LEXICON PHARMACEUTICALS, INC. Contracts & Agreements

Separation Agreement, dated September 13, 2024, with Jeffrey L. Wade (Filed With SEC on September 16, 2024)

Consulting Agreement, dated September 13, 2024, with Jeffrey L. Wade (Filed With SEC on September 16, 2024)

Offer Letter, dated July 3, 2024, with Michael Exton, Ph.D (Filed With SEC on July 8, 2024)

Sixth Amendment to Loan and Security Agreement, dated June 28, 2024, with Oxford Finance, LLC and the lenders listed therein (Filed With SEC on July 1, 2024)

Summary of Non-Employee Director Compensation (Filed With SEC on March 25, 2024)

Form of Restricted Stock Unit Agreement with Officers (Filed With SEC on March 25, 2024)

Preferred Stock Purchase Agreement, dated as of March 11, 2024, among Lexicon Pharmaceuticals, Inc. and the purchasers party thereto (Filed With SEC on March 11, 2024)

Fifth Amendment to Loan and Security Agreement, dated March 6, 2024, with Oxford Finance, LLC and the lenders listed therein (Filed With SEC on March 11, 2024)

Fourth Amendment to Loan and Security Agreement, dated December 29, 2023, with Oxford Finance, LLC and the lenders listed therein (Filed With SEC on December 29, 2023)

Open Market Sale AgreementSM, by and between Jefferies LLC and the Company, dated December 29, 2023 (Filed With SEC on December 29, 2023)

Third Amendment to Loan and Security Agreement, dated June 23, 2023, with Oxford Finance, LLC (Filed With SEC on June 28, 2023)

Underwriting Agreement, dated as of May 31, 2023, by and among Lexicon Pharmaceuticals, Inc. and Citigroup Global Markets Inc., Jefferies LLC and Piper Sandler & Co., as... (Filed With SEC on June 2, 2023)

Purchase Agreement, dated as of May 31, 2023, among Lexicon Pharmaceuticals, Inc. and Artal International S.C.A., Artal Group S.A., Artal International Management S.A., Invus... (Filed With SEC on June 2, 2023)

Second Amendment to Loan and Security Agreement, date May 1, 2023, with Oxford Finance, LLC (Filed With SEC on May 2, 2023)

2017 Equity Incentive Plan, as amended (Filed With SEC on April 27, 2023)

2017 Non-Employee Directors Equity Incentive Plan, as amended (Filed With SEC on April 27, 2023)

Form of Restricted Stock Unit Agreement (Filed With SEC on March 3, 2023)

First Amendment to Loan and Security Agreement, dated August 29, 2022, with Oxford Finance, LLC (Filed With SEC on September 2, 2022)

Underwriting Agreement, dated as of July 27, 2022, by and among Lexicon Pharmaceuticals, Inc. and Citigroup Global Markets Inc. and Piper Sandler & Co., as representatives of the... (Filed With SEC on July 29, 2022)

Purchase Agreement, dated as of July 27, 2022, among Lexicon Pharmaceuticals, Inc. and Artal International S.C.A., Artal Group S.A., Artal International Management S.A., Invus... (Filed With SEC on July 29, 2022)

Purchase Agreement, dated as of July 27, 2022, among Lexicon Pharmaceuticals, Inc. and Invus US Partners LLC (Filed With SEC on July 29, 2022)

Description of Common Stock (Filed With SEC on March 10, 2022)

Offer Letter (Filed With SEC on March 10, 2022)

Form of Restricted Stock Unit Agreement with Officers (Filed With SEC on March 10, 2022)

2017 Non-Employee Directors Equity Incentive Plan, as amended (Filed With SEC on May 3, 2021)

Description of Common Stock (Filed With SEC on March 12, 2021)

Release and Severance Agreement (Filed With SEC on March 12, 2021)

Sublease Agreement (Filed With SEC on February 12, 2021)

Supplement No. 3 to the Transaction Agreements (Filed With SEC on December 18, 2020)

Subscription Agreement (Filed With SEC on December 11, 2020)

Placement Agency Agreement (Filed With SEC on December 11, 2020)

Open Market Sale Agreement (Filed With SEC on October 30, 2020)

Real Estate Purchase and Sale Agreement, dated October 16, 2020, between Lex-Gen Woodlands, L.P. and Nurix Therapeutics, Inc (Filed With SEC on October 22, 2020)

Asset Purchase and Sale Agreement, dated July 29, 2020, by and between Lexicon Pharmaceuticals, Inc. and TerSera Therapeutics LLC (Filed With SEC on September 11, 2020)

First Amendment to (Filed With SEC on September 11, 2020)

