EMPLOYMENTAGREEMENT

Exhibit 10.35

EMPLOYMENT AGREEMENT

THIS EMPLOYMENT AGREEMENT (the “Agreement”) is made and entered into effective as of July 22, 2004, by and between Maxim Pharmaceuticals, Inc., (the “Company”), and Richard A. Mafrica (“Executive”).  The Company and Executive are hereinafter collectively referred to as the “Parties,” and individually referred to as a “Party.”

RECITALS

A.                                    The Company desires assurance of the association and services of Executive in order to retain Executive’s experience, skills, abilities, background and knowledge, and is willing to engage Executive’s services on the terms and conditions set forth in this Agreement.

B.                                    Executive desires to be in the employ of the Company, and is willing to accept such employment on the terms and conditions set forth in this Agreement.

AGREEMENT

In consideration of the foregoing recitals and the mutual promises and covenants herein contained, and for other good and valuable consideration, the Parties, intending to be legally bound, agree as follows:

1.                                       EMPLOYMENT.

1.1                                 The Company hereby employs Executive, and Executive hereby accepts continued employment by the Company, upon the terms and conditions set forth in this Agreement, effective as of the date first set forth above (“Commencement Date”).  This Agreement shall continue in effect until terminated pursuant to Section 5 below.

1.2                                 Executive shall be the Vice-President, Commercial Affairs of the Company (or a position of at least comparable status) and shall serve in such other capacity or capacities as the Chief Executive Officer and/or the Company’s Board of Directors (“Board”) may from time to time prescribe.

1.3                                 Executive shall do and perform all services, acts or things necessary or advisable to manage and conduct the business of the Company, which are (i) consistent with the Bylaws of the Company and (ii) subject to the direction and policies from time to time established by the Board and/or the Chief Executive Officer.

1.4                                 Unless the Parties otherwise agree in writing, during the term of this Agreement, Executive shall perform the services he is required to perform pursuant to this Agreement at the Company’s offices, located at 8899 University Center Lane, Suite 400 or at any other place at which the Company maintains an office; provided, however, that the Company may from time to time require Executive to travel temporarily to other locations in connection with the Company’s business.

2.                                       LOYAL AND CONSCIENTIOUS PERFORMANCE; NONCOMPETITION.

2.1                                 During his employment by the Company, Executive shall devote his full business energies, interest, abilities and productive time to the proper and efficient performance of his duties under this Agreement.

2.2                                 During the term of this Agreement, Executive shall not engage in competition with the Company, either directly or indirectly, in any manner or capacity, as adviser, principal, agent, partner, officer, director, employee, member of any association or otherwise, in any phase of the business of developing, manufacturing and marketing of products which are in the same field of use or which otherwise compete with the products or proposed products of the Company.

2.3                                 Ownership by Executive, as a passive investment, of less than one percent (1%) of the outstanding shares of capital stock of any corporation with one or more classes of its capital stock listed on a national securities exchange or publicly traded in the over-the-counter market shall not constitute a breach of this paragraph.

3.                                       COMPENSATION OF EXECUTIVE.

3.1                                 While employed by the Company, as compensation for proper and satisfactory performance of all duties to be performed hereunder, the Company shall pay Executive an annual base salary of Two Hundred Eighty Thousand Dollars, $280,000 per year (the “Base Salary”), payable in regular periodic payments in accordance with Company policy.  Such salary shall be prorated for any partial year of employment on the basis of a 365-day fiscal year.  In addition, Executive will be eligible for an incentive bonus of up to 25% of base salary, based upon defined milestones.

3.2                                 Executive’s compensation may be changed from time to time by mutual agreement of Executive and the Board.

3.3                                 All of Executive’s compensation shall be subject to customary withholding taxes and any other employment taxes as are commonly required to be collected or withheld by the Company.

3.4                                 Executive shall be entitled to vacation and illness days consistent with the Company’s standard practice for its employees generally.

3.5                                 Executive shall, at the discretion of the Board, be entitled to participate in the benefits for which he is eligible under the terms and conditions of the standard Company benefits which may be in effect from time to time and provided by the Company.

4.                                       EXPENSE REIMBURSEMENT.

4.1                                 Executive shall be entitled to receive prompt reimbursement of all reasonable business and travel expenses incurred by Executive in connection with the business of the Company.  Such expenses must be properly accounted for under the policies and procedures established by the Company.

