Intellectual Property Asset Purchase Agreement, dated July 17, 2020, by and between the Registrant and Alexion Pharmaceuticals, Inc

Exhibit 2.1

EXECUTION VERSION

CONFIDENTIAL

Certain identified information has been excluded from the exhibit because it is both (i) not

material and (ii) would likely cause competitive harm to the Company, if publicly disclosed.

Double asterisks denote omissions.

INTELLECTUAL PROPERTY ASSET PURCHASE AGREEMENT

THIS INTELLECTUAL PROPERTY ASSET PURCHASE AGREEMENT (this “Agreement”) is entered into as of July 17, 2020 (the “Effective Date”) by and between Inozyme Pharma, Inc., a Delaware corporation with its principal office at 321 Summer Street, Floor 4, Boston, MA 02210 (the “Buyer”), on the one hand, and Alexion Pharmaceuticals, Inc., a Delaware corporation, with its principal office at 121 Seaport Boulevard, Boston, MA 02210 (the “Seller”, with Seller and Buyer each, individually, a “Party” and, collectively, the “Parties”), on the other hand.

WHEREAS the Buyer desires to purchase, and the Seller desires to sell, the Assets (as defined below), subject to the terms and conditions of this Agreement;

NOW THEREFORE, in consideration of the mutual promises hereinafter set forth and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereby agree as follows:

ARTICLE 1

INTERPRETATION

The terms defined herein shall have, for all purposes of this Agreement, the following meanings, unless the context expressly or by necessary implication otherwise requires:

“Affiliate” means, with respect to a Party, any Person that, directly or indirectly through one or more intermediaries, controls, is controlled by or is under common control with such Party. A Person shall be deemed to “control” another Person if the first Person (a) owns, directly or indirectly, beneficially or legally, at least fifty percent (50%) of the outstanding voting securities or capital stock (or such lesser percentage which is the maximum allowed to be owned by such Person in a particular jurisdiction) of such second Person, or has other comparable ownership interest with respect to any entity other than a corporation; or (b) has the power, whether pursuant to contract, ownership of securities or otherwise, to direct the management and policies of the second Person.

“Assets” means, collectively, the Assigned Data, the Assigned Know-How, the Assigned Materials, and the Assigned Patent Rights.

“Assigned Data” means solely the items described on Exhibit B, which, for the avoidance of doubt, do not include any contractual obligations.

“Assigned Know-How” means solely the Know-How described on Exhibit B, which, for the avoidance of doubt, do not include any contractual obligations.

“Assigned Materials” means solely the Materials described on Exhibit B, which, for the avoidance of doubt, do not include any contractual obligations.

“Assigned Patent Rights” means (a) Seller’s exclusive rights in the patents and patent applications identified on Exhibit A-1 and Seller’s joint ownership rights in the jointly-owned patents and patent applications identified on Exhibit A-2, (b) Seller’s exclusive or joint-ownership rights, as applicable, in all national, regional and international patents and patent applications deriving priority or issuing from any of the patent rights described in clause (a), (c) Seller’s exclusive or joint-ownership rights, as applicable, in all patent applications filed after the Effective Date that derive priority from the patent rights described in clause (a), including substitutions, divisionals, continuations, continuations-in-part, provisional patent applications, converted provisional patent applications, re-issues and re-examinations, and continued prosecution applications of such patent rights, (d) Seller’s exclusive or joint-ownership rights, as applicable, in any and all patents that have issued or in the future issue from any patent applications covered by clauses (a) – (c), including utility models, petty patents and design patents and certificates of invention, and (e) Seller’s exclusive or joint-ownership rights, as applicable, in any and all extensions or restorations by existing or future extension or restoration mechanisms, including revalidations, reissues, re-examinations and extensions (including any supplementary protection certificates, patent term extensions and the like) of the patents or patent applications covered by clauses (a) – (d).

“Buyer Permitted Encumbrance” means (a) statutory Encumbrances arising out of operation of law with respect to a Liability incurred in the ordinary course of business and which is not delinquent; (b) Encumbrances for taxes not yet due, payable, delinquent or subject to penalties for nonpayment, or which are being contested in good faith through appropriate proceedings; (c) imperfections of title or encumbrances, if any, that, individually or in the aggregate, do not materially impair, and are not reasonably likely to materially impair, the continued operation of Buyer’s business, (d) mechanics’, materialmens’, carriers’, workmens’, warehousemens’, repairmens’, landlords’ or other like Encumbrances and security obligations that are incurred in the ordinary course of business and are not delinquent, and (e) non-exclusive licenses granted by Buyer or its Affiliates under any assets in the ordinary course of business.