Real Estate Purchase and Sale Agreement, dated July 10, 2020 (Filed With SEC on July 15, 2020)

First Amendment to Real Estate Purchase and Sale Agreement (Filed With SEC on April 27, 2020)

Second Amendment to Real Estate Purchase and Sale Agreement (Filed With SEC on April 27, 2020)

2017 Equity Incentive Plan, as amended (Filed With SEC on April 27, 2020)

2017 Equity Incentive Plan (Filed With SEC on March 12, 2020)

Form of Restricted Stock Unit Agreement with Officers (Filed With SEC on March 12, 2020)

Second Amendment (Filed With SEC on March 12, 2020)

Real Estate Purchase and Sale Agreement, dated January 10, 2020, between Lex-Gen Woodlands, L.P. and FFC Equity Holdings, L.P (Filed With SEC on January 16, 2020)

Confidential Termination and Settlement Agreement and Mutual Releases, dated September 9, 2019, with Sanofi-Aventis Deutschland GmbH (Filed With SEC on November 7, 2019)

Summary of Non-Employee Director Compensation (Filed With SEC on May 1, 2019)

Form of Notice of Stock Option Grant to Directors under the 2017 Non-Employee Directors Equity Incentive Plan (Filed With SEC on May 1, 2019)

Form of Notice of Restricted Stock Unit Grant to Directors under the 2017 Non-Employee Directors Equity Incentive Plan (Filed With SEC on May 1, 2019)

2017 Equity Incentive Plan, as amended (Filed With SEC on April 26, 2019)

Offer Letter (Filed With SEC on March 15, 2019)

2017 Non-Employee Directors Equity Incentive Plan (Filed With SEC on March 15, 2019)

Amendment One to Commercial Supply Agreement (Filed With SEC on March 15, 2019)

Amendment Two to Commercial Supply Agreement (Filed With SEC on March 15, 2019)

Term Loan and Security Agreement, dated as of August 30, 2018, between Lex-Gen Woodlands, L.P. and Revere Credit Opportunities Fund III, LP (Filed With SEC on September 4, 2018)

Seventh Amendment to Loan and Security Agreement and to Other Loan Documents, dated April 20, 2018, between Lex-Gen Woodlands, L.P. and iStar Lex Lender LLC (Filed With SEC on April 23, 2018)

Form of Stock Option Agreement with Officers (Filed With SEC on March 1, 2018)

Form of Restricted Stock Unit Agreement with Officers (Filed With SEC on March 1, 2018)

Form of Notice of Stock Option Grant to Directors (Filed With SEC on March 1, 2018)

Loan and Security Agreement, dated April 21, 2004, between Lex-Gen Woodlands, L.P. and iStar Financial Inc., as amended (Filed With SEC on March 1, 2018)

Loan Agreement, dated as of December 4, 2017, among Lexicon Pharmaceuticals, Inc., as Borrower, certain subsidiaries of the Borrower, as Guarantors, BioPharma Credit PLC, as... (Filed With SEC on December 5, 2017)

Amendment No. 1 to Collaboration and License Agreement, dated July 1, 2017, with Sanofi-Aventis Deutschland GmbH (Filed With SEC on November 8, 2017)

COMMERCIAL SUPPLY AGREEMENT (Telotristat Etiprate (LX-1606 Hippurate) immediate release compressed powder 250mg tablets (as free base)) (Filed With SEC on May 4, 2017)

LEXICON PHARMACEUTICALS, INC. 2017 EQUITY INCENTIVE PLAN (Filed With SEC on April 27, 2017)

LEXICON PHARMACEUTICALS, INC. 2017 NON-EMPLOYEE DIRECTORS EQUITY INCENTIVE PLAN (Filed With SEC on April 27, 2017)

Summary of Non-Employee Director Compensation (Filed With SEC on April 27, 2017)

SIXTH AMENDMENT TO LOAN AND SECURITY AGREEMENT AND TO OTHER LOAN DOCUMENTS (Filed With SEC on April 21, 2017)

LEXICON PHARMACEUTICALS, INC. EQUITY INCENTIVE PLAN (Filed With SEC on March 6, 2017)

LEXICON PHARMACEUTICALS, INC. NON-EMPLOYEE DIRECTORS EQUITY INCENTIVE PLAN (Filed With SEC on March 6, 2017)

RESTRICTED STOCK UNIT AGREEMENT (Officer Restricted Stock Unit) (Filed With SEC on March 6, 2017)

SECOND AMENDMENT TO COLLABORATION AND LICENSE AGREEMENT (Filed With SEC on November 7, 2016)

