Separation Agreement between the Company and Alicia Grande

Separation of Employment. Employee has advised the Company of her intent to retire as the Company’s Vice President, Treasurer and Chief Financial Officer, effective at 11:59 PM ET, on December 31, 2023 (the “Termination Date”). The Company has agreed to provide Employee with the severance benefits set forth in Section 3 herein based on her long service to the Company and her agreement to abide by the terms of this Agreement. Employee acknowledges that payment of any amounts to, or on behalf of, Employee under this Agreement does not in any way extend Employee’s employment beyond the Termination Date or confer any rights or benefits other than those set forth expressly herein. Regardless of whether Employee enters into this Agreement:

The Company will pay Employee all accrued wages earned through December 31, 2023, plus accrued paid time off that remains unused through and including the Termination Date, less applicable withholdings, in accordance with the Company’s regular payroll practices.

If not already paid prior to the Termination Date, the Company will pay Employee a cash bonus for her 2023 services (the “2023 Bonus”), payable at the same time as the Company’s other executive officers receive their cash bonus for 2023 services, but no later than January 30, 2024, and based on the bonus target previously established for Employee by the Compensation Committee of the Company’s Board of Directors. For example, if the Compensation Committee awards executive officers 100% of their bonus target for 2023, Employee will receive a bonus of [***], which is the amount that Employee would have been entitled to receive since she was an employee of the Company for all for calendar year 2023.

Provided Employee is already enrolled in Company healthcare insurance benefits coverage as of the Termination Date, Employee shall continue to receive such coverage through the Termination Date. If Employee wishes to continue healthcare insurance benefits coverage beyond the Termination Date, Employee must timely elect such coverage under the Consolidated Omnibus Budget Reconciliation Act (“COBRA”); thereafter, Employee shall be eligible to receive the benefit of the COBRA Reimbursement (as defined in Section 3(b) herein) subject to the conditions provided for in Section 3(b) herein. Any other benefits, including any equity grants, will be governed by the applicable benefit plan documents. Except as expressly provided in the applicable benefit plan documents, the Plans (as defined in Section 2 herein), or in this Agreement, Employee will receive no additional compensation, bonus, severance, commissions, equity, or other benefits (including, but not limited to, under the Company’s Executive Severance and Change-in-Control Plan (the “Severance Plan”)) after the Termination Date.

Survival of Post-Termination Rights and Obligations. Employee acknowledges and understands that the Parties’ post-termination obligations and rights under (a) the Employee Invention Assignment, Confidentiality Agreement and Non-Competition Agreement previously entered into by and between the Parties (the “Confidentiality Agreement”), and (b) any equity award agreements (“Award Agreements”) granted to Employee under the Company’s 2018 Stock Incentive Plan or 2014 Stock Incentive Plan (the “Plans”), shall survive the termination of Employee’s employment with the Company and shall remain in full force and effect following Employee’s execution of this Agreement and the Reaffirmation attached hereto as Exhibit 1 (the “Reaffirmation”).

Severance Benefits. Pursuant to the terms of this Agreement and the Reaffirmation, Employee is receiving certain severance and other benefits to which Employee would not otherwise be entitled. In exchange for promises by Employee in this Agreement and the Reaffirmation, including but not limited to a release of claims, restrictive covenants, promise to provide consulting services, and promise to cooperate post-termination, and provided that (x) Employee’s employment with the Company has not been terminated prior to the Termination Date as a result of voluntary termination by Employee without Good Reason (as defined in the Severance Plan) or involuntary termination by the Company for Cause (as defined in the Severance Plan), and (y) both this Agreement and the Reaffirmation are timely signed by Employee, returned to the Company, and not revoked as set forth in Section 17 of this Agreement and Section 9 of the Reaffirmation, the Company shall provide the following consideration to Employee (collectively, the “Severance Benefits”):

During calendar year 2024 (the “Severance Period”), the Company will pay Employee the total gross amount of $475,000 (the “Severance Payments”), less applicable taxes and withholdings. Provided Employee does not breach the terms of this Agreement or the Confidentiality Agreement, [***].

Provided that Employee (i) timely and properly elects healthcare insurance continuation coverage under COBRA, (ii) timely pays the applicable COBRA premium directly to the COBRA administrator, and (iii) remits documentation of Employee’s payment of the applicable COBRA premium to Cathy DeRose, VP Human Resources, [***], no later than thirty (30) days after Employee pays the applicable COBRA premium, then the Company will reimburse Employee within thirty (30) days thereafter for the premiums for Employee to continue healthcare insurance coverage at the level in effect as of the Termination Date under the Company’s healthcare insurance plan (the “COBRA Reimbursement”) until the earlier of: (A) eighteen (18) months following the Separation Date; or (B) the date Employee is no longer eligible to receive COBRA continuation coverage.

