HERON THERAPEUTICS, INC. Contracts & Agreements

Amendment No. 1 to Co-Promotion Agreement, dated as of January 5, 2024, by and between the Company and Crosslink Network, LLC (Filed With SEC on November 12, 2024)

Amendment No. 2 to Co-Promotion Agreement, dated as of January 5, 2024, by and between the Company and Crosslink Network, LLC (Filed With SEC on November 12, 2024)

Co-Promotion Agreement, dated as of January 5, 2024, by and between the Company and Crosslink Network, LLC (Filed With SEC on May 7, 2024)

Executive Employment Agreement, dated April 3, 2023, by and between the Company and Craig Collard (Filed With SEC on August 14, 2023)

Management Retention Agreement, dated June 6, 2023, by and between the Company and William Forbes (Filed With SEC on August 14, 2023)

Management Retention Agreement, dated June 16, 2023, by and between the Company and Ira Duarte (Filed With SEC on August 14, 2023)

Working Capital Facility Agreement, dated August 9, 2023, by and among the Company, the several banks and other financial institutions or entities from time to time party thereto,... (Filed With SEC on August 14, 2023)

Securities Purchase Agreement, dated July 21, 2023, by and among the Company and the Purchasers signatory thereto (Filed With SEC on July 24, 2023)

Amendment to Executive Employment Agreement, dated May 5, 2023, by and between the Company and David Szekeres (Filed With SEC on July 24, 2023)

Cooperation Agreement, dated February 21, 2023, by and among Heron Therapeutics, Inc., Rubric Capital Management LP, the persons and entities listed on Schedule A thereto, Velan... (Filed With SEC on February 22, 2023)

Securities Purchase Agreement, dated August 8, 2022, by and among the Company and the Purchasers signatory thereto (Filed With SEC on August 10, 2022)

Executive Employment Agreement, dated March 17, 2016, by and between the Company and David Szekeres (Filed With SEC on August 9, 2022)

Amendment to Executive Employment Agreement, dated July 15, 2019, as amended on August 8, 2022, by and between the Company and John Poyhonen (Filed With SEC on August 9, 2022)

Amendment to Management Retention Agreement, dated January 14, 2020, as amended on August 8, 2022, by and between the Company and Lisa Peraza (Filed With SEC on August 9, 2022)

Fourth Amendment to Lease, dated October 13, 2021, by and between the Company and ARE-SD Region No. 61, LLC (Filed With SEC on November 3, 2021)

Note Purchase Agreement, dated as of May 24, 2021, by and among Heron Therapeutics, Inc. and funds affiliated with Baker Bros. Advisors LP (Filed With SEC on May 25, 2021)

Description of the Registrants Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934 (Filed With SEC on March 2, 2020)

Third Amendment to Lease, dated December 19, 2019 (Filed With SEC on December 20, 2019)

Underwriting Agreement, dated October 3, 2019, among Heron Therapeutics, Inc. and Jefferies LLC, Cowen and Company, LLC and Evercore Group L.L.C., as representatives of the... (Filed With SEC on October 8, 2019)

Executive Employment Agreement, dated July 15, 2019, by and between the Company and John Poyhonen (Filed With SEC on August 5, 2019)

Underwriting Agreement, dated June 25, 2018, between Heron Therapeutics, Inc. and Jefferies LLC (Filed With SEC on June 28, 2018)

Second Amendment to Lease, dated May 8, 2018, by and between Heron Therapeutics, Inc. and AP3-SD1 Campus Point LLC (Filed With SEC on May 10, 2018)

Underwriting Agreement, dated March 28, 2018, among Heron Therapeutics, Inc. and Jefferies LLC, Cowen and Company, LLC and Evercore Group L.L.C., as representatives of the several... (Filed With SEC on April 3, 2018)

Waiver, dated March 28, 2018, between Heron Therapeutics, Inc. and Tang Capital Partners, LP (Filed With SEC on April 3, 2018)

Underwriting Agreement, dated December 4, 2017, between Heron Therapeutics, Inc. and Cantor Fitzgerald & Co (Filed With SEC on December 7, 2017)