AMENDMENT NO. 1 TO AMENDED AND RESTATED PURCHASE OPTION AGREEMENT (Filed With SEC on October 5, 2016)

Summary of Non-Employee Director Compensation (Filed With SEC on March 11, 2016)

LEXICON PHARMACEUTICALS, INC. EQUITY INCENTIVE PLAN (Filed With SEC on March 11, 2016)

LEXICON PHARMACEUTICALS, INC. NON-EMPLOYEE DIRECTORS EQUITY INCENTIVE PLAN (Filed With SEC on March 11, 2016)

NOTICE OF STOCK OPTION GRANT (Non-Employee Director Stock Option) (Filed With SEC on March 11, 2016)

REAL ESTATE PURCHASE AND SALE AGREEMENT BETWEEN LEX-GEN WOODLANDS, L.P. AND TC HOUSTON OFFICE DEVELOPMENT, INC. CONCERNING PROPERTY COMMONLY KNOWN AS 8800 TECHNOLOGY FOREST PLACE... (Filed With SEC on January 22, 2016)

FIRST AMENDMENT TO LICENSE AND COLLABORATION AGREEMENT (Filed With SEC on May 5, 2015)

COLLABORATION AND LICENSE AGREEMENT between LEXICON GENETICS INCORPORATED and BRISTOL-MYERS SQUIBB COMPANY Collaboration and License Agreement (Filed With SEC on May 5, 2015)

First Amendment to Collaboration and License Agreement (Filed With SEC on May 5, 2015)

LEXICON PHARMACEUTICALS, INC. EQUITY INCENTIVE PLAN (Filed With SEC on April 23, 2015)

LEXICON PHARMACEUTICALS, INC. NON-EMPLOYEE DIRECTORS EQUITY INCENTIVE PLAN (Filed With SEC on April 23, 2015)

LEXICON PHARMACEUTICALS, INC. AND WELLS FARGO BANK, NATIONALASSOCIATION, as Trustee INDENTURE Dated as ofNovember 26, 2014 5.25% Convertible Senior Notes due 2021 TABLE OF CONTENTS (Filed With SEC on November 28, 2014)

49,751,244 Shares LEXICON PHARMACEUTICALS, INC. COMMON STOCK, PAR VALUE $0.001 PER SHARE UNDERWRITING AGREEMENT (Filed With SEC on November 21, 2014)

$80,000,000 LEXICONPHARMACEUTICALS, INC. 5.25% Convertible Notes Due 2021 PURCHASE AGREEMENT (Filed With SEC on November 21, 2014)

PURCHASE AGREEMENT (Filed With SEC on November 21, 2014)

LICENSE AND COLLABORATION AGREEMENT By and Between IPSEN PHARMA SAS and LEXICON PHARMACEUTICALS, INC (Filed With SEC on November 6, 2014)

STOCK OPTION AGREEMENT (Non-Employee Director Stock Option) (Filed With SEC on March 7, 2014)

$34,000,000 LOAN AND SECURITY AGREEMENT between LEX-GEN WOODLANDS, L.P., a Delaware limited partnership as Borrower and iSTAR FINANCIAL INC., as Lender Dated as of April21, 2004... (Filed With SEC on March 7, 2014)

FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT AND TO OTHER LOAN DOCUMENTS (Filed With SEC on September 19, 2013)

RESTRICTED STOCK UNIT AGREEMENT (Officer Restricted Stock Unit) (Filed With SEC on March 11, 2013)

17,500,000 Shares LEXICON PHARMACEUTICALS, INC. COMMON STOCK, PAR VALUE $0.001 PER SHARE UNDERWRITING AGREEMENT (Filed With SEC on October 19, 2012)

LEXICON PHARMACEUTICALS, INC. EQUITY INCENTIVE PLAN (Filed With SEC on April 27, 2012)

LEXICON PHARMACEUTICALS, INC. NON-EMPLOYEE DIRECTORS' EQUITY INCENTIVE PLAN (Filed With SEC on April 27, 2012)

Summary of Non-Employee Director Compensation (Filed With SEC on April 27, 2012)

Sincerely,/s/ Arthur T. Sands, M.D., Ph.D.Arthur T. Sands, M.D., Ph.D.President and Chief Executive Officer Accepted and agreed:/s/ Pablo Lapuerta, M.D.Pablo Lapuerta,... (Filed With SEC on March 8, 2012)

Summary of 2012 Named Executive Officer Cash Compensation (Filed With SEC on March 8, 2012)

STOCK OPTION AGREEMENT (Officer Incentive Stock Option) (Filed With SEC on March 8, 2012)

RESTRICTED STOCK UNIT AGREEMENT (Officer Restricted Stock Unit) (Filed With SEC on March 8, 2012)