“Confidentiality Agreements” means each of (i) that certain Confidential Disclosure Agreement by and between Seller and Buyer, dated November 6, 2017, and (ii) that certain Confidential Disclosure Agreement by and between Seller and Buyer, dated May 8, 2020.

2

“ENPP1” means ectonucleotide pyrophosphatase/phosphodiesterase 1 proteins (NPP1/ENPP1/PC-1), enzymatically active fragments thereof, fusion polypeptides containing such proteins or fragments, and nucleotide sequences encoding any of the foregoing, derived from any species. Exemplary sequences for full-length ENPP1 polypeptides include: Human (NCBI accession no. NP_006199.2), Mouse (NCBI accession no. NP_001295256.1), Cow (NCBI accession no. NP_001193141), Rabbit (NCBI accession no. NP_001162404.1), and Baboon (NCBI accession no. NP_001076211.2).

“Fraud” means, with respect to any Party, common law fraud, as interpreted under the laws and by the courts of the State of Delaware; provided that Fraud shall only be deemed to exist if such Party had the specific intent to deceive and mislead the other Party.

“Fundamental Representations” means the representations and warranties contained in Sections 3.1(a) (Organization), 3.1(b) (Authorization) and 3.1(e) (Ownership of the Assets).

“GAAP” shall mean generally accepted accounting principles in the United States.

“Know-How” means any and all proprietary and non-public ideas, inventions, discoveries, data, results, records, formulae, designs, specifications, scientific methods, trade secrets, business plans, business methods, processes, formulations, techniques, technology, practices, know-how, technical information (including structural and functional information), process information, pre-clinical information, and clinical information, and any and all proprietary biological, chemical, pharmacological, toxicological, pre-clinical, clinical, assay, control and manufacturing data, in each case whether or not patented or patentable.

“Knowledge of Seller” means the actual knowledge of [**].

“Liabilities” means, with respect to any Person, any and all debts, obligations, Losses, interest obligations, deficiencies and assessments, whether accrued or fixed, absolute or contingent, known or unknown, matured or unmatured or determined or determinable, due or to become due, whether directly incurred or consequential, whether or not required under GAAP to be accrued on the financial statements of such Person, and including those arising under any law, action or order and those arising under any contract, agreement, arrangement, commitment or undertaking.

“Losses”, in respect of any matter, means all claims, demands, proceedings, losses, damages, awards, liabilities, penalties, fees, deficiencies, fines, costs and expenses (including all reasonable legal and other professional fees and disbursements, interest, penalties and amounts paid in settlement) and judgments arising directly or indirectly as a consequence of such matter.

3

“Materials” means any and all physical embodiments of chemical or biological materials.

“Person” means any individual, partnership, limited partnership, corporation, limited liability company, business trust, joint stock company, trust, unincorporated association, joint venture, governmental entity or other entity or organization.

“Product” means any enzyme replacement therapy, agonist, gene therapy, compound or other pharmaceutical preparation that (a) constitutes ENPP1 or whose primary method of action is to replace ENPP1 or to directly modulate ENPP1 or to directly increase or decrease ENPP1 levels and (b) was researched, developed, manufactured, commercialized or otherwise exploited by or on behalf of Seller prior to the Effective Date. For clarity, Product shall include prodrugs, analogs, salts, free acids, free bases, clathrates, solvates, hydrates, hemihydrates, anhydrides, esters, chelates, conformers, congeners, crystal forms, crystal habits, polymorphs, amorphous solids, homologs, isomers, stereoisomers, enantiomers, racemates, isotopic or radiolabeled equivalents, metabolites and conjugates of any of the above.

“Program” means any program conducted by or on behalf of Seller prior to the Effective Date that was directed to the research, development, manufacture, commercialization or other exploitation any Product.

“Regulatory Authority” means any governmental entity with jurisdiction or authority over the development, manufacture, commercialization or other exploitation of pharmaceutical products, and any corresponding national or regional regulatory authorities.

“Regulatory Submissions” means all filings, applications and submissions with or to any Regulatory Authority in support of the development, manufacture, commercialization or other exploitation of any Product, and all formal and informal, written or electronic correspondence or communications with or from any relevant Regulatory Authority with respect to any Product, as well as minutes of any material meetings, telephone conferences, or discussions with any Regulatory Authority with respect to any Product.

“Representatives” means, with respect to either Party, such Party’s Affiliates and its and their respective employees, directors, officers and managers.

