Re: Amendment to Commercial Real Estate Lease

Exhibit 10.68

December 14, 2011

Durect Corporation

2 Results Way

Cupertino, CA 95014

Attention: James E. Brown

Re: Amendment to Commercial Real Estate Lease

Reference is made to that Commercial Real Estate Lease (as amended) (the “Lease”) entered into by and between EWE, Inc., an Alabama corporation (“LESSOR”) and Durect Corporation, a Delaware corporation, (“LESSEE”) dated September 21, 2004. All capitalized terms used herein shall have the meaning ascribed to such terms in the Lease.

LESSOR and LESSEE hereby agree as follows, effective on the date that both LESSOR and LESSEE have executed this Amendment:

The PREMISES set forth in Paragraph 1, as amended, shall be defined as:

Building 2683 Pelham Parkway, Pelham, Alabama 35124 only.

The TERM of the Lease set forth in Paragraph 3, as amended, shall be extended by an additional two months such that the Lease shall terminate on March 31, 2012 instead of January 31, 2012.

The RENTAL during the additional extension period from February 1, 2012 to March 31, 2012 shall be $7500.00 per month.

Except as expressly modified above, all remaining terms of the Lease, as amended, shall remain the same. LESSOR and LESSEE have hereunto set or caused to be set their respective signatures and seals on the dates set forth herein.

Sincerely,

/s/ Jim English

Vice President, EWE Inc.