AMENDED AND RESTATED EMPLOYMENT AGREEMENT

EXHIBIT 10.1

AMENDED AND RESTATED EMPLOYMENT AGREEMENT

This AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this “Agreement”), dated as of                     , 2007, between Indevus Pharmaceuticals, Inc., a Delaware Corporation having a place of business at 33 Hayden Avenue, Lexington, Massachusetts 02421 (the “Corporation”) and Glenn L. Cooper, M.D., an individual residing at                                          (the “CEO”).

WHEREAS, the Corporation and CEO entered into that certain Employment Agreement dated October 1, 2002 (the “Original Employment Agreement”);

WHEREAS, the Corporation and CEO desire to amend and restate the Original Employment Agreement pursuant to Section 10 thereof, all as hereinafter provided;

WHEREAS, the CEO, in his capacity of Chief Executive Officer of the Corporation, the stock of which is publicly traded, shall be deemed a “specified employee” as defined under Section 409A(a)(2)(B) of the Internal Revenue Code of 1986, as amended (“Code”); and

WHEREAS, this Agreement is intended to comply with Code Section 409A and the guidance thereunder, and shall be interpreted as operating in accordance therewith to the extent that there is any ambiguity as to the terms of the Agreement.

NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements herein contained, the Parties agree as follows:

1. EMPLOYMENT; DUTIES; REPORTING

(a) The Corporation engages and employs the CEO, and the CEO hereby accepts engagement and employment, as Chief Executive Officer, to direct, supervise and have responsibility for the daily operations of the Corporation, including, but not limited to: (i) directing and supervising the business and research and development efforts of the Corporation; (ii) managing the other executives and personnel of the Corporation; (iii) evaluating, negotiating, structuring and implementing business transactions with the Corporation’s licensees, customers and suppliers; (iv) attending meetings of the Board of Directors of the Corporation (the “Board”); and performing such other services and duties as the Board shall determine.

(b) The Corporation will provide office facilities, secretarial, and clerical support consistent with customary practices of the Corporation. The CEO shall perform his duties hereunder from the Corporation’s executive offices in Massachusetts or such other locations as the CEO and Corporation may agree, provided, however, that the CEO acknowledges and agrees that the performance by the CEO of his duties hereunder may require significant domestic and international travel by the CEO.

(c) The CEO shall devote his best efforts and entire working time and attention to the proper discharge of his duties and responsibilities under this Agreement.

(d) During the Employment Term, the CEO shall be required to report to the Board.

(e) Except upon the prior written consent of the Board, during the Employment Term, the CEO will not: (i) accept any other employment; or (ii) engage, directly or indirectly, in any other business activity (whether or not pursued for pecuniary advantage) that is competitive with, or that places him in a competing position to, the Corporation. Personal passive investments and personal business affairs not inconsistent with this Agreement, or teaching, writing or publicly speaking are permitted, so long as these activities do not interfere or conflict with the CEO’s duties hereunder.

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2. TERM

Subject to any earlier termination pursuant to Section 6, the CEO’s employment hereunder shall be for a term of three (3) years commencing on October 1, 2007 (the “Effective Date”) and continuing through the earlier of (a) the third anniversary of such date or (b) the date on which this Agreement is terminated in accordance with Section 6; provided, that unless terminated earlier in accordance with Section 6, this Agreement shall automatically renew for periods of one (1) year unless either the CEO or the Corporation gives written notice to the other not less than sixty (60) days prior to the date of any such anniversary of such party’s election not to extend the term of this Agreement. The initial three year term and any successive term shall hereinafter be referred to as the “Employment Term.”

3. COMPENSATION

As compensation for the performance of his duties under this Agreement, the CEO shall be compensated as follows:

(a) Salary; Bonuses, Equity Awards:

The Corporation shall withhold all applicable federal, state and local taxes, social security and workers’ compensation contributions and such other amounts as may be required by law and any plans pursuant to which such compensation is generated or as agreed upon by the parties with respect to the compensation payable to the CEO pursuant to section 3(a) hereof.