Effective on January 1, 2024, Employee’s unvested stock options and unvested RSUs granted under the Award Agreements that would have vested within the fifteen-month period following the Termination Date will immediately vest, and except as set forth in the Appendix A described below, the expiration date of the vested stock options that she holds will be extended until March 31, 2025 (all as more particularly set forth on Appendix A hereto). Employee acknowledges and understands that she will receive a Form 1099 from the Company for the taxable income she will earn on the accelerated vesting of her unaccelerated RSUs.

Assistance Seeking to Retain the Company’s Finance Team. Employee agrees to use commercially reasonable efforts to help the Company’s management retain the Company’s employees who are currently on the Company’s financial team following the announcement of her retirement.

Consultancy. Effective on January 1, 2024, Employee will become a consultant to the Company and make herself available to the Company for consultation, which shall include such services as are reasonably requested by the Company’s Chief Executive Officer and Chief Financial Officer with regard to the Company’s accounting, finance, and treasury matters (the “Consulting Services”). Employee’s consulting term shall begin on January 1, 2024 and end on December 31, 2024 (the “Consulting Period”). [***]

Non-Competition. Because of Catalyst’s legitimate business interests and the good and valuable consideration offered to Employee hereunder, Employee agrees that during the Consulting Period and for a period of one-year thereafter, Employee shall not, directly or indirectly, [***]

Non-Solicitation. Employee understands and acknowledges that Catalyst has expended and continues to expend significant time and expense in recruiting and training its employees, and that the loss of employees would cause significant and irreparable harm to Catalyst. In consideration of Catalyst’s legitimate business interests and the good and valuable consideration offered to Employee hereunder, Employee agrees that during the Consulting Period, Employee shall not, directly or indirectly (whether orally, in writing, through electronic means such as social media, websites, emails, text messages, instant messages, or through other individuals), solicit, hire, recruit, or attempt to solicit, hire, or recruit, any employee or consultant of the Company for employment or engagement with any entity or individual other than the Company, or induce any employee or consultant of the Company to terminate their relationship with the Company.

Releases.

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Waiver of Unknown Claims. The Parties understand and agree the Release in Section 8 above includes not only claims presently known to Employee, but also all unknown or unanticipated claims, rights, demands, actions, obligations, and liabilities of every kind that are covered by the Release. Employee understands that Employee may later discover facts different from what Employee now believes to be true, which, if known, could have materially affected Employee’s decision to sign this Agreement, but Employee nevertheless waives any claims or rights based on such different or additional facts.

No Claims Filed; Covenant Not to Sue. Employee affirms that Employee has not filed nor caused to be filed, and is not presently a party to, any lawsuits or arbitrations against any of the Released Parties in any forum; provided, however, [***].

Release Exclusions; Protected Rights. Nothing in the Release in Section 8 above or anything else in this Agreement or the Reaffirmation limits or otherwise affects: rights to any vested retirement benefits or other accrued benefits to which Employee is already entitled; claims for workers’ or unemployment compensation; claims that arise after the date Employee signs this Agreement; claims to enforce this Agreement or the Reaffirmation; claims that cannot lawfully be waived; and claims for or rights to indemnification or legal defense under the bylaws of the Company or applicable law, or to be covered under any applicable directors’ and officers’ liability insurance policies, related to actions or conduct that occurred in the scope of the Employee’s employment with the Company. In addition, nothing in the Release in Section 8 above or anything else in this Agreement, the Reaffirmation, the Confidentiality Agreement, any Company policy or agreement, or elsewhere, limits or otherwise affects Employee’s rights to engage in the following, without providing notice to or obtaining the consent of the Company: file a claim, complaint, or charge with, provide information to, communicate directly with, testify to or before, or participate in an investigation or proceeding conducted by, any federal, state or local government agency responsible for enforcing any law, including, but not limited to, the SEC, the Department of Justice, the Equal Employment Opportunity Commission, and the National Labor Relations Board; report possible violations of any law or regulation to any such agency; make other disclosures protected under whistleblower provisions of any law or regulation; or disclose or discuss a sexual assault or sexual harassment dispute (collectively, “Protected Rights”). Notwithstanding the above, Employee expressly waives all rights to recover damages and to be awarded equitable and/or injunctive relief in connection with any administrative or court action brought against the Company or any of the other Released Parties, whether brought by Employee, on Employee’s behalf, or by any government agency or other party, related in any way to any claim released by Employee in the Release in Section 8 above. However, Employee may recover money properly awarded by the SEC as a reward for providing information to the SEC.

