Patent Purchase Agreement between BioMimetic Therapeutics, Inc. and Institute of Molecular Biology, Inc.

  Exhibit 10.23 PATENT PURCHASE AGREEMENT THIS PATENT PURCHASE AGREEMENT is made and entered into on this the 4th day of November, 2005, by and among BioMimetic Therapeutics, Inc. ("BMTI" or "Buyer") and Institute of Molecular Biology, Inc. ("IMB" or "Seller"). RECITALS Seller desires to sell to Buyer, and Buyer desires to purchase from Seller all right, title and interests in and to certain Patent Rights (as defined below), in exchange for certain consideration as set forth herein, and upon the other terms and conditions set forth in this Agreement. NOW, THEREFORE, in consideration of the mutual agreements and covenants contained herein, the parties hereto agree as follows: 1. PURCHASE AND SALE OF ASSETS. 1.1. ASSETS SOLD. Subject to and in accordance with the terms and conditions hereof, Buyer hereby purchases from Seller, and Seller will sell, assign, transfer and convey to Buyer all of its right, title and interest in and to the following (collectively the "Assets"): all patents and patent applications (including all continuations, divisionals, continuations-in-part, reissues and the rights to apply for patents anywhere in the world and any rights to sue for past infringements thereof) described on Schedule 1.1 attached hereto (collectively, the "Patent Rights"). 1.2. LIABILITIES RETAINED BY SELLER. Buyer shall not assume, or in any way be liable or responsible for, any liabilities, obligations or indebtedness of Seller, whether due or to become due, absolute or contingent, known or unknown (the "Retained Obligations") other than the obligations of Seller to Sullivan & Worcester LLP, Seller's special counsel in an amount not to exceed ** and obligations, if any, arising after Closing under any contracts related to the Patent Rights that are specifically assumed by Buyer in writing at the Closing. 2. PURCHASE PRICE. 2.1. PAYMENT OF PURCHASE PRICE. The consideration to be paid by Buyer to Seller, in consideration of the sale and transfer of the Assets, shall be **. 3. DELIVERIES. 3.1. DELIVERIES OF SELLER. Seller is hereby delivering to Buyer duly executed assignments of all patents and patent applications contained in the Patent Rights, in the form of Exhibit 3.1. ** REPRESENTS MATERIAL WHICH HAS BEEN REDACTED AND SEPARATELY FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS AMENDED.  4. REPRESENTATIONS AND WARRANTIES OF SELLER. Seller hereby represents and warrants to Buyer as follows: 4.1. CORPORATE ORGANIZATION. Seller is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware and has full corporate power and authority to carry on the business of Seller as it is now being conducted. Attached as Exhibit 4.1 is a certificate of good standing from the State of Delaware. 4.2. AUTHORIZATION. Seller has full corporate power and authority to enter into this Agreement and to carry out the transactions contemplated hereby. The Board of Directors and stockholders of Seller have taken all action required by law to be taken to authorize the execution and delivery by Seller of this Agreement, and no other corporate proceedings on the part of Seller are required to authorize such execution and delivery of this Agreement and the consummation of the transactions contemplated hereby. Attached as Exhibit 4.2 are copies of the stockholder and board of directors minutes authorizing the sale to Buyer. This Agreement has been duly executed and delivered by Seller and is a valid and binding obligation of Seller enforceable in accordance with its terms. 4.3. NO VIOLATION. Neither the execution and delivery of this Agreement nor the consummation of the transactions contemplated hereby will violate any provision of the Certificate of Incorporation or Bylaws of Seller or violate, or be in conflict with, or constitute a default (or an event which, with notice or lapse of time or both, would constitute a default) under any debt or obligation of Seller or violate any statute or law or any judgment, decree, order, regulation or rule of any court or governmental authority. 4.4. TITLE TO ASSETS; ENCUMBRANCES. Seller has good, valid and marketable title to the Assets, free and clear of all material liens, claims, charges, security interests or other encumbrances of any nature, other than liens for taxes not yet due and payable. Seller has not granted any license or other right in or to the Patent Rights. There are no contracts or agreements of any nature related to or affecting the Patent Rights. 4.5. LITIGATION. There is no action, suit, inquiry, proceeding or investigation by or before any court or governmental or other regulatory or administrative agency known to Seller which questions or challenges the validity of this Agreement or any action taken or to be taken by Seller pursuant to this Agreement or which questions or challenges the validity of any of the Patent Rights; nor to Seller's knowledge is there any valid basis therefore. 4.6. CONSENTS. No consent of any person is necessary to the consummation of the transactions contemplated hereby. 4.7. GOOD TITLE CONVEYED. Seller has or will at the Closing have the power and the right to sell, assign, transfer and deliver to Buyer, and upon consummation of the transactions contemplated by this Agreement, Buyer will acquire good, valid and marketable title to the Assets, free and clear of all mortgages, pledges, liens, security interests or other such encumbrances, interests or charges of any kind. 2  4.8. NO BUYER WAIVER. The representations and warranties of Seller shall not be deemed waived or otherwise affected by any investigation by Buyer. 5. FURTHER ASSURANCES. 