“Seller Permitted Encumbrance” means (a) statutory Encumbrances arising out of operation of law with respect to a Liability incurred in the ordinary course of business and which is not delinquent; (b) Encumbrances for taxes not yet due, payable, delinquent or subject to penalties for nonpayment, or which are being contested in good faith through appropriate proceedings; (c) imperfections of title or encumbrances, if any, that, individually or in the aggregate, do not materially impair, and are not reasonably likely to materially impair, the continued use and operation of the Assets, (d) mechanics’, materialmens’, carriers’, workmens’, warehousemens’, repairmens’, landlords’ or other like Encumbrances and security obligations that are incurred in the ordinary course of business and are not delinquent, and (e) non-exclusive licenses granted by Seller or its Affiliates under any Assets in the ordinary course of business.

4

“Third Party” means any Person other than the Buyer, the Seller or their respective Affiliates.

Grammatical variations of any terms defined herein have similar meanings to such defined terms; words importing number include the singular and the plural; words importing gender include the feminine, neuter and masculine genders; the words “include”, “includes,” and “including” will be deemed to be followed by the phrase “without limitation,”; the term “or” will be interpreted in the inclusive sense commonly associated with the term “and/or”; the word “will” will be construed to have the same meaning and effect as the word “shall”; any reference herein to any Person will be construed to include such Person’s successors and assigns; the words “herein,” “hereof” and “hereunder,” and words of similar import, will be construed to refer to this Agreement in its entirety and not to any particular provision hereof; all references herein to Sections, Schedules or Exhibits will be construed to refer to Sections, Schedules or Exhibits of this Agreement, and references to this Agreement include all Schedules and Exhibits hereto; provisions that require that a Party, the Parties or any committee hereunder “agree,” “consent” or “approve” or the like will require that such agreement, consent or approval be specific and in writing, whether by written agreement, letter, e-mail (solely with return receipt), approved minutes or otherwise (but excluding e-mail without return receipt and instant messaging); references to any specific law, rule or regulation, or article, section or other division thereof, will be deemed to include the then current amendments thereto or any replacement or successor law, rule or regulation thereof; and any action or occurrence deemed to be effective as of a particular date will be deemed to be effective as of 11:59 PM ET on such date.

The captions and headings contained herein are for the convenience of the Parties and in no way alter, modify, amend, limit or restrict the contractual obligations of the Parties.

Each Party represents that it has been represented by legal counsel in connection with this Agreement and acknowledges that it has participated in the drafting hereof. In interpreting and applying the terms and provisions of this Agreement, the Parties agree that no presumption will apply against the Party that drafted such terms and provisions.

The following exhibits and schedules are attached to and form part of this Agreement:

5

ARTICLE 2

SALE AND DELIVERY OF THE ASSETS

Subject to and upon the terms and conditions of this Agreement, the Seller hereby sells, transfers, conveys, assigns and delivers to the Buyer, and agrees to cause its Affiliates to sell, assign and transfer to the Buyer, and the Buyer hereby purchases from the Seller and its Affiliates, Seller’s and its Affiliates’ entire right, title and interest in and to the Assets.

Without limiting Section 2.1, the Seller hereby sells, assigns and transfers, and agrees to cause its Affiliates to sell, assign and transfer, to the Buyer Seller’s and its Affiliates’ entire right, title and interest in all countries, including Seller’s and its Affiliates’ rights of priority and rights to sue for past infringement, in the Assigned Patent Rights, and Seller’s and its Affiliates’ rights in and to all patents in any country that, following the Effective Date, may be or are granted with respect to the Assigned Patent Rights, including any divisional, continuation, continuation-in-part, reexamination, reissue or other patent applications or patents based in whole or in part thereon. The Seller hereby authorizes and requests the Commissioner of Patents and Trademarks of the United States to issue such rights to the Buyer and its successors and assigns, and further authorizes and requests officials of patent offices in countries other than the United States to issue such rights, as may be granted upon said Assigned Patent Rights, including any divisional, continuation, continuation-in-part, reexamination, reissue or other patent applications or patents based in whole or in part thereon, to the Buyer and its successors and assigns, to the full end of the term for all said patents that may be granted, as fully and entirely as the same would have been held by the Seller had this assignment and sale not been made.

6

7

The Seller hereby covenants and agrees that neither it nor any of its Affiliates shall institute, participate in, cooperate with or finance, or assist any Third Party to institute, participate in, cooperate with or finance, any proceedings or actions challenging the Buyer’s ownership, or the validity or enforceability, of any of the Assigned Patent Rights, including through any interference or similar proceeding, or in connection with any challenge to the

8

ownership, validity or enforceability of any of the Assigned Patent Rights. Notwithstanding anything to the contrary herein, in no event will the foregoing be deemed to limit or restrict Seller’s or its Affiliates’ purchase of equity, debt or other convertible securities issued by a Third Party without a bona fide purpose by or on behalf of Seller or its Affiliates to directly finance proceedings or actions challenging the Buyer’s ownership, or the validity or enforceability, of any of the Assigned Patent Rights, including through any interference or similar proceeding, or in connection with any challenge to the ownership, validity or enforceability of any of the Assigned Patent Rights.

