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|Execution Copy || ||CONFIDENTIAL|
FIRST AMENDMENT TO LICENSE AGREEMENT
This First Amendment (the Amendment) to the license agreement (JHU Agreement [####]) with an Effective Date of July 21, 2015 (the Agreement), is entered into as of July 22, 2018 (Amendment Effective Date), by and among the Johns Hopkins University, a corporation of the State of Maryland, in the United States of America, having a principal place of business at 3400 N. Charles Street, Baltimore, Maryland ###-###-#### (hereinafter JHU), the Trustees of the University of Pennsylvania, a nonprofit corporation of the State of Pennsylvania, in the United States of America, having a principal place of business at 3160 Chestnut Street, Suite 200, Philadelphia, Pennsylvania 19104 (hereinafter PENN), and Apcintex Limited, a corporation of England and Wales having a principal place of business at c/o Medicxi, 25 Great Pulteney Street, England, W1F 9LT (hereinafter Company).
WHEREAS, on July 21, 2015 (Effective Date), JHU, PENN and Serpin Haemostatics Limited (Serpin or Company) entered into a non-exclusive license (the Agreement) for JHU Ref. C09948 and PENN Ref. H1264 entitled A Mouse Model of Hemophilia A, and
WHEREAS, on or about April 2, 2016, Serpin Haemostatics Limited changed its name to Apcintex Limited (Apcintex) and all of Serpins rights, powers, interest and obligations under various agreements with third parties, including this Agreement and this First Amendment are now vested in Apcintex and any reference to Company will name to mean Apcintex; and
WHEREAS, the parties desire to amend the Agreement to extend the Term and update Notice and Payment Information.
NOW THEREFORE, based upon the above premises, the parties agree as follows:
1. Change of Name. All references in the Agreement to Serpin Haemostatics Limited (Serpin) are changed to Apcintex Limited (Apcintex) and any reference to Company will mean Apcintex.
2. Terms. Capitalized terms in this Amendment shall have the same meaning as those in the Agreement, unless specifically defined in this Amendment. All section and paragraph references refer to sections or paragraphs as applicable, in the Agreement. References to the term Agreement in the Agreement shall be deemed to include the Amendment.
3. Interpretation. Except as expressly modified herein, the Agreement shall remain in full force and effect in accordance with its terms. To the extent there are any inconsistencies or ambiguities between this Amendment and the Agreement, the terms of this Amendment shall supersede the Agreement.
4. Amendment Fee. Company shall pay a non-refundable Amendment Fee of [####] within [####] of the date the last party hereto has executed this First Amendment.
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