Second Amendment to Co-Development, Supply and Commercialization Agreement, dated as of April 15, 2022, by and between the Registrant and Bharat Biotech International Limited

Bharat Biotech International Limited, whose registered address is at Genome Valley, Shameerpet, Hyderabad — 500078 Telangana India (together with its Affiliates, subsidiaries, successors and permitted assigns, “BBIL”),

WHEREAS, the Parties have previously entered into the Co-Development, Supply and Commercialization Agreement (hereinafter “Agreement”) dated as of January 31, 2021;

WHEREAS, Parties have previously amended the Agreement, by executing the First Amendment to Co-Development, Supply and Commercialization Agreement on May 29, 2021 (hereinafter “First Amendment”); and

WHEREAS, the Parties mutually desire to amend the Agreement for a second time as provided herein and incorporate the terms set forth herein into the Agreement.

NOW, THEREFORE, in consideration of the foregoing premises, the Parties agree as follows:

1.Ocugen Territory. As per clause 1.53 of the Agreement, the Ocugen Territory is currently defined solely as the United States and Canada. The Parties desire and hereby agree to expand the Ocugen Territory by including Mexico therein, subject to the following terms and conditions:

(i)    With respect to the first procurement Sale of the Product in Mexico, BBIL shall be first entitled to [***]% of the Operating Profit up to a maximum of USD [***] (the “Up-Front Profit Share”); provided, that any Operating Profit with respect to such first procurement Sale in excess of USD [***] will be shared by Ocugen and BBIL as set forth in Section 8.1 of the Agreement; and provided further that the amount of Up-Front Profit Share received by BBIL in excess of [***] ([***]%) of the Operating Profit on such first procurement Sale shall be deducted from future Operating Profit Payments to BBIL with respect to Sales in Mexico.

b.To the extent that BBIL has made any Regulatory Filings or obtained any Regulatory Approvals for the Mexico territory prior to the date hereof, BBIL shall promptly transfer such Regulatory Filings and Regulatory Approvals to Ocugen to the extent permitted by Applicable Law. In the event that any such Regulatory Approval cannot be transferred pursuant to Applicable Law, the Parties shall cooperate to provide Ocugen with the rights and benefits of such Regulatory Approvals until such time that they may be transferred to Ocugen, if ever.

c.The Parties hereby agree that, except as specifically provided in Clause 1(a)(i) of this Second Amendment, the Profit Share as stated in the Agreement shall remain same and BBIL shall have no obligation whatsoever to any third party in the Territory under the Agreement.

3.No Other Modifications. Except as expressly set forth in this Second Amendment, the Agreement and all provisions thereof in effect as of the date of this Second Amendment shall continue in full force and effect without any modification or amendment, and the terms of this Second Amendment shall stand as an integral part of the Agreement.