Subject to the terms and conditions of this Agreement and the Series A-2 Convertible Preferred Stock Purchase Agreement by and between the Parties, dated as of the Effective Date (the “SPA”), in consideration for the sale of the Assets by the Seller to the Buyer, the Buyer shall issue to the Seller, pursuant to the terms of the SPA, 8,294,360 shares of the Buyer’s Series A-2 Convertible Preferred Stock, par value $0.0001 per share, as set forth in the SPA.

The Seller expressly agrees that, except for the Internal Research License (as defined below), the sale of the Assets under this Agreement constitutes a complete and irrevocable transfer of all of its and its Affiliates’ rights, title and interest in and to the Assets, and that the Seller and its Affiliates reserve no rights to research, develop, manufacture, commercialize or otherwise exploit, or to encumber, market or otherwise transfer the Assets.

Buyer acknowledges and agrees that, other than the Assets and, to the extent assigned pursuant to Section 2.3(c), the Additional Assets, it is not acquiring any right, title or interest in, to or under any assets, property, rights and interests of Seller or its Affiliates (collectively, the “Excluded Assets”). Notwithstanding anything to the contrary herein, to the extent the Assets (other than the Assigned Patent Rights) or Additional Assets include any assets, property, rights and interests of Seller or its Affiliates that are not solely related to any Product, such assets, property, rights and interests of Seller or its Affiliates shall be deemed Excluded Assets for all purposes under this Agreement.

Without limiting either Party’s indemnification obligations set forth in Article 5, (a) Seller and its Affiliates retain, and will be responsible for and timely satisfy and discharge all Liabilities of Seller and its Affiliates arising out of or relating to (i) the Assets, solely to the extent arising out of or relating to any actions or occurrence prior to the Effective Date, (ii) the Additional Assets, solely to the extent arising out of or relating to any actions or occurrences prior to the date such Additional Assets are assigned and transferred to the Buyer hereunder or (iii) payment of money in respect of any Seller Permitted Encumbrance that attached to the applicable Asset or Additional Asset prior to the effective date of assignment and transfer of

9

such Asset or Additional Asset, respectively, to the Buyer pursuant to this Agreement; provided, that, notwithstanding anything to the contrary herein, neither Seller nor any of its Affiliates shall have any obligation to satisfy, discharge, terminate, modify or otherwise dispose of any Encumbrance set forth in clause (e) of the definition of “Seller Permitted Encumbrances” (clauses (a)(i)-(a)(iii), collectively, the “Retained Liabilities”), and (b) Buyer agrees to assume and to timely satisfy and discharge all Liabilities (other than the Retained Liabilities) that (i) arise out of or relate to the Assets on or following the Effective Date or the Additional Assets on or after the date such Additional Assets are assigned and transferred to the Buyer hereunder, including Liabilities of Seller or its Affiliates under any Transferred Contract that constitutes an Additional Asset and (ii) are incurred in connection with Buyer’s or its Representative’s exploitation of the Assets on or after the Effective Date or the Additional Assets on or after the date such Additional Assets are assigned and transferred to the Buyer hereunder (clauses (b)(i)-(b)(ii), collectively, the “Assumed Liabilities”).

Subject to the terms and conditions of this Agreement, the Buyer hereby grants, and agrees to grant, to the Seller and its Affiliates a non-exclusive, non-assignable, non-sublicensable (except to Representatives acting on behalf of Seller or its Affiliates), fully-paid, royalty-free, perpetual (except as set forth in Section 6.2) license to use the Assets and Additional Assets solely for internal, non-clinical research purposes (the “Internal Research License”).

