Amendment, dated January 8, 2018, to Second Amended and Restated License Agreement, dated June 15, 2017, between Cell Cure Neurosciences, Ltd. and Hadasit Medical Research Services and Development
FIRST AMENDMENT TO SECOND AMENDED AND RESTATED LICENSE
AGREEMENT
This First Amendment (this “Amendment”) is made on November __, 2017 as an amendment to the Second Amended and Restated License Agreement of June 15, 2017 (the "Agreement"), by and between HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (“Hadasit”) and CELL CURE NEUROSCIENCES LTD. (the “Company”) (each a “Party” and jointly the “Parties”), effective as of the same date as the Agreement.
| WHEREAS: | The Parties have discussed the terms of the Agreement and have mutually agreed to further amend the Agreement terms as set out herein. |
NOW THEREFORE THE PARTIES DO HEREBY AGREE AS FOLLOWS:
| 1. | Capitalized terms used but not defined herein shall, unless otherwise indicated, have the meaning ascribed to such terms in the Agreement. |
| 2. | Annex A which lists the Licensed Patents is hereby replaced, in its entirety, with the updated listing dated October 24, 2017 attached hereto and marked “Annex A – Patents”. |
| 3. | The Parties hereby acknowledge and confirm that while Cell Cure has borne the costs of US patent ###-###-#### directed at undifferentiated stem cell culture systems, such patent is not included in the Licensed Patents. Therefore, Hadasit shall reimburse Cell Cure for such costs in a total of NIS 146,656.08 by no later than November 15, 2017. Cell Cure shall be entitled to set any unpaid portion of this debt off against any amounts that become due to be paid by Cell Cure to Hadasit under the Agreement from time to time, by written notice to Hadasit. |
| 4. | Except as specifically provided in and required by this Amendment, the terms and conditions of the Agreement shall remain in full force and effect. In the event of a contradiction between the provisions of this Amendment and the provisions of the Agreement, the provisions of this Amendment shall prevail. |
| 1 |
IN WITNESS WHEREOF, the Parties have duly executed this Amendment:
| HADASIT | CELL CURE NEUROSCIENCES Ltd. | ||||
| By: | /s/ Dr. Tamar Raz | By: | /s/ Rami Skaliter | ||
| Name: | Dr, Tamar Raz | Name: | Rami Skaliter | ||
| Title: | Chief Executive Officer | Title: | Chief Executive Officer | ||
| Date: | December 18, 2017 | Date: | January 8, 2018 | ||
Attached: Annex A - Patents
| 2 |
Appendix A – Patent Listing
| Family: | 3440 | Title: | Reverse hexagonal mesophases (hii) and uses thereof |
| Inventor | University | Faculty | Department | |||||||
| Amar-Yuli Idit | HUJI | Faculty of Science | The Institute of Chemistry | |||||||
| Aserin Abraham | HUJI | Faculty of Science | The Institute of Chemistry | |||||||
| Bitan-Cherbachovsky Liron | HUJI | Faculty of Science | The Casali Center for Applied Chemistry | |||||||
| Libster Dima | HUJI | Faculty of Science | The Casali Center for Applied Chemistry | |||||||
| Mishraki Tehila | HUJI | Faculty of Science | The Casali Center for Applied Chemistry | |||||||
| Garti Nissim | HUJI | Faculty of Science | The Institute of Chemistry |
| Patent ID | Application Status | Country | Date | Publication Number | Date | Patent Number | ||||||
| 3440-00 | Expired | US | 25/06/2009 | 61/220,398 | ||||||||
| 3440-01 | Expired | US | 09/02/2010 | 61/302,649 | ||||||||
| 3440-02 | Exhausted | PCT | 24/06/2010 | PCT/IL2010/000507 | 29/12/2010 | WO 2010/150262 | ||||||
| 3440-03 | Examination | Europe | 24/06/2010 | 10738041.2 | 19/09/2012 | 2498754 | ||||||
