LEASE AMENDMENT ENDO BUILDING #100

Exhibit 10.45.2

LEASE AMENDMENT

ENDO BUILDING #100

THIS IS AN AMENDMENT made this 6^th day of November, 2006, effective February 1, 2006, by and between PAINTERS’ CROSSING TWO ASSOCIATES, L. P. (“Landlord”) and ENDO PHARMACEUTICALS INC. (“Tenant”).

W I T N E S S E T H:

WHEREAS, the parties entered into a Lease Agreement dated November 13, 2003, (“Lease”) for approximately five (5 +/-) acres of land (“Land”) together with a 64,424+/- square feet of space in a Building to be constructed and to be known as the Painters’ Crossing Two Building (“Building”) in the Painters’ Crossing Office Campus, Chadds Ford Township, Delaware County, Commonwealth of Pennsylvania. The Building and Land are sometimes hereinafter referred to as the “Demised Premises”; and

WHEREAS, by Lease Amendment Number One, the parties established February 1, 2005 as the Commencement Date, pursuant to paragraph 2 of the Lease, and acknowledged Substantial Completion of the Demised Premises, inter alia; and

WHEREAS, by Lease Amendment Number Two, the parties amended the Notice paragraph to reflect that the post office address of the Building had been changed to: 100 Endo Boulevard, Chadds Ford, PA, where notices are to be sent; and

WHEREAS, the parties now wish to amend the Lease to reflect their agreement that Tenant shall: (i) employ its own janitorial services for the Building and (ii) perform all of the general maintenance and repair of every part of the Demised Premises, including, but not limited to, windows, doors and glass, all plumbing, electrical and telephone systems (but excluding the roof and structural components of the Building), and in return, the Base Rent and Operating Expense Allowance will be adjusted to reflect the Landlord’s decreased obligations.

NOW, THEREFORE, the parties hereto, in consideration of the mutual promises and covenants contained herein and intending to be legally bound hereby, agree as follows:

1. Tenant Assumed Duties. Effective on February 1, 2006, Tenant hereby agrees to perform, cause to be performed, assumes the obligation to perform and releases Landlord from any obligation to perform, the following duties and responsibilities:

(a) All janitorial duties within the Building as specifically set forth on Exhibit “D” to the Lease, as well as the shampooing of carpeting and appropriate cleaning of floor surfaces in the lobby and central areas of the Building which would generally be considered “common areas” at least every six (6) months, or more often as required to maintain them in good and safe condition. Provided however, Landlord shall continue to wash the windows, inside and outside, in the Building once annually, or more often if requested by Tenant.

(b) All of the general maintenance, service and repair of the Building and every part of the Demised Premises, including, but not limited to, windows, doors and glass, all plumbing, electrical and telephone systems (but excluding the roof and structural components of the Building), in order to retain the Building and the Demised Premises in good operational condition and repair and to prevent the diminution in the expected life of the Building, to contract with such reputable contractors, reasonably satisfactory to

1

LEASE AMENDMENT

ENDO BUILDING #100

Landlord, as Tenant deems necessary to maintain, service and repair the entire Demised Premises in accordance with this Lease. Any interruption in service or performance of any Building system that is part of the Tenant Assumed Duties (as defined below) is not a breach of the Lease by Landlord. Notwithstanding the foregoing, Tenant shall not be responsible for repair of any items which will be repaired by the manufacturer or installer pursuant to their warranty of their materials or work, and Tenant shall not be responsible for the repair of latent defects in the construction of the Building.

(c) As of November 1, 2006, Landlord shall terminate its contract for maintenance of the Heating Ventilation and Air Conditioning System (“HVAC”), and Tenant, at its own expense, shall maintain the HVAC for the Building under a contract with an HVAC repair service reasonably acceptable to Landlord (“Maintenance Contract”) and shall provide Landlord with a copy of same. The specifications for the Maintenance Contract are attached hereto as Exhibit “C”. All documents prepared by the HVAC contractor in accordance with the HVAC specifications set forth on Exhibit “C” shall be maintained on the Demised Premises for inspection by Landlord or its contractor, as may be necessary. In the event that the HVAC system, or any part of the HVAC system requires replacement, such replacements shall be at Tenant’s cost and expense.

All of the foregoing duties (as set forth in paragraph 1 (a) – (c)) are hereinafter referred to as “Tenant Assumed Duties”.

In assuming the Tenant Assumed Duties, Tenant agrees to perform same, or cause same to be performed, in a good and workmanlike manner and in accordance with the standards in the applicable industry. In the event that Tenant fails to perform the Tenant Assumed Duties, Landlord shall notify Tenant of Tenant’s default, and Tenant shall have thirty (30) days, from such notice to perform such duties, except in the case of emergency (inwhich case, notice shall not be required). At the expiration of the thirty (30) day period or in the case of emergency, Landlord may, but shall not be obligated to, perform all or any part of the Tenant Assumed Duties on Tenant’s behalf, and the actual costs of same shall be invoiced to Tenant, along with a reasonably management fee for same, and shall be payable as Additional Rent when the next installment of Rent is due.

Further, Tenant agrees to indemnify and hold the Landlord, its partners, agents, servants and employees, harmless from and against any and all liabilities, costs, expenses, including reasonable attorney’s fees, suits, causes of action, fines and penalties, that may be asserted against Landlord, its partners, agents, servants and employees, including the cost of compliance with the provisions of all laws, ordinances or regulations applicable to the Tenant’s performance of the Tenant Assumed Duties on or about the Demised Premises, injury or death to persons and damages to property, and any other expenses or damages arising out of Tenant’s negligence or failure to fully and faithfully perform its obligations under this Paragraph.