(b) Expenses. The Corporation shall reimburse the CEO for all normal, usual and necessary expenses incurred by the CEO in furtherance of the business and affairs of the Corporation, including reasonable travel and entertainment, against receipt by the Corporation of appropriate vouchers or other proof of the CEO’s expenditures and otherwise in accordance with the expense reimbursement policies and procedures as may from time to time be adopted by the Board of Directors of the Corporation. Any reimbursements hereunder shall be paid to the CEO promptly in a lump sum in accordance with such expense reimbursement policies and procedures then in effect but in no event later than the March 15 of the calendar year next following the year in which the CEO incurred the reimbursable expense.

(c) Benefits. The CEO shall have the right to participate in and to receive benefits from all present and future life, vacation, accident, disability, medical, pension, and savings plans and all similar benefits made available generally to executives of the Company. The amount and extent of benefits to which the CEO is entitled shall be governed by any applicable benefit plan, as it may be amended from time to time. The CEO shall receive no less than four (4) weeks paid vacation each year which shall accrue if not used in any year and be paid to CEO or carried forward to subsequent years consistent with Corporation policy. The Corporation shall also carry D&O Liability Insurance coverage for the benefit of its officers and directors including CEO.

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(d) Life Insurance. The Corporation shall make available to the CEO and his dependents, such medical, disability, life insurance and such other health benefits as the Corporation makes available to its senior officers and directors. The CEO’s life insurance coverage shall not be less than $1,000,000.

4. NON-COMPETITION

(a) The CEO understands and recognizes that his services to the Corporation are special and unique and agrees that, during the term of this Agreement and, unless such termination is by the CEO pursuant to 6(a)(iii) below and provided the Corporation is not in material default to CEO on any of its obligations under this Agreement, for a period of one (1) year from the date of termination of his employment hereunder, he shall not in any manner, directly or indirectly, on behalf of himself or any person, firm, partnership, joint venture, corporation or other business entity (“Person”), enter into or engage in any business engaged in the development of commercialization of products directly competitive with products of the Corporation, including any subsidiary of the Corporation (a “Subsidiary”), including products under development by the Corporation or a Subsidiary within the geographic area of the Corporation’s business.

(b) During the term of this Agreement and for one (1) year thereafter, CEO shall not, directly or indirectly, without the prior written consent of the Corporation, solicit or induce any employee of the Corporation or any affiliate to leave the employ of the Corporation or any affiliate or hire for any purpose any employee of the Corporation or any affiliate or any employee who has left the employment of the Corporation or any affiliate within six months of the termination of said employee’s employment with the Corporation.

(c) During the term of this Agreement and for one (1) year thereafter, the CEO shall not, directly or indirectly, without the prior written consent of the Corporation:

(d) In the event that the Officer breaches any provisions of this Section 4 or there is a threatened breach, then, in addition to any other rights which the Corporation may have, the Corporation shall be entitled, without the posting of a bond or other security, to injunctive relief to enforce the restrictions contained herein. In the event that an actual proceeding is brought in equity to enforce the provisions of this Section 4, the Officer shall not urge as a defense that there is an adequate remedy at law nor shall the Corporation be prevented from seeking any other remedies which may be available.

5. CONFIDENTIAL INFORMATION

(a) The CEO agrees that during the course of his employment or at any time after termination, he will not disclose or make accessible to any other person, the Corporation’s products, services and technology, both current and under development, promotion and marketing programs, lists, trade secrets, litigation information and other confidential and proprietary business information of the Corporation, any Subsidiary or any of its clients. The CEO agrees: (i) not to use any such information for himself or others; and (ii) not to take any such material or reproductions thereof from the Corporation’s facilities at any time during his employment by the Corporation, except as required in the CEO’s duties to the Corporation. The CEO agrees immediately to return all such material and reproductions thereof in his possession to the Corporation upon request and in any event upon termination of employment.

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(b) Except with prior written authorization by the Corporation, the CEO agrees not to disclose or publish any of the confidential, technical or business information or material of the Corporation, any Subsidiary, its clients or any other party to whom the Corporation owes an obligation of confidence, at any time during or after his employment with the Corporation.

(c) The CEO hereby assigns to the Corporation all right, title and interest he may have or may acquire in all inventions (including patent rights) developed by the CEO during the term of this Agreement (“Inventions”) and agrees that all Inventions shall be the sole property of the Corporation and its assigns, and the Corporation and its assigns shall be the sole owner of all patents, copyrights and other rights in connection therewith. The CEO further agrees to assist the Corporation in every proper way (but at the Corporation’s expense) to obtain and from time to time enforce patents, copyrights or other rights on said Inventions in any and all countries.

