Agreement and Plan of Merger by and between Metagenomi Technologies, LLC and Metagenomi, Inc., dated January 24, 2024

Exhibit 2.1

AGREEMENT AND PLAN OF MERGER

This Agreement and Plan of Merger (this “Agreement”) is entered into as of January 24, 2024, by and among Metagenomi Technologies, LLC a Delaware limited liability company (the “Parent”) and Metagenomi, Inc., a Delaware corporation and wholly owned subsidiary of Parent (the “Company”).

RECITALS

WHEREAS, the Parent is a limited liability company duly organized and validly existing under the laws of the State of Delaware, with (i) 15,417,788 common units issued and outstanding (the “Common Units”) and (ii) 41,813,375 preferred units issued and outstanding (the “Preferred Units”, and together with the Common Units, the “Parent Units”).

WHEREAS, the Company is a corporation duly formed and validly existing under the laws of the State of Delaware, with all of its issued and outstanding shares of capital stock owned by the Parent; and

WHEREAS, in connection with the contemplated initial public offering, the Parent and the Company have determined that the merger (the “Merger”) of the Parent with and into the Company upon the terms and conditions set forth in this Agreement is advisable, and have approved and adopted this Agreement.

AGREEMENT

NOW, THEREFORE, in consideration of the premises and upon the terms and conditions set forth in this Agreement, the Parent and the Company agree as follows:

ARTICLE I

THE MERGER

1.1 Merger. In accordance with the provisions of this Agreement, the Delaware General Corporation Law (the “DGCL”) and the Delaware Limited Liability Company Act (“DLLCA”), at the Effective Time (as defined below), the Parent will be merged with and into the Company, the Parent’s separate existence will cease and the Company will be the surviving corporation in the Merger. The Company as the surviving corporation after the Merger is herein sometimes referred to as the “Surviving Corporation.”

1.2 Filings and Effectiveness. As promptly as practicable following the date of this Agreement, the parties will cause a Certificate of Ownership and Merger (the “Certificate of Ownership and Merger”) in substantially the form of Exhibit A hereto, meeting the requirements of Section 267 of the DGCL and Section 18-209(i) of the DLLCA, to be executed and filed with the Secretary of State of the State of Delaware. The Merger will become effective upon the filing of the Certificate of Ownership and Merger with the Secretary of State of the State of Delaware (the “Effective Time”).

1.3 Effect of the Merger.

(a) General. At the Effective Time, all of the property, rights, privileges, powers and franchises of the Parent and the Company shall vest in the Surviving Corporation, and all debts, liabilities and duties of the Parent and the Company shall become the debts, liabilities and duties of the Surviving Corporation.

(b) Certificate of Incorporation and Bylaws. The Company’s certificate of incorporation as in effect immediately prior to the Effective Time, in the form attached hereto as Exhibit B, will be the Surviving Corporation’s certificate of incorporation until thereafter amended in accordance with the provisions thereof and applicable law. The Company’s bylaws as in effect immediately prior to the Effective Time, in the form attached hereto as Exhibit C, will be the Surviving Corporation’s bylaws until thereafter amended in accordance with the provisions thereof and applicable law.

(c) Directors and Officers. The directors and officers of the Parent immediately prior to the Effective Time shall be the directors and officers of the Surviving Corporation immediately after the Effective Time, each to hold such office in accordance with the provisions of the certificate of incorporation and bylaws of the Surviving Corporation.

(d) Effect on Parent Units and Company Stock. At and as of the Effective Time, without any action on the part of the Parent or the Company, as the case may be, or of any holder of any Parent Units or shares of capital stock of or other equity interest in the Company, (i) the Common Stock issued by the Company to the Parent shall be cancelled and no payment shall be made with respect thereto and (ii) the Parent Units shall be converted on a pro rata basis in accordance with Schedule I of this Agreement (the “Conversion Methodology”).

ARTICLE 2

MISCELLANEOUS PROVISIONS

2.1 Further Assurances. Prior to the Effective Time, the Parent and the Company shall take all such action as shall be necessary or appropriate to effect the Merger. If, at any time after the Effective Time, any such further action is necessary or desirable to carry out the purposes of this Agreement and to vest the Surviving Corporation with full right, title and possession to all assets, property, rights, privileges, powers, and franchises of the Company and the Parent, the officers and directors of the Surviving Corporation are fully authorized, in the name of and on behalf of the Company and the Parent, to take, and the Parent and the Company will cause them to take, all such lawful and necessary action.

2.2 Termination. The Parent and the Company, by written agreement, may terminate this Agreement, and the Merger may be abandoned by the Parent and the Company for any reason whatsoever, at any time prior to the Effective Time.

2.3 No Third Party Beneficiaries. There are no third party beneficiaries having rights under or with respect to this Agreement.

2.4 Governing Law. This Agreement will be governed by and construed in accordance with the laws of the State of Delaware, without giving effect to any choice of law principles.

2.5 Amendments. This Agreement may not be amended or modified except by a writing signed by all of the parties.

2.6 Entire Agreement. This Agreement, together with the Exhibits hereto, constitutes the entire agreement and understanding of the parties in respect of its subject matter and supersedes all prior understandings, agreements or representations by or among the parties, written or oral, to the extent they relate in any way to the subject matter hereof.

2.7 Severability. Any provision of this Agreement that is invalid or unenforceable in any jurisdiction shall be ineffective to the extent of such invalidity or unenforceability without invalidating or rendering unenforceable the remaining provisions hereof, and any such invalidity or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction.

2.8 Successors and Assigns. This Agreement shall be binding upon each of the parties hereto and each of their respective successors and assigns, if any. This agreement shall inure to the benefit of the Parent, the Company and their respective successors and assigns, if any.

2.9 Counterparts. This Agreement may be executed electronically and in any number of counterparts, each of which will be deemed to be an original and all of which together will constitute one and the same instrument.

[Signature Page Follows]

IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above written.

[Signature Page to the Agreement and Plan of Merger]

EXHIBIT A

CERTIFICATE OF OWNERSHIP AND MERGER

MERGING

METAGENOMI TECHNOLOGIES, LLC

a Delaware limited liability company

WITH AND INTO

METAGENOMI, INC.

a Delaware corporation