5.1. FURTHER ASSURANCES. Upon the request of either Buyer or Seller, the other party will execute and deliver to the requesting party, or such party's nominee, all such instruments and documents of further assurance or otherwise, and will do any and all such acts and things as may reasonably be required to carry out the obligations of such party hereunder, to vest in Buyer good and marketable title to the Assets to be transferred hereunder and to more effectively consummate the transactions contemplated hereby. Seller will cooperate with Buyer from time-to-time at Buyer's request and expense and provide all information in its possession in order to enable Buyer to enforce the Patent Rights and to defend any claims challenging or involving the Patent Rights. 6. MISCELLANEOUS. 6.1. NOTICES. All notices, approvals or other communications provided for herein to be sent or given to Buyer shall be deemed validly and properly given or made if in writing and delivered by hand or by certified or registered mail, return receipt requested, addressed to: If to Buyer: BioMimetic Therapeutics, Inc. 389-A Nichol Mill Lane Franklin, TN 37067 ATTN: General Counsel with a copy to: John Blackwood Harwell Howard Hyne Gabbert & Manner, P.C. 315 Deaderick Street, #1800 Nashville, TN ###-###-#### if to Seller: Institute of Molecular Biology, Inc. P.O. Box 4278 Shrewsbury, MA 01545 Attn: John Naples with a copy to: Sullivan & Worcester LLP One Post Office Square Boston, MA 02109 Attn: Alexander A. Notopoulos, Jr., Esq. 3  Either of the parties hereto may give notice to the other at any time by the methods specified above of a change in the address at which, or the persons to whom, notices addressed to it are to be delivered in the future, and such notice shall be deemed to amend this Section until superseded by a later notice of the same type. Any notice given by mail as aforesaid shall be conclusively deemed to have been received by a party hereto and be effective on the second business day after the day on which mailed to the address set forth above. 6.2. HEADINGS. The headings of the Sections and Articles of this Agreement are inserted for convenience only and shall not constitute a part hereof or affect in any way the meaning or interpretation of this Agreement. 6.3. ASSIGNMENT. This Agreement shall be binding upon and shall inure to the benefit of the parties hereto and their respective successors and assigns, provided, however, that none of such parties shall assign this Agreement or its rights hereunder without the written consent of the other. 6.4. COUNTERPARTS. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 6.5. GOVERNING LAW. This Agreement shall be governed by and construed in accordance with the laws of the State of Delaware. 6.6. AMENDMENT AND MODIFICATION. Any amendment, modification or supplement to this Agreement shall be in writing signed by the party or parties to be charged. 6.7. ENTIRE AGREEMENT. This Agreement, the Exhibits hereto and the other documents delivered pursuant hereto constitute the entire agreement of the parties in respect of the subject matter hereof and supersede all prior agreements, communications, representations or warranties, whether oral or written, among the parties in respect to such subject matter. 4  IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed as of the day and year first written above. BIOMIMETIC THERAPEUTICS, INC. By: /s/ Samuel Lynch --------------------------------- Title: President INSTITUTE FOR MOLECULAR BIOLOGY, INC. By: /s/ John M. Naples --------------------------------- Title: President 5  Exhibit A C & E REF. NO. COUNTRY TYPE STATUS APPLICATION NO. FILED PATENT NO. ISSUED PATENT EXP. DATE - -------------- ------------- ---- --------- --------------- ------------ ---------- ----------- ---------------- WOUND HEALING AND BONE REGENERATION 02854-007AT 1 Austria EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 13-Nov-07 02854-007AU1 Australia PCT Granted 83289/87 13-Nov-1987 600069 02-Aug-1990 13-Nov-03 02854-007BE1 Belgium EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 13-Nov-03 02854-007CA1 Canada PCT Granted 551,909 16-Nov-1987 1,322,714 05-Oct-1993 5-Jan-10 02854-007CH1 Switzerland EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 13-Nov-03 02854-007CN1 China PCT Granted 87101250.2 14-Nov-1987 87101250.2 30-Oct-1994 14-Nov-02 02854-007DE1 Germany EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 13-Nov-03 02854-007DK1 Denmark PCT Allowed 3932/88 13-Nov-1987 02854-007EP1 Europe PCT Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 13-Nov-07 02854-007FR1 France EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 13-Nov-03 02854-007FR2 France EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 13-Nov-03 02854-007GB1 Great Britain EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 13-Nov-03 02854-007IE1 Ireland PCT Granted 3075/87 13-Nov-1987 60517 20-Jul-1994 13-Nov-03 02854-007IT1 Italy EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 13-Nov-03 02854-007JP1 Japan PCT Granted 500179/87 13-Nov-1987 1868245 26-Aug-1994 13-Nov-07 02854-007KR1 Korea PCT Granted 88-700829 13-Nov-1987 106280 17-Oct-1996 1-May-11 02854-007LU1 Luxembourg EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 13-Nov-03 02854-007NL1 Netherlands EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 13-Nov-03 02854-007NZ1 New Zealand PCT Granted 222551 16-Nov-1987 222551 16-Nov-03 02854-007SE1 Sweden EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 13-Nov-03 02854-007TW1 Taiwan PCT Granted 76107672 15-Dec-1987 NI-51493 30-Jan-1992 14-Dec-05 02854-007ZA1 South Africa PCT Granted 87/8566 16-Nov-1987 87/8566 26-Jul-1989 16-Nov-07 WOUND HEALING 02854-010AT1 Austria EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 20-Dec-08 02854-010AU1 Australia PCT Granted 37472/89 20-Dec-1988 613776 03-Dec-1991 22-Dec-04 