Supplemental Agency Agreement

IntelGenx Technologies Corp. (the “Corporation”);

Desjardins Securities Inc. (the “Lead Agent”);

Laurentian Bank Securities Inc. (“Laurentian”); and

Echelon Wealth Partners Inc. (“Echelon” and, collectively with the Lead Agent and Laurentian, the “Agents”).

The Agents and the Corporation entered into an agency agreement dated June 28, 2017 (the “Agency Agreement”) in respect of the issue and offer for sale by the Corporation of a minimum of $5,000,000 and a maximum of $10,000,000 aggregate principal amount of Debentures, the whole upon and subject to the terms set forth in the Indenture (the “Offering”).

In connection with the Offering, the Corporation prepared and filed the Final Prospectus and all other necessary documents concurrently with the execution of the Agency Agreement in order to create, authorize and issue the Debentures and to qualify the Debentures for distribution to the public in each of the Qualifying Jurisdictions and has obtained the Final Receipt in respect thereto.

Further in connection with the Offering, the Agents were appointed by the Corporation to act as sole agents to the Corporation to effect the sale of the Debentures on behalf of the Corporation on a best efforts basis to Purchasers in the Qualifying Jurisdictions and, in consideration for such services, the Corporation paid the Agents the Agents’ Fee, the whole as set forth in the Agency Agreement.

Following the execution of the Agency Agreement and the filing of the Final Prospectus, the Corporation issued an aggregate principal amount of $6,838,000 of Debentures at the Offering Price (the “Initial Offering”) on July 12, 2017 (the “Initial Offering Closing Date”) to Purchasers in the Qualifying Jurisdictions.

The Corporation and the Agents wish to complete a supplemental offering of an aggregate principal amount of $762,000 Debentures at the Offering Price (the “Supplemental Offering”) on the date hereof (the “Supplemental Offering Closing Date”) and enter into this supplemental agency agreement (the “Supplemental Agency Agreement”) to reconfirm each party’s rights and obligations under, and the terms and conditions of, the Supplemental Offering.

The obligations of the Agents on the Supplemental Offering Closing Date shall be subject to the performance by the Corporation of its obligations hereunder and the following additional conditions, which conditions the Corporation covenants to exercise its commercially reasonable best efforts to have fulfilled on or prior to the Supplemental Offering Closing Date and which conditions may be waived in writing in whole or in part by the Agents:

Necessary Filings: the Corporation will have made or obtained the necessary filings, approvals, consents and acceptances to or from, as the case may be, the Securities Commissions, the SEC and the TSXV (subject to the Standard Listing Conditions) required to be made or obtained by the Corporation in connection with the Supplementary Offering, on terms which are acceptable to the Corporation and the Agents, acting reasonably, prior to the Supplemental Offering Closing Date, it being understood that the Agents will do all that is reasonably required to assist the Corporation to fulfil this condition;

TSXV Acceptance: the Debentures issued and sold pursuant to the Supplemental Offering, including the underlying Common Shares, will have been accepted for listing by the TSXV, subject only to the satisfaction by the Corporation of Standard Listing Conditions;

Board Authorization: the Corporation’s board of directors will have authorized and approved this Supplemental Agency Agreement, the sale and issuance of the Debentures pursuant to the Supplemental Offering and the issuance of Common Shares upon the conversion of the Debentures issued and sold pursuant to the Supplemental Offering, and all matters relating to the foregoing;

Legal Opinions: the Agents shall have received at the Supplemental Closing Time a customary legal opinion from the Corporation’s Canadian Counsel and the Corporation’s U.S. Counsel (or other local counsel to the Corporation, as applicable) covering the laws of the Qualifying Jurisdictions and U.S. federal securities laws, addressed to the Agents and the Selling Group Members, in which counsel may rely as to matters of fact, on certificates of the Corporation’s officers and other documentation standard for legal opinions in transactions of a similar nature, in form and substance acceptable to the Agents, acting reasonably, with respect to the following matters with such opinions being subject to usual and customary assumptions and qualifications, including the qualifications set out below:

the Corporation being a corporation incorporated and existing under the laws of Delaware and having all requisite corporate power and capacity to enter into this Supplemental Agency Agreement and to perform its obligations hereunder;

the Corporation is a reporting issuer or the equivalent in each of the Qualifying Jurisdictions and not in default under the Securities Laws in the Qualifying Jurisdictions;

the authorized share capital of the Corporation;

the Corporation having all necessary corporate power and capacity: (i) to execute and deliver this Supplemental Agency Agreement and perform its obligations under this Supplemental Agency Agreement, and (ii) to create and issue the Debentures issued and sold pursuant to the Supplemental Offering and to issue the Common Shares upon conversion of the Debentures issued and sold pursuant to the Supplemental Offering in accordance with the terms of the Indenture;

