Second Amendment, dated as of March 13, 2023, to the License Agreement, by and between the University of Florida Research Foundation, Inc. and the Registrant

Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) is the type of information that the registrant treats as private or confidential. Double asterisks denote omissions.

Exhibit 10.3

SECOND AMENDMENT TO

LICENSE AGREEMENT NO. A19433

WHEREAS, the University of Florida Research Foundation, Inc., a not-for-profit corporation duly organized and existing under the laws of the State of Florida and having its principal office at 223 Grinter Hall, Gainesville, Florida, 32611, U.S.A. (hereinafter referred to as “UFRF”), and Decibel Therapeutics, Inc., a corporation duly organized under the laws of the State of Delaware, and having its principal office at 1325 Boylston Street, Suite 500, Boston, MA 02215 (hereinafter referred to as “Licensee”) entered into a license agreement effective October 29, 2020 (hereinafter “License Agreement”) as amended by the First Amendment effective June 13, 2022;

WHEREAS, the parties now wish to amend the License Agreement;

NOW THEREFORE, in consideration of the premises and mutual covenants contained herein the parties hereto agree as follows;

Section 3.3 Diligence Milestones:

Specifically milestone stated as “[**]” is hereby replaced with “[**]”; and milestone stated as “[**]” is hereby replaced with “[**]”