Second Amendment to Loan and Security Agreement by and between Cidara Therapeutics, Inc. and Pacific Western Bank, dated July 27, 2018

This Second Amendment to Loan and Security Agreement (this “Amendment”) is made and entered into as of July 27, 2018 by and between PACIFIC WESTERN BANK, a California state chartered bank (“Bank”), and CIDARA THERAPEUTICS, INC. (“Borrower”).

Borrower and Bank are parties to that certain Loan and Security Agreement dated as of October 3, 2016 (as amended from time to time, the “Agreement”). The parties desire to amend the Agreement in accordance with the terms of this Amendment.

NOW, THEREFORE, the parties agree as follows:

(iii)    Repayment. Interest shall accrue from the date of each Term Loan at the rate specified in Section 2.3(a), and prior to the Interest-Only End Date shall be payable monthly beginning on the 3rd day of the month next following the date such Term Loan is funded, and continuing on the same day of each month thereafter. Any Term Loans that are outstanding on the Interest-Only End Date shall be payable in equal monthly installments of principal, plus all accrued interest, beginning on the Amortization Start Date and continuing on the same day of each month thereafter through the Term Loan Maturity Date, at which time all amounts due in connection with the Term Loans and any other amounts due under this Agreement shall be immediately due and payable. Term Loans, once repaid, may not be reborrowed.

(a)    Interest Rate for Term Loans. Except as set forth in Section 2.3(b), the Term Loans shall bear interest, on the outstanding daily balance thereof, at a variable annual rate equal to the greater of (A) 0.75% above the Prime Rate then in effect or (B) 4.50%.

6.6    Primary Depository. Borrower shall maintain all of its depository and operating accounts with Bank and all of its investment accounts with Bank or Bank’s Affiliates. Notwithstanding the foregoing, Borrower may maintain Cash in one or more accounts outside of Bank (the “Outside Accounts”), provided that the total aggregate amount of Cash maintained in the Outside Accounts does not exceed $100,000 at any time. For the avoidance of doubt, no control agreements shall be required for the Outside Accounts. In addition, commencing on July 27, 2018, on approximately the fifteenth day and the last day of each month, Borrower shall transfer funds at Bank’s Affiliates to Bank as current securities mature, with all such funds transferred to Bank by November 3, 2018 (with the exception of (a) accrued interest on securities maturing on or about November 3, 2018, (b) funds intended to cover management and custodian

fees associated with the accounts in which such securities are held, and (c) any residual amounts in such accounts, all of which Borrower shall transfer to Bank on or before December 3, 2018). After December 3, 2018, except for funds in the Outside Accounts as permitted above, Borrower shall no longer maintain any funds in accounts with Bank’s Affiliates or in any accounts outside of Bank.

7.8    Capitalized Expenditures. Make Capitalized Expenditures in excess of $1,000,000 in the aggregate in any fiscal year of Borrower; provided, however, that Capitalized Expenditures in connection with any leasehold improvements shall not be subject to the foregoing limitation.

“Amortization Start Date” means the 3rd day of the month immediately following the Interest-Only End Date.

“Interest-Only End Date” means July 31, 2019; provided, however, that if Borrower achieves the Milestone Covenant, the defined term “Interest-Only End Date” shall instead mean October 31, 2019.

“Term Loan Maturity Date” means January 3, 2022.

“Tranche B Draw Period” means the period on or before October 3, 2018.

a)    this Amendment, duly executed by Borrower;

b)    payment of all Bank Expenses, including Bank’s reasonable expenses for the documentation of this Amendment, and any UCC, good standing and intellectual property search or filing fees, which may be debited from any of Borrower’s accounts with Bank; and

c)    such other documents and completion of such other matters, as Bank may reasonably deem necessary or appropriate.

IN WITNESS WHEREOF, the undersigned have executed this Amendment as of the first date above written.