all necessary corporate action having been taken by the Corporation to authorize the execution and delivery of this Supplemental Agency Agreement and the performance of its obligations hereunder and as to the Supplemental Agency Agreement having been duly authorized, executed and delivered on behalf of the Corporation, and constituting a legal, valid and binding obligation of the Corporation, enforceable against the Corporation in accordance with its terms, subject to standard assumptions and qualifications;

the Common Shares issuable upon the conversion of the Debentures issued and sold pursuant to the Supplemental Offering have been validly reserved for issuance by the Corporation and, upon the payment of the exercise price therefor and the issue thereof, the Common Shares will be validly issued as fully paid and non-assessable Common Shares;

the execution and delivery of this Supplemental Agency Agreement, the performance by the Corporation of its obligations hereof and the issuance, sale and delivery of the Debentures pursuant to the Supplemental Offering and the issuance of the Common Shares on conversion of the Debentures issued and sold pursuant to the Supplemental Offering does not and will not (as the case may be) conflict with or result in a breach or violation of any of the terms or provisions of, or constitute a default under, whether after notice or lapse of time or both (i) the provisions of the applicable laws of the jurisdiction of incorporation of the Corporation, and (ii) the constating documents and by-laws of the Corporation;

all necessary documents having been filed, all requisite proceedings having been taken and all approvals, permits, authorizations and consents of the appropriate regulatory authority in each of the Qualifying Jurisdictions (and, if applicable, the other Selling Jurisdictions) having been obtained by the Corporation to qualify the distribution of the Debentures issued and sold pursuant to the Supplemental Offering and the issuance of the Common Shares upon conversion of the Debentures issued and sold pursuant to the Supplemental Offering in accordance with the terms thereof in each of the Qualifying Jurisdictions (and, if applicable, the other Selling Jurisdictions) through or to investment dealers or brokers registered under the applicable securities laws who have complied with the relevant provisions of such applicable securities laws and the terms of such registrations; and

the Debentures issued and sold pursuant to the Supplemental Offering and the underlying Common Shares having been accepted for listing on the TSXV, subject to the Standard Listing Conditions;

Bring Down Auditors’ Comfort Letter: the Agent shall have received at the Supplemental Closing Time a letter dated the Supplemental Offering Closing Date from the Corporation’s Auditors addressed to the Agents, the Corporation and the directors of the Corporation, in form and substance satisfactory to the Agent and Agents’ Counsel, acting reasonably, confirming the continued accuracy of the comfort letter to be delivered to the Agents pursuant to Section 2.5(b) of the Agency Agreement with such changes as may be necessary to bring the information in such letter forward to within two Business Days of the Supplemental Offering Closing Date, which changes shall be acceptable to the Agent and Agents’ Counsel, acting reasonably;

Corporate Certificate: the Agent shall have received at the Supplemental Closing Time certificates dated the Supplemental Offering Closing Date, signed by an appropriate officer of the Corporation addressed to the Agents and the Selling Group Members, with respect to: (i) the articles and by-laws of the Corporation, and (ii) the authorizing resolutions relating to the distribution of the Debentures issued and sold pursuant to the Supplemental Offering in each of the Qualifying Jurisdictions, allotment, issue (or reservation for issue) and sale of the Debentures issued and sold pursuant to the Supplemental Offering and the underlying Common Shares, and the authorization, execution and delivery of this Supplemental Agency Agreement and the other agreements and transactions contemplated by this Agreement;

Closing Certificate: the Agents shall have received at the Supplemental Closing Time a certificate or certificates dated the Supplemental Offering Closing Date, and signed on behalf of the Corporation by two senior officers of the Corporation addressed to the Agents and the Selling Group Members certifying for and on behalf of the Corporation, after having made due enquiry and after having carefully examined the Prospectus, that:

the Corporation has duly complied with all covenants and satisfied in all material respects all the terms and conditions in this Supplemental Agency Agreement on its part to be performed or satisfied at or prior to the Supplemental Closing Time;

no order, ruling or determination having the effect of suspending the sale or ceasing, suspending or restricting the trading of the Debentures or any other securities of the Corporation in the United States or any of the Qualifying Jurisdictions (or, if applicable, the other Selling Jurisdictions) has been issued or made by any stock exchange, securities commission or regulatory authority and is continuing in effect and no proceedings, investigations or enquiries for that purpose have been instituted, are pending or, to the knowledge of such officers, are contemplated or threatened under Securities Laws or by any other regulatory authority;

other than the Offering and the Supplemental Offering, there has been no material change or change in a material fact contained in the Prospectus, the U.S. Final Prospectus or any Supplementary Material which fact or change is or may be, of such a nature as to result in a misrepresentation in the Prospectus, the U.S. Final Prospectus or any Supplementary Material or which would result in the Prospectus not complying with applicable Canadian Securities Laws or the U.S. Final Prospectus or Registration Statement not complying with applicable requirements of the U.S. Securities Act; and

the representations and warranties of the Corporation contained in the Agency Agreement are true and correct in all material respects (except for representations and warranties subject to a materiality qualification, which are true and correct in all respects) as of the Supplemental Closing Time, with the same force and effect as if made at and as of the Supplemental Closing Time (other than those which are in respect of a specific date, which shall be accurate in all material respects as of such date), after giving effect to the transactions contemplated by this Supplemental Agency Agreement;

Transfer Agent Certificate: the Agents and the Selling Group Members shall have received at the Supplemental Closing Time a certificate from the Transfer Agent dated the Supplemental Offering Closing Date and signed by an authorized officer of the Transfer Agent, confirming the issued share capital of the Corporation.

