Fourth Supplemental Indenture, dated March 22, 2018, among Devon Energy Corporation and The Bank of New York Mellon Trust Company, N.A. (as successor to The Bank of New York), as trustee, to the Indenture, dated as of March 1, 2002, among Devon Energy Corporation and The Bank of New York Mellon Trust Company, N.A

Exhibit 4.1

DEVON ENERGY CORPORATION

to

THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A.,

as Trustee

Supplemental Indenture No. 4

Dated as of March 22, 2018

to

Indenture

Dated as of March 1, 2002

As supplemented by Supplemental Indenture No. 1

Dated as of March 25, 2002

7.95% Senior Debentures due 2032

SUPPLEMENTAL INDENTURE NO. 4 dated as of March 22, 2018 (this “Fourth Supplemental Indenture”), between DEVON ENERGY CORPORATION, a corporation duly organized and existing under the laws of the State of Delaware (herein called the “Company”), and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A. (as successor to The Bank of New York), a New York banking corporation, as Trustee (herein called the “Trustee”).

RECITALS OF THE COMPANY

The Company has heretofore delivered to the Trustee an Indenture dated as of March 1, 2002 (the “Senior Indenture”), providing for the issuance from time to time of Debt Securities of the Company (the “Debt Securities”), as supplemented by Supplemental Indenture No. 1 (the “First Supplemental Indenture”), dated as of March 25, 2002 (together with the Senior Indenture, the “Indenture”), pursuant to which the Company has issued its 7.95% Senior Debentures due 2032 (the “Debentures”).

Section 12.02 of the Senior Indenture permits the Company and the Trustee to enter into an indenture supplemental to the Senior Indenture for the purpose of adding any provisions to, or changing in any manner or eliminating any of the provisions of, the Senior Indenture, subject to certain conditions, including the consent of the Holders of at least a majority in aggregate principal amount of the affected Debt Securities then outstanding.

The Holders of at least a majority in aggregate outstanding principal amount of the Debentures have duly consented to certain proposed amendments to the Indenture (the “Proposed Amendments”) as set forth in the Offer to Purchase and Consent Solicitation Statement of the Company, dated as of March 7, 2018 (as amended or supplemented from time to time, the “Offer to Purchase”), relating to the Company’s tender offers and consent solicitations with respect to the Debentures and certain other securities of the Company (collectively, the “Tender Offers and Consent Solicitations”), and the Company, in accordance with Section 12.02 of the Senior Indenture, is undertaking to execute and deliver this Fourth Supplemental Indenture to effectuate the Proposed Amendments.

The Board of Directors of the Company has authorized and approved the execution and delivery of this Fourth Supplemental Indenture.

All the conditions and requirements necessary to make this Fourth Supplemental Indenture, when duly executed and delivered, a valid and legally binding agreement in accordance with its terms and for the purposes herein expressed, have been performed and fulfilled.

NOW, THEREFORE, THIS INDENTURE WITNESSETH:

For and in consideration of the foregoing and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the Company and the Trustee mutually covenant and agree for the equal and ratable benefit of the Holders as follows:

ARTICLE I

RELATION TO SENIOR INDENTURE; DEFINITIONS

SECTION 1.1 RELATION TO SENIOR INDENTURE. This Fourth Supplemental Indenture constitutes an integral part of the Indenture. The provisions set forth in this Fourth Supplemental Indenture shall be effective solely in respect of the Debentures and not any other series of Debt Securities under the Senior Indenture.

SECTION 1.2 DEFINITIONS. Capitalized terms used but not defined herein shall have the respective meanings assigned to them in the Senior Indenture.

ARTICLE II

AMENDMENTS AND WAIVERS

SECTION 2.1 AMENDMENTS TO THE INDENTURE. Effective and operative immediately prior to Company’s payment to the Depositary of an amount of money sufficient to pay the aggregate consideration for all Debentures validly tendered and accepted pursuant to the Tender Offers and Consent Solicitations (and the acceptance of consents of the Holders representing at least a majority in aggregate principal amount of the Debentures then outstanding) in accordance with the terms set forth in the Offer to Purchase:

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ARTICLE III

MISCELLANEOUS

SECTION 3.1 RATIFICATION OF INDENTURE; FOURTH SUPPLEMENTAL INDENTURE PART OF INDENTURE. Except as expressly modified or amended hereby, the Senior Indenture continues in full force and effect and is in all respects ratified, confirmed and preserved.

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SECTION 3.2 GOVERNING LAW. This Fourth Supplemental Indenture shall be governed by and construed in accordance with the laws of the State of New York. This Fourth Supplemental Indenture is subject to the provisions of the Trust Indenture Act of 1939, as amended, and shall, to the extent applicable, be governed by such provisions.

SECTION 3.3 COUNTERPARTS. This Fourth Supplemental Indenture may be executed in any number of counterparts, each of which so executed shall be deemed to be an original, but all such counterparts shall together constitute but one and the same instrument.

SECTION 3.4 RECITALS. The recitals contained herein shall be taken as statements of the Company, and the Trustee assumes no responsibility for their correctness. The Trustee makes no representations as to the validity or sufficiency of this Fourth Supplemental Indenture.

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IN WITNESS WHEREOF, the parties hereto have caused this Fourth Supplemental Indenture to be duly executed by their respective officers hereunto duly authorized, all as of the day and year first written above.