| 3440-04 | Allowed | Israel | 24/06/2010 | 217115 | ||||||||
| 3440-05 | Examination | US | 24/06/2010 | 13/379,769 | 07/02/2013 | US-2013/0034538 |
| Family: | 6150 | Title: | A novel method for the solubilization of cannabis based on improved modified NSSL |
| Inventor | University | Faculty | Department | |||||||
| Aserin Abraham | HUJI | Faculty of Science | The Institute of Chemistry | |||||||
| GARTI LEVI Sharon | ||||||||||
| Garti Nissim | HUJI | Faculty of Science | The Institute of Chemistry |
| Patent ID | Application Status | Country | Date | Publication Number | Date | Patent Number | ||||||
| 6150-00 | Filed | NA | 29/09/2016 | 248149 |
| Family: | 6151 | Title: | A novel process for the extraction of CBD/THC using NSSL |
| Inventor | University | Faculty | Department | |||||||
| Aserin Abraham | HUJI | Faculty of Science | The Institute of Chemistry | |||||||
| Edri Rotem | ||||||||||
| GARTI LEVI Sharon | ||||||||||
| Garti Nissim | HUJI | Faculty of Science | The Institute of Chemistry |
| Patent ID | Application Status | Country | Date | Publication Number | Date | Patent Number | ||||||
| 6151-00 | Filed | Israel | 29/09/2016 | 248150 |
| 3 |
APPENDIX C – DEVELOPMENT PLAN
| Stage | Description (Activities to be done either by the Company, a Company Affiliate or a Sublicensee) | Timeline Milestones – each an Essential Milestone | ||
| Toxicology | Completion of formal pre-clinical toxicology studies | 50 months from the Effective Date | ||
| Phase I | Initiation of a Phase I clinical trial with the selected formulated drug | 72 months from the Effective Date | ||
| Phase III | Initiation of a Phase III clinical trial with the selected formulated drug | 90 months from the Effective Date | ||
| First Commercial Sale | First Commercial Sale of the selected formulated drug | 108 months from the Effective Date |
For purposes of this Appendix C, Effective Date shall mean the date of the Third Amendment (i.e. February 9, 2017).
| 4 |
October 24, 2017
Annex A
Patents
Part I – Licensed Patents on the Effective Date (status as of the Date of the Second Amendment)
STEM CELLS CULTURE SYSTEMS – Only claims 20-39 of PCT application IL2005/001397 (249-01) and the parts of the correponding National Phase applications that include the mentioned claims are included in the exclusive license granted to the Company. In addition CellCure will have a limited non-exclusive right under claims 1-3 of PCT application IL2005/001397 (249-01) and the parts of the correponding National Phase applications that include the mentioned claims, solely to the extent necessary to use the Licensed Feeder Cell Line (as such term is defined in the Agreement) in accordance with the terms of the Agreement. CellCure will not have any other rights under claims 1-3. Without limiting the generality of the foregoing, no rights are granted under claims 1-3 of the abovementioned patent applications with respect to any feeder cell lines other than the Licensed Feeder Cell Lines.
| |||||||
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
47631 249-00 | USA PRO | 29-Dec-2004 60/639,809 | Expired | Hadasit Medical Research Services and Development Ltd. BEN-SHUSHAN Etti ; TANNENBAUM Shelly ; ITSYKSON Pavel ; BANIN Eyal ; REUBINOFF Benjamin Eithan | |||
47632 249-01 | PCT | 29-Dec-2004 60/639,809 | 29-Dec-2005 IL2005/001397 | Publ. Date: 06-Jul-2006 Publ. #: WO2006/070370 | Expired | Hadasit Medical Research Services and Development Ltd. BEN-SHUSHAN Etti ; TANNENBAUM Shelly ; ITSYKSON Pavel ; BANIN Eyal ; REUBINOFF Benjamin Eithan | |