02854-010BE1 Belgium EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 20-Dec-08 02854-010CA1 Canada PCT Granted 586,562 21-Dec-1988 1,322,164 14-Sep-1993 17-Sep-10 02854-010CH1 Switzerland EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 20-Dec-08 02854-010CN1 China PCT Granted 88109273.8 21-Dec-1988 88109273.8 19-Jul-1994 21-Dec-03 02854-010DE1 Germany EPC Granted 89901681.0 20-Dec-1988  ###-###-####.0 27-Oct-1993 20-Dec-08  02854-010DK1 Denmark PCT Allowed 4122/89 20-Dec-1988 02854-010EP1 Europe PCT Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 20-Dec-08 02854-010FR1 France EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 20-Dec-08 02854-010GB1 Great Britain EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 20-Dec-08 02854-010IE1 Ireland PCT Granted 3833/88 21-Dec-1988 61283 14-Oct-1994 20-Dec-08 02854-010IT1 Italy EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 20-Dec-08 02854-010JP1 Japan PCT Granted 501944/89 20-Dec-1988 1923551 25-Apr-1995 20-Dec-08 02854-010LU1 Luxembourg EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 20-Dec-08 02854-010MX1 Mexico PCT Granted 14307 22-Dec-1988 164966 09-Oct-1992 20-Dec-08 02854-010NL1 Netherlands EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 20-Dec-08 02854-010NZ1 New Zealand PCT Granted 227429 21-Dec-1988 227429 14-May-1991 21-Dec-04 02854-010SE1 Sweden EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 20-Dec-08 02854-010TW1 Taiwan PCT Granted 78100693 01-Feb-1989 NI-51930 20-Feb-1992 10-Nov-06 02854-010ZA1 South Africa PCT Granted 88/9594 22-Dec-1988 88/9594 27-Sep-1989 22-Dec-08 WOUND HEALING 02854-011AT1 Austria EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 22-May-09 02854-011AT2 Austria EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 30-May-11 02854-011BE1 Belgium EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 22-May-09 02854-011BE2 Belgium EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 30-May-11 02854-011CA2 Canada PCT Granted 2,082,420 30-May ###-###-#### 20-Jul-2004 30-May-11 02854-011CH1 Switzerland EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 22-May-09 02854-011CH2 Switzerland EPC Granted 91910904.1 30-May-1991 531425 14-Aug-2002 30-May-11 02854-011DE1 Germany EPC Granted 89906917.3 22-May-1989 P68917300.8 03-Aug-1994 22-May-09 02854-011DE2 Germany EPC Granted 69133087.5 30-May-1991 0531425 14-Aug-2002 30-May-11 02854-011DK2 Denmark EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 30-May-11 02854-011EP1 Europe PCT Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 22-May-09 02854-011EP2 Europe PCT Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 30-May-11 02854-011ES2 Spain EPC Granted 0531425 30-May-1991 0531425 14-Aug-2002 30-May-11 02854-011FR1 France EPC Granted 0419534 22-May-1989 0419534 03-Aug-1994 22-May-09 02854-011FR2 France EPC Granted 0531425 30-May-1991 0531425 14-Aug-2002 30-May-11 02854-011GB1 Great Britain EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 22-May-09 02854-011GB2 Great Britain EPC Granted 0531425 30-May-1991 0531425 14-Aug-2002 30-May-11 02854-011GR2 Greece EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 30-May-11 02854-011IT1 Italy EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 22-May-09 02854-011IT2 Italy EPC Granted 0531425 30-May-1991 0531425 14-Aug-2002 30-May-11  02854-011JP1 Japan PCT Granted 506485/89 22-May-1989 1924479 25-Apr-1995 22-May-09 02854-011JP2 Japan PCT Granted 3-510861 30-May-1991 3,377,524 06-Dec-2002 30-May-11 02854-011LI2 Liechtenstein EPC Granted 91910904.1 30-May-1991 531425 14-Aug-2002 30-May-11 02854-011LU1 Luxembourg EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 22-May-09 02854-011LU2 Luxembourg EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 30-May-11 02854-011NL1 Netherlands EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 22-May-09 02854-011NL2 Netherlands EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 30-May-11 02854-011SE1 Sweden EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 22-May-09 02854-011SE2 Sweden EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 30-May-11 WOUND HEALING 02854-012AT1 Austria EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 9-Aug-09 02854-012BE1 Belgium EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 9-Aug-09 02854-012CA1 Canada PCT Granted 607,968 10-Aug-1989 1336816 29-Aug-1995 29-Aug-12 02854-012CH1 Switzerland EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 9-Aug-09 02854-012DE1 Denmark EPC Granted 89910545.6 10-Aug-1989 P68912758 26-Jan-1994 9-Aug-09 02854-012DE1 Germany EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 9-Aug-09 02854-012EP1 Europe PCT Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 9-Aug-09 02854-012FR1 France EPC Granted 89910545.6 10-Aug-1989 382841 26-Jan-1994 9-Aug-09 02854-012GB1 Great Britain EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 9-Aug-09 02854-012IT1 Italy EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 9-Aug-09 02854-012JP1 Japan PCT Granted 509811/89 10-Aug-1989 1975393 27-Sep-1995 10-Aug-09 02854-012LU1 Luxembourg EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 9-Aug-09 02854-012NL1 Netherlands EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 9-Aug-09 02854-012SE1 Sweden EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 9-Aug-09 WOUND HEALING USING PDGF AND IGF-II 02854-014AT1 Austria EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10 02854-014BE1 Belgium EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10 02854-014CA1 Canada PCT Granted 2,060,208 10-Apr-1990 2,060,208 20-Feb-2001 10-Apr-10 02854-014CH1 Switzerland EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10 02854-014DE1 Germany EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10 02854-014DK1 Denmark EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10 02854-014EP1 Europe PCT Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10 02854-014ES1 Spain EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10 02854-014FR1 France EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10  02854-014GB1 Great Britain EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10 02854-014IT1 Italy EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10 02854-014JP1 Japan PCT Granted 507475/90 10-Apr-1990 ###-###-#### 19-Mar-1996 10-Apr-10 02854-014LU1 Luxembourg EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10 02854-014NL1 Netherlands EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10 02854-014SE1 Sweden EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 10-Apr-10 WOUND HEALING 02854-016CA1 Canada PCT Pending 2,040,410 07-Sep-1990 02854-016JP1 Japan PCT Granted 2-512565 07-Sep-1990 1969836 18-Sep-1995 7-Sep-10 BONE REGENERATION 02854-026CA1 Canada PCT Abandoned 2,123,803 24-Nov-1992 02854-026JP1 Japan PCT Abandoned Hei-05-510253 26-May-1994 02854-026EP1 Europe PCT Abandoned 93900683.9 24-Nov-1992 MEDICAMENT FOR PROMOTING GROWTH OF MAMMALIAN NERVE - IMB ONLY 02854-027AU1 Australia PCT Granted 30668/92 04-Nov-1992 673659 12-Mar-1997 4-Nov-12 02854-027CA1 Canada PCT Granted 2,123,685 04-Nov-1992 2,123,685 07-Oct-2003 4-Nov-12 02854-027CH1 Switzerland PCT Granted 2309/93-2 04-Nov-1992 684573 31-Oct-1994 4-Nov-12 02854-027JP1 Japan PCT Pending 5-510115 04-Nov-1992 PYRIDINOLINE CROSSLINKS AS MARKERS OF PERIODONTAL AND PERI-IMPLANT DISEASE ACTIVITY 02854-034AT1 Austria EPC Granted 95909234.7 13-Jan-1995 E220458 10-Jul-2002 13-Jan-15 02854-034BE1 Belgium EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 13-Jan-15 02854-034CA1 Canada PCT Pending 2,183,452 13-Jan-1995 02854-034CH1 Switzerland EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 13-Jan-15 02854-034DE1 Germany EPC Granted 95909234.7 13-Jan-1995 69527350.7 10-Jul-2002 13-Jan-15 02854-034DK1 Denmark PCT Granted 95909234.7 13-Jan-1995 0745221 07-Oct-2002 13-Jan-15 02854-034EP1 Europe PCT Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 13-Jan-15 02854-034ES1 Spain EPC Granted 95909234.7 13-Jan-1995 ES2179867T3 10-Jul-2002 13-Jan-15 02854-034FR1 France EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 13-Jan-15  02854-034GB1 Great Britain EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 13-Jan-15 02854-034GR1 Greece EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 13-Jan-15 02854-034IE1 Ireland PCT Granted 95909234.7 13-Jan-1995 0745221 13-Jan-15 02854-034IT1 Italy EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 13-Jan-15 02854-034JP1 Japan PCT Granted 7-521795 13-Jan-1995 3,521,913 20-Feb-2004 13-Jan-15 02854-034KP1 N. Korea PCT Granted 96-0594 16-Aug-1996 31,331 22-Jan-1998 13-Jan-15 02854-034NL1 Netherlands EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 13-Jan-15 02854-034PT1 Portugal EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 13-Jan-15 02854-034PT1 Sweden EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 13-Jan-15 02854-034CN1 China PCT Abandoned 95192443.5 13-Jan-1995 02854-034KR1 S. Korea PCT Abandoned 1996-704491 16-Aug-1996  PATENT EXP. C & E REF. NO. STATUS TITLE APPLICATION NO. FILED PATENT NO. ISSUED DATE - -------------- ------ -------------------------- --------------- ----------- ---------- ----------- ----------- 02854-009001 Issued WOUND HEALING AND BONE 07/120,943 16-Nov-1987 4,861,757 29-Aug-1989 29-Aug-2006 REGENERATION USING PDGF AND IGF-1 02854-010001 Issued WOUND HEALING 07/136,399 22-Dec-1987 4,874,746 17-Oct-1989 17-Oct-2006 COMPOSITION OF TGF-ALPHA AND PDGF 02854-011001 Issued WOUND HEALING USING IGF-I 07/196,975 20-May-1988 4,983,581 8-Jan-1991 8-Jan-2008 AND TGF'b' 02854-011003 Issued WOUND HEALING USING IGF-II 07/857,713 25-Mar-1992 5,256,644 26-Oct-1993 8-Jan-2008 AND TGF 02854-012001 Issued PROCESS OF WOUND HEALING 07/231,145 10-Aug-1988 5,034,375 23-Jul-1991 23-Jul-2008 USING PDGF AND EGF 02854-014001 Issued WOUND HEALING USING PDGF 07/272,090 16-Nov-1988 5,019,559 28-May-1991 28-May-2008 AND IGF-II 02854-015002 Issued METHOD OF PERIDONTAL 07/582,332 13-Sep-1990 5,124,316 23-Jun-1992 23-Jul-2009 REGENERATION 02854-016001 Issued WOUND HEALING COMPOSITION 07/403,969 7-Sep-1989 5,035,887 30-Jul-1991 30-Jul-2008 OF IL-1 AND PDGF OR IGF-1 02854-027001 Issued NERVE REGENERATION 08/198,542 18-Feb-1994 6,506,727 14-Jan-2003 14-Jan-2020 02854-033001 Issued DEVICE TO PROMOTE DRUG- 08/187,210 26-Jan-1994 5,656,605 12-Aug-1997 12-Aug-2014 INDUCED NERVE REGENERATION 02854-034001 Issued PYRIDINOLINE CROSSLINKS 08/197,131 16-Feb-1994 5,516,699 14-May-1996 14-May-2013 AS MARKERS OF PERIODONTAL AND PERI-IMPLANT DISEASE ACTIVITY  ASSIGNMENT For valuable consideration, we, - -------------------------------------------------------------------------------- State (and Country if Full Name of Assignor City not USA) - -------------------------------------------------------------------------------- Institute of Molecular Delaware P.O. Box 4278 Biology, Inc. Shrewsbury, MA 01545 - -------------------------------------------------------------------------------- hereby assign to - -------------------------------------------------------------------------------- Full Name of Assignee State of Incorporation Business Address - -------------------------------------------------------------------------------- BioMimetic Therapeutics, Inc. Delaware 389 Nichol Mill Lane Franklin, TN 37067 - -------------------------------------------------------------------------------- and to its successors and assigns (collectively hereinafter called "the Assignee"), the entire right, title, and interest throughout the world in the inventions and improvements which are the subject of one