Time shall be of the essence of this Supplemental Agency Agreement.

This Supplemental Agency Agreement shall be governed by and construed in accordance with the laws of the Province of Québec and the laws of Canada applicable therein.

All funds referred to in this Supplemental Agency Agreement shall be in Canadian dollars unless otherwise stated herein.

Unless herein otherwise expressly provided, any notice, request, direction, consent, waiver, extension, agreement or other communication that is required to or may be given or made hereunder shall be in and shall be sufficiently given if delivered personally, or via email to such party, as follows:

in the case of the Corporation:

IntelGenx Technologies Corp.

in the case of the Agents and the Selling Group Members:

Desjardins Securities Inc. 1170 Peel Street, Suite 300 Montreal, Québec H3B 0A9

Any party hereto may change its address for service from time to time by notice given to each of the other parties hereto in accordance with the foregoing provisions.

If any provision of this Supplemental Agency Agreement shall be adjudged by a competent authority to be invalid or for any reason unenforceable in whole or in part, such invalidity or unenforceability shall not affect the validity, enforceability or operation of any other provision of this Supplemental Agency Agreement and such void or unenforceable provision shall be severable from this Supplemental Agency Agreement.

Except as required by law or as deemed necessary to the Corporation in connection with legal or regulatory proceedings, the written or verbal advice or opinions of the Agents and the Selling Group Members, including any background or supporting materials or analysis, will not be publicly disclosed or referred to or provided to any third party by the Corporation without the prior written consent of the Agents (for and on behalf of the Agents and the Selling Group Members), in each specific instance such consent not to be unreasonably withheld. The Agents (for and on behalf of the Agents and the Selling Group Members) expressly disclaim any liability or responsibility by reason of any unauthorized use, publication, distribution of or reference to any written or verbal advice or opinions or materials provided by the Agents or the Selling Group Members or any unauthorized reference to the Agents, the Selling Group Members or this Agreement.

The Corporation agrees that the Agents and the Selling Group Members may, subsequent to the announcement of the Supplemental Offering, make public its involvement with the Corporation in the Supplemental Offering, including the right of the Agents or the Selling Group Members, as applicable, at its own expense to, following completion of the Supplemental Offering, place advertisements describing its services to the Corporation in financial, news or business publications.

The Corporation acknowledges that it has retained the Agents under this Supplemental Agency Agreement and the Agency Agreement solely to provide the services set forth in such agreements. In rendering such services, the Agents will act as independent contractors, and the Agents owe their duties arising out of this Supplemental Agency Agreement and the Agency Agreement solely to the Corporation and to no other person. The Corporation acknowledges that nothing in this Supplemental Agency Agreement or the Agency Agreement is intended to create duties to the Corporation beyond those expressly provided for in this Supplemental Agency Agreement and the Agency Agreement, and the Agents, the Selling Group Members and the Corporation specifically disclaim the creation of any partnership, joint venture, fiduciary, agency or non- contractual relationship between, or the imposition of any partnership, joint venture, fiduciary, agency or non- contractual duties on, either party. Except as set out in Article 11 of the Agency Agreement, nothing in this Supplemental Agency Agreement or the Agency Agreement is intended to confer upon any other person any rights or remedies under this Supplemental Agency Agreement and the Agency Agreement or by reason of this Supplemental Agency Agreement and the Agency Agreement. For greater certainty, the Agents and the Selling Group Members will not provide any legal, tax, accounting or regulatory advice, either pursuant to this Supplemental Agency Agreement or the Agency Agreement or otherwise. The Corporation will be solely responsible for engaging and instructing such legal, tax, accounting and regulatory professionals as it deems necessary for purposes of the subject matter of this Supplemental Agency Agreement and the Agency Agreement.

This Supplemental Agency Agreement may be executed by any one or more of the parties to this Supplemental Agency Agreement by facsimile or electronic transmission and in any number of counterparts, each of which shall be deemed to be an original, and all such counterparts together shall constitute one and the same instrument.

This Supplemental Agency Agreement and the Agency Agreement shall constitute the entire agreements between the parties with respect to the subject matter of this Supplemental Agency Agreement and the Agency Agreement and shall not be changed, modified or rescinded, except in writing signed by the parties.

The parties hereto have required that this agreement and all documents and notices related thereto and/or resulting therefrom be drawn up in English only. Les parties aux présentes ont exigé que la présente convention ainsi que tous les documents et avis qui s’y rattachent et/ou découleront soient rédigés en langue anglaise seulement.