EXECUTIVE EMPLOYMENT AGREEMENT (Filed With SEC on August 9, 2017)

FIRST AMENDMENT TO LEASE (Filed With SEC on March 17, 2017)

12,300,000 Shares of Common Stock HERON THERAPEUTICS, INC. UNDERWRITING AGREEMENT (Filed With SEC on January 24, 2017)

WAIVER (Filed With SEC on January 24, 2017)

SECURITY AGREEMENT (Filed With SEC on November 8, 2016)

Pursuant to 17 CFR 20.24b-2, confidential information has been omitted in places marked *** and has been filed separately with theSecurities and Exchange Commission pursuant to a... (Filed With SEC on November 8, 2016)

LEASE GENESIS CAMPUSPOINT AP3-SD1 CAMPUS POINT LLC, a Delaware limited liability company as Landlord, and HERON THERAPEUTICS, INC., aDelaware corporation as Tenant TABLE OF... (Filed With SEC on November 8, 2016)

EXECUTIVE EMPLOYMENT AGREEMENT (Filed With SEC on May 5, 2016)

FOURTH AMENDMENT TO LEASE (Filed With SEC on April 15, 2016)

Pursuant to 17 CFR 20.24b-2, confidential information has been omitted in places marked *** and has been filed separately with theSecurities and Exchange Commission pursuant to a... (Filed With SEC on February 19, 2016)

EXECUTIVE EMPLOYMENT AGREEMENT (Filed With SEC on November 6, 2015)

4,800,000 Shares of Common Stock HERON THERAPEUTICS, INC. UNDERWRITING AGREEMENT (Filed With SEC on June 10, 2015)

SUSTOL® (GRANISETRON EXTENDEDRELEASE) INJECTION COMMERCIAL MANUFACTURING SERVICES AGREEMENT FINISHED FINAL DRUG PRODUCT (Filed With SEC on May 29, 2015)

AMENDMENT TO EXECUTIVEEMPLOYMENT AGREEMENT (Filed With SEC on May 8, 2015)

AMENDMENT TO MANAGEMENTRETENTION AGREEMENT (Filed With SEC on May 8, 2015)

AMENDMENT TO EXECUTIVEEMPLOYMENT AGREEMENT (Filed With SEC on May 8, 2015)

4,500,000 Shares of Common Stock and Pre-FundedWarrants to Purchase 600,000 Shares of Common Stock HERON THERAPEUTICS, INC. UNDERWRITING AGREEMENT (Filed With SEC on June 27, 2014)

HERON THERAPEUTICS, INC. FORM OF WARRANT TO PURCHASE COMMON STOCK (Filed With SEC on June 27, 2014)

123 Saginaw Drive Redwood City, CA 94063 Phone: 650 ###-###-#### Fax: 650 ###-###-#### www.appharma.com (Filed With SEC on March 7, 2014)

123 SaginawDrive Redwood City, CA 94063 Phone: 650 ###-###-#### Fax: 650 ###-###-#### www.appharma.com (Filed With SEC on March 7, 2014)

A.P. PHARMA, INC. MANAGEMENT RETENTION AGREEMENT (Filed With SEC on March 7, 2014)

EXECUTIVE EMPLOYMENT AGREEMENT (Filed With SEC on March 7, 2014)

150,000,000 A.P.PHARMA, INC. UNDERWRITING AGREEMENT (Filed With SEC on November 22, 2013)

A.P. PHARMA, INC. NON-QUALIFIED STOCKOPTION AGREEMENT TERMS AND CONDITIONS (Filed With SEC on August 8, 2013)

123 Saginaw Drive | Redwood City, CA 94063 (Filed With SEC on August 8, 2013)

EXECUTIVE EMPLOYMENT AGREEMENT (Filed With SEC on May 10, 2013)

A.P. PHARMA, INC. MANAGEMENT RETENTION AGREEMENT (Filed With SEC on March 1, 2013)

SECURITIES PURCHASE AGREEMENT (Filed With SEC on July 25, 2012)

REGISTRATION RIGHTS AGREEMENT (Filed With SEC on July 25, 2012)