or more of the patents and applications listed on Schedule A, which is attached hereto. This assignment includes the patents and applications listed in the attached Schedule A, any and all United States and foreign patents, utility models, and design registrations granted for any of said inventions or improvements, and the right to claim priority based on the filing date of any of the patents and applications listed in the attached Schedule A under the International Convention for the Protection of Industrial Property, the Patent Cooperation Treaty, the European Patent Convention, and all other treaties of like purposes; and we authorize the Assignee to apply in all countries in our names or in its own name for patents, utility models, design registrations, and like rights of exclusion, and for inventors' certificates for said inventions and improvements; and we agree for ourselves and our respective heirs, legal representatives and assigns, without further compensation, to perform such lawful acts and to sign such further applications, assignments, Preliminary Statements, and other lawful documents as the Assignee may reasonably request to effectuate fully this assignment.  IN WITNESS WHEREOF, I hereto set my hand and seal at Shrewsbury Massachusetts, this 4th day of November, 2005. /s/ John M. Naples L.S. - ------------------------------------ John M. Naples Institute of Molecular Biology, Inc. STATE OF MASSACHUSETTS: :ss. COUNTY OF WORCESTER: Before me this 4th day of November, 2005, before me, the undersigned notary public, personally appeared John M. Naples, proved to me through satisfactory evidence of identification, which consisted of Massachusetts Driver's License, to be the person whose name is subscribed to the foregoing Assignment, and acknowledged that he executed the same as his free act and deed for the purposes therein contained. /s/ Patricia MacIsaac ------------------------------ Notary Public My Commission Expires: 020708 [Notary Seal]  SCHEDULE A (PAGE 1 OF 5) C & E REF. NO. STATUS TITLE APPLICATION NO. FILED PATENT NO. ISSUED - -------------- --------- -------------------------- --------------- ----------- ----------- ----------- WOUND HEALING AND BONE 02854-007001 Abandoned REGENERATION 06/930,762 14-Nov-1986 WOUND HEALING AND BONE REGENERATION USING PDGF 02854-009001 Issued AND IGF-1 07/120,943 16-Nov-1987 4,861,757 29-Aug-1989 WOUND HEALING COMPOSITION OF TGF-ALPHA 02854-010001 Issued AND PDGF 07/136,399 22-Dec-1987 4,874,746 17-Oct-1989 WOUND HEALING USING IGF-I 02854-011001 Issued AND TGF'b' 07/196,975 20-May-1988 4,983,581 8-Jan-1991 WOUND HEALING USING IGF-I 02854-011002 Abandoned AND TGF'b' 07/530,649 30-May-1990 WOUND HEALING USING IGF-II 02854-011003 Issued AND TGF 07/857,713 25-Mar-1992 5,256,644 26-Oct-1993 PROCESS OF WOUND HEALING 02854-012001 Issued USING PDGF AND EGF 07/231,145 10-Aug-1988 5,034,375 23-Jul-1991 02854-013003 Abandoned WOUND HEALING 07/449,303 5-Dec-1989 02854-013004 Abandoned WOUND HEALING 07/639,060,303 9-Jan-1991 WOUND HEALING USING PDGF 02854-014001 Issued AND IGF-II 07/272,090 16-Nov-1988 5,019,559 28-May-1991 02854-015001 Abandoned WOUND HEALING 07/299,763 23-Jan-1989 METHOD OF PERIDONTAL 02854-015002 Issued REGENERATION 07/582,332 13-Sep-1990 5,124,316 23-Jun-1992 WOUND HEALING COMPOSITION OF IL-1 AND 02854-016001 Issued PDGF OR IGF-1 07/403,969 7-Sep-1989 5,035,887 30-Jul-1991 02854-026001 Abandoned BONE REGENERATION 07/799,375 27-Nov-1991 02854-027001 Issued NERVE REGENERATION 08/198,542 18-Feb-1994 6,506,727 14-Jan-2003 DEVICE TO PROMOTE DRUG- INDUCED NERVE 02854-033001 Issued REGENERATION 08/187,210 26-Jan-1994 5,656,605 12-Aug-1997 PYRIDINOLINE CROSSLINKS AS MARKERS OF PERIODONTAL AND PERI-IMPLANT DISEASE 02854-034001 Issued ACTIVITY 08/197,131 16-Feb-1994 5,516,699 14-May-1996  SCHEDULE A (PAGE 2 OF 5) C & E REF. NO. COUNTRY TYPE STATUS APPLICATION NO. FILED PATENT NO. ISSUED - -------------- ------------- ---- --------- --------------- ----------- ----------- ----------- WOUND HEALING AND BONE REGENERATION 02854-007AT 1 Austria EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 02854-007AU1 Australia PCT Granted 83289/87 13-Nov-1987 600069 02-Aug-1990 02854-007BE1 Belgium EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 02854-007CA1 Canada PCT Granted 551,909 16-Nov-1987 1,322,714 05-Oct-1993 02854-007CH1 Switzerland EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 02854-007CN1 China PCT Granted 87101250.2 14-Nov-1987 87101250.2 30-Oct-1994 02854-007DE1 Germany EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 02854-007DK1 Denmark PCT Granted 3932/88 13-Nov-1987 25-Jul-81 30-May-05 02854-007EP1 Europe PCT Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 02854-007FR1 France EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 02854-007FR2 France EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 02854-007GB1 Great Britain EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 02854-007IE1 Ireland PCT Granted 3075/87 13-Nov-1987 60517 20-Jul-1994 02854-007IT1 Italy EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 02854-007JP1 Japan PCT Granted 500179/87 13-Nov-1987 1868245 26-Aug-1994 02854-007KR1 Korea PCT Granted 88-700829 13-Nov-1987 106280 17-Oct-1996 02854-007LU1 Luxembourg EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 02854-007NL1 Netherlands EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 02854-007NZ1 New Zealand PCT Granted 222551 16-Nov-1987 222551 02854-007SE1 Sweden EPC Granted 87907900.2 13-Nov-1987 0289584 05-May-1993 02854-007TW1 Taiwan PCT Granted 76107672 15-Dec-1987 NI-51493 30-Jan-1992 02854-007ZA1 South Africa PCT Granted 87/8566 16-Nov-1987 87/8566 26-Jul-1989 02854-007OA1 Africa (OAPI) PCT Abandoned PV59385 13-Nov-1987 9159 31-Mar-1992 02854-007MX1 Mexico