Amendment No. 1 to Loan and Security Agreement between Lighthouse Capital Partners V, L.P. and CombinatoRx, Incorporated

Summary

This amendment updates the Loan and Security Agreement between Lighthouse Capital Partners V, L.P. and CombinatoRx, Incorporated. It changes the definition of the "Commitment Termination Date" to the earliest of October 15, 2005, any default, or a significant change in the borrower's board or management. All other terms of the original agreement remain unchanged. The amendment is effective as of September 30, 2005.

EX-10.15.1 3 a2163427zex-10_151.txt EX-10.15.1 Exhibit 10.15.1 AMENDMENT NO. 01 Dated September 30, 2005 TO that certain Loan and Security Agreement No. 4201 dated as of September 7, 2004, ("AGREEMENT"), by and between LIGHTHOUSE CAPITAL PARTNERS V, L.P. ("LENDER") AND COMBINATORX, INCORPORATED ("BORROWER"). (All capitalized terms not otherwise defined herein shall have the meanings given to such terms in the Agreement.) Without limiting or amending any other provisions of the Agreement, Lender and Borrower agree to the following: SECTION 1.1, the following definitions of the Agreement shall be deleted in its entirety and replaced with the following: "COMMITMENT TERMINATION DATE" means the earliest to occur of (I) October 15, 2005; (II) any Default or Event of Default, or (III) in Lender's sole judgment, any adverse change in the management or composition of Borrower's Board of Directors after the date hereof. Except as amended hereby, the Agreement remains unmodified and unchanged. BORROWER: LENDER: COMBINATORX, INCORPORATED LIGHTHOUSE CAPITAL PARTNERS, V, L.P. By: /s/ R. FORRESTER By: LIGHTHOUSE MANAGEMENT PARTNERS V, L.L.C., its general partner Name: R. Forrester Title: EVP & CFO By: /s/ illegible --------------------------------- Name: ------------------------------- Title: ------------------------------