THIRD AMENDMENT TO LEASE (Filed With SEC on August 3, 2011)

SECURITIES PURCHASE AGREEMENT (Filed With SEC on June 30, 2011)

AMENDMENT TO SENIOR SECURED CONVERTIBLE NOTES DUE 2021 (Filed With SEC on June 30, 2011)

SECURITIES PURCHASE AGREEMENT AMONG A.P. PHARMA, INC., TANG CAPITAL PARTNERS, LP, BAKER BROS. INVESTMENTS II, L.P., BAKER BROTHERS LIFE SCIENCES, L.P., AND 14159, L.P. DATED AS OF... (Filed With SEC on April 28, 2011)

SENIOR SECURED CONVERTIBLE NOTE DUE 2021 (Filed With SEC on April 28, 2011)

SECURITY AGREEMENT (Filed With SEC on April 28, 2011)

SECOND AMENDMENT TO LEASE (Filed With SEC on April 28, 2011)

A.P. PHARMA, INC. MANAGEMENT RETENTION AGREEMENT (Filed With SEC on April 28, 2011)

SEPARATION AGREEMENT AND GENERAL RELEASE (Filed With SEC on June 1, 2010)

A.P. PHARMA, INC 2007 EQUITY INCENTIVE PLAN DIRECTORS RESTRICTED STOCK AWARD AGREEMENT (Filed With SEC on May 17, 2010)

A.P. PHARMA, INC. (Filed With SEC on November 16, 2009)

A.P. PHARMA, INC. SECURITIES PURCHASE AGREEMENT (Filed With SEC on October 22, 2009)

REGISTRATION RIGHTS AGREEMENT (Filed With SEC on October 22, 2009)

WARRANT TO PURCHASE SHARES OF COMMON STOCK OF A.P. PHARMA, INC. (Filed With SEC on October 22, 2009)

SECOND AMENDMENT TO RIGHTS AGREEMENT (Filed With SEC on October 22, 2009)

EXHIBIT A Offer Letter (Filed With SEC on March 31, 2009)

A.P. PHARMA, INC. AMENDMENT NO. 1 TO MANAGEMENT RETENTION AGREEMENT (Filed With SEC on March 31, 2009)

FIRST AMENDMENT TO RIGHTS AGREEMENT (Filed With SEC on October 7, 2008)

Exhibit 10-U (Filed With SEC on August 14, 2008)

A.P. PHARMA, INC. 1997 EMPLOYEE STOCK PURCHASE PLAN (Filed With SEC on March 31, 2008)

A.P. PHARMA, INC 2007 EQUITY INCENTIVE PLAN (Filed With SEC on March 31, 2008)

A.P. PHARMA, INC. 2002 EQUITY INCENTIVE PLAN (Filed With SEC on March 31, 2008)

Restricted Stock Award Agreement between A.P. Pharma, Inc. and pursuant to the A.P. Pharma, Inc. 2002 Equity Incentive Plan (Filed With SEC on March 31, 2008)

INDEMNIFICATION AGREEMENT (Filed With SEC on March 31, 2008)

AMENDED AND RESTATED RETENTION AND NON-COMPETITION AGREEMENT (Filed With SEC on November 14, 2007)

A.P. PHARMA, INC. MANAGEMENT RETENTION AGREEMENT (Filed With SEC on November 14, 2007)

AMENDMENTS TO ADVANCED POLYMER SYSTEMS, INC. NON-QUALIFIED STOCK PLAN (Filed With SEC on November 14, 2007)

A.P. PHARMA, INC. [ ] Sharesof Common Stock (Par Value $0.01 Per Share) UNDERWRITING AGREEMENT (Filed With SEC on May 25, 2007)

INDEMNIFICATION AGREEMENT (Filed With SEC on May 25, 2007)

AMENDED AND RESTATED RETENTION AND NON-COMPETITION AGREEMENT (Filed With SEC on April 5, 2007)

CHANGE OF CONTROL AGREEMENT (Filed With SEC on April 5, 2007)

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HERON THERAPEUTICS, INC. Contracts & Agreements