6. TERMINATION

(a) The term of this Agreement shall continue for the period set forth in Section 2 hereof unless sooner terminated upon the first to occur of the following events (the “Termination Date”):

(b) Upon termination pursuant to subparagraphs (i), (ii) or (v) of paragraph (a) above, the CEO (or his estate in the event of termination pursuant to subparagraph (i)), shall be entitled to receive the Base Salary, bonuses and reimbursement of business expenses accrued but unpaid as of the date of termination. Any unpaid, accrued salary, bonuses and expense reimbursements should be paid within thirty (30) days of the date of termination and no later than the March 15^th after the calendar year of the termination of employment of the CEO under subparagraph (i), (ii) or (v) of paragraph 6(a).

(c) Upon termination pursuant to subparagraph (a) (iii)(A) or (B) above, the CEO shall be entitled to receive an amount equal to eighteen (18) months of Base Salary plus a bonus incentive equal to the target bonus set forth in

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the CEO’s bonus plan in effect as of the Termination Date as if such targets had been achieved. At the discretion of the Corporation (except if the CEO elects to receive monthly installments), (i) such Base Salary may be paid either in one lump sum or in monthly installments throughout the remaining term of this Agreement, and (ii) such bonus incentive amount may be paid either in one lump sum or in monthly installments for up to twenty four (24) months from the Termination Date, provided that reference is made to the limitations in Section 6(k) below and that for (i) or (ii), monthly installments may only be selected if they would not trigger a taxable event under Section 409A of the Code.

(d) Upon termination pursuant to subparagraph (a) (iii)(C) above, the CEO shall be entitled to receive an amount equal to twenty four (24) months of Base Salary plus a bonus incentive equal to the target bonus set forth in the CEO’s bonus plan in effect as of the Termination Date as if such targets had been achieved. At the discretion of the Corporation (except if the CEO elects to receive monthly installments), (i) such Base Salary may be paid either in one lump sum or in monthly installments throughout the remaining term of this Agreement, and (ii) such bonus incentive amount may be paid either in one lump sum or in monthly installments for up to twenty four (24) months from the Termination Date, provided that reference is made to the limitations in Section 6(k) below and that for (i) or (ii), monthly installments may only be selected if they would not trigger a taxable event under Section 409A of the Code.

The commencement of the cash payout will be governed by a standard “double trigger” mechanism approved by the Board and will commence upon the occurrence of the second trigger (defined below), provided further that if such second trigger does not occur no cash payout shall be due hereunder. The first “trigger” is the “Change of Control” event and the “second trigger” is the earliest of the following:

(i) the CEO is not offered prior to the Change in Control, (1) a comparable executive position of the acquirer or of the division of the acquirer which assumes the business of the corporation after the Change in Control (comparable to be determined by the CEO in his reasonable discretion) and (2) a total compensation and benefits package substantially similar (and no less than) to that provided to the CEO under this Agreement; or

(ii) the CEO accepts an employment agreement discussed in (d)(i) above and within twenty four (24) months of the effectiveness of such agreement, is terminated without “just cause” (as defined in Section 6(a)(ii) above) or experiences a “constructive termination” which shall include any of the actions or omissions described in Section 6(a)(iii) above by the acquirer or division thereof.

(e) In addition, upon termination pursuant to subparagraph (a)(iii) above, the Corporation shall provide continuation of health benefits for a period equal to (i) eighteen (18) months from the Termination Date for termination pursuant to subparagraph (a)(iii)(A) or (B), and (ii) twenty four (24) months from the Termination Date for termination pursuant to subparagraph (a)(iii)(C), each to the extent authorized by and consistent with 29 U.S.C. § 1161 et seq. (commonly known as “COBRA”), with the cost of the regular premium for such benefit shared in the same relative proportion by the Corporation and the CEO as in effect on the Termination Date. Notwithstanding the foregoing, nothing in this Section 6(e) shall be construed to affect the CEO’s right to receive COBRA continuation entirely at the CEO’s own cost to the extent that the CEO may continue to be entitled to COBRA continuation after the CEO’s right to cost sharing under this Section 6(e) ceases, provided further the continued health benefits provided hereunder shall supplement, and not in any manner be construed to replace or otherwise limit, the periods of COBRA continuation that the CEO would have otherwise been entitled to.