5.                                       TERMINATION.

5.1                                 The Company may terminate Executive’s employment under this Agreement “for cause” by delivery of written notice to Executive specifying the cause or causes relied upon for such termination.  Any notice of termination delivered pursuant to this Section 5.1 shall effect

2

termination as of the date specified in such notice or, in the event no such date is specified, on the last day of the month in which such notice is delivered or deemed delivered as provided in Section 9 below.  If Executive’s employment under this Agreement is terminated by the Company for cause under this section, Executive shall be entitled to receive only accrued Base Salary and other accrued benefits required by law, prorated to the date of termination.  Executive will not be entitled to severance pay, pay in lieu of notice or any other such compensation.  Grounds for the Company to terminate this Agreement “for cause” shall be limited to the occurrence of any of the following events:

5.1.1                        Executive’s material breach of any provision of this Agreement;

5.1.2                        Executive’s engaging or in any manner participating in any activity which is competitive with or intentionally injurious to the Company or which violates any provision of Section 7 of this Agreement;

5.1.3                        Executive’s commission of any fraud against the Company or use or appropriation for his personal use or benefit of any funds or properties of the Company;

5.1.4                        Executive’s conviction of any crime involving dishonesty or moral turpitude;

5.1.5                        Conduct by Executive which in good faith and reasonable determination of the Board demonstrates gross unfitness to serve.

Any notice of termination given pursuant to this Section 5.1 shall effect termination as of the date specified in such notice or, in the event no such date is specified, on the last day of the month in which such notice is delivered or deemed delivered as provided in Section 9 below.

5.2                                 The Company may terminate the Executive’s employment at any time without cause upon delivery of written notice to the Executive.  Any notice of termination given pursuant to this Section 5.2 shall effect termination as of the date specified in such notice or, in the event no such date is specified, on the last day of the month in which such notice is delivered or deemed delivered as provided in Section 9 below.  If such termination shall occur under this Section 5.2, then in lieu of all other remedies, and upon the Executive’s furnishing to the Company an effective waiver and release of claims (in a form acceptable to the Company), Executive shall be entitled to continuation of Base Salary and health benefits for a period of six (6) months from said date of termination with such Base Salary continuation to be at the rate set forth in Section 3.1 or, if greater, at the rate of Executive’s then current salary in effect as of the date of termination.

5.3                                 The parties may mutually agree at any time to terminate this Agreement upon such terms and conditions as may be agreed upon in writing.

5.4                                 This Agreement shall terminate without notice upon the date of Executive’s death or the date when Executive becomes “completely disabled” as that term is defined in Section 6.2.  In the event of termination due to death or complete disability, Executive or his estate or personal representative, as the case may be, shall be entitled to receive only accrued Base Salary and other accrued benefits required by law, prorated to the date of Executive’s death or the date when Executive becomes completely disabled.

5.5                                 Notwithstanding any provision to the contrary herein, unless otherwise provided herein or unless otherwise provided by law, Executive may at any time terminate his employment with the Company hereunder.  In such event, the Company shall not be liable to Executive for the

3

payment of any amount other than accrued Base Salary and other accrued benefits required by law, prorated to the date of termination.  The effective date of termination of Executive’s employment under this Section 5.5 shall be determined by the Board upon its receipt of notice of such termination.  Executive will not be entitled to severance pay, pay in lieu of notice or any other such compensation.

6.                                       DEATH OR DISABILITY DURING TERM OF EMPLOYMENT.

6.1                                 Upon termination of Executive’s employment pursuant to Section 5.4, Executive or his estate or personal representative, as the case may be, shall be entitled to receive Executive’s Base Salary and benefits for a period of one month following the date of death or the date when Executive becomes completely disabled.

6.2                                 The term “completely disabled” as used in this Agreement shall mean the inability of Executive to perform the essential functions of his position under this Agreement by reason of any incapacity, physical or mental, which the Board of the Company, based upon medical advice or an opinion provided by a licensed physician acceptable to the Board of the Company and approved by the Executive, which approval shall not be unreasonably withheld, determines to have incapacitated Executive from satisfactorily performing any or all essential functions of his position for the Company during the foreseeable future.  Based upon such medical advice or opinion, the determination of the Board of the Company shall be final and binding and the date such determination is made shall be the date of such complete disability for purposes of this Agreement.

