Amendment to License Agreement Between Ludwig Institute for Cancer Research Ltd and KaloBios Pharmaceuticals Inc.

Exhibit 10.8

9 October 2008

RE:     Amendment to License Agreement Between LICR and KaloBios (LICR Ref: LUD2240)

1.     The full name of LICR is hereby amended to “Ludwig Institute for Cancer Research Limited” to comply with a change in Swiss Law under which LICR was incorporated.

2.     The parties wish to formally incorporate new Joint Program Patent that has resulted from the Joint Program Research carried out under the Collaborative Research Agreement (LUD2259.2) to Exhibit A of the License Agreement (LUD2240) between LICR and KaloBios (“the Agreement”).

Addition - Exhibit A should have inserted the following:

Patent 4

(a)                                 Provisional patent application US60/893,848 filed on 8 March 2007 and entitled “EphA3 Antibodies for the Treatment of Solid Tumor”;

(b)                                 all patent applications (including foreign applications) that are filed or may later be filed based on or corresponding to the application in (a);

(c)                                  all divisional and continuations, in whole or in part, applications, and reissue applications based on any of the foregoing patent applications;

(d)                                 all issued and unexpired patents resulting from any application in (a), (b), or (c) above;

(e)                                  all issued and unexpired reissue, re-examination, renewal or extension patents that may be based on any such patents; and

(f)                                   any invention or discovery; manner, method or process of manufacture; method or principle of construction; chemical composition or formulation; biological material; or scientific, technical or engineering information or document which is encompassed or taught in the patents or patent applications referred to in paragraphs (a) to (e).

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To indicate the parties’ agreement to this addition of Joint Program Patent please sign and date the acknowledgement at the end of this letter (the “Letter Agreement”) and send one copy by facsimile to the other party as indicated above.

Unless defined expressly in this Letter Agreement, capitalised letters in this Letter Agreement have the meanings given to them in the Agreement.

Yours sincerely,

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