66284 249-10 | Europe DIV | 29-Dec-2004 60/639,809 | 15-Jul-2011 | 29-Dec-2005 11174158.3 | Publ. Date: 25-Jan-2012 Publ. #: 2410044 | Pending | Hadasit Medical Research Services and Development Ltd. BEN-SHUSHAN Etti ; TANNENBAUM Shelly ; ITSYKSON Pavel ; BANIN Eyal ; REUBINOFF Benjamin Eithan |
| 249-03 | 05821535.1 Europe Validated in 7 European countries | 29-Dec-2004 60/639,809 | 29-Dec-2005
| EP1844136 B1 |
Granted
27.8.14 | Hadasit Medical Research Services and Development Ltd. BEN-SHUSHAN Etti ; TANNENBAUM Shelly ; ITSYKSON Pavel ; BANIN Eyal ; REUBINOFF Benjamin | |
| 249-09 |
US 13/005,978 | 29-Dec-2004 60/639,809 | January 13, 2011 | 29-Dec-2005 | US20110177594 US9005965 BB | Issued April 14, 2015 | Hadasit Medical Research Services and Development Ltd. BEN-SHUSHAN Etti ; TANNENBAUM Shelly ; ITSYKSON Pavel ; BANIN Eyal ; REUBINOFF Benjamin |
| STEM CELL-DERIVED RETINAL PIGMENT EPITHELIAL CELLS | |||||||
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
47433 315-01 | PCT
| 18-Apr-2007 60/907,818 | 27-Apr-2008 IL2008/000556 | Publ. Date: 30-Oct-2008 Publ. #: WO2008/129554 | Expired | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan | |
47434 315-04 | USA NP | 18-Apr-2007 60/907,818 | 19-Oct-2009 | 27-Apr-2008 12/450,943 | Publ. Date: 03-Feb-2011 Publ. #: 2011-0027333-A1 17-Feb-2015 8,956,866 | Granted | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
| RETINAL PIGMENT EPITHELIAL CELLS DIFFERENTIATED FROM EMBRYONIC STEM CELLS WITH NICOTINAMIDE AND ACTIVIN | |||||||
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
61423 315-14 | USA DIV | 18-Apr-2007 60/907,818 | 29-Dec-2014 | 27-Apr-2008 14/583,838 | Publ. Date: 07-May-2015 Publ. #: 2015-0125506-A1 | Pending | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
61424 315-15 | USA DIV | 18-Apr-2007 60/907,818 | 29-Dec-2014 | 27-Apr-2008 14/583,848 | Publ. Date: 30-Apr-2015 Publ. #: 2015-0118749-A1 | Pending | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
| Page 1 of 6 |
| STEM CELL-DERIVED RETINAL PIGMENT EPITHELIAL CELLS | |||||||
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
47435 315-03 | Europe NP | 18-Apr-2007 60/907,818 | 18-Nov-2009 | 27-Apr-2008 08738258.6 | Publ. Date: 27-Jan-2010 Publ. #: 2147094 08-Oct-2014 2147094 | Granted | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
49360 315-10 | Hong Kong NP | 18-Apr-2007 60/907,818 | 20-Jul-2010 | 27-Apr-2008 10107017.2 | Publ. Date: 22-Oct-2010 Publ. #: 1140791A 27-Mar-2015 HK1140791 | Granted | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
54561 315-11 | Europe DIV | 18-Apr-2007 60/907,818 | 21-Aug-2012 | 27-Apr-2008 12181140.0 | Publ. Date: 06-Feb-2013 Publ. #: 2554661 19-Nov-2014 2554661 | Granted | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
61018 315-12 | Europe DIV | 18-Apr-2007 60/907,818 | 18-Nov-2014 | 27-Apr-2008 14193621.1 | Publ. Date: 24-Jun-2015 Publ. #: 2886646 | Pending | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
56710 315-16
| Hong Kong DIV | 18-Apr-2007 60/907,818 | 04-Jun-2013 | 27-Apr-2008 13106571.9 | 24-Jul-2015 HK1179647 | Granted | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
64780 315-17 | Hong Kong DIV | 18-Apr-2007 60/907,818 | 16-Dec-2015 | 27-Apr-2008 15112372.6 | Publ. Date: 27-May-2016 Publ. #: 1211619A | Pending | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
47436 315-08 | Australia NP | 18-Apr-2007 60/907,818 | 17-Nov-2009 | 27-Apr-2008 2008242106 | 29-Aug-2013 2008242106 | Granted | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
47437 315-02 | Canada NP | 18-Apr-2007 60/907,818 | 16-Oct-2009 | 27-Apr-2008 2,684,460 | 03-Jan-2017 2,684,460 | Granted | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