PCT Abandoned 930672 16-Nov-1987 170454 23-Aug-1993 02854-007NO1 Norway PCT Abandoned 88/3127 13-Nov-1987 02854-007WO1 International PCT Expired PCT/US87/02975 13-Nov-1987 WOUND HEALING 02854-010AT1 Austria EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 02854-010AU1 Australia PCT Granted 37472/89 20-Dec-1988 613776 03-Dec-1991 02854-010BE1 Belgium EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 02854-010CA1 Canada PCT Granted 586,562 21-Dec-1988 1,322,164 14-Sep-1993 02854-010CH1 Switzerland EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 02854-010CN1 China PCT Granted 88109273.8 21-Dec-1988 88109273.8 19-Jul-1994 02854-010DE1 Germany EPC Granted 89901681.0 20-Dec-1988  ###-###-####.0 27-Oct-1993 02854-010DK1 Denmark PCT Granted 4122/89 20-Dec-1988 175947 08-Aug-2005 02854-010EP1 Europe PCT Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 02854-010FR1 France EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 02854-010GB1 Great Britain EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 02854-010IE1 Ireland PCT Granted 3833/88 21-Dec-1988 61283 14-Oct-1994 02854-010IT1 Italy EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 02854-010JP1 Japan PCT Granted 501944/89 20-Dec-1988 1923551 25-Apr-1995 02854-010LU1 Luxembourg EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 02854-010MX1 Mexico PCT Granted 14307 22-Dec-1988 164966 09-Oct-1992 02854-010NL1 Netherlands EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 02854-010NZ1 New Zealand PCT Granted 227429 21-Dec-1988 227429 14-May-1991 02854-010SE1 Sweden EPC Granted 89901681.0 20-Dec-1988 0394349 27-Oct-1993 02854-010TW1 Taiwan PCT Granted 78100693 01-Feb-1989 NI-51930 20-Feb-1992 02854-010ZA1 South Africa PCT Granted 88/9594 22-Dec-1988 88/9594 27-Sep-1989 02854-010OA1 Africa (OAPI) PCT Abandoned PV59630 20-Dec-1988 9129 31-Oct-1991 02854-010KR1 Korea PCT Abandoned 89/701555 20-Dec-1988 02854-010NO1 Norway PCT Abandoned 89/3346 20-Dec-1988 02854-010RU1 Russian PCT Abandoned ###-###-####.14 20-Dec-1988 Federation 02854-010WO1 International PCT Expired PCT/US88/04557 20-Dec-1988  SCHEDULE A (PAGE 3 OF 5) C & E REF. NO. COUNTRY TYPE STATUS APPLICATION NO. FILED PATENT NO. ISSUED - -------------- ------------- ---- --------- --------------- ----------- ----------- ----------- WOUND HEALING 02854-011AT1 Austria EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 02854-011AT2 Austria EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 02854-011BE1 Belgium EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 02854-011BE2 Belgium EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 02854-011CA2 Canada PCT Granted 2,082,420 30-May ###-###-#### 20-Jul-2004 02854-011CH1 Switzerland EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 02854-011CH2 Switzerland EPC Granted 91910904.1 30-May-1991 531425 14-Aug-2002 02854-011DE1 Germany EPC Granted 89906917.3 22-May-1989 P68917300.8 03-Aug-1994 02854-011DE2 Germany EPC Granted 69133087.5 30-May-1991 0531425 14-Aug-2002 02854-011DK2 Denmark EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 02854-011EP1 Europe PCT Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 02854-011EP2 Europe PCT Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 02854-011ES2 Spain EPC Granted 0531425 30-May-1991 0531425 14-Aug-2002 02854-011FR1 France EPC Granted 0419534 22-May-1989 0419534 03-Aug-1994 02854-011FR2 France EPC Granted 0531425 30-May-1991 0531425 14-Aug-2002 02854-011GB1 Great Britain EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 02854-011GB2 Great Britain EPC Granted 0531425 30-May-1991 0531425 14-Aug-2002 02854-011GR2 Greece EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 02854-011IT1 Italy EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 02854-011IT2 Italy EPC Granted 0531425 30-May-1991 0531425 14-Aug-2002 02854-011JP1 Japan PCT Granted 506485/89 22-May-1989 1924479 25-Apr-1995 02854-011JP2 Japan PCT Granted 3-510861 30-May-1991 3,377,524 06-Dec-2002 02854-011LI2 Liechtenstein EPC Granted 91910904.1 30-May-1991 531425 14-Aug-2002 02854-011LU1 Luxembourg EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 02854-011LU2 Luxembourg EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 02854-011NL1 Netherlands EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 02854-011NL2 Netherlands EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 02854-011SE1 Sweden EPC Granted 89906917.3 22-May-1989 0419534 03-Aug-1994 02854-011SE2 Sweden EPC Granted 91910904.1 30-May-1991 0531425 14-Aug-2002 02854-011ES1 Spain PCT Abandoned 531425 30-May-1991 02854-011WO1 International PCT Expired PCT/US89/02229 22-May-1989 02854-011WO2 International PCT Expired PCT/US91/03829 30-May-1991 WOUND HEALING 02854-012AT1 Austria EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 02854-012BE1 Belgium EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 02854-012CA1 Canada PCT Granted 607,968 10-Aug-1989 1336816 29-Aug-1995 02854-012CH1 Switzerland EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 02854-012DE1 Denmark EPC Granted 89910545.6 10-Aug-1989 P68912758 26-Jan-1994 02854-012DE1 Germany EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 02854-012EP1 Europe PCT Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 02854-012FR1 France EPC Granted 89910545.6 10-Aug-1989 382841 26-Jan-1994 02854-012GB1 Great Britain EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 02854-012IT1 Italy EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 02854-012JP1 Japan PCT Granted 509811/89 10-Aug-1989 1975393 27-Sep-1995 02854-012LU1 Luxembourg EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 02854-012NL1 Netherlands EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 02854-012SE1 Sweden EPC Granted 89910545.6 10-Aug-1989 0382841 