10

ARTICLE 3

REPRESENTATIONS AND WARRANTIES

The Seller hereby represents and warrants to the Buyer that, as of the Effective Date:

11

12

The Buyer hereby represents and warrants to the Seller that, as of the Effective Date:

13

ARTICLE 4

ADDITIONAL COVENANTS

From and after the Effective Date, all information to the extent that it relates solely to the Assets, including the Assigned Know-How, that has not, as of the Effective Date, been disclosed to the public shall constitute confidential and proprietary information of the Buyer, and shall be deemed not to be Seller’s “Information” (as defined in each Confidentiality Agreement) under either Confidentiality Agreement. The Seller agrees not to, and to ensure that its Representatives do not, (a) use any such information for any purpose other than the Internal Research License or (b) disclose to any Third Party any such information; except that the obligations set forth in this Section 4.1 shall not apply to (i) any information that is or becomes, without any fault of the Seller or any of its Representatives, part of the public domain, (ii) any information that is lawfully provided, after the Effective Date, to Seller or any of its Representatives by any Third Party rightfully in possession of such information without a duty of confidentiality owed to Buyer or (iii) any information which Seller or its Affiliates develop after the Effective Date without the use or application of any Assets or (iv) any information which Seller or its Affiliates develop after the Effective Date in practicing the Internal Research License, other than information that relates solely to any enzyme replacement therapy, agonist, gene therapy, compound or other pharmaceutical preparation that is intended by Seller or any of its Affiliates to constitute, replace or increase ENPP1 or is intended by Seller or any of its Affiliates to be directed against ENPP1. Neither Party shall disclose, and each Party shall ensure that its Representatives do not disclose, the terms of this Agreement to any Third Party, except as permitted in Section 4.2 or under the Confidentiality Agreements.

The Buyer may issue the press release attached as Exhibit C. Except with respect to the press release attached as Exhibit C, neither Party shall originate any publicity, news release or other public announcement, written or oral, relating to this Agreement without the prior written consent of the other Party (whether such other Party is named in such publicity, news release or

14

other public announcement or not), which consent shall not be unreasonably withheld, conditioned or delayed, except where such publicity, news release or other public announcement is required by law or any listing or trading agreement concerning its publicly traded securities, provided that, in such event, the Party issuing the same shall still be required to consult with the other Party (whether such other Party is named in such publicity, news release or public announcement or not) at least [**] (or, in respect of Buyer’s Form S-1 filed with the SEC on July 2, 2020 or any Form S-1/A thereto, at least [**]) prior to its release to allow the other Party to comment thereon and, after its release, shall provide the other Party with a copy thereof. If Buyer, based on the advice of its counsel, determines that this Agreement must be filed with the United States Securities and Exchange Commission (“SEC”) or any other similar governmental entity, then Buyer, at least [**] prior to making any such filing, shall provide Seller and its counsel with a redacted version of this Agreement which it intends to file and any draft correspondence with the SEC requesting the confidential treatment by the SEC of those redacted sections of the Agreement, and will give due consideration to any timely, reasonable comments provided by Seller or its counsel and use commercially reasonable efforts to ensure the confidential treatment by the SEC of those sections specified by Seller or its counsel. Notwithstanding anything to the contrary herein, each Party may, without the prior written consent of, or notice to, the other Party, disclose in such Party’s periodic filings with the SEC the existence and amount of Seller’s equity interests held in Buyer.

15

All rights and licenses granted under or pursuant to any section of this Agreement are, for purposes of 11 U.S.C. § 365(n) or any analogous provisions in any other country or jurisdiction (the “Bankruptcy Code”), licenses of rights to “intellectual property” as defined in Section 101(56) of the Bankruptcy Code (and any equivalent provisions under the bankruptcy or insolvency laws of any other relevant jurisdiction). The Parties shall retain and may fully exercise all of their respective rights and elections under the Bankruptcy Code. The non-bankrupt Party shall further be entitled to a complete duplicate of, or complete access to, any such intellectual property and all embodiments of such intellectual property, which, if not already in its possession, shall be promptly delivered to the non-bankrupt Party (a) upon the commencement of a bankruptcy proceeding upon the non-bankrupt Party’s written request therefor, unless the Party subject to such proceeding elects to continue to perform all of its obligations under this Agreement, or (b) if not delivered under clause (a) above, following the rejection of this Agreement by or on behalf of the Party subject to such proceeding upon written request therefor by the non-bankrupt Party.

16

ARTICLE 5

INDEMNIFICATION

The Seller shall indemnify and defend the Buyer and its Affiliates from and against any and all Losses suffered or incurred by the Buyer or any of its Affiliates to the extent as a result of or arising, directly or indirectly, out of or in connection with:

The Buyer shall indemnify and defend the Seller and its Affiliates from and against any and all Losses suffered or incurred by the Seller or any of its Affiliates to the extent as a result of or arising, directly or indirectly, out of or in connection with:

17

18

If a Party (the “Indemnified Party”) wishes to be indemnified with respect to any claim, demand, dispute, action, suit, examination, audit, proceeding, investigation, inquiry or other similar matter that may give rise to an indemnification obligation hereunder (each, a “Claim”) against the other Party (the “Indemnifying Party”) pursuant to Section 5.1 or 5.2, such Party shall deliver promptly to the other Party a written notice setting forth in reasonable particularity:

