Amendment No. 2 to Development, Commercialization and Supply License Agreement between DURECT Corporation and Endo Pharmaceuticals Inc.

Summary

DURECT Corporation and Endo Pharmaceuticals Inc. have agreed to amend their existing Development, Commercialization and Supply License Agreement. The amendment changes certain deadlines in the agreement, moving dates from January 1 and January 31, 2005, to January 1 and January 31, 2006. All other terms of the original agreement remain unchanged. Both parties have signed to confirm their acceptance of these changes.

EX-10.42.3 3 b402591_ex10-423.txt EXHIBIT 10.42.3 Exhibit 10.42.3 [DURECT LETTERHEAD] November 22, 2004 BY FACSIMILE AND EXPRESS MAIL CONFIDENTIAL Peter A. Lankau President Endo Pharmaceuticals Inc. 100 Painters Drive Chadds Ford, PA 19317 Re: Amendment 2 to Development, Commercialization and Supply License Agreement Dear Peter: Reference is made to the Development, Commercialization and Supply License Agreement between Endo Pharmaceuticals Inc. (Endo) and DURECT Corporation (DURECT) effective November 8, 2002, as amended effective January 28, 2004 (Agreement). Effective on the date written above, Endo and DURECT hereby agree to amend the Agreement as follows: 1. Amendment to Section 4.6(a). Section 4.6(a) of the Agreement shall be amended to replace each instance of January 1, 2005 with January 1, 2006. 2. Amendment to Section 4.6(c). Section 4.6(c) of the Agreement shall be amended to replace each instance of January 1, 2005 with January 1, 2006. 3. Amendment to Section 13.3(e). Section 13.3(e) of the Agreement shall be amended to replace January 1, 2005 with January 1, 2006 and January 31, 2005 with January 31, 2006. Except as set forth above, all other terms of the Agreement shall remain the same. Please sign below to indicate Endos agreement to the foregoing. Very truly yours, /S/ JAMES E. BROWN James E. Brown President and CEO AGREED TO BY ENDO: By: /S/ PETER A. LANKAU ------------------------ Peter A. Lankau President Date: Nov. 22, 2004