AMENDMENT

EX-10.1(IV) 2 ex10-1iv.htm EXHIBIT 10.1(IV) ex10-1iv.htm
EXHIBIT 10.1(iv)
 
AMENDMENT

This Amendment is made as of this 24th day of January 2011, by and between YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., of Hi Tech Park, Edmond J. Safra Campus, Givat Ram, Jerusalem 91390, Israel (“Yissum”); and

BIOCANCELL THERAPEUTICS ISRAEL LTD. of Beit Beck, Har Hotzvim, Jerusalem, Israel (the “Company"), of the second part;

WHEREAS, the Company and Yissum executed an amended and restated license agreement on November 14, 2005, as supplemented and amended (the “License Agreement”), pursuant to which the Company obtained an exclusive license to certain patents owned by Yissum; and

WHEREAS the Parties wish to amend the License Agreement to add new patents and patent applications to the list of Patents exclusively licensed to the Company as part of the Licensed Technology.
 
 
NOW THEREFORE, in consideration of the mutual promises and covenants set forth herein, the parties hereby agree, as follows:

1.
All capitalized terms not defined herein shall have the meaning ascribed to them in the License Agreement.

2.
Appendix 1 of the License Agreement shall be amended to add the following patents and patent applications:

 
·
NUCLEIC ACID CONSTRUCTS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING SAME FOR TREATING CANCER (H19 + Tnf Alpha), Yissum Ref# 2989

 
·
NUCLEIC ACID AGENTS FOR DOWNREGULATING H19, AND METHODS OF USING SAME, Yissum Ref# 3025

 
·
NUCLEIC ACID CONSTRUCTS AND METHODS FOR SPECIFIC SILENCING OF H19   (siRNA H19 - cancer + stem cells) Yissum Ref# 3309

 
·
H19 SILENCING NUCLEIC ACID AGENTS FOR TREATING RHEUMATOID ARTHRITIS   (siRNA - RA), Yissum Ref# 3310

 
·
CONSTRUCTS CONTAINING MULTIPLE EXPRESSION CASSETTES FOR CANCER THERAPY, Yissum Ref# 3423

A new Appendix 1 to the License Agreement, including Yissum Reference Numbers, is annexed to this Amendment.

3.
All other provisions of the License Agreement, including, without limitation, all terms of the Amendment to License Agreement dated September 11, 2007 which shall apply to the terms hereof,  shall continue to have the same force and effect as they had prior to this Addendum.


IN WITNESS WHEREOF, the parties have executed this Agreement as a deed and delivered on the date first above written.

                                                                                                                                                         
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
 
 
BIOCANCELL THERAPEUTICS ISRAEL, LTD.
By: /s/ Shoshi Keynan
Shoshi Keynan
/s/ Yaakov Michlin
Yaakov Michlin
 
By: /s/ Uri Danon
Uri Danon
 /s/ Ira Weinstein
Ira Weinstein
Title: VP Licensing, Pharmaceuticals
 President & CEO  
Title: CEO
 CFO
Date: 30/1/2011
  30/1/2011  
Date: 24/1/11
  24/1/11

 
 

 

APPENDIX 1 – THE PATENTS


Family:
2148
Title:
Sensitive Cancer Assay
         
                 
                 
Inventor
Faculty/Department
             
Ariel Ilana
Hadassah
             
Hochberg Avraham
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
             
                 
                 
 
Application
Publication
Patent
Patent ID
Status
Country
Date
Number
Date
Number
Date
Number
2148-00
Granted
Israel
7/3/1994
108879
   
31/08/2000
108879
2148-01
Published
PCT
6/3/1995
PCT/EP95/00823
4/9/1995
WO95/24503
   
2148-03
Granted
US
6/9/1996
08/704,786
   
21/09/1999
5,955,273
2148-04
Granted
Europe
6/3/1995
95927570
   
29/05/2002
759092
                 
                 
Family:
2324
Title:
Methods and Compositions for Inducing Tumor-Specific Cytotoxicity
         
                 
                 
Inventor
Faculty/Department
             
Ayesh Suhail
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
             
Hochberg Avraham
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
             
                 
 
 
 
 

 
 
                 
 
Application
Publication
Patent
Patent ID
Status
Country
Date
Number
Date
Number
Date
Number
2324-00
Abandoned
US
3/10/1997
08/943,608
       
2324-01
Exhausted
PCT
4/10/1998
PCT/IL98/00486
8/12/1999
WO 99/18195
   
2324-02
Exhausted
PCT
22/10/2002
PCT/IL02/00843
1/5/2003
WO 03/035883
   
2324-03
Granted
US
1/10/1998
09/165,240
   
11/7/2000
6,087,164
2324-04
Granted
China
4/10/1998
98811834
   
30/11/2005
ZL 98811833.5
2324-05
Granted
Europe
4/10/1998
98947759
 
1019499
10/9/2008
1019499
2324-06
Filed
Hungary
4/10/1998
P0003745
       
2324-07
Granted
Israel
4/10/1998
135430
19/08/2007
Pat & Designs J. 6/2007
20/11/2007
135430
2324-08
Granted
Korea
4/10/1998
2000 ###-###-####
   
