FOURTHAMENDMENT TO LEASE

Date of Lease:

January 7, 2000

Date of Amendments:

First Amendment

June 27, 2000

Second Amendment

January 21, 2005

Third Amendment

February 24, 2006

Fourth Amendment

January 5, 2009

Landlord:

John H. Spurr, Jr. and William G. Constable, Trustees of 1050 Hingham Street Realty Trust.

Landlord’s Address:

20 Winthrop Square, Boston, Massachusetts 02110-1229.

Tenant:

BioSphere Medical, Inc., a Delaware Corporation.

Tenant’s Address:

1050 Hingham Street

Rockland, Massachusetts 02370

Property:

Landlord’s land and improvements thereon known as 1050 Hingham Street, Rockland, Massachusetts 02370.

Building:

The three-story building located on the Property.

Leased Premises:

The entire first floor (excluding the common entrance lobby) of the Building as shown on Exhibit A-1.

Rentable Square Footage

of the Leased Premises:

Prior to First Amendment 7,797 square feet.

Prior to Second Amendment 12,995 square feet.

Prior to Third Amendment 7,797 square feet.

Prior to the Fourth Amendment 12,995 square feet.

After Fourth Amendment 12,995 square feet.

Total Rentable Square

Footage of the Building:

39,771 square feet.

Use of Leased Premises:

Administrative offices for a medical device company and ancillary uses related thereto including research and development and light manufacturing to the extent described in Exhibit D attached hereto and incorporated herein, provided that such research and development involve no hazardous materials, solid waste, noise or

fumes beyond the Leased Premises or any impact on the Building, its operations or the operations of other tenants in the Building.

Lease Term:

Nine (9) years, eleven (11) months (original term – five (5) years, extension per Second Amendment – two (2) years of which only eleven months were completed prior to the Third Amendment, extension per Third Amendment – three (3) years ending February 28, 2009 - extension per Fourth Amendment – one (1) year ending February 28, 2010)

Specified Commencement

Date:

March 15, 2000

Commencement Date:

The Specified Commencement Date or such other date as is determined in accordance with the terms of Section 3.

Second Amendment

Commencement Date:

April 1, 2005

Third Amendment

Commencement Date:

March 1, 2006

Fourth Amendment

Commencement Date:

March 1, 2009

Base Rent:

Annual

Monthly

Periods

Base Rent

Installment

March 15, 2000 to July 14, 2000

$

155,940.00

$

12,995.00

July 15, 2000 to March 14, 2003

$

270,296.00

$

22,524.67

March 15, 2003 to March 31, 2005

$

276,143.75

$

23,011.98

April 1, 2005 to February 28, 2006

$

155,940.00

$

12,995.00

March 1, 2006 to February 28, 2010

$

233,910.00

$

19,492.50

Lease Security:

An irrevocable letter of credit (the “Letter of Credit”) or cash Security

Deposit of $140,000 at the Commencement Date and $234,000 after the execution of the First Amendment, to be reduced as scheduled below, subject to Section 4.

Period

Amount

3/15/00 – First Amendment Execution

$

140,000

First Amendment Execution – 3/14/01

$

234,000

3/15/01 – 3/14/02

$

198,000

3/15/02 – 3/14/03

$

157,800

3/15/03 – 3/14/04

$

110,500

3/15/04 – 2/28/10

$

58,000

Base Operating Costs:

Prior to Second Amendment: Operating Costs for the calendar year 2000, grossed up to reflect 100% occupancy for a full calendar year.

Prior to Third Amendment: Operating Costs for the calendar year 2004, grossed up to reflect 100% occupancy for a full calendar year.

Prior to Fourth Amendment: Operating Costs for the calendar year 2004, grossed up to reflect 100% occupancy for a full calendar year ($324,954.44). This base year amount is net of the annual amount paid towards such costs by the basement tenant and Operating Costs for all subsequent years shall be adjusted to reflect the amount borne by the basement tenant in those years.

After Fourth Amendment: Operating Costs for the calendar year 2004, grossed up to reflect 100% occupancy for a full calendar year ($324,954.44). This base year amount is net of the annual amount paid towards such costs by the basement tenant and Operating Costs for all subsequent years shall be adjusted to reflect the amount borne by the basement tenant in those years.

Base Taxes:

Prior to Second Amendment: Taxes for the fiscal year ended June 30, 1999.

Prior to Third Amendment: Taxes for the fiscal year ended June 30, 2005.

Prior to Fourth Amendment: Taxes for the fiscal year ended June 30, 2005 ($47,493.11). This base year amount is net of the annual amount paid toward such costs by the basement tenant and Taxes for all subsequent years shall be adjusted to reflect the amount borne by the basement tenant in those years.

After Fourth Amendment: Taxes for the fiscal year ended June 30, 2005 ($47,493.11). This base year amount is net of the annual amount paid toward such costs by the basement tenant and Taxes for all subsequent years shall be adjusted to reflect the amount borne by the basement tenant in those years.

Electricity:

Prior to First Amendment $6,627.45 per year or $552.29 per month. After First Amendment $11, 825.00 per year or $985.42

per month.

After Second, Third and Fourth Amendments Tenant shall be responsible for the cost of electricity consumed through lights and outlets, which shall be sub-metered and billed to Tenant as per current practice.

Tenant’s Proportionate

Share:

Prior to First Amendment 19.605%.

Prior to Second Amendment 32.675%.

Prior to Third Amendment 19.605%

Prior to Fourth Amendment 32.675%

After Fourth Amendment Commencement Date 32.675%

Insurance:

$1,000,000/$3,000,000 per occurrence public liability;

$1,000,000 per occurrence property damage.

Personal Property insurance for all risks to full insurable value of personalty in the Leased Premises.

Condition of Leased

Premises:

Per Paragraph 7 of Fourth Amendment to Lease