First Amendment to the Sponsored Research Agreement, effective as of June 8, 2024, by and between Coya Therapeutics, Inc. and Methodist Hospital Research Institute dba Houston Methodist Research Institute

FIRST AMENDMENT TO SPONSORED RESEARCH AGREEMENT

This first amendment (“Amendment 1”) to that certain Sponsored Research Agreement dated December 8, 2022 (“Agreement”), is by and between Coya Therapeutics, Inc. (“COMPANY”) and The Methodist Hospital Research Institute dba Houston Methodist Research Institute (“HMRI”). This Amendment 1 is effective as of June 8, 2024 (“Amendment 1 Effective Date”).

WHEREAS, COMPANY and HMRI are parties to the Agreement pursuant to which HMRI is performing certain research activities;

WHEREAS, COMPANY and HMRI desire to amend the Agreement to: (i) extend the Term for an additional fifteen (15) month period to allow work on the Research to continue, (ii) revise HMRI’s notice address for non-technical matters, and (iii) modify Exhibits A and B to add the workscope and funding, respectively, for Funding Term 2; and

WHEREAS, the parties desire to amend the Agreement on the terms and conditions hereinafter set forth.

NOW, THEREFORE, in consideration of the mutual agreement among the parties hereto, it is agreed as follows:

“1.15 “Term” shall mean the period commencing on the Effective Date of this Agreement and terminating on the earlier of: (i) completion of the Research or (ii) thirty-three (33) months from the Effective Date, or if extended in accordance with its terms, terminating on the date specified in the extension. The first eighteen months of the Term is hereinafter referred to as “Funding Term 1.” The fifteen-month period following Funding Term 1 is hereinafter referred to as “Funding Term 2.”

If to HMRI with respect to all non-technical matters:

The Methodist Hospital Research Institute

Attn: Office of Research Contracts

6670 Bertner Ave, R12-107

Houston, Texas 77030

[Signature Page Follows]

IN WITNESS WHEREOF, the parties hereto have caused this Amendment 1 to be executed by their duly authorized representatives to be effective as of the Amendment 1 Effective Date.

Exhibit A-1

WORKSCOPE for Funding Term 1

EXHIBIT B-1

BUDGET