26-Jan-1994 02854-012WO1 International PCT Expired PCT/US89/03490 10-Aug-1989  SCHEDULE A (PAGE 4 OF 5) C & E REF. NO. COUNTRY TYPE STATUS APPLICATION NO. FILED PATENT NO. ISSUED - -------------- ------------- ---- --------- --------------- ----------- ----------- ----------- WOUND HEALING USING PDGF AND IGF-II 02854-014AT1 Austria EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014BE1 Belgium EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014CA1 Canada PCT Granted 2,060,208 10-Apr-1990 2,060,208 20-Feb-2001 02854-014CH1 Switzerland EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014DE1 Germany EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014DK1 Denmark EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014EP1 Europe PCT Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014ES1 Spain EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014FR1 France EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014GB1 Great Britain EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014IT1 Italy EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014JP1 Japan PCT Granted 507475/90 10-Apr-1990 ###-###-#### 19-Mar-1996 02854-014LU1 Luxembourg EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014NL1 Netherlands EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014SE1 Sweden EPC Granted 90907577.2 10-Apr-1990 0479799 06-Aug-1997 02854-014WO1 International PCT Expired PCT/US90/01936 10-Apr-1990 WOUND HEALING 02854-016CA1 CANADA PCT PENDING 2,040,410 07-SEP-1990 02854-016JP1 Japan PCT Granted 2-512565 07-Sep-1990 1969836 18-Sep-1995 02854-016EP1 Europe PCT Abandoned 90913582.4 07-Sep-1990 02854-016WO1 International PCT Expired PCT/US90/05062 07-Sep-1990 BONE REGENERATION 02854-026CA1 Canada PCT Abandoned 2,123,803 24-Nov-1992 02854-026JP1 Japan PCT Abandoned Hei-05-510253 26-May-1994 02854-026EP1 Europe PCT Abandoned 93900683.9 24-Nov-1992 02854-026WO1 International PCT Expired PCT/US92/10214 24-Nov-1992 MEDICAMENT FOR PROMOTING GROWTH OF MAMMALIAN NERVE - IMB ONLY 02854-027AU1 Australia PCT Granted 30668/92 04-Nov-1992 673659 12-Mar-1997 02854-027CA1 Canada PCT Granted 2,123,685 04-Nov-1992 2,123,685 07-Oct-2003 02854-027CH1 Switzerland PCT Granted 2309/93-2 04-Nov-1992 684573 31-Oct-1994 02854-027JP1 Japan PCT Allowed 5-510115 04-Nov-1992 02854-027JP2 Japan PCT Pending 2005-292267 28-Sep-2005 02854-027EP1 Europe PCT Abandoned 92924312.9 04-Nov-1992 02854-027PL1 Poland PCT Abandoned P303981 04-Nov-1992 02854-027ZA1 South Africa PCT Abandoned 04-Nov-1992 02854-027WO1 International PCT Expired PCT/US92/09545 04-Nov-1992  SCHEDULE A (PAGE 5 OF 5) C & E REF. NO. COUNTRY TYPE STATUS APPLICATION NO. FILED PATENT NO. ISSUED - -------------- ------------- ---- --------- --------------- ----------- ----------- ----------- A DEVICE TO PROMOTE DRUG-INDUCED NERVE REGENERATION 02854-033WO1 International PCT Expired PCT/US95/00985 25-Jan-1995 PYRIDINOLINE CROSSLINKS AS MARKERS OF PERIODONTAL AND PERI-IMPLANT DISEASE ACTIVITY 02854-034AT1 Austria EPC Granted 95909234.7 13-Jan-1995 E220458 10-Jul-2002 02854-034BE1 Belgium EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 02854-034CA1 CANADA PCT PENDING 2,183,452 13-JAN-1995 02854-034CH1 Switzerland EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 02854-034DE1 Germany EPC Granted 95909234.7 13-Jan-1995 69527350.7 10-Jul-2002 02854-034DK1 Denmark PCT Granted 95909234.7 13-Jan-1995 0745221 07-Oct-2002 02854-034EP1 Europe PCT Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 02854-034ES1 Spain EPC Granted 95909234.7 13-Jan-1995 ES2179867T3 10-Jul-2002 02854-034FR1 France EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 02854-034GB1 Great Britain EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 02854-034GR1 Greece EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 02854-034IE1 Ireland PCT Granted 95909234.7 13-Jan-1995 0745221 02854-034IT1 Italy EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 02854-034JP1 Japan PCT Granted 7-521795 13-Jan-1995 3,521,913 20-Feb-2004 02854-034KP1 N. Korea PCT Granted 96-0594 16-Aug-1996 31,331 22-Jan-1998 02854-034NL1 Netherlands EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 02854-034PT1 Portugal EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 02854-034PT1 Sweden EPC Granted 95909234.7 13-Jan-1995 0745221 10-Jul-2002 02854-034CN1 China PCT Abandoned 95192443.5 13-Jan-1995 02854-034KR1 S. Korea PCT Abandoned 1996-704491 16-Aug-1996 02854-034WO1 International PCT Expired PCT/US95/00509 13-Jan-1995  INSTITUTE OF MOLECULAR BIOLOGY, INC. SECRETARY'S CERTIFICATE The undersigned, John M. Naples, the duly qualified and elected Secretary of Institute of Molecular Biology, Inc., a Delaware corporation (the "Company"), does hereby certify in his capacity as Secretary of the Company that: 1. Attached to this certificate as Exhibits A and B, respectively, are true, correct and complete copies of resolutions duly adopted by the Board of Directors of the Company on November 4, 2005, and by the stockholders of the Company on November 4, 2005. Such resolutions have not been amended, modified, altered, repealed or rescinded and are in full force and effect on the date hereof; and such resolutions are the only resolutions adopted by the Board of Directors of the Company, and by the stockholders of the Company, relating to the matters referred to therein. 