SUPPLEMENT NO. 2 TO TRANSACTION AGREEMENTS (Filed With SEC on February 24, 2012)

LEXICON PHARMACEUTICALS, INC. NON-TRANSFERABLE SUBSCRIPTION RIGHTS CERTIFICATE AND ELECTION FORM Investor ID Number (Filed With SEC on November 22, 2011)

AMENDMENT NO. 1 TO CONSULTING AGREEMENT (Filed With SEC on March 16, 2011)

Summary of 2011 Named Executive Officer Cash Compensation (Filed With SEC on February 25, 2011)

STOCK BONUS AGREEMENT (Filed With SEC on February 25, 2011)

RESTRICTED STOCK UNIT AGREEMENT (Officer Restricted Stock Unit) (Filed With SEC on February 25, 2011)

[LEXICON GENETICS LETTERHEAD] February 19, 2003 (Filed With SEC on November 8, 2010)

AMENDED AND RESTATED PURCHASE OPTION AGREEMENT (Filed With SEC on August 2, 2010)

AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT between LEXICON PHARMACEUTICALS, INC. and SYMPHONY ICON HOLDINGS LLC _______________________________ Dated as of July 30, 2010... (Filed With SEC on August 2, 2010)

Collaboration and License Agreement (Filed With SEC on May 10, 2010)

PURCHASEAGREEMENT SUPPLEMENT (Filed With SEC on March 19, 2010)

Exhibit No (Filed With SEC on March 16, 2010)

STOCKOPTION AGREEMENT (Non-EmployeeDirector Stock Option) (Filed With SEC on March 8, 2010)

STOCKOPTION AGREEMENT (OfficerIncentive Stock Option) (Filed With SEC on March 8, 2010)

Summary of 2010 NamedExecutive Officer Cash Compensation (Filed With SEC on February 19, 2010)

RESTRICTEDSTOCK UNIT AGREEMENT (Filed With SEC on February 19, 2010)

PURCHASEAGREEMENT SUPPLEMENT (Filed With SEC on October 14, 2009)

Exhibit1.1 19,894,076Shares LEXICONPHARMACEUTICALS, INC. COMMONSTOCK, PAR VALUE $0.001 PER SHARE UNDERWRITINGAGREEMENT (Filed With SEC on October 9, 2009)

AMENDMENTTO SECURITIESPURCHASE AGREEMENT (Filed With SEC on October 7, 2009)

[LEXICONPHARMACEUTICALS LETTERHEAD] (Filed With SEC on June 2, 2009)

LEXICONPHARMACEUTICALS, INC. EQUITY INCENTIVEPLAN (Filed With SEC on April 28, 2009)

Exhibit10.2 LEXICONPHARMACEUTICALS, INC. NON-EMPLOYEEDIRECTORS STOCK OPTION PLAN (Filed With SEC on April 28, 2009)

Summary of Non-EmployeeDirector Compensation (Filed With SEC on April 28, 2009)

Summary of 2009 NamedExecutive Officer Cash Compensation (Filed With SEC on February 19, 2009)

RESTRICTEDSTOCK BONUS AGREEMENT (Filed With SEC on February 19, 2009)

[LEXICONPHARMACEUTICALS, INC. LETTERHEAD] April29, 2008 (Filed With SEC on May 1, 2008)

Summary of 2008 NamedExecutive Officer Cash Compensation (Filed With SEC on February 13, 2008)

STOCKOPTION AGREEMENT (OfficerIncentive Stock Option) (Filed With SEC on February 13, 2008)

Novated and Restated Technology License Agreement (Filed With SEC on August 8, 2007)

Amended and Restated Research and Development Agreement (Filed With SEC on August 8, 2007)

Purchase Option Agreement (Filed With SEC on August 8, 2007)

Research Cost Sharing, Payment and Extension Agreement (Filed With SEC on August 8, 2007)

SECURITIES PURCHASE AGREEMENT (Filed With SEC on June 19, 2007)

WARRANT AGREEMENT Dated as of June 17, 2007 among Lexicon Pharmaceuticals, Inc. and Invus, L.P. (Filed With SEC on June 19, 2007)

REGISTRATION RIGHTS AGREEMENT (Filed With SEC on June 19, 2007)

STOCKHOLDERS AGREEMENT (Filed With SEC on June 19, 2007)

Summary of 2007 Named Executive Officer Cash Compensation (Filed With SEC on February 16, 2007)

First Amendment to Collaboration and License Agreement (Filed With SEC on August 4, 2006)

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LEXICON PHARMACEUTICALS, INC. Contracts & Agreements