Amendment No. 4 to Development, Commercialization and Supply License Agreement between Endo Pharmaceuticals Inc. and DURECT Corporation
This amendment, dated April 26, 2007, updates the existing Development, Commercialization and Supply License Agreement between Endo Pharmaceuticals Inc. and DURECT Corporation. The amendment extends certain deadlines in the agreement by one year, changing dates in specific sections from 2007 to 2008. All other terms of the original agreement remain unchanged. Both parties have agreed to these modifications as indicated by their signatures.
Exhibit 10.42.5
April 26, 2007
BY FACSIMILE AND EXPRESS MAIL
CONFIDENTIAL
Peter A. Lankau
President and CEO
Endo Pharmaceuticals Inc.
100 Endo Boulevard
Chadds Ford, PA 19317
Re: Amendment 4 to Development, Commercialization and Supply License Agreement
Dear Peter:
Reference is made to the Development, Commercialization and Supply License Agreement between Endo Pharmaceuticals Inc. (Endo) and DURECT Corporation (DURECT) effective November 8, 2002, as last amended January 20, 2006 (Agreement). Effective on the date written above, Endo and DURECT hereby agree to amend the Agreement as follows:
1. | Amendment to Section 4.6(a). Section 4.6(a) of the Agreement shall be amended to replace each instance of May 1, 2007 with May 1, 2008. |
2. | Amendment to Section 4.6(c). Section 4.6(c) of the Agreement shall be amended to replace each instance of May 1, 2007 with May 1, 2008 and each instance of March 31, 2007 with March 31, 2008. |
3. | Amendment to Section 13.3(e). Section 13.3(e) of the Agreement shall be amended to replace March 31, 2007 with March 31, 2008 and April 30, 2007 with April 30, 2008. |
Except as set forth above, all other terms of the Agreement shall remain the same. Please sign below to indicate Endos agreement to the foregoing.
Very truly yours, |
/s/ JAMES E. BROWN |
James E. Brown |
President and CEO |
AGREED TO BY ENDO: | ||
By: | /s/ PETER A. LANKAU | |
Peter A. Lankau | ||
President and CEO | ||
Date: | April 30, 2007 |