1.81 Know-How means any scientific or technical information, including discoveries, improvements, modifications, processes, methods, protocols, formulas, data, inventions, know-how and trade secrets, patentable or otherwise, but excluding any of the foregoing claimed in any Patent Rights and excluding any Regulatory Materials.
1.82 Law means any federal, state, local, foreign or multinational law, statute, standard, ordinance, code, rule, regulation, resolution or promulgation, or any order by any Governmental Authority, or any license, franchise, permit or similar right granted under any of the foregoing, or any similar provision having the force or effect of law.
1.83 Licensed Compound means (a) any Collaboration Compound, (b) any Select Related Compound, and (c) any metabolite, salt, hydrate, solvate, enantiomer, free acid form, free base form, ester, deuterated form, crystalline form, co-crystalline form, amorphous form, pro drug form, racemate, polymorph, chelate, stereoisomer, tautomer, or optically active form of any compound in the preceding clause (a) or (b).
1.84 Licensed Covering Claim means a Covering Claim in a Licensed Patent.
1.85 Licensed IP means all Licensed Patents and Licensed Know-How.
1.86 Licensed Know-How means (a) all Know-How that is (i) Controlled by Syros or its Affiliates as of the Effective Date, and (ii) necessary or useful for the research, Development, manufacture or Commercialization of Licensed Compounds or Products, and (b) without limitation to clause (a), Syros Sole Know-How, Syros Sole Inventions and Syros interests in any Joint Know-How and Joint Inventions; excluding in each case ((a) and (b)) Syros Excluded IP.
1.87 Licensed Patents means the Syros Sole Patents, any Other Syros Patents, and Syros interest in any Joint Patents.
1.88 Losses is defined in Section 9.1.
1.89 MAA or Marketing Authorization Application means an application to the appropriate Regulatory Authority for approval to commercially sell a Product in a particular jurisdiction, and all amendments and supplements thereto, including an NDA in the United States.
1.90 Major Market means any of the United Kingdom, Germany, France, Italy and Switzerland.
1.91 Materials is defined in Section 2.9.
1.92 NDA means a New Drug Application, as defined in the U.S. Federal Food, Drug & Cosmetic Act, as amended, and applicable regulations promulgated thereunder by the FDA, including 21 C.F.R. Part 314.
1.93 Net Sales means, with respect to any Product, in a particular period, the sum of (a) and (b) below: