EPIRUS Biopharmaceuticals, Inc. Contracts & Agreements

Granted Under the 2015 Equity Incentive Plan of EPIRUS Biopharmaceuticals, Inc. (Filed With SEC on March 29, 2016)

EPIRUS BIOPHARMACEUTICALS, INC. AMENDED AND RESTATED Non-Employee DIRECTOR COMPENSATION POLICY (Filed With SEC on March 29, 2016)

EPIRUS BIOPHARMACEUTICALS, INC. As Vendor - and - TARO PHARMACEUTICALS INC. As Purchaser - Regarding – ZALICUS PHARMACEUTICALS LTD. SHARE PURCHASE AGREEMENT OCTOBER 1, 2015 (Filed With SEC on March 29, 2016)

Incentive Stock Option Granted Under the 2015 Equity Incentive Plan of EPIRUS Biopharmaceuticals, Inc. (Filed With SEC on March 29, 2016)

Nonstatutory Stock Option Granted Under the 2015 Equity Incentive Plan of EPIRUS Biopharmaceuticals, Inc. (Filed With SEC on March 29, 2016)

EPIRUS BIOPHARMACEUTICALS, INC. UP TO $30,000,000 OF COMMON STOCK (par value $0.001 per share) AT-THE-MARKET SALES AGREEMENT (Filed With SEC on March 1, 2016)

COLLABORATION AGREEMENT BY AND BETWEEN EPIRUS SWITZERLAND GMBH AND SWISS PHARMA INTERNATIONAL AG JULY 13, 2015 (Filed With SEC on November 16, 2015)

New Collaboration Compound Supplement to the Collaboration Agreement by and between EPIRUS SWITZERLAND GmbH and LIVZON MABPHARM INC. (Filed With SEC on November 16, 2015)

STOCK PURCHASE AGREEMENT REGARDING THE SALE AND TRANSFER OF ALL OUTSTANDING SHARES IN BIOCEROS HOLDING B.V. (BIOCEROS) BY AND AMONG EPIRUS BIOPHARMACEUTICALS, INC., (EPIRUS) AND... (Filed With SEC on September 9, 2015)

ONE EXETER PLAZA BOSTON, MASSACHUSETTS (THE BUILDING) SECOND AMENDMENT MAY 29, 2015 LANDLORD: CPT One Exeter Plaza, LLC, a Delaware limited liability company with a principal... (Filed With SEC on August 12, 2015)

SETTLEMENT AGREEMENT Under RLS Epirus BOW015 Manufacturing and Supply Agreement (Filed With SEC on May 13, 2015)

WARRANT TO PURCHASE STOCK (Subdivided Warrant: of ) (Filed With SEC on March 31, 2015)

Schedule of Warrants (Filed With SEC on March 31, 2015)

Vest Type (Filed With SEC on March 31, 2015)

<<Name>> Award Number: <<Number>> <<Address>> Plan: 2004 (Filed With SEC on March 31, 2015)

9,600,000 Shares EPIRUS BIOPHARMACEUTICALS, INC. Common Stock, Par Value $0.001 Per Share UNDERWRITING AGREEMENT (Filed With SEC on January 30, 2015)

EPIRUS BIOPHARMACEUTICALS, INC. SEVERANCE PLAN (Filed With SEC on January 26, 2015)

AMENDMENT No. 1 to RANBAXY EPIRUS LICENSE AGREEMENT (Filed With SEC on November 10, 2014)

EXCLUSIVE LICENSE AND COLLABORATION AGREEMENT BY AND BETWEEN EPIRUS SWITZERLAND GmbH AND LIVZON MABPHARM INC. (Filed With SEC on November 10, 2014)

ONE EXETER PLAZA BOSTON, MASSACHUSETTS (THE BUILDING) FIRST AMENDMENT MAY 15, 2014 (Filed With SEC on November 10, 2014)

SECOND AMENDMENT TO THE REVENUE AND NEGOTIATION RIGHTS AGREEMENT (Filed With SEC on October 31, 2014)

WARRANT AGREEMENT To Purchase Shares of the Common Stock of EPIRUS Biopharmaceuticals, Inc. Dated as of September 30, 2014 (the Effective Date) (Filed With SEC on October 3, 2014)

LOAN AND SECURITY AGREEMENT (Filed With SEC on October 3, 2014)

FIRST AMENDMENT TO THE REVENUE AND NEGOTIATION RIGHTS AGREEMENT (Filed With SEC on September 29, 2014)

FOURTEEN22, INC. WARRANT TO PURCHASE SERIES A PREFERRED STOCK (Filed With SEC on August 11, 2014)

FOURTEEN22, INC. WARRANT TO PURCHASE PREFERRED STOCK (Filed With SEC on August 11, 2014)

GPEx® CELL LINE SALE AGREEMENT (Filed With SEC on August 11, 2014)

REVENUE AND NEGOTIATION RIGHTS AGREEMENT (Filed With SEC on August 11, 2014)

LICENSE AGREEMENT (Filed With SEC on August 11, 2014)

SECOND DEFENITIVE LICENSE AGREEMENT (Filed With SEC on August 11, 2014)

LICENSE AGREEMENT (Filed With SEC on August 11, 2014)

LEASE AGREEMENT ONEEXETER PLAZA 699 BOYLSTON ST., BOSTON, MASSACHUSETTS L E A S E FROM CPT ONE EXETER PLAZA, LLC, A DELAWARE LIMITED LIABILITY COMPANY TO EPIRUSBIOPHARMACEUTICALS,... (Filed With SEC on August 11, 2014)

EPIRUS Biopharmaceuticals, Inc. Non-Employee Director Compensation Policy (Filed With SEC on July 18, 2014)

EXCLUSIVE LICENSE AGREEMENT (Filed With SEC on June 18, 2014)

ASSET PURCHASE AGREEMENT BY AND AMONG HORIZONDISCOVERY LIMITED, HORIZON DISCOVERY INC., AND ZALICUS INC. Dated as of May 14, 2014 TABLE OF CONTENTS (Filed With SEC on May 15, 2014)

AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER AND REORGANIZATION (Filed With SEC on May 8, 2014)

FOURTEEN22, INC. 2011EQUITY INCENTIVE PLAN (Filed With SEC on May 8, 2014)

EPIRUS BIOPHARMACEUTICALS, INC. 2011 EQUITY INCENTIVE PLAN STOCK OPTION AGREEMENT (Filed With SEC on May 8, 2014)

AGREEMENT AND PLAN OF MERGER AND REORGANIZATION among: ZALICUS INC., a Delaware corporation; BRUNNING, INC., aDelaware corporation; and EPIRUS BIOPHARMACEUTICALS, INC., a Delaware... (Filed With SEC on April 16, 2014)

VOTING AGREEMENT (Filed With SEC on April 16, 2014)

ZALICUS INC. Restricted Stock Unit Agreement Granted Under CombinatoRx, Incorporated Amended and Restated 2004 Incentive Plan (Filed With SEC on March 7, 2013)

ZALICUS INC. Performance-Based Nonstatutory Stock Option Granted Under the CombinatoRx, Incorporated Amended and Restated 2004 Incentive Plan (Filed With SEC on March 7, 2013)

Amendment (Filed With SEC on May 4, 2012)

CONSENT AND FIRST LOAN MODIFICATION AGREEMENT (Filed With SEC on March 9, 2012)

ZALICUS INC. Performance-Based Nonstatutory Stock Option Granted Under the CombinatoRx, Incorporated Amended and Restated 2004 Incentive Plan (Filed With SEC on May 5, 2011)

ZALICUS INC. EQUITY DISTRIBUTION AGREEMENT (Filed With SEC on February 9, 2011)

AGREEMENT (Filed With SEC on May 12, 2010)

DONALD RIX BUILDING UNIVERSITY OF BRITISH COLUMBIA SUBLEASE RENEWAL AND AMENDMENT AGREEMENT (Filed With SEC on March 26, 2010)

SECOND AMENDMENT TO LEASE (Filed With SEC on March 26, 2010)

COLLABORATION AGREEMENT BY AND BETWEEN PGX HEALTH, LLC AND COMBINATORX, INC. EFFECTIVE ON AUGUST 11, 2009 (Filed With SEC on August 13, 2009)

WARRANT (Filed With SEC on August 7, 2009)

245 First Street, Cambridge, MA 02142 Ph: 617 ###-###-#### Fax: 617 ###-###-#### www.combinatorx.com (Filed With SEC on August 7, 2009)

ASSET PURCHASE AGREEMENT BETWEEN NEUROMED DEVELOPMENT INC. AND MALLINCKRODT INC. (Filed With SEC on August 7, 2009)

DEVELOPMENT AND TRANSITION SERVICES AGREEMENT (Filed With SEC on August 7, 2009)

WWW.MPMCAPITAL.COM (Filed With SEC on August 7, 2009)

Page 2 (Filed With SEC on August 7, 2009)

EMPLOYMENT AGREEMENT (Filed With SEC on August 7, 2009)

Schedule B (Filed With SEC on August 7, 2009)

Schedule A (Filed With SEC on August 7, 2009)

EMPLOYMENT AGREEMENT (Filed With SEC on August 7, 2009)

NEUROMED TECHNOLOGIES INC. (Filed With SEC on August 7, 2009)

INDEMNIFICATION AGREEMENT (Filed With SEC on August 7, 2009)

INDEMNITY AGREEMENT (Filed With SEC on August 7, 2009)

Rent shall be made payable to an entity, and sent to the address or addresses, Landlord designates in writing to Tenant and shall be made by good and sufficient check payable in... (Filed With SEC on August 4, 2009)

AGREEMENT AND PLAN OF MERGER (Filed With SEC on July 1, 2009)

ESCROW AGREEMENT (Filed With SEC on July 1, 2009)

VOTING AGREEMENT (Filed With SEC on July 1, 2009)

REGISTRATION RIGHTS AGREEMENT (Filed With SEC on July 1, 2009)

CONSULTING AGREEMENT (Filed With SEC on July 1, 2009)

[The remainder of this page is intentionally blank] (Filed With SEC on June 2, 2009)

- 4 - (Filed With SEC on June 2, 2009)

INTELLECTUAL PROPERTY ASSIGNMENT AGREEMENT (Filed With SEC on June 2, 2009)

- 8 - (Filed With SEC on June 2, 2009)

ASSIGNMENT AND TERMINATION AGREEMENT (Filed With SEC on June 2, 2009)

[The remainder of this page is intentionally blank] (Filed With SEC on May 20, 2009)

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS ([*]),HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO... (Filed With SEC on May 11, 2009)

SOFTWARE LICENSE AGREEMENT (Filed With SEC on May 11, 2009)

AMENDMENT (Filed With SEC on March 16, 2009)

245 First Street, Cambridge, MA 02142 Ph: 617 ###-###-#### Fax: 617 ###-###-#### www.combinatorx.com (Filed With SEC on March 16, 2009)

AMENDMENT (Filed With SEC on March 16, 2009)

245 First Street, Cambridge, MA 02142 Ph: 617 ###-###-#### Fax: 617 ###-###-#### www.combinatorx.com (Filed With SEC on March 16, 2009)

AMENDMENT (Filed With SEC on March 16, 2009)

245 First Street, Cambridge, MA 02142 Ph: 617 ###-###-#### Fax: 617 ###-###-#### www.combinatorx.com (Filed With SEC on March 16, 2009)

AMENDMENT (Filed With SEC on March 16, 2009)

245 First Street, Cambridge, MA 02142 Ph: 617 ###-###-#### Fax: 617 ###-###-#### www.combinatorx.com (Filed With SEC on March 16, 2009)

CONSORTIUM AGREEMENT Relating to Anti-Symbiotic Treatment of Filariasis Consortium (A-WOL) (Filed With SEC on March 16, 2009)

LIVERPOOL SCHOOL OF TROPICAL MEDICINE (Filed With SEC on March 16, 2009)

Project Agreement Liverpool School of Tropical Medicine (1) and (Filed With SEC on March 16, 2009)

DATED 8 October 2008 LIVERPOOL SCHOOL OF TROPICAL MEDICINE (1) (Filed With SEC on March 16, 2009)

COMBINATORX, INCORPORATED 2004 Incentive Plan (Filed With SEC on November 10, 2008)

[CombinatoRx Letterhead] (Filed With SEC on November 10, 2008)

EXHIBIT A RESEARCH PLAN (Filed With SEC on October 22, 2008)

Page 2 of 3 (Filed With SEC on May 8, 2008)

COMBINATORX, INCORPORATED 2004 Incentive Plan (Filed With SEC on May 8, 2008)

PROMISSORY NOTE December 21, 2007 (Date) (Filed With SEC on December 21, 2007)

5,600,000 Shares COMBINATORX, INCORPORATED (Filed With SEC on October 11, 2007)

AUTHORIZATION FOR RELEASE OF INFORMATION (Filed With SEC on June 28, 2007)

AMENDED AND RESTATED RESEARCH AND LICENSE AGREEMENT (Filed With SEC on June 12, 2007)

PROMISSORY NOTE March 29, 2007 (Date) (Filed With SEC on April 4, 2007)

COMBINATORX, INCORPORATED 2004 Incentive Plan Amended and Restricted Stock Award Agreement (Filed With SEC on March 15, 2007)

COMBINATORX, INCORPORATED 2004 Incentive Plan Amended and Restated Restricted Stock Award Agreement (Filed With SEC on March 15, 2007)

AMENDED AND RESTATED RESEARCHAGREEMENT (Filed With SEC on March 15, 2007)

DEED OF DEBENTURE (Filed With SEC on February 21, 2007)

CORPORATEGUARANTY (Filed With SEC on February 21, 2007)

COMBINATORX, INCORPORATED 2004 Incentive Plan Amended and Restated Restricted Stock Award Agreement (Filed With SEC on January 22, 2007)

COMBINATORX, INCORPORATED OMNIBUSAMENDMENT AGREEMENT (Filed With SEC on December 6, 2006)

EMPLOYMENT, CONFIDENTIALITY AND NON-COMPETITION AGREEMENT (Filed With SEC on September 26, 2006)

AMENDMENTTO RESEARCH AND LICENSE AGREEMENT (Filed With SEC on June 30, 2006)

GENERAL TERMS ANDCONDITIONS (Filed With SEC on June 30, 2006)

CERTAINCONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS([*]),HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGECOMMISSION PURSUANT TO... (Filed With SEC on June 5, 2006)

COMBINATORX,INCORPORATED AMENDED AND RESTATED 2004 INCENTIVE PLAN (Filed With SEC on June 5, 2006)

COMBINATORX, INCORPORATED 2004 Incentive Plan RestrictedStock Award Agreement (Filed With SEC on April 24, 2006)

COMBINATORX,INCORPORATED 2004Incentive Plan RestrictedStock Award Agreement (Filed With SEC on January 26, 2006)

COMBINATORX, INCORPORATED 2004 Incentive Plan Restricted Stock AwardAgreement (Filed With SEC on January 26, 2006)

COMBINATORX,INCORPORATED 2004 Incentive Plan Restricted Stock Award Agreement (Filed With SEC on January 26, 2006)

COMBINATORX,INCORPORATED 2004Incentive Plan RestrictedStock Award Agreement (Filed With SEC on January 26, 2006)

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EPIRUS Biopharmaceuticals, Inc. Contracts & Agreements