If the Indemnified Party receives notice or otherwise obtains knowledge of the commencement or threat of any Claim instituted by a Third Party (a “Third Party Claim”) for which the Indemnified Party desires to seek indemnification from the Indemnifying Party hereunder, then the Indemnified Party shall promptly deliver to the Indemnifying Party a written notice describing such Claim, but any failure to so notify the Indemnifying Party shall relieve the Indemnifying Party from liability under this Agreement with respect to such Claim only if, and only to the extent that, such failure to notify the Indemnifying Party results in the forfeiture by the Indemnifying Party of rights and defenses otherwise available to the Indemnifying Party with respect to such Claim, or the opportunity to defend or participate in the defense of such Claim, or otherwise actually prejudices the Indemnifying Party with respect to such Claim. The Indemnifying Party shall have the right, upon written notice delivered to the Indemnified Party within [**] after receipt of any such notice of a Claim, to assume the defense and control of such Claim, including the employment of counsel reasonably satisfactory to the Indemnified Party and the payment of the fees and disbursements of such counsel. In the event that the Indemnifying Party assumes, and continues to pursue in good faith, the defense and control of such Claim using counsel reasonably satisfactory to the Indemnified Party, then the Indemnified Party shall be entitled to participate in (but not control) the defense of such Claim, with its counsel and at its own expense. In the event that the Indemnifying Party declines or fails to assume and control, or ceases to pursue in good faith, the defense of the Claim or to employ counsel reasonably satisfactory to the Indemnified Party, then the Indemnified Party may employ counsel, reasonably acceptable to the Indemnifying Party, to represent or defend the Indemnified Party in any such Claim, and the Indemnifying Party shall pay the reasonable fees and disbursements of such counsel as incurred, subject to the monetary limitations set forth in this Article 5; except that the Indemnifying Party shall not be required to pay the fees and disbursements of more than one (1) counsel in any jurisdiction in any single Claim and the Indemnifying Party nevertheless shall have the right to participate in the defense of any Third Party Claim and, at its own expense, to employ counsel of its own choosing for such purpose. The Indemnified Party may not settle or compromise any claim or consent to the entry of any judgment with respect to which indemnification is sought hereunder without the prior written consent of the Indemnifying Party, which shall not be unreasonably withheld, conditioned or delayed. The Indemnifying Party shall not settle any claim or assertion in any manner that would impose any obligation on the

19

Indemnified Party (other than solely financial obligations against which Indemnifying Party fully indemnifies the Indemnified Party in accordance with this Article 5), unless the Indemnified Party consents in writing to such settlement, which consent shall not be unreasonably withheld, conditioned or delayed.

Buyer shall not be entitled to any indemnification hereunder with respect to any breach of any representation or warranty with respect to which Buyer had actual knowledge of such breach as of the Effective Date.

NOTWITHSTANDING ANYTHING TO THE CONTRARY CONTAINED HEREIN, WITH THE EXCEPTION (I) OF RELIEF MANDATED BY STATUTE AND (II) A PARTY’S INDEMNIFICATION OBLIGATIONS FOR ANY LOSS INCURRED OR SUFFERED AS A RESULT OF ANY THIRD PARTY CLAIM, NO PARTY TO THIS AGREEMENT SHALL BE LIABLE TO OR OTHERWISE RESPONSIBLE TO THE OTHER PARTY OR ANY AFFILIATE OF THE OTHER PARTY FOR LOST REVENUES OR PROFITS DAMAGES OR INDIRECT, INCIDENTAL, CONSEQUENTIAL, PUNITIVE, EXEMPLARY OR MULTIPLIED DAMAGES OR ATTORNEYS FEES, COSTS OR PREJUDGMENT INTEREST THAT ARISE OUT OF OR RELATE TO THIS AGREEMENT OR THE PERFORMANCE OR BREACH HEREOF OR ANY LIABILITY RETAINED OR ASSUMED HEREUNDER.

Except as set forth in Section 6.6, this Article 5 provides the sole and exclusive means by which a Party may assert and remedy any claims arising under this Agreement. Except as set forth in Section 6.6, each Party hereby waives and releases any other remedies or claims that it may have against the other Party (or any of its Affiliates) with respect to the matters arising out of or in connection with this Agreement, except that nothing herein shall limit the liability of any Party hereto for Fraud. With respect to any Losses arising under this Agreement, the Parties agree that they shall only seek such Losses from the other Party and hereby waive the right to seek Losses from or equitable remedies, such as injunctive relief, against any Affiliate of the other Party or any Representative thereof (or any of its Affiliates).

