KUBOTA PHARMACEUTICAL HOLDINGS CO LTD Contracts & Agreements

SUB-SUBLEASE (Filed With SEC on May 25, 2017)

THIRD AMENDMENT TO LEASE [Nexus Canyon Park LLC / Acucela Inc.] (Filed With SEC on March 15, 2017)

SUB-SUBLEASEAGREEMENT (Filed With SEC on March 15, 2017)

EMPLOYMENT AGREEMENT (Filed With SEC on March 15, 2017)

CONSULTING AGREEMENT (Filed With SEC on March 15, 2017)

EMPLOYMENT AGREEMENT (Filed With SEC on March 15, 2017)

1 of 11 (Filed With SEC on March 15, 2017)

SEPARATION AGREEMENT AND RELEASE (Filed With SEC on November 4, 2016)

AGREEMENT AND PLAN OF MERGER (Filed With SEC on August 10, 2016)

OPTION AND LICENSE AGREEMENT (Filed With SEC on May 10, 2016)

STOCK OPTION AGREEMENT GLOBAL ACUCELA INC. 2014 EQUITY INCENTIVE PLAN (Filed With SEC on March 11, 2016)

RESTRICTED STOCK UNIT AGREEMENT GLOBAL ACUCELA INC. 2014 EQUITY INCENTIVE PLAN (Filed With SEC on March 11, 2016)

AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on March 11, 2016)

AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on December 15, 2015)

SECOND AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on December 15, 2015)

REGISTRATION RIGHTS AGREEMENT (Filed With SEC on November 27, 2015)

EMPLOYMENT AGREEMENT (Filed With SEC on July 2, 2015)

EMPLOYMENT AGREEMENT (Filed With SEC on May 7, 2015)

ACUCELA INC. SEVERANCE AND CHANGE IN EFFECTIVE CONTROL AGREEMENT (Filed With SEC on March 30, 2015)

EXHIBIT 10.21 (Filed With SEC on March 30, 2015)

ACUCELA INC. Date __, 2015 (Filed With SEC on March 30, 2015)

1301 Second Avenue, Suite 4200Seattle, WA 98101-3805(P) 206 ###-###-#### (Filed With SEC on March 26, 2015)

SECOND AMENDMENT TO LEASE [Nexus Canyon Park LLC / Acucela Inc.] (Filed With SEC on September 22, 2014)

SEVENTH AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on September 19, 2014)

9,200,000 Shares ACUCELA INC. CommonStock (No Par Value) UNDERWRITING AGREEMENT (Filed With SEC on January 27, 2014)

[Translation of Japanese original text and For reference purposes only] Agreement Concerning ShareLending Transaction of Shares of Common Stock of Acucela Inc. (Filed With SEC on January 27, 2014)

CO-DEVELOPMENT AND COMMERCIALIZATION AGREEMENT dated as of September 4, 2008 by and among ACUCELA INC. and OTSUKA PHARMACEUTICAL CO., LTD. (Filed With SEC on January 27, 2014)

THIS CERTIFICATE IS TRANSFERRABLE IN NEW YORK CITY, NY OR CHICAGO, IL (Filed With SEC on December 17, 2013)

ACUCELA INC. AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT (Filed With SEC on December 17, 2013)

ACUCELA INC. INDEMNIFICATION AGREEMENT (Filed With SEC on December 17, 2013)

ACUCELA INC. 2002 STOCK OPTION AND RESTRICTED STOCK PLAN EFFECTIVE AS OF JUNE 28, 2002 AMENDED APRIL 11, 2011 TABLE OF CONTENTS (Filed With SEC on December 17, 2013)

ACUCELA INC. 2012 EQUITY INCENTIVE PLAN As Adopted on September 5, 2012 (Filed With SEC on December 17, 2013)

ACUCELA INC. 2014 EQUITY INCENTIVE PLAN (Filed With SEC on December 17, 2013)

LEASE (Nexus Canyon Park / Acucela) (Filed With SEC on December 17, 2013)

FIRST AMENDMENT TO LEASE [Nexus Canyon Park LLC / Acucela Inc.] (Filed With SEC on December 17, 2013)

OFFICE LEASE between THE NORTHWESTERN MUTUAL LIFE INSURANCE COMPANY (Landlord) and ACUCELA INC. (Tenant) 1301 Second Avenue Seattle, Washington IRE 334246 TABLE OF CONTENTS (Filed With SEC on December 17, 2013)

FIRST AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on December 17, 2013)

CO-DEVELOPMENT AND COMMERCIALIZATION AGREEMENT dated as of September 4, 2008 by and among ACUCELA INC. and OTSUKA PHARMACEUTICAL CO., LTD. (Filed With SEC on December 17, 2013)

DEVELOPMENT AND COLLABORATIONAGREEMENT by and between OTSUKA PHARMACEUTICAL CO., LTD. and ACUCELA INC. dated as of September 15, 2010 TABLE OF CONTENTS (Filed With SEC on December 17, 2013)

AGEEMENT FOR STOCK PURCHASE (Filed With SEC on December 17, 2013)

ACUCELA INC. CONSULTING AGREEMENT (Filed With SEC on December 17, 2013)

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KUBOTA PHARMACEUTICAL HOLDINGS CO LTD Contracts & Agreements