ORIGINAL EQUIPMENT MANUFACTURING AGREEMENT BETWEEN COOK INCORPORATED &FOXHOLLOW TECHNOLOGIES, INC.

Exhibit 10.20

ORIGINAL EQUIPMENT MANUFACTURING AGREEMENT

BETWEEN COOK INCORPORATED & FOXHOLLOW TECHNOLOGIES, INC.

This Original Equipment Manufacturing Agreement (“Agreement”) is effective as of the 4th day of May, 2006 (“Effective Date”) by and between Cook Incorporated and (“Cook”), an Indiana corporation, with offices located at 750 Daniels Way, Bloomington Indiana, 46404, and FoxHollow Technologies, Inc. (“FTI”), a Delaware corporation with its principal place of business at 740 Bay Road, Redwood City, California, 94063.

Preliminary Statements

1. Cook is engaged in the manufacture of certain medical devices including [***] (the “Product”);

2. FTI is engaged in the sale and marketing of medical devices;

3. Cook is willing and able to manufacture the Product to specifications approved by both FTI and Cook, and to sell the Product to FTI on the terms and conditions set forth herein; and

4. FTI desires to have Cook act as an original equipment manufacturer for the Product.

In consideration of the promises hereof, and the mutual obligations herein made and undertaken and for valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows:

Agreement

(a) This Agreement shall commence on the Effective Date and shall continue for an initial period which shall expire on December 31, 2007 unless sooner terminated as provided herein (the “Initial Term”).

(b) Cook may elect to renew this Agreement for successive one (1) year periods (each a “Renewal Period”) by giving written notice to FTI sixty (60) days prior to the expiration of the Initial Term or the then current Renewal Period, as the case may be, unless FTI sends notice to Cook of FTI’s intent not to renew this Agreement at least thirty (30) days prior to the expiration of the then current term.

(c) The “Term” of this Agreement means the Initial Term and any Renewal Period(s) of this Agreement as provided under Sections 1(a) and (b) above.

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FTI may only return the Products to Cook if the Products fail to meet the Specifications. FTI, at its own option, will inspect and examine the Product within fourteen (14) days of delivery at FTI’s facility. If FTI, upon examination of the Product, becomes aware of any defect in the Product, FTI shall notify Cook within fourteen (14) business days of detection of such defect in the Product. If, and to the extent FTI fails to examine the delivery of the Product or fails to notify Cook, the Product shall be deemed to have been accepted by FTI in satisfactory condition and as meeting the Specifications.

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obligations to FTI under this Agreement, including, but not limited to, the manufacturing, packaging, sterilization, labeling and distribution of the Product for and to FTI.

Cook warrants that the Products supplied by Cook shall comply with the Specifications. COOK GIVES NO OTHER WARRANTY, EXPRESS OR IMPLIED, IN RESPECT OF THE QUALITY OF THE PRODUCT AND, IN PARTICULAR, GIVES NO WARRANTY OF MERCHANTABILITY OR OF FITNESS FOR ANY PARTICULAR PURPOSE.

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impose any obligations on the Indemnitee in addition to those set forth herein, in order for it to exercise such rights, without Indemnitee’s prior written consent, which shall not be unreasonably withheld or delayed. The Indemnitee and its respective directors, officers, employees, subcontractors and agents shall fully cooperate with the Indemnitor in the investigation and defense of any matter covered by the indemnification obligations of this Section 10. The Indemnitee shall have the right, but not the obligation, to be represented in such defense by counsel of its own selection and at its own expense.

In the event FTI shall be required to recall any Product, or FTI product incorporating any Product because such Product may violate local, state or federal laws or regulations, the laws or regulations of any applicable foreign government or agency or the Specifications, or in the event that FTI elects to institute a voluntary recall, FTI shall be responsible for coordinating such recall. Cook shall cooperate with FTI in connection with any recall, at Cook’s expense. FTI shall be responsible for all costs and expenses of such recall except as follows: in the event a recall, product withdrawal or field correction is necessary because Cook has delivered a non-conforming Product to FTI, Cook will bear all reasonable costs associated with such recall, product withdrawal or field correction. For purposes of this Agreement, non-conforming means any Product that does not conform to the Specifications as set forth in Exhibit A.

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except for the performance of that other party’s obligations under this Agreement. (“Confidential Information”). The obligations of non-use and confidentiality contained in this Section 13 shall not apply to any information which (i) was already in the possession of the recipient or in the public domain prior to its disclosure by the other party, (ii) is purchased or otherwise legally acquired by the recipient at any time from a third party having good title thereto, or (iii) comes into the public domain, otherwise than through the fault of the recipient or is disclosed under compulsion of law to any court or government or regulatory authority.

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[Signature Page Follows]

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IN WITNESS WHEREOF, the parties have set their hands and seals as of the 4th day of May, 2006 to this original equipment manufacturing agreement.

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EXHIBIT A

PRODUCT SPECIFICATIONS

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EXHIBIT B

PACKAGING AND LABELING

Product shall be labeled with the FTI label as described in this Exhibit B, and include “Manufactured by Cook.”

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EXHIBIT C

PURCHASE PRICE

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