AMENDMENTNO. 3 TO MANAGEMENT SERVICES AGREEMENT BETWEENLIFE SCIENCES RESEARCH LIMITED AND FOCUSEDHEALTHCARE PARTNERS

Exhibit 10.1

AMENDMENT NO. 3 TO MANAGEMENT SERVICES AGREEMENT

BETWEEN LIFE SCIENCES RESEARCH LIMITED AND

FOCUSED HEALTHCARE PARTNERS

This Amendment No. 3, dated as of June 3, 2009 (the “Amendment”), to that certain Service Agreement, dated as of August 7, 1998 and amended as of January 26, 2000 and April 15, 2002, between Life Sciences Research Limited (the “Company”) and Focused Healthcare Partners (the “Consultant”) (the “Agreement”).  Capitalized terms used by not defined herein shall have the meanings ascribed to them in the Agreement.

In consideration of the promises and mutual covenants set forth herein and in the Agreement, the parties hereto agree as follows:

1.	The fee of the Consultant set forth in Section 5(1) of the Agreement shall be amended by deleting the words “£150,000 per annum” and replacing them with the words “£370,000 per annum.”

2.           The first paragraph of Section 18 is amended in its entirety to read as follows:

“If within twelve months following a Change of Control of Parent the Agreement is terminated by the Company without Cause or the Consultant gives notice of termination for Good Reason, then within 30 days after such termination or resignation the Company shall make a lump sum payment in cash to Consultant in an amount equal to (i) 2.99 times the Consultant’s then current annualized consulting fee plus (ii) 2.99 times any additional compensation (such as bonus or incentive compensation) earned by Executive or Consultant during the 12 months prior to such termination or resignation; provided, that, with respect to any distribution to the Consultant pursuant to the Company’s 2007 Long Term Incentive Plan (“LTIP”) during the 12 months prior to such termination or resignation, only one-third (1/3) of such LTIP distribution shall be considered ‘additional compensation’ for purposes of calculating the Consultant’s payment hereunder.”

3.	A new Section 19 is added to the Agreement as follows:

“In the event that any payments or benefits received or to be received by the Executive in connection with the Executive’s employment with the Company (or termination thereof or otherwise) would subject the Executive to the excise tax imposed under Section 4999 of the Internal Revenue Code of 1986, as amended (the “Excise Tax”), and if the net-after-tax amount (taking into account all applicable taxes payable by the Executive, including without limitation any Excise Tax) that the Executive would receive with respect to such payments or benefits does not exceed the net-after tax amount the Executive would receive if the amount of such payments and benefits were reduced to the maximum amount which could otherwise be payable to the Executive without the imposition of the Excise Tax, then, only to the extent necessary to eliminate the imposition of the Excise Tax, such payments and benefits shall be so reduced in the following order (i) cash payments and benefits shall first be reduced (if necessary, to zero) and (ii) all other non-cash payments and benefits shall next be reduced.”

4.	Except as specifically set forth and changed herein, the Agreement is reaffirmed and remains unchanged.

The parties hereto have executed and delivered this amendment as of the date first above written.

LIFE SCIENCES RESEARCH LIMITED

By:  ____________________________

Name:

Title:

FOCUSED HEALTHCARE PARTNERS

By:  ____________________________

Name:

Title: