Mutual Termination Agreement, dated December 12, 2022, by and between Exicure, Inc. and Ipsen Biopharm Limited

THIS MUTUAL TERMINATION AGREEMENT (“Mutual Termination Agreement”) is made and entered into as of December 12th, 2022 (the “Termination Effective Date”)

WHEREAS Exicure and Northwestern University, an Illinois not-for-profit corporation with a principal place of business at 633 Clark Street, Evanston, Illinois, 60208 (“NU”) are parties to that certain License Agreement, made with effect from May 27, 2014, and that certain Restated License Agreement, made August 15, 2015 and effective as of December 12, 2011, each as amended from time to time.

WHEREAS, Exicure and Ipsen have decided to mutually terminate the Agreement and to provide for certain additional terms to apply to their relationship after such termination.

NOW, THEREFORE, in consideration of the premises and the mutual promises and conditions hereinafter set forth, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties agree as follows:

1.Termination. The Agreement is hereby mutually terminated as of the Termination Effective Date.

2.Defined Terms. Capitalized terms used in this Mutual Termination Agreement that are not otherwise defined herein shall have the meanings set forth in the Agreement.

3.Rodent Target Engagement Milestone. Section 13.5(e) of the Agreement shall no longer apply, is hereby irrevocably waived by Exicure, and shall not survive termination of the Agreement. Accordingly, Ipsen will have no obligation to pay the Rodent Target Engagement Milestone for any program.

5.Waiver of Exclusivity. Section 7.6 of the Agreement shall no longer apply, is irrevocably waived by each Party, and shall not survive termination of the Agreement.

6.R&D Term IP. Notwithstanding anything to the contrary in the Agreement, including Section 9.1(b) of the Agreement, the Parties shall jointly own R&D Term IP and Patents Covering the R&D Term IP, with each Party owning an equal, undivided interest in and to such R&D Term IP and Patents, and each Party shall have the right to Exploit such jointly-owned R&D Term IP and Patents without a duty of seeking consent from or accounting to the other Party. In the event that co-ownership is legally not available in a country, Exicure shall issue to Ipsen a nonexclusive, fully paid up and irrevocable license (with the full right to sub-license) to the applicable Patent.

8.JSC. The JSC shall be disbanded as of the Termination Effective Date.

9.NU Side Letter. Exicure will notify NU about the termination of the Agreement as soon as practicable after the Termination Effective Date.

10.Survival. Section 13.8 (Survival) of the Agreement will continue to apply as modified by the terms of this Mutual Termination, provided that Sections 7.3(b), 9.4, 9.5, 13.1, shall not survive the termination of the Agreement.

This Mutual Termination will be governed by, and enforced and construed in accordance with, the laws of the State of New York, without regard to its conflicts of law provisions. Notwithstanding any other provision in this Agreement, the Parties expressly reject the application of (a) the United Nations Convention on Contracts for the International Sale Of Goods, and (b) the 1974 Convention on the Limitation Period in the International Sale of Goods, as amended by that certain Protocol, concluded at Vienna, Austria on April 11, 1980.

This Mutual Termination Agreement may be executed in counterparts, all of which taken together shall be regarded as one and the same instrument.

IN WITNESS WHEREOF, the parties have executed this Mutual Termination Agreement by their duly authorized representatives as of Termination Effective Date.

IN WITNESS WHEREOF, the parties have executed this Mutual Termination Agreement by their duly authorized representatives as of Termination Effective Date.