2. Attached to this certificate as Exhibit C is a certificate of good standing of the Company issued by the Secretary of State of the State of Delaware. IN WITNESS WHEREOF, the undersigned hereby certifies the above to be true and has executed this Certificate as of the 15th day of November, 2005. /s/ John M. Naples ---------------------------- John M. Naples, Secretary  EXHIBIT A RESOLUTIONS OF THE BOARD OF DIRECTORS APPROVAL OF IP PORTFOLIO SALE RESOLVED: That this Board of Directors declares the sale of the IP Portfolio to Purchaser to be advisable and in the best interests of the Corporation, and does hereby direct that said sale of the IP Portfolio be presented for the approval of the stockholders of the Corporation either by written consent or at a special meeting of the stockholders to be called for such purpose. APPROVAL OF PATENT PURCHASE AGREEMENT AND EXHIBITS RESOLVED: That the form, terms and provisions of the Patent Purchase Agreement substantially in the form attached hereto as Exhibit A (the "Purchase Agreement"), along with any ancillary agreements or instruments delivered by the Corporation in connection therewith (collectively, the "Ancillary Agreements"), and the transactions contemplated thereby be, and they hereby are, ratified and approved; and that the execution, delivery and performance of the Purchase Agreement and the Ancillary Documents, in the name and on behalf of the Corporation, by the President, any Vice President, and the Treasurer of this Corporation at the time in office (the "Authorized Officers"), each acting singly, is hereby ratified, authorized, and approved, with such additions, deletions and changes as the Authorized Officer so acting may by his execution approve; the execution and delivery of the Purchase Agreement and the Ancillary Agreements to be conclusive evidence that the same have been authorized and approved by the Directors of the Corporation; and further RESOLVED: That the Authorized Officers be, and they hereby are and each of them singly hereby is, authorized, directed and empowered, from time to time, in the name and on behalf of the Corporation, to execute, make oath to, acknowledge and deliver, or cause to be executed, acknowledged and delivered, under the seal of the Corporation if so desired, all such other and further documents, instruments, orders, directions, certificates, receipts, forms and other papers or instruments, and to perform or cause to be performed all such other and further acts, as the officer or officers so acting may in his, her or their absolute discretion approve in connection with the consummation of the transactions contemplated by the Purchase Agreement or the Ancillary Agreements or for the purpose of carrying out the intent and purpose thereof or the execution, acknowledgment or delivery thereof or the taking of any such action to be conclusive evidence that the same has been authorized and approved by this Board of Directors.  EXHIBIT B RESOLUTIONS OF THE STOCKHOLDERS APPROVAL OF IP PORTFOLIO SALE RESOLVED: That the sale of the IP Portfolio to Purchaser is hereby authorized, approved and ratified. APPROVAL OF PATENT PURCHASE AGREEMENT AND EXHIBITS RESOLVED: That the form, terms and provisions of the Patent Purchase Agreement substantially in the form attached hereto as Exhibit A (the "Purchase Agreement"), along with any ancillary agreements or instruments delivered by the Corporation in connection therewith (collectively, the "Ancillary Agreements"), and the transactions contemplated thereby be, and they hereby are, ratified and approved; and that the execution, delivery and performance of the Purchase Agreement and the Ancillary Documents, in the name and on behalf of the Corporation, by the President, any Vice President, and the Treasurer of this Corporation at the time in office (the "Authorized Officers"), each acting singly, is hereby ratified, authorized, and approved, with such additions, deletions and changes as the Authorized Officer so acting may by his execution approve; the execution and delivery of the Purchase Agreement and the Ancillary Agreements to be conclusive evidence that the same have been authorized and approved by the stockholders of the Corporation; and further RESOLVED: That the Authorized Officers be, and they hereby are and each of them singly hereby is, authorized, directed and empowered, from time to time, in the name and on behalf of the Corporation, to execute, make oath to, acknowledge and deliver, or cause to be executed, acknowledged and delivered, under the seal of the Corporation if so desired, all such other and further documents, instruments, orders, directions, certificates, receipts, forms and other papers or instruments, and to perform or cause to be performed all such other and further acts, as the officer or officers so acting may in his, her or their absolute discretion approve in connection with the consummation of the transactions contemplated by the Purchase Agreement or the Ancillary Agreements or for the purpose of carrying out the intent and purpose thereof or the execution, acknowledgment or delivery thereof or the taking of any such action to be conclusive evidence that the same has been authorized and approved by the stockholders of the Corporation.  EXHIBIT C CERTIFICATE OF GOOD STANDING (see attached)  PAGE 1 Delaware --------------- The First State I, HARRIET SMITH WINDSOR, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY CERTIFY "INSTITUTE OF MOLECULAR BIOLOGY, INC." IS DULY INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE AND IS IN GOOD STANDING AND HAS A LEGAL CORPORATE EXISTENCE SO FAR AS THE RECORDS OF THIS OFFICE SHOW, AS OF THE FOURTH DAY OF NOVEMBER, A.D. 2005. AND I DO HEREBY FURTHER CERTIFY THAT THE FRANCHISE TAXES HAVE BEEN PAID TO DATE. AND I DO HEREBY FURTHER CERTIFY THAT THE ANNUAL REPORTS HAVE BEEN FILED TO DATE. AND I DO HEREBY FURTHER CERTIFY THAT THE SAID "INSTITUTE OF MOLECULAR BIOLOGY, INC." WAS INCORPORATED ON THE SIXTEENTH DAY OF JANUARY, A.D. 1985. [SEAL] /s/ Harriet Smith Windsor ----------------------------------------- Harriet Smith Windsor, Secretary of State ###-###-#### AUTHENTICATION: 4277347 050905116 DATE: 11-04-05