(f) Upon termination pursuant to subparagraph (a) (iv) above, the CEO shall be entitled to receive an amount equal to eighteen (18) months of Base Salary plus a bonus incentive equal to the target bonus set forth in the CEO’s bonus plan in effect as of the Termination Date as if such targets had been achieved. At the discretion of the Corporation (except if the CEO elects to receive monthly installments), (i) such Base Salary may be paid either in one lump sum or in monthly installments throughout the remaining term of this Agreement, and (ii) such bonus incentive amount may be paid either in one lump sum or in monthly installments for up to twenty four (24) months from the Termination Date, provided that reference is made to the limitations in Section 6(k) below and that for (i) or (ii), monthly installments may only be selected if they would not trigger a taxable event under Section 409A of the Code.

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In addition, upon termination pursuant to subparagraph (a)(iv) above, the Corporation shall provide continuation of health benefits for a period equal to the longer of (a) the remainder of the term of this Agreement, or (b) eighteen (18) months from the Termination Date to the extent authorized by and consistent with 29 U.S.C. § 1161 et seq. (commonly known as “COBRA”), with the cost of the regular premium for such benefit shared in the same relative proportion by the Corporation and the CEO as in effect on the Termination Date. Notwithstanding the foregoing, nothing in this Section 6(f) shall be construed to affect the CEO’s right to receive COBRA continuation entirely at the CEO’s own cost to the extent that the CEO may continue to be entitled to COBRA continuation after the CEO’s right to cost sharing under this Section 6(f) ceases, provided further the continued health benefits provided hereunder shall supplement, and not in any manner be construed to replace or otherwise limit, the periods of COBRA continuation that the CEO would have otherwise been entitled to.

(g) For purposes of this Agreement, a “Change in Control of the Corporation” shall be deemed to have occurred upon any one of the following events:

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(h) Adjustment. Anything in this Agreement to the contrary notwithstanding except for the limitation in the following paragraph, in the event it shall be determined that as a result of any payment or distribution by the Corporation to or for the benefit of the CEO whether paid or payable or distributed or distributable pursuant to the terms of this Agreement or otherwise (the “Payments”), the CEO would be subject to the excise tax imposed by Section 4999 of the Internal Revenue Code (the “Code”) or any interest or penalties are incurred by the CEO with respect to such excise tax (such excise tax, together with any such interest and penalties, are hereinafter collectively referred to as the “Excise Tax”), the CEO shall be entitled to promptly receive an additional payment (a “Gross-Up Payment”) in an amount such that, after payment by the CEO of all taxes (including any interest or penalties imposed with respect to such taxes), including, without limitation, any income taxes and Excise Tax imposed upon the Gross-Up Payment, the CEO is in the same after-tax position as if no Excise Tax had been imposed upon the CEO with respect to the Payments, provided further that such Gross-Up Payment shall not exceed $1,250,000 under any circumstances.

Notwithstanding the above provisions of this Section (h), the CEO’s Payments, shall be reduced to an amount (not less than zero) which shall not cause any portion of the Payments to be subject to Excise Tax, provided that no such reduction shall be made if the CEO’s Payments, after the reduction and after the application of Federal income tax at the highest rate applicable to individual taxpayers, shall not be greater than the present value (determined in accordance with Section 280G of the Code) of the Payments and any applicable Gross-Up Payment before the reduction but after the application of (i) excise tax under Section 4999 of the Code and (ii) Federal income tax at the highest rate applicable to individual taxpayers.

(i) Cooperation: Pending Litigation

(j) SPECIFIED EMPLOYEE STATUS. Notwithstanding anything herein to the contrary, if the CEO is deemed a specified employee, as defined under §409A(a)(2)(B)(i) of the Internal Revenue Code of 1986, as amended, as of the date of his separation from service for any reason, then the payment dates hereunder shall be adjusted so that no payment of deferred compensation hereunder that is subject to §409A may be made before the expiration of six (6) months after the date of the CEO’s separation from service, or if earlier, the CEO’s death.

(k) Notwithstanding anything herein to the contrary contained herein, with regards to the determination of lump sum or monthly installment payments to be made under Sections 6(c), (d) and (f) above, the Board shall determine the form of payment not later than the December 31 prior to the calendar year in which the payment hereunder becomes binding, and provided further that any installments designated hereunder are treated as a series of separate payments in substantially equal amounts payable over such period as the Board irrevocably designates as of the December 31 prior to the year in which the CEO’s right to the amount hereunder becomes binding.

