Promissory Note Extension Agreement dated February 6, 2018 (to November 2017 Note)

Exhibit 4.8

PROMISSORY NOTE EXTENSION AGREEMENT

This Promissory Note Extension Agreement, hereinafter referred to as “Extension Agreement,” entered into this Sixth day of February, 2018, by and between DERMAdoctor, LLC, a Missouri corporation (“Maker”), and Papillon Partners, Inc., a Missouri corporation, or its successors or assigns (“Holder”),

WHEREAS, Maker and Holder have entered into a Promissory Note dated November 9, 2017 for the amount of One Hundred Thousand Dollars ($100,000), hereinafter referred to as the “Note”. The Note is due and payable on a date that is ninety (90) days from the original date of the Note.

WHEREAS, Maker and Holder desire to enter into this Extension Agreement in order to extend the date when all the outstanding principal and accrued and unpaid interest is due and payable to one hundred eighty (180) days from the original date of the Note.

NOW, THEREFORE, it is duly agreed by both Maker and Holder to extend the due date of the Note to May 8, 2018.

All other provisions the original Note shall prevail unless otherwise written.

IN WITNESS WHEREOF, the undersigned Maker and Holder have duly executed this Extension Agreement, extending the due date of the Note as of the day and year first written above.