Eighteenth Amendment to Lease Agreement by and between the Registrant and Princeton Corporate Plaza, LLC, dated January 4, 2019

Exhibit 10.1

EIGHTEENTH AMENDMENT TO LEASE

Amendment made this 4^th day of January 2019, amending the Lease dated March 9, 2000 and amended on October 26, 2000, March 12, 2001, April 22, 2002, March 8, 2005, April 5, 2006, January 31, 2007, October 1, 2008, February 19, 2010, March 7, 2011, March 3, 2012, April 16, 2013 May 5, 2014, December 12, 2014, January 5, 2016, June 27, 2016, April 3, 2017, September 6, 2017 and July 17, 2018 (collectively, the "Lease")

Between Princeton Corporate Plaza, LLC ("Landlord")

And Cytosorbents, Inc., f/k/a Medasorb Corporation ("Tenant")

Witnesseth that in consideration of the mutual understanding between them, Landlord and Tenant hereby agree to amend the Lease as follows:

Landlord does hereby lease to Tenant and Tenant does hereby rent from Landlord the following described premises: approximately 1,973 square feet in Landlord's Building at 11 Deer Park Drive, Suite 113 (the "Eleventh Expansion Space") in the Township of South Brunswick in the County of Middlesex and State of New Jersey, which space is further described as the cross hatched area on the Floor Plan marked Exhibit A-34 attached hereto and made a part hereof,

Upon the following Conditions and Covenants:

$1,778.00 per month for gas.

a. Tenant does not have any pending or potential causes of action, suits, liabilities, debts, damages, controversies, agreements, trespasses, judgments, executions, demands and claims of any nature whatsoever, whether in law or in equity, against Landlord, its predecessors, successors and assigns, its parents, subsidiaries, officers, directors, shareholders, employees, agents and attorneys, any affiliated corporations, their officers, directors, shareholders and employees, by reason of any matter or cause whatsoever related to or arising from the Lease, or any other matter which has arisen prior to the date of execution of this Amendment.

b. The Lease is in full force and effect and there are no defaults thereunder by Tenant (or to Tenant's knowledge, by Landlord), nor are there any conditions which with the passage of time or giving of notice or both would become a default under the Lease.

c. The Lease is the only agreement between Tenant and the Landlord affecting the Premises, and the Lease has not been assigned, amended, modified, changed, altered or supplemented, except as expressly specified herein. Tenant has no notice or knowledge of any person claiming rights as landlord or as tenant under the Lease other than Landlord and Tenant respectively.

d. Tenant is in full and complete possession of the Premises pursuant to the terms of the Lease. There are no options by Tenant or rights to extend or renew Tenant's leasehold or to expand the Premises provided for in the Lease, except as may be expressly provided in the Lease.

e. All duties of an inducement nature and all inducement clauses have been fulfilled by Landlord in all respects, including any allowance and rent and other financial concessions.

f. Tenant has not, at the Premises or within the building, generated, stored, handled or otherwise dealt with any hazardous or toxic waste or material, radioactive materials, or other contaminants, the removal of which is required or the maintenance of which is prohibited, regulated or penalized by an local, state or federal agency, authority or government unit except as expressly permitted in the Lease.

g. No petition, suit or proceeding involving Tenant's bankruptcy, insolvency, reorganization, receivership, or general assignment for the benefit of creditors is currently pending or contemplated.

IN WITNESS WHEREOF, the parties hereto have hereunto set their hands and seals, or caused these presents to be signed by their proper corporate officers or other duly authorized representatives and their proper corporate seal (if applicable) to be hereto affixed, as of the day and year first above written.