1st Amendment to Option Assignment Agreement, dated as of December 7, 2018, by and between IO Biotech ApS and Herlev and Gentofte Hospital

Exhibit 10.9

*Portions of this exhibit have been excluded because it both (i) is not material and (ii)

would be competitively harmful if publicly disclosed.

1^st AMENDMENT TO

OPTION ASSIGNMENT AGREEMENT

BETWEEN

HERLEV AND GENTOFTE HOSPITAL

AND

IO BIOTECH ApS

(1^st amendment to Option Assignment Agreement of Arginase 1)

On December 7^th 2018, the following parties

Herlev and Gentofte Hospital

[***]

(hereinafter referred to as “Herlev Hospital”)

and

IO Biotech ApS

[***]

(hereinafter referred to as the “Company”)

(hereinafter all the above mentioned parties collectively referred to as the “Parties” and individually as a “Party”)

have entered into this amendment to the assignment agreement entered into between the Parties on 27 March 2017 regarding the grant by the Hospitals to the Company of an option to acquire certain intellectual property rights.

RECITALS

NOW THEREFORE, the Parties have entered into this Amendment where the Patent Application number is updated with the PA number:

___000___

(signature page follows)

1

SIGNATURES

For and on behalf of Herlev and Gentofte Hospital Date

2