Amendment to Note, dated May 20, 2021, between Dresch Inc. and Cingulate Therapeutics, LLC

Exhibit 10.17

Mr. Edward Dresch

Dresch Inc.

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Dear Mr. Dresch,

The undersigned parties to Promissory Note dated January 27, 2020 (the “Note”), by and between Edward Dresch (“Lender”), and Cingulate Therapeutics LLC (“Borrower”), for a total principle of $500,000.00 hereby mutually agree to amend said Note to change the Paid in Full dated to “February 1, 2022”. All other items of the Contract shall remain in full force and effect.

IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first set forth above.