47438 315-05 | Japan NP | 18-Apr-2007 60/907,818 | 19-Oct-2009 | 27-Apr-2008 2010-503665 | 25-Oct-2013 5,395,058 | Granted | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan |
| Page 2 of 6 |
| METHODS OF GENERATING PLURIPOTENT STEM CELL-DERIVED RETINAL PIGMENT EPITHELIAL CELLS | |||||||
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
47439 315-06 | Israel NP | 18-Apr-2007 60/907,818 | 18-Oct-2009 | 27-Apr-2008 201600 | Publ. Date: 24-Mar-2013 Publ. #: 201600 25-Jun-2013 201600 | Granted | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
56027 315-19 | Israel DIV | 18-Apr-2007 60/907,818 | 11-Mar-2013 | 27-Apr-2008 225163 | Pending | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak | |
47440 315-07 | China NP | 18-Apr-2007 60/907,818 | 18-Dec-2009 | 27-Apr-2008 200880020748.0 | Publ. Date: 31-Mar-2010 Publ. #: 101688178 04-Dec-2013 200880020748.0 | Granted | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
57677 315-13
| China DIV | 18-Apr-2007 60/907,818 | 16-Oct-2013 | 27-Apr-2008 201310484803.4 | Publ. Date: 05-Feb-2014 Publ. #: CN 103555654 A 20-Apr-2016 ZL201310484803.4 | Granted | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
59417 315-18 | Hong Kong DIV | 18-Apr-2007 60/907,818 | 19-May-2014 | 27-Apr-2008 14104657.0 | Publ. Date: 25-Jul-2014 Publ. #: 1191377A | Allowed | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak |
47441 315-09 | India NP | 18-Apr-2007 60/907,818 | 18-Nov-2009 | 27-Apr-2008 6790/CHENP/2009 | Pending | Hadasit Medical Research Services and Development Ltd. IDELSON Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak | |
| Page 3 of 6 |
Part II – Hadasit IP
| LARGE SCALE PRODUCTION OF RETINAL PIGMENT EPITHELIAL CELLS – | |||||||
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
62470 558-00 | USA PRO |
| 29-Jul-2015 62/198,160 | Expired | Hadasit Medical Research Services and Development Ltd. REUBINOFF Benjamin Eithan ; SINGER Orna | ||
66071 558-01 | PCT
| 29-Jul-2015 62/198,160 | 28-Jul-2016 IL2016/050829 | Filed | Hadasit Medical Research Services and Development Ltd. REUBINOFF Benjamin Eithan ; SINGER Orna | ||
| METHODS OF PRODUCING PHOTORECEPTOR CELLS FOR THE TREATMENT OF RETINAL DISEASES– | |||||||
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
69074 655-00 | USA PRO |
| 08-Feb-2017 62/456,155 | Filed | Hadasit Medical Research Services and Development Ltd. Banin Eyal, Idelson Masha, Khaner Hanita, Obolensky Alexey, Reubinoff Benjamin E | ||
Part III – Joint IP
| METHODS OF SELECTING RETINAL PIGMENTED EPITHELIAL CELLS | |||||||
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
52753 485-00 | USA PRO | 31-Jan-2012 61/592,635 | Expired | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. REUBINOFF Benjamin Eithan ; YACHIMOVICH-COHEN Nurit ; MATZRAFI Limor | |||
55700 485-01 | PCT
| 31-Jan-2012 61/592,635 | 29-Jan-2013 IL2013/050077 | Publ. Date: 08-Aug-2013 Publ. #: WO2013/114360 | Expired | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. REUBINOFF Benjamin Eithan ; YACHIMOVICH-COHEN Nurit ; MATZRAFI Limor | |
60058 485-02 | USA NP | 31-Jan-2012 61/592,635 | 29-Jul-2014 | 29-Jan-2013 14/375,195 | Publ. Date: 08-Jan-2015 Publ. #: 2015-0010922-A1 | Allowed | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. REUBINOFF Benjamin Eithan ; YACHIMOVICH-COHEN Nurit ; MATZRAFI Limor |
60059 485-03 | Canada NP | 31-Jan-2012 61/592,635 | 29-Jul-2014 | 29-Jan-2013 2,863,172 | Pending | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. REUBINOFF Benjamin Eithan ; YACHIMOVICH-COHEN Nurit ; MATZRAFI Limor | |
