Addendum No. 2 to Supply Contract, dated August 19, 2021, by and between Isoray Medical, Inc. and Joint Stock Company

Exhibit 10.1

Certain identified information has been excluded from this exhibit because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed.

Addendum No. 2 dated 2021.08.16 to

Contract No. 840/08625142/31/22-21

Date of signature: 2021.03.18

THE SELLER

Isotope - Regional Alliance, Joint-Stock Company (Isotope JSC)

Pogodinskaya str., 22, Moscow, 119435, Russia.

Phone: +7(495) 981-96-16

THE BUYER

The Company Isoray Medical Inc.

350 Hills Street, Suite 106

Richland, WA ###-###-#### USA

THE BUYER and THE SELLERS have mutually agreed about the following:

The following company is determined by the Buyer as a Supplier of the Goods, produced by JSC "SSC RIAR": MedikorPharma-Ural LLC, 620109,  Sverdlovskaya region, Yekaterinburg, Krulya Street, 2, apartment 192, Tel.:  8(343) 270-75-29, E-mail: ***@***. The Buyer is responsible to the Seller for MedikorPharma-Ural LLC fulfillment of its obligations. The cost of services, provided by MedikorPharma-Ural LLC, shall not exceed USD [**] [**].

The present addendum is the integral part of contract 840/08625142/31/22-21 and may be signed by E-mail.

All other terms and conditions are in accordance with Contract No. 840/08625142/31/22-21, Appendices 1 and 2, Addendum 1.