AMENDMENT TO EMPLOYMENT AGREEMENT - DAVID TUCK

THIS AMENDMENT (the “Amendment”) is made as of March 7, 2017 between Curis, Inc., a Delaware corporation (the “Company”), and David Tuck, M.D. (the “Employee”).

WHEREAS, Employee’s employment with the Company is subject to the terms and conditions of an employment agreement currently in effect by and between Employee and the Company, dated as of February 29, 2016 (the “Employment Agreement”); and

WHEREAS, the Compensation Committee of the Company’s Board of Directors has determined it appropriate to increase the severance that would be potentially payable to the Employee in certain terminations of employment following a change in control.

NOW THEREFORE, in consideration of the mutual covenants and agreements contained herein and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Employee and the Company hereby agree to amend the Employment Agreement as follows:

1.Clause (iii) in Section 4(d)(ii) is revised by replacing “within ninety (90) days following the initial existence of the condition” with “no later than 30 days following the last day of the cure period in clause (ii).”

2.Section 5(b) is revised by deleting the words “(or if the base salary was reduced within 12 months following a Change in Control Event from the level in effect immediately before the consummation of that event, the level before such reduction).”

3.Section 5(c) is renumbered Section 5(d) and a new Section 5(c) is inserted to read as follows:

In the event that, within 12 months following a Change in Control Event, the Employee’s employment terminates as a result of a termination by the Employee for Good Reason, or a termination by the Company or its successor without Cause, in addition to the compensation and benefits described in Section 5(a), the Employee shall receive, reduced by all applicable taxes and withholdings, (i) the Employee’s then base salary (or if the base salary was reduced within 12 months following a Change in Control Event from the level in effect immediately before the consummation of that event, the level before such reduction) paid ratably over a period of 12 months in accordance with the Company’s then current payroll policies and practices, (ii) an amount equal to the full target bonus for the year of termination, and (iii) an amount equal to a portion of the same year’s target bonus, pro-rated to reflect days elapsed from the beginning of the bonus year to the date of termination over 365, with the payments in clauses (ii) and (iii) to be made on or around the date of the first installment of the payments under clause (i). If severance is due under the proceeding sentence, the Company will also pay any difference between the COBRA premium and the amount the Employee would otherwise be responsible for with respect to the medical and dental coverage elected for a period of 12 months from the date of such termination or as long as the Employee is eligible for and elects to be covered by COBRA, whichever period is shorter. At the end of this period, the Employee is eligible to continue coverage for the balance of the statutory period under COBRA, provided that the Employee pays the COBRA premium. Notwithstanding the foregoing, the Company may end the payment of premiums earlier (but not the Employee’s eligibility for COBRA) if it

reasonably determines that applicable laws or regulations are reasonably likely to cause the payment of these premiums to trigger taxes or penalties on the Company or other participants or, to the extent the Employee would be taxed on more than the amount of the premiums, to the Employee. The benefits provided under this Section 5(c) shall be in lieu of any benefits to which the Employee would have otherwise been entitled pursuant to Section 5(b) of this Agreement.

4.Section 5(e), as renumbered, is revised to say “The benefits provided for the Employee under this Agreement shall be the sole payments and benefits for which the Employee shall be eligible at the conclusion of his employment with the Company for any reason (other than as provided under the terms of any equity compensation plans or awards) and shall supersede any and all prior agreements or arrangements for post-termination severance.”

5.Except as specifically amended herein, the Employment Agreement shall remain in full force and effect in accordance with its terms.

Title:    President and CEO