the Participant. Accordingly, the Participant covenants and agrees that: (i) during the Participant’s service with the Company and for one year thereafter, the Participant may not directly or indirectly induce, attempt to induce, solicit, attempt to solicit or encourage any employee, consultant, or contractor to leave the employment or engagement with the Company or any Affiliate; and (ii) during the Participant’s service with the Company, the Participant may not divert or take advantage of any actual or potential business opportunities of the Company in which it has a current interest or is actively pursuing.

(e) Non-Disparagement. The Participant hereby agrees that during the Participant’s service to the Company and at all times thereafter, the Participant shall not make any public statement, or engage in any conduct, that is disparaging, derogatory, or otherwise is a negative or false statement about the Company or about any of its executives, officers, directors, or shareholders, including, but not limited to, any statement that disparages the products, services, finances, financial condition, capabilities or any other aspect of the business of the Company. Notwithstanding any term to the contrary herein, the Participant shall not be in breach of this Paragraph 12(e) for the making of truthful statements under oath or in a judicial or other proceeding.

(f) Definitions.

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13. Grant Agreement Subject to Plan; Acceptance. This Grant Agreement is made pursuant to all of the provisions of the Plan, which is incorporated herein by this reference, and is intended, and shall be interpreted in a manner to comply therewith. In the event of any conflict between the provisions of this Grant Agreement and the provisions of the Plan, the provisions of the Plan govern. By accepting this Award, the Participant: (a) acknowledges receipt of and represents that the Participant has read and is familiar with this Grant Agreement, the Plan, and a prospectus for the Plan prepared in connection with the registration of the Common Stock to be issued pursuant to the Plan with the Securities and Exchange Commission, (b) acknowledges that this Option Award is subject to all of the terms and conditions of this Grant Agreement and the Plan, and (c) agrees to accept as binding, conclusive, and final all decisions or interpretations of the Administrator on any questions arising under the Grant Agreement or the Plan.

[Signature Page Follows]

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IN WITNESS WHEREOF, the parties have executed this Grant Agreement as of the date first written above.