20

ARTICLE 6

GENERAL

Any notices or other communications required or permitted hereunder shall be in writing and shall be sufficiently given if delivered personally or sent by facsimile, internationally recognized overnight courier or registered or certified mail, postage prepaid, addressed as follows (or such other address for a Party as may be specified in a notice provided pursuant to this Section 6.1):

Unless otherwise specified herein, each such notice or other communication will be deemed received (a) on the date delivered, if delivered personally, (b) on the date the facsimile was successfully transmitted to the receiving Party or (c) on the date the registered, certified or overnight mail was received by the receiving Party.

21

Neither this Agreement nor any of the rights, interests or obligations hereunder shall be assigned or delegated by any Party (whether by operation of law or otherwise) without the prior written consent of the other Party. Notwithstanding the immediately preceding sentence, (a) either Party may, without the other Party’s prior written consent, assign or delegate this Agreement or any of its rights, interests or obligations hereunder, in whole or in part, to an Affiliate and (b) either Party may, without the other Party’s prior written consent, assign or delegate this Agreement or any of its rights or obligations hereunder, in whole or in part, to a Third Party that acquires, by or otherwise in connection with any merger, sale of assets or otherwise, all or substantially all of the business of such Party to which the subject matter of this Agreement relates; except that (x) in the case of an acquisition of less than all or substantially all of the entire business of Seller, neither Seller nor any of its Affiliates may assign the Internal Research License to any Third Party and, upon any such assignment of this Agreement in the case of an acquisition of less than all or substantially all of the entire business of Seller, the Internal Research License shall immediately terminate, (y) any Third Party assignee of Seller’s rights under this Agreement must agree in writing to assume all of Seller’s obligations under this Agreement, including Seller’s obligations under Section 2.3, and (z) the assigning Party shall not be relieved of any of its obligations under this Agreement. All of the covenants and agreements in this Agreement shall be binding upon the Parties and their respective successors and permitted assigns and shall inure to the benefit of and be enforceable by the Parties and their respective successors and permitted assigns. Any purported assignment in violation of this Section 6.2 will be null and void ab initio. Other than in respect of Section 6.12, there are no express or implied Third Party beneficiaries hereunder.

Nothing contained in this Agreement is intended or shall be deemed or construed to create any relationship of employer and employee, agent and principal, partnership or joint venture between the Parties, including for all applicable tax purposes. Each Party is an independent contractor. No Party shall assume, either directly or indirectly, any liability of or for the other Party. No Party shall have any express or implied right or authority to assume or create any obligations on behalf of, or in the name of, the other Party, nor to bind the other Party to any contract or other agreement or undertaking with any Third Party.

This Agreement shall be construed and enforced in accordance with, and the respective rights and obligations of the Parties shall be governed by, the laws of the State of Delaware, without reference to conflicts of laws principles.

22

Each Party irrevocably submits to the exclusive jurisdiction of (a) the Suffolk County Superior Court of the Commonwealth of Massachusetts and (b) the United States District Court for the District of Massachusetts ((a) and (b), collectively, the “Courts”), for the purposes of any suit, action or other proceeding arising out of this Agreement or out of any transaction contemplated hereby. Each Party agrees to commence any such action, suit or proceeding either in the United States District Court for the District of Massachusetts or, if such suit, action or other proceeding may not be brought in such court for jurisdictional reasons, in the Suffolk County Superior Court of the Commonwealth of Massachusetts. Each Party irrevocably and unconditionally waives any objection to the laying of venue of any action, suit or proceeding arising out of this Agreement or the transactions contemplated hereby in any Court, and hereby and thereby further irrevocably and unconditionally waives and agrees not to plead or claim in any such Court that any such action, suit or proceeding brought in any such Court has been brought in an inconvenient forum. Each Party agrees that service of any court paper may be made in the manner provided for in Section 6.1 (excluding facsimile) or such other as may be provided under applicable laws or court rules governing service of process. Notwithstanding anything to the contrary in this Section 6.5, each Party shall have the right to bring any action, suit or proceeding in any court anywhere in the world to the extent necessary to enforce any judgment obtained in any action, suit or proceeding brought in any Court. THE PARTIES HERETO HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVE, AND AGREE TO CAUSE THEIR RESPECTIVE AFFILIATES TO WAIVE, THE RIGHT TO TRIAL BY JURY IN ANY ACTION DIRECTLY OR INDIRECTLY ARISING OUT OF, UNDER OR IN CONNECTION WITH THIS AGREEMENT OR ANY OF THE TRANSACTIONS CONTEMPLATED HEREBY. EACH PARTY CERTIFIES AND ACKNOWLEDGES THAT (I) NO REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER, (II) EACH PARTY UNDERSTANDS AND HAS CONSIDERED THE IMPLICATIONS OF THIS WAIVER, (III) EACH PARTY MAKES THIS WAIVER VOLUNTARILY, AND (IV) EACH PARTY HAS BEEN INDUCED TO ENTER INTO THIS AGREEMENT BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 6.5.

