Amendment No. 4 to Development, Commercialization and Supply License Agreement between Endo Pharmaceuticals Inc. and DURECT Corporation

Summary

This amendment, dated April 26, 2007, updates the existing Development, Commercialization and Supply License Agreement between Endo Pharmaceuticals Inc. and DURECT Corporation. The amendment extends certain deadlines in the agreement by one year, changing dates in specific sections from 2007 to 2008. All other terms of the original agreement remain unchanged. Both parties have agreed to these modifications as indicated by their signatures.

EX-10.42.5 2 dex10425.htm AMENDMENT NO. 4 TO THE DEVELOPMENT, COMMERCIALIZATION & SUPPLY LICENSE AGREEMENT Amendment No. 4 to the Development, Commercialization & Supply License Agreement

Exhibit 10.42.5

April 26, 2007

BY FACSIMILE AND EXPRESS MAIL

CONFIDENTIAL

Peter A. Lankau

President and CEO

Endo Pharmaceuticals Inc.

100 Endo Boulevard

Chadds Ford, PA 19317

Re: Amendment 4 to Development, Commercialization and Supply License Agreement

Dear Peter:

Reference is made to the Development, Commercialization and Supply License Agreement between Endo Pharmaceuticals Inc. (“Endo”) and DURECT Corporation (“DURECT”) effective November 8, 2002, as last amended January 20, 2006 (“Agreement”). Effective on the date written above, Endo and DURECT hereby agree to amend the Agreement as follows:

 

  1. Amendment to Section 4.6(a). Section 4.6(a) of the Agreement shall be amended to replace each instance of “May 1, 2007” with “May 1, 2008”.

 

  2. Amendment to Section 4.6(c). Section 4.6(c) of the Agreement shall be amended to replace each instance of “May 1, 2007” with “May 1, 2008” and each instance of “March 31, 2007” with “March 31, 2008”.

 

  3. Amendment to Section 13.3(e). Section 13.3(e) of the Agreement shall be amended to replace “March 31, 2007” with “March 31, 2008” and “April 30, 2007” with “April 30, 2008”.

Except as set forth above, all other terms of the Agreement shall remain the same. Please sign below to indicate Endo’s agreement to the foregoing.

 

Very truly yours,

/s/ JAMES E. BROWN

James E. Brown
President and CEO

 

AGREED TO BY ENDO:
By:  

/s/ PETER A. LANKAU

  Peter A. Lankau
  President and CEO
Date:   April 30, 2007