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7. NOTICES

Any notice or other communication under this Agreement shall be in writing and shall be deemed to have been given: when delivered personally against receipt therefore; one (1) day after being sent by Federal Express or similar overnight delivery; or three (3) days after being mailed registered or certified mail, postage prepaid, return receipt requested, to either party at the address set forth above, or to such other address as such party shall give by notice hereunder to the other party.

8. INDEMNIFICATION

The Corporation will continue to indemnify the CEO pursuant to the indemnification agreement previously entered into between the Corporation and the CEO which shall remain in force and effect, and otherwise Corporation will enter into an indemnification agreement with the CEO substantially identical to the previously one.

9. SEVERABILITY OF PROVISIONS

If any provision of this Agreement shall be declared by a court of competent jurisdiction to be invalid, illegal or incapable of being enforced in whole or in part, such provision shall be interpreted so as to remain enforceable to the maximum extent permissible consistent with applicable law and the remaining conditions and provisions or portions thereof shall nevertheless remain in full force and effect and enforceable to the extent they are valid, legal and enforceable, and no provision shall be deemed dependent upon any other covenant or provision unless so expressed herein.

10. ENTIRE AGREEMENT: MODIFICATION

This Agreement contains the entire agreement of the parties relating to the subject matter hereof, and the parties hereto have made no agreements, representations or warranties relating to the subject matter of this Agreement which are not set forth herein. No modification of this Agreement shall be valid unless made in writing and signed by the parties hereto.

11. BINDING EFFECT

The rights, benefits, duties, and obligations under this Agreement shall inure to, and be binding upon, the Corporation, its successors and assigns, and upon the CEO and his legal representatives. This Agreement constitutes a personal service agreement, and the performance of the CEO’s obligations hereunder may not be transferred or assigned by the CEO.

12. NON-WAIVER

The failure of either party to insist upon the strict performance of the terms, conditions and provisions of this Agreement shall not be construed as a waiver or relinquishment of future compliance therewith, and said terms, conditions and provisions shall remain in full force and effect. No waiver of any term or condition of this Agreement on the part of either party shall be effective for any purpose whatsoever unless such waiver is in writing and signed by such party.

13. GOVERNING LAW

The validity, interpretation, enforceability, and performance of this Agreement shall, to the extent not otherwise preempted by federal law, be governed by and construed in accordance with the law of the Commonwealth of Massachusetts without giving effect to its conflict of state laws principles.

14. HEADINGS

The headings of paragraphs are inserted for convenience and shall not affect the interpretation of this Agreement on the day and year first above written.

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15. TAXES.

All payments hereunder shall be subject to applicable withholdings and reported as wages to the applicable state and federal authorities. Notwithstanding anything herein to the contrary, no particular tax result for the CEO with respect to any income recognized by the CEO in connection with this Agreement is guaranteed, and the CEO shall be responsible for any taxes, penalties and interest imposed on him including, but not limited to, under Section 409A of the Code in connection with the Agreement.

16. ACKNOWLEDGMENT.

The CEO acknowledges: (i) that he has consulted with or has had the opportunity to consult with independent counsel of his own choice concerning this Agreement and has been advised to do so by the Corporation; and (ii) that he has read and understands the Agreement, is fully aware of its legal effect, and has entered into it freely based on his own judgment.

17. NO ASSIGNMENT.

(a) Neither this Agreement nor any right or interest hereunder shall be assignable by the CEO, his beneficiaries, or legal representatives without the Corporation’s prior written consent; provided that nothing in this subsection 17(a) shall preclude the CEO from designating a beneficiary to receive, upon his death, any benefit payable hereunder, or the executors, administrators, or other legal representatives of the CEO’s estate from assigning any rights hereunder to the person or persons entitled thereto.

(b) Except as otherwise required by law, without the Corporation’s prior written consent, no right to receive payments under this Agreement shall be subject to anticipation, commutation, alienation, sale, assignment, encumbrance, charge, pledge, or hypothecation, or to exclusion, attachment, levy, or similar process or assignment by operation of law, and any attempt, voluntary or involuntary, to effect any such action shall be null, void, and of no effect.

The parties have duly executed this Agreement as of the date first written above.

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