Taxes and Indemnification. Employee agrees to pay all taxes (other than payroll taxes) found to be owed based upon the Severance Benefits provided to or on behalf of Employee under this Agreement and to indemnify and hold the Company harmless for any federal, state and local tax liability (including taxes, interest, penalties or the like, and required withholdings), which may be asserted against or imposed upon the Company by any taxing authority related to such Severance Benefits due to Employee’s non-payment of taxes for which Employee is legally responsible. Employee understands and agrees that the Company may file any necessary tax documentation regarding the Severance Benefits provided to or on behalf of Employee under this Agreement. Employee and the Company acknowledge that nothing herein constitutes tax advice to the other Party.

Employee Representations. Employee represents and warrants that Employee has: (a) been paid all compensation owed (including, but not limited to, bonus compensation) for all hours worked; (b) received all the leave and leave benefits and protections for which Employee was eligible, under the Family and Medical Leave Act or otherwise; and (c) not suffered any on-the-job injury for which Employee has not already filed a claim. In addition, it is Company policy to encourage reporting within the Company all possible violations of any law, and no one has interfered with Employee’s reporting of any such violations. Employee further represents that: (i) Employee has not alleged any claim against the Company or any other Released Parties, the factual foundation for which involves sexual harassment under applicable law; (ii) no part of the monies paid pursuant to this Agreement is a payment related to sexual harassment or sexual abuse as set forth in Section 162(q) of the Internal Revenue Code; and (iii) Employee does not contend and is not aware of any facts to suggest that Employee has been subjected at any time to any acts of discrimination, retaliation, sexual harassment or sexual abuse by the Company or any other Released Parties.

Cooperation. Employee agrees that, following the Termination Date, Employee will cooperate fully with the Company in connection with: (a) any defense, prosecution, or investigation of claims or demands by or against third parties; or (b) other matters arising from or related to events during Employee’s employment by the Company. Such cooperation includes, without limitation, being available to the Company upon reasonable notice, without subpoena, to provide truthful and accurate information in witness interviews plus deposition and trial testimony. The Company will reimburse Employee for reasonable out-of-pocket expenses incurred in connection with any such cooperation (excluding forgone wages, salary, or other compensation) and will make reasonable efforts to accommodate Employee’s scheduling needs.

Non-Admission. This Agreement is intended to facilitate an amicable separation of Employee’s employment with the Company and is not intended and shall not be construed as an admission of wrongdoing by either Party.

Effect of Breach; Attorney’s Fees. If the Company in its reasonable discretion determines that Employee has breached Sections 5, 6, or 7 hereof, then the Company shall provide Employee with written notice containing the reasons for the Company’s determination and ten (10) days to cure the breach (the “Cure Period); provided, however, that the breach is, in fact, curable, as determined in the reasonable discretion of Company. In no event shall Employee have more than one cure opportunity with respect to the recurrence of the same or similar actions or inactions constituting breach of Sections 5, 6 or 7 hereof by Employee. [***].

Time to Consult, Consider and Revoke; Effective Date. By this Agreement, Employee has been advised to consult with an attorney before signing this Agreement and the Reaffirmation. Employee acknowledges and understands that the Release in Section 8 above effectively waives all claims under the ADEA, and agrees that this Agreement complies with the OWBPA. Employee further acknowledges that Employee has had the opportunity to consider this Agreement and the Reaffirmation for twenty-one (21) days before signing this Agreement, although Employee may choose to sign it sooner. Any

Integration; Modification. Employee acknowledges that this Agreement, the Reaffirmation, as well as the surviving terms of the Confidentiality Agreement and the Award Agreements, constitute the entire agreement between the Parties pertaining to the subject matter hereof, and supersede any other agreements and understandings between Employee and the Company, whether written or oral, express or implied, regarding Employee’s employment, termination and benefits. Employee has not relied on any statement or promises by anyone other than those contained in this Agreement and has entered into this Agreement knowingly without reliance upon any other representation, promise, or inducement not set forth herein. This Agreement shall not be modified unless in writing and signed by both the Company and Employee.