Each Party acknowledges and agrees that the other Party would be damaged irreparably in the event that such Party’s obligation to effect the transactions contemplated by this Agreement is not performed or is otherwise breached or violated. Accordingly, each Party agrees that, without posting bond or other undertaking, the non-breaching Party shall be entitled to an injunction or injunctions to prevent breaches or violations of the obligation of the breaching Party to enforce specifically this Agreement and the terms and provisions hereof in any action instituted in any court specified in Section 6.5 in addition to any other remedy to which the non-breaching Party may be entitled, at law or in equity. Each Party further agrees that, in the event of any action for an injunction or specific performance in respect of any such threatened or actual breach or violation, it shall not assert that a remedy at law would be adequate.

23

This Agreement (including the Exhibits attached hereto) and the Confidentiality Agreements constitute the entire agreement between the Parties with respect to the subject matter hereof, and supersede all prior and contemporaneous agreements, understandings, negotiations and discussions, whether oral or written, with respect thereto between the Parties. In the event of any conflict between any term in any Confidentiality Agreement and any term in this Agreement, this Agreement shall govern. The Parties may amend or modify this Agreement, in such manner as may be agreed upon by the Parties, by a written instrument executed by the Buyer and the Seller.

This Agreement should not be considered only as an indivisible whole. If any provision of this Agreement is invalid, illegal or unenforceable in any respect, all other provisions of this Agreement shall nevertheless remain in full force and effect so long as the economic and legal substance of the transactions contemplated hereby remains consistent with the original intent of the Parties as of the date of this Agreement.

No waiver of any of the provisions of this Agreement shall be binding on a Party unless consented to in writing by that Party; no waiver shall constitute or shall be deemed to constitute a waiver of any other provision (whether or not similar); nor shall any waiver constitute a continuing waiver unless otherwise expressed or provided in a writing signed by the waiving Party.

Except as otherwise expressly provided herein, the Buyer and the Seller shall each pay their own expenses in connection with this Agreement and the transactions contemplated hereby.

This Agreement may be executed in counterparts, all of which taken together will be regarded as one and the same instrument. Counterparts may be delivered via electronic mail, including Adobe^™ Portable Document Format (PDF) or any electronic signature complying with the U.S. Federal ESIGN Act of 2000, and any counterpart so delivered will be deemed to be original signatures, will be valid and binding upon the Parties, and, upon delivery, will constitute due execution of this Agreement.

Buyer acknowledges and agrees that Seller is a client of Ropes & Gray LLP (the “Firm”). Buyer agrees that Buyer and its Affiliates shall not disqualify the Firm from representing, and Buyer hereby agrees that the Firm may represent, Seller in connection with any dispute that may arise between the Parties or their respective Affiliates in connection with this Agreement or the transactions contemplated hereby. Buyer consents thereto, and waives any conflict of interest

24

arising therefrom. Buyer acknowledges that such consent and waiver is voluntary, that it has been carefully considered, and that Buyer has consulted with counsel or has been advised they should do so in this connection. Buyer hereby acknowledges that any attorney-client privilege or attorney work-product protection between the Firm and Seller solely in connection with the negotiation, documentation and consummation of the transactions contemplated by this Agreement prior to the Effective Date shall, on and after the Effective Date, belong to and be controlled by Seller and constitute Excluded Assets (the “Retained Privilege”). In connection with any such dispute that may arise between the Parties or their respective Affiliates in connection with this Agreement or the transactions contemplated hereby, Seller shall have the sole right to decide whether or not to waive the Retained Privilege. Notwithstanding any other provision herein, no term of this Section 6.12 may be amended, waived or modified, without the prior written consent of Seller and the Firm.

[Signature page follows]

25

IN WITNESS WHEREOF the Parties have executed this Intellectual Property Asset Purchase Agreement as of the date first above written.

[Signature Page to Intellectual Property Asset Purchase Agreement]

IN WITNESS WHEREOF the Parties have executed this Intellectual Property Asset Purchase Agreement as of the date first above written.

[Signature Page to Intellectual Property Asset Purchase Agreement]