Second Amendment to the Sponsored Research Agreement, effective as of October 9, 2024, by and between Coya Therapeutics, Inc. and Methodist Hospital Research Institute dba Houston Methodist Research Institute

SECOND AMENDMENT TO SPONSORED RESEARCH AGREEMENT

This second amendment (“Amendment 2”) to that certain Sponsored Research Agreement dated December 8, 2022 and as amended (“ Agreement”), is by and between Coya Therapeutics, Inc. (“COMPANY”) and The Methodist Hospital Research Institute dba Houston Methodist Research Institute (“HMRI”). This Amendment 2 is effective as of the last date of signature (“Amendment 2 Effective Date”).

WHEREAS, COMPANY and HMRI are parties to the Agreement pursuant to which HMRI is performing certain research activities;

WHEREAS, COMPANY and HMRI desire to amend the Agreement to modify Exhibits A and B to expand the Workscope and Budget for Funding Term 2; and

WHEREAS, the parties desire to amend the Agreement on the terms and conditions hereinafter set forth.

NOW, THEREFORE, in consideration of the mutual agreement among the parties hereto, it is agreed as follows:

[Signature Page Follows]

IN WITNESS WHEREOF, the parties hereto have caused this Amendment 2 to be executed by their duly authorized representatives to be effective as of the Amendment 2 Effective Date.

Exhibit A-2

WORKSCOPE for Funding Term 1

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EXHIBIT B-2

BUDGET