Amendment No. 4 to Agreement Between Bayer AG and Millennium Pharmaceuticals, Inc.

Summary

Bayer AG and Millennium Pharmaceuticals, Inc. have agreed to amend their original agreement, first signed in 1998, by updating the payment schedule outlined in Exhibit D. This amendment, effective December 1, 2000, replaces the previous payment schedule with a new one specifying revised payment dates and amounts. All other terms of the original agreement remain unchanged and in effect. The amendment is signed by authorized representatives of both companies.

EX-10.14 5 a2040039zex-10_14.txt EXHIBIT 10.14 Exhibit 10.14 Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. AMENDMENT NO. 4 to AGREEMENT by and between BAYER AG AND MILLENNIUM PHARMACEUTICALS, INC. This is Amendment No. 4, dated as of December 1, 2000 ("Amendment No. 4"), to the Agreement, dated as of September 22, 1998 and as subsequently amended (the "Agreement"), by and between Bayer AG, located at D 51368 Leverkusen, Germany and Millennium Pharmaceuticals, Inc., located at 75 Sidney Street, Cambridge, Massachusetts 02139. INTRODUCTION The Parties have determined that it is in their mutual best interests to amend the Agreement in the manner set forth below. Accordingly, in accordance with Section 11.5 of the Agreement, the Parties agree to amend the Agreement as follows: 1. Use of Terms. Capitalized terms used herein and not defined herein shall have the respective meanings ascribed to such terms in the Agreement. 2. Exhibit D. Exhibit D of the Agreement is hereby amended by deleting Exhibit D in its entirety and by substituting the following in its place: Program Payment Schedule Date Payment Due ---- ----------- February 1, 1999 $[**] May 1, 1999 $[**] August 1, 1999 $[**] November 1, 1999 $[**] December 1, 1999 $[**] February 1, 2000 $[**] May 1, 2000 $[**] August 1, 2000 $[**] Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. November 1, 2000 $[**] December 8, 2000 $[**] February 1, 2001 $[**] May 1, 2001 $[**] August 1, 2001 $[**] November 1, 2001 $[**] February 1, 2002 $[**] May 1, 2002 $[**] August 1, 2002 $[**] November 1, 2002 $[**] February 1, 2003 $[**] May 1, 2003 $[**] August 1, 2003 $[**] 2. General. In all other respects, the Agreement is hereby ratified and confirmed. IN WITNESS WHEREOF, the Parties have executed this Amendment No. 4 as of the date set forth above. BAYER AG By: /s/ WOLFGANG HARTWIG ----------------------------- Title: Prof. Dr. Wolfgang Hartwig By: /s/ HELMUT PASTOR ----------------------------- Title: Senior Counsel MILLENNIUM PHARMACEUTICALS, INC. By: /s/ KEVIN STARR ----------------------------- Title: Chief Financial Officer -2-