Amendment No. 1 dated April 30, 2025 to Master Research Collaboration Agreement by and among COMPASS Pathfinder Limited, King's College London and South London and Maudsley NHS Foundation Trust, dated March 22, 2022

This Amendment No. 1 (the “Amendment”), effective as of 30 April 2025 (the “Amendment Effective Date”), is made by and between:

(1)COMPASS PATHFINDER LIMITED, a company registered in England under number 10229259, whose registered office is at 3rd Floor, 1 Ashley Road, Altrincham, Cheshire, WA14 2DT, United Kingdom (“COMPASS”); and

(2)KING’S COLLEGE LONDON, with its registered offices at Strand Building, Strand Campus, Strand, London, WC2R 2LS, United Kingdom (“KCL”); and

(3)SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST, with its registered offices at Bethlem Royal Hospital, Monks Orchard Road, Beckenham BR3 3BX, United Kingdom (“SLaM”).

COMPASS, KCL, and SLaM are referred to herein collectively as the “Parties” and individually as a “Party”.

WHEREAS, COMPASS, KCL, and SLaM are parties to that certain Master Research Collaboration Agreement dated 22 March 2022 (the “MRCA”);

WHEREAS, the Parties now desire to amend the MRCA in order to outline the terms and process for COMPASS’s review of requests by the Academic Parties to conduct non-Compass sponsored studies using the facilities at 5 Windsor Walk, a property owned by SLaM and leased to COMPASS.

NOW, THEREFORE, in consideration of the foregoing premises and the terms and conditions set forth below, the Parties agree as follows:

1.Section 10.5.1 of the MRCA shall be deleted in its entirety and replaced with the following:

Notwithstanding anything to the contrary in this Agreement, during the term of the Maudsley Hospital (5 Windsor Walk) Lease, none of the Academic Parties shall, directly or indirectly, use such leased premises for any purpose outside of those contemplated by this collaboration without COMPASS’s express written permission; provided however, COMPASS shall act reasonably when determining whether or not to grant the aforementioned express written permission, taking into account idle capacity and reasonable rental returns; further provided that as between the parties, such permission shall remain within COMPASS’s sole discretion.

If the Academic Parties desire to use the facilities at 5 Windsor Walk for non-Compass sponsored studies, the following request process shall be followed:

(1) a request form template in the form attached hereto as Schedule 10 must be completed and submitted by the Academic Parties to COMPASS; and

(2) all requests must be submitted as soon as practicable to allow COMPASS ample time to review, in any event no less than two (2) weeks notice, it being understood that COMPASS may require additional time to review based on the complexity or nature of the request.

If a request is granted by COMPASS, the Academic Parties agree that:

(a) COMPASS-sponsored studies retain priority for use of the facilities at 5 Windsor Walk;

(b) the conduct of non-Compass sponsored studies at 5 Windsor Walk must not negatively impact COMPASS-sponsored studies, and Academic Parties will take appropriate steps to model capacity at 5 Windsor Walk accordingly;

(c) the costing template in Schedule 10 shall be used to charge non-Compass sponsors for use of the facilities at 5 Windsor Walk; and

(d) any and all funds which SLaM receives from non-Compass sponsors for use of the facilities at 5 Windsor Walk must be used to offset the annual costs incurred by COMPASS. Offset costs, less management fee of [***] to SLaM, should be recognised by reducing the next invoice to Compass for its quarterly rent payments, as summarized in Schedule 5, by the corresponding amount.

When (i) the Bethlem Hospital facility is available for use for trials or research and (ii) the Maudsley Hospital Lease has expired or terminated (in whole or in part); then SLaM shall be free to utilize the Maudsley Hospital premises for any purposes without the requirement of COMPASS’s express written permission.”

2.A new Schedule 10 entitled “SCHEDULE 10 – FACILITIES USE REQUEST FORM (5 WINDSOR WALK” shall be incorporated into the MRCA in the form attached hereto as Appendix 1.

3.Section 17.1 of the MRCA shall be updated to list the following notice address(es) for COMPASS:

To the extent there are any inconsistencies between this Amendment and the MRCA, this Amendment will control but solely as to the subject matter herein. Capitalized terms not otherwise defined herein shall have the same meaning given those terms in the MRCA, it being the intent of the Parties that the MRCA and this Amendment will be applied and construed as a single instrument. The MRCA, as modified by this Amendment as well as any existing riders, constitutes the entire agreement between the Parties regarding the subject matter of this Amendment and supersedes all prior or contemporaneous writings and understandings between the Parties regarding the same.

This Amendment may be executed in counterparts, each of which, when executed and delivered, shall be deemed to be an original and all of which together shall constitute one and the same document.

IN WITNESS WHEREOF, the Parties have caused this Amendment to be duly executed as of the Amendment Effective Date.