Amendment 2 to Monitoring Services Agreement between Cubist Pharmaceuticals, Inc. and Clindev (Proprietary) Limited

Summary

This amendment updates the contract between Cubist Pharmaceuticals, Inc. (the Sponsor) and Clindev (Proprietary) Limited for monitoring services related to a clinical study. The amendment revises the payment terms, specifying the contract price and payment schedule based on the number of patients included and completed. Both parties have agreed to these changes, which cover all activities from protocol review to study closeout. The amendment is signed by authorized representatives of both companies.

EX-10.57 10 a2042768zex-10_57.txt EXHIBIT 10.57 EXHIBIT 10.57 CONFIDENTIAL TREATMENT CONTRACT OF MONITORING SERVICES AMENDMENT 2 Between CUBIST PHARMACEUTICALS, INC Duly represented by Michael F. de Bruin (Hereinafter referred to as "SPONSOR") And CLINDEV (PROPRIETARY) LIMITED Duly represented by MRS. A. LESSING (Hereinafter referred to as "Clindev") *Confidential treatment requested: Material has been omitted and filed with the Commission. -2- Upon mutual agreement of the parties the following sections of the contract are amended as follows: *Confidential treatment requested: Material has been omitted and filed with the Commission. -3- SECTION 4. PAGE 3 PAYMENT FOR SERVICES 4.1 SPONSOR shall pay to Clindev $[ ]* (the "Contract Price") for the services rendered under the Agreement in accordance with the payment schedule set forth in section 4.2. For the purposes of the Agreement, the contract value is based on the inclusion of [ ]* patients ($[ ]* per completed patient) and includes all activities from the first review of the Protocol till the Study is finally closed out and all correction log forms have been processed subject to section 3. In witness whereof, the parties have caused this Amendment to the Agreement to be executed by the respective duly authorized officers as of the dates set forth below Thus done and signed at: Cambridge, MA, USA on this the 20th Day of December 2000. For: the SPONSOR By: /s/ MICHAEL F. DEBRUIN ---------------------- Name: Michael F. DeBruin, M.D. Title: Vice President, Clinical Research WITNESS: 1. By: /s/ EDWARD S. CAMPANARO ------------------------ Name: Edward S. Campanaro Title: Sr. Director, Clinical Operations *Confidential treatment requested: Material has been omitted and filed with the Commission. -4- 2. By: /s/ ANDREW G. KNAPP -------------------- Name: Andrew G. Knapp Title: Director, Clinical Research Thus done and signed at Lynnwood, Pretoria, on this the 8th Day of November 2000. For: Clindev (Pty) Ltd By: /s/ ANITA LESSING ----------------- Name: Anita Lessing Title: Director WITNESS: 1. By: /s/ SONIA SUTHERLAND -------------------- Name: Sonia Sutherland Title: Director 2. By: /s/ CATHY NASH -------------- Name: Cathy Nash Title: Project Manager *Confidential treatment requested: Material has been omitted and filed with the Commission.