7.                                       CONFIDENTIAL INFORMATION; NONSOLICITATION.

7.1                                 Executive recognizes that his employment with the Company will involve contact with information of substantial value to the Company, which is not generally known in the trade, and which gives the Company an advantage over its competitors who do not know or use it, including but not limited to, techniques, designs, drawings, processes, inventions, developments, equipment, prototypes, sales and customer information, and business and financial information relating to the business, products, practices and techniques of the Company (hereinafter referred to as “Confidential Information”).  Executive will at all times regard and preserve as confidential such Confidential Information obtained by Executive from whatever source and will not, either during his employment with the Company or thereafter, publish or disclose any part of such Confidential Information in any manner at any time, or use the same except on behalf of the Company, without the prior written consent of the Company.  As a condition of this Agreement, Executive will sign and return a copy of the Company’s “Proprietary Information and Inventions Agreement,” attached as Exhibit A.

7.2                                 While employed by the Company and for one (1) year thereafter, the Executive agrees that in order to protect the Company’s confidential and proprietary information from unauthorized use, that Executive will not, either directly or through others, solicit or attempt to solicit any employee, consultant or independent contractor of the Company to terminate his or her relationship with the Company in order to become an employee, consultant or independent contractor to or for any other person or business entity; or the business of any customer, vendor or distributor of the Company which, at the time of termination or one (1) year immediately prior thereto, was listed on Company’s customer, vendor or distributor list.

4

8.                                       ASSIGNMENT AND BINDING EFFECT.

8.1                                 This Agreement shall be binding upon and inure to the benefit of Executive and Executive’s heirs, executors, personal representatives, assigns, administrators and legal representatives.  Because of the unique and personal nature of Executive’s duties under this Agreement, neither this Agreement nor any rights or obligations under this Agreement shall be assignable by Executive.  This Agreement shall be binding upon and inure to the benefit of the Company and its successors, assigns and legal representatives.

9.                                       NOTICES.

9.1                                 All notices or demands of any kind required or permitted to be given by the Company or Executive under this Agreement shall be given in writing and shall be personally delivered (and receipted for) or mailed by certified mail, return receipt requested, postage prepaid, addressed as follows:

Any such written notice shall be deemed received when personally delivered or three (3) days after its deposit in the United States mail as specified above.  Either Party may change its address for notices by giving notice to the other Party in the manner specified in this section.

10.                                 CHOICE OF LAW.

10.1                           This Agreement is made in San Diego, California.  This Agreement shall be construed and interpreted in accordance with the laws of the State of California.

11.                                 INTEGRATION.

11.1                           This Agreement contains the complete, final and exclusive agreement of the Parties relating to the subject matter of this Agreement, and supersedes all prior oral and written employment agreements or arrangements between the Parties.

12.                                 AMENDMENT.

12.1                           This Agreement cannot be amended or modified except by a written agreement signed by Executive and the Company.

5

13.                                 WAIVER.

13.1                           No term, covenant or condition of this Agreement or any breach thereof shall be deemed waived, except with the written consent of the Party against whom the wavier is claimed, and any waiver or any such term, covenant, condition or breach shall not be deemed to be a waiver of any preceding or succeeding breach of the same or any other term, covenant, condition or breach.

14.                                 SEVERABILITY.

14.1                           The finding by a court of competent jurisdiction of the unenforceability, invalidity or illegality of any provision of this Agreement shall not render any other provision of this Agreement unenforceable, invalid or illegal.  Such court shall have the authority to modify or replace the invalid or unenforceable term or provision with a valid and enforceable term or provision which most accurately represents the parties’ intention with respect to the invalid or unenforceable term or provision.

15.                                 INTERPRETATION; CONSTRUCTION.

15.1                           The headings set forth in this Agreement are for convenience of reference only and shall not be used in interpreting this Agreement.  This Agreement has been drafted by legal counsel representing the Company, but Executive has been encouraged, and has consulted with, his own independent counsel and tax advisors with respect to the terms of this Agreement.  The Parties acknowledge that each Party and its counsel has reviewed and revised, or had an opportunity to review and revise, this Agreement, and the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of this Agreement.

16.                                 REPRESENTATIONS AND WARRANTIES.

16.1                           Executive represents and warrants that he is not restricted or prohibited, contractually or otherwise, from entering into and performing each of the terms and covenants contained in this Agreement, and that his execution and performance of this Agreement will not violate or breach any other agreements between Executive and any other person or entity.

17.                                 COUNTERPARTS.

17.1                           This Agreement may be executed in two counterparts, each of which shall be deemed an original, all of which together shall contribute one and the same instrument.

6

IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

7