Transfer of Claims. Employee has not assigned, transferred, or purported to assign or transfer to any person or entity any claims released under Section 8 above. Employee agrees to indemnify and hold the Released Parties harmless against all rights, claims, warranties, demands, debts, obligations, liabilities, costs, legal costs (including attorneys’ fees) or judgments based on or arising out of any such assignment or transfer. Employee further warrants that nothing prohibits Employee from entering into this Agreement.

Binding Effect. This Agreement shall bind and inure to the benefit of the Parties’ representatives, agents, successors, assigns, heirs, attorneys, current and future affiliates, and predecessors, as well as any of the Released Parties. This Agreement shall not benefit any other person or entity except as specified in this Agreement.

Sufficiency of Consideration; Severability; Independent Covenants. Employee agrees that the Severance Benefits provided to Employee hereunder are good and valuable consideration for Employee’s signing of this Agreement and the Reaffirmation. Should a court of competent jurisdiction determine that the Release in Section 8 above or the release in Section 3 of the Reaffirmation is invalid, void or unenforceable, then Employee agrees the Company’s obligations under this Agreement and the Reaffirmation are null and void and Employee shall be required to repay to the Company all of the Severance Benefits already paid to or on behalf of Employee, including, but not limited to, any stock

Conflicting Terms. In the event of any conflict or disagreement between the terms of this Agreement and the Confidentiality Agreement, the terms that provide the greater protection to the Company shall control and take precedence. The restrictive covenants and other obligations of Employee in this Agreement and the Confidentiality Agreement shall be deemed separate and distinct provisions and each applicable time period shall run concurrently in accordance with their terms for the benefit of the Company.

Governing Law, Interpretation, Jurisdiction and Venue; Jury Trial Waiver. This Agreement and the Reaffirmation shall be governed by and construed in accordance with the laws of the State of Florida, without regard to its choice of law principles. This Agreement and the Reaffirmation shall be construed as a whole, according to their fair meaning, and not in favor of or against any Party for any reason. Any and all disputes between the Parties arising from or related to this Agreement or the Reaffirmation shall be exclusively heard and determined before a federal or state court located in Miami-Dade County, Florida. The Parties hereto acknowledge that such court has the jurisdiction to interpret and enforce the provisions of this Agreement and the Reaffirmation, and the Parties waive any and all objections that they may have as to personal jurisdiction or venue in any of the above courts. BY SIGNING BELOW, BOTH PARTIES WAIVE THE RIGHT TO A TRIAL BY JURY OF ANY ACTION ARISING OUT OF THIS AGREEMENT, THE REAFFIRMATION, THE TERMINATION OF EMPLOYEE’S EMPLOYMENT OR THE EMPLOYMENT RELATIONSHIP.

Representation by Counsel. The Parties acknowledge that (a) they have had the opportunity to consult counsel in regard to this Agreement and the Reaffirmation, and (b) they have read and understand this Agreement and the Reaffirmation and are fully aware of their legal effect.

Return of Company Property. Except to the extent the Company authorizes Employee to retain Company property necessary for Executive’s performance of the Consulting Services, Employee represents and agrees that: (a) on or before the Termination Date, Employee shall return to the Company all property of the Company in Employee’s possession or control, including but not limited to, confidential and proprietary information and trade secrets, products, business records, electronically stored information, forms, tools, specifications, software, hardware, designs, files, papers and other writings related to the Company’s business; and (b) Employee shall not retain any copies or duplicates of the Company’s property after the Termination Date. Immediately after the end of the Consulting Period, Employee agrees to return to the Company all property of the Company in Employee’s possession or control.

No Waiver. No waiver of any claim for breach or other rights under this Agreement shall be deemed a broader waiver unless the broader waiver is acknowledged in a writing executed by the waiving Party.

Headings, Electronic Transmissions and Counterparts. Headings in this Agreement are for reference purposes only and shall not in any way affect this Agreement’s meaning or interpretation. This Agreement may be executed in several counterparts and by electronic transmissions (e-mail, facsimile and/or scanner) and all so executed copies shall constitute one Agreement, binding on all the Parties hereto, even though the Parties are not signatories to the original or same counterpart.

Acceptance. To accept this Agreement, Employee must sign and date below and return this Agreement within twenty-one (21) days of the date of Employee’s receipt of this Agreement, to the Company’s outside corporate counsel, Philip B. Schwartz of Akerman LLP [***].

/s/ Alicia Grande

/s/ Patrick J. McEnany