60060 485-04 | Australia NP | 31-Jan-2012 61/592,635 | 15-Aug-2014 | 29-Jan-2013 2013216382 | Pending | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. REUBINOFF Benjamin Eithan ; YACHIMOVICH-COHEN Nurit ; MATZRAFI Limor | |
69345 485-05 | US DIV | 31-Jan-2012 61/592,635 | 15-Aug-2014 | 28-Mar-2017 15/470,926 | Pending | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. REUBINOFF Benjamin Eithan ; YACHIMOVICH-COHEN Nurit ; MATZRAFI Limor | |
| Page 4 of 6 |
| HIGH THROUGHPUT SCREENING OF AGENTS ON HUMAN PLURIPOTENT-DERIVED DOPAMINERGIC NEURONS | |||||||
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
55925 496-00 | USA PRO | 13-Feb-2013 61/764,031 | Expired | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. MORDECHAI DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan | |||
| HIGH THROUGHPUT SCREENING OF AGENTS ON DOPAMINERGIC NEURONS | |||||||
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
55931 496-01 | USA PRF | 13-Feb-2013 61/764,031 | 18-Mar-2013 61/802,814 | Expired | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. MORDECHAI DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan | ||
58434 496-02 | PCT
| 13-Feb-2013 61/764,031 | 12-Feb-2014 IL2014/050149 | Publ. Date: 21-Aug-2014 Publ. #: WO2014/125481 | Expired | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. MORDECHAI DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan | |
63486 496-03 | Europe NP | 13-Feb-2013 61/764,031 | 28-Aug-2015 | 12-Feb-2014 14751359.2 | Publ. Date: 23-Dec-2015 Publ. #: 2956539 | Pending | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. MORDECHAI DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan |
65929 496-06 | Hong Kong NP | 13-Feb-2013 61/764,031 | 13-Apr-2016 | 12-Feb-2014 16104232.2 | Publ. Date: 28-Oct-2016 Publ. #: 1216258A | Pending | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. MORDECHAI DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan |
63487 496-04 | USA NP | 13-Feb-2013 61/764,031 | 10-Aug-2015 | 12-Feb-2014 14/766,784 | Publ. Date: 31-Dec-2015 Publ. #: 2015-0377864-A1 | Pending | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. MORDECHAI DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan |
63488 496-05 | Israel NP | 13-Feb-2013 61/764,031 | 06-Aug-2015 | 12-Feb-2014 240415 | Pending | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. MORDECHAI DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan | |
66894 496-07 | Canada NP | 13-Feb-2013 61/764,031 | 11-Jul-2016 | 12-Feb-2014 2,936,486 | Pending | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. MORDECHAI DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan | |
| PREPARATION OF RETINAL PIGMENT EPITHELIUM CELLS | |||||||
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
64082 603-00 | USA PRO | 26-Oct-2015 62/246,214 | Expired | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. REUBINOFF Benjamin Eithan ; SINGER Orna | |||
67196 603-01 | PCT
| 26-Oct-2015 62/246,214 | 26-Oct-2016 IL2016/051155 | Filed | Cell Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd. REUBINOFF Benjamin Eithan ; SINGER Orna ; BOHANA-KASHTAN Osnat ; WISER Ofer | ||
| Page 5 of 6 |
Part IV – OCS Funded
| METHODS OF TREATING RETINAL DISEASES | |||||||
Our Ref Client Ref | Country | Earliest Priority | Entry Date | Filing Date Application No. | Publication Date + No. Issue Date + Patent No. | Status | Assignee Inventor |
61895 602-03 | PCT
| 30-Dec-2014 62/097,753 | 30-Apr-2015 IL2015/050456 | Publ. Date: 07-Jul-2016 Publ. #: WO2016/108219 | Published | Cell Cure Neurosciences Ltd. BANIN Eyal ; REUBINOFF Benjamin Eithan ; BOHANA-KASHTAN Osnat ; NETZER Nir ; IRVING Charles Sherard | |
| Page 6 of 6 |
