Third Amendment to License Agreement, between CytoPherx, Inc. and the Regents of the University of Michigan, dated July 31, 2014

Exhibit 10.17

THIRD AMENDMENT TO LICENSE AGREEMENT

This amendment dated 31 July, 2014, is by and between Cytopherx (“LICENSEE”) and the Regents of the University of Michigan (“MICHIGAN”).

WHEREAS, Nephrion, now doing business as Cytopherx (“LICENSEE”) and MICHIGAN entered into a license agreement dated 16 October 2007, entered into a First Amendment 22 March 2011, and entered into a Second Amendment 8 August 2013 (collectively the “License Agreement”); and

WHEREAS, MICHIGAN and LICENSEE desire to modify certain provisions of the License Agreement as provided herein.

NOW THEREFORE, MICHIGAN and LICENSEE hereby agree as follows:

1. The annual minimum royalties due under Paragraph 4.3 for 2014 shall be deferred and paid in full with the 2015 Annual Fee. For clarity, in June 30, 2015, a total of $70,000 shall be due.

2. Patent costs owed by LICENSEE as of July 31, 2014 of $31,316.90 shall be payable in two installments of $15,658.45 on August 31, 2014 and September 30, 2014. All ongoing costs incurred by MICHIGAN after July 31, 2014 shall be paid according to Paragraph 7.3.

3. Except as specifically modified and amended above, all other terms and conditions of the License Agreement remain unchanged and in effect and are hereby ratified and adopted as though fully set forth herein.

IN WITNESS WHEREOF, the parties have entered into this Amendment to the Amended Agreement as of the date and year first above-written.

APPENDIX A: MICHIGAN FILES 37178

PATENT APPLICATIONS, ISSUED PATENTS AND MICHIGAN FILES

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