In all contracts with third parties and prior to their commencing work on the Demised Premises, Tenant shall obtain from them: (i) certificates of general liability insurance in such amounts and in such forms as Tenant is required to carry, pursuant to the paragraph “General Liability Insurance Provisions” of the Lease. Such certificates of insurance shall be forwarded to Landlord prior to commencement of work in the Demised Premises; (ii) executed Waivers of Mechanics’ Liens. Said Waiver of Liens shall be returned to Landlord with proof that said Waiver of Liens was filed of record prior to contractor’s commencing work in the Demised

2

LEASE AMENDMENT

ENDO BUILDING #100

Premises, and (iii) all necessary permits for work on the Demised Premises from the state and local authorities. Copies of such permits shall be supplied to Landlord at least forty-eight (48) hours prior to commencing work on the Demised Premises.

2. Release of Landlord. The Lease shall be deemed amended to remove Landlord’s obligation, if any, to perform any of the Tenant Assumed Duties. Paragraph 18 c is hereby deleted from the lease and is replaced with the following:

c. Repairs and Maintenance. Landlord shall, at its cost, repair: all structural defects and latent defects in the construction of the Building, and all damaged exterior windows and glass, if such windows or glass are damaged as a result of a structural building defect or latent defect in the window. Landlord shall take steps to enforce any warranties of workmanship or materials for the Building, and to have repaired by the manufacturer or installer, any items which require repair pursuant to the warranty of materials or work. In the event that any repair is required by reason of the negligence or abuse of Tenant or its agents, employees, invitees or of any other person using the Demised Premises with Tenant’s consent, express or implied, if Tenant fails or refuses to make such repair, Landlord may, but shall not be required to, make such repair, and shall invoice the actual cost thereof to Tenant, which invoice will become due within fifteen (15) days after presentation or when the next installment of rent is due, whichever is the later.

3. Amendment of Base Rent Provisions. In consideration for Tenant’s assuming the Tenant Assumed Duties, the Base Rent as set forth in the Reference Data section and paragraph 4 of the Lease shall be amended as follows:

Annual Base Rent. From February 1, 2006 until January 31, 2010, Annual Base Rent shall be One Million, Two Hundred Ninety-four Thousand, Three Hundred Eighteen and 10/00 Dollars ($1,294,318.10) lawful money of the United States of America, payable in monthly installments in advance during the said term of this Lease, in sums of One Hundred Seven Thousand, Eight Hundred Fifty-nine and 84/00 Dollars ($107,859.84) on the first day of each month.

From February 1, 2010, until January 31, 2015, Annual Base Rent shall be One Million Five Hundred Five Thousand Eight Hundred Four and 80/00 Dollars ($1,505,804.80) lawful money of the United States of America, payable in monthly installments in advance during the said term of this Lease, or any renewal hereof, in sums of One Hundred Twenty-Five Thousand, Four Hundred Eighty-three and 73/00 Dollars ($125,483.73) on the first day of each month.

All references, in the Lease to the Base Rent shall be deemed amended as set forth in this paragraph.

4. Amendment of Operating Expense Allowance and Operating Expense Provisions. In consideration for Tenant’s assuming the Tenant Assumed Duties, the Operating Expense Allowance as set forth in the Reference Data section and paragraph 5 b of the Lease and the Operating Expense as set forth in paragraph 5 d of the Lease, shall be adjusted as follows:

3

LEASE AMENDMENT

ENDO BUILDING #100

b. Operating Expense Allowance. From February 1, 2006, the Operating Expense Allowance shall be Two Hundred Sixty-five Thousand Three Hundred Eighty-two and 00/00 Dollars ($265,382.00) per year. All references, in the Lease to the Operating Expense Allowance shall be deemed amended as set forth in this paragraph.

d. Operating Expense. Subsections 2 and 6 are deleted in their entirety.

e. Operating Expense Exclusions. The following is added to the end of paragraph 5e:

8. All costs and expenses of the Tenant Assumed Duties, unless Landlord performs same on behalf of Tenant at Tenant’s request or after Tenant has defaulted in the performance of such obligations.

5. Amendment of Janitorial Access Provision. Paragraph 14 g of the Lease, regarding Janitorial Access is hereby deleted and replaced by the following:

g. Janitorial Access. For the purpose of cleaning the insides of the windows, and in the event that Tenant is in default of the Tenant Assumed Duties as set forth in paragraph 1 (a), Tenant shall permit the janitors and cleaners of Landlord to have access to and to clean the Demised Premises in accordance with the attached Exhibit “D”. Tenant waives any right it may have to a claim against Landlord for any damage done to the furniture or other property or effects of Tenant by the janitors or cleaners or other employees of Landlord or by any other person, or for any loss of property of any kind whatever from the Demised Premises, however occurring.

6. Lease Ratified. Except as herein provided, all other terms and conditions of the Lease are hereby ratified and remain in full force and effect. To the extent, if any, that the terms of the Lease conflict with any of the modifications set forth herein, the modifications set forth herein shall control.

4

LEASE AMENDMENT

ENDO BUILDING #100

IN WITNESS WHEREOF, the parties have hereunto duly executed this Amendment to Lease the day and year first above written.

5

LEASE AMENDMENT

ENDO BUILDING #100

MAINTENANCE SERVICE SPECIFICATIONS FOR ENDO HVAC SYSTEMS

Service Agreements must include the following items:

EXHIBIT "C"

6