20/10/2005
524262
2324-09
Filed
Mexico
4/10/1998
2000-003843
       
2324-10
Abandoned
New Zealand
4/10/1998
503843
       
2324-11
Allowed
Norway
4/10/1998
20001684
       
2324-12
Abandoned
Poland
4/10/1998
P339949
       
2324-13
Granted
Russian Federation
4/10/1998
2E+09
 
2214280
20/10/2003
2214280
2324-14
Granted
US
10/5/2000
09/568,059
   
23/10/2001
6,306,833
2324-15
Granted
US
22/10/2001
10/012,131
29/04/2004
US-2004-0082529
9/5/2006
7,041,654
2324-16
Granted
Australia
4/10/1998
94571/98
   
19/12/2002
755774
2324-17
Examination
Japan
4/10/1998
2000-514993
       
2324-18
Granted
Canada
4/10/1998
2,308,124
   
8/7/2008
2,308,124
2324-19
Granted
Singapore
4/10/1998
200001824-2
   
4/6/2002
72207
2324-20
Granted
Czech Republic
4/10/1998
PV2000-1201
   
16/02/2005
294694
2324-21
Abandoned
Europe
22/10/2002
2779859.4
21/07/2004
1438412
   
2324-22
Abandoned
China
22/10/2002
2825940.8
       
2324-23
Abandoned
Japan
22/10/2002
2003-538383
       
2324-24
Abandoned
Israel
22/10/2002
161553
       
2324-25
Abandoned
Canada
22/10/2002
2,464,394
       
2324-26
Abandoned
Australia
22/10/2002
2.002E+09
       
2324-27
Abandoned
Mexico
22/10/2002
PAa2004/003732
       
2324-28
Granted
Czech Republic
18/06/2004
PV 2004-741
   
14/02/2005
294941
2324-29
Allowed
Brazil
4/10/1998
PI9812717-9
       
2324-30
Examination
Japan
24/05/2006
2006-144648
9/11/2006
2006-304801
   
2324-31
Granted
Mexico
4/10/1998
PA/a/2000/03251
   
10/4/2007
244867
2324-32
Examination
Japan
24/05/2006
2007-270777
19/06/2008
2008-136480
   
2324-33
Filed
Norway
 
20093194
       
                 
                 
 
 
 
 

 
 
                 
                   
Family:
2989
Title:
Nucleic Acid Constructs, Pharmaceutical Compositions and Methods of Using Same for Treating Cancer (H19 + Tnf Alpha)
         
                 
                 
Inventor
Faculty/Department
             
Hochberg Avraham
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
             
                 
                 
 
Application
Publication
Patent
Patent ID
Status
Country
Date
Number
Date
Number
Date
Number
2989-00
Expired
US
22/09/2005
60/719,178
       
2989-01
Exhausted
PCT
21/09/2006
PCT/IL2006/001110
29/03/2007
WO 2007/034487
   
2989-02
Examination
US
21/09/2006
12/067,410
       
2989-03
Examination
Israel
21/09/2006
190311
       
2989-04
Published
Japan
21/09/2006
2008-531883
5/3/2009
2009-508516
   
2989-05
Granted
Europe
21/09/2006
6780498.9
4/6/2008
1926814
28/04/2010
1926814
                 
                 
Family:
3025
Title:
NUCLEIC ACID AGENTS FOR DOWNREGULATING H19, AND METHODS OF USING SAME
         
                 
                 
Inventor
Faculty/Department
             
Matouk Imad
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
             
Hochberg Avraham
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
             
                 
                 
 
Application
Publication
Patent
Patent ID
Status
Country
Date
Number
Date
Number
Date
Number
3025-00
Expired
US
7/7/2005
60/696,795
       
3025-01
Exhausted
PCT
6/7/2006
PCT/IL2006/000785
18/01/2007
WO 2007/007317
   
3025-02
Examination
US
16/01/2008
12/015,325
       
3025-03
Published
Japan
6/7/2006
2008-520061
11/12/2008
2008-545011
   
3025-04
Examination
US
6/7/2006
11/994,810
4/6/2009
US- 2009/0143321 A1
   
3025-05
Filed
Canada
6/7/2006
2,614,531
       
3025-06
Exhausted
Australia
6/7/2006
2.006E+09
       
3025-07
Examination
Europe
6/7/2006
6766118.1
30/04/2008
1915448
   
3025-08
Filed
India
6/7/2006
2008/DELNP/758
       
3025-09
Examination
China
21/05/2006
2.007E+11
       
3025-10
Examination
Israel
 
188501
       
                 
                 
Family:
3309
Title:
NUCLEIC ACID CONSTRUCTS AND METHODS FOR SPECIFIC SILENCING OF H19 (siRNA H19 - cancer + stem cells)
         
                 
                 
Inventor
Faculty/Department
             
Hochberg Avraham
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
             
                 
                 
                 
 
Application
Publication
Patent
Patent ID
Status
Country
Date
Number
Date
Number
Date
Number
3309-00
Expired
US
16/01/2007
60/880,425
       
3309-01
Exhausted
PCT
16/01/2008
PCT/IL2008/000072
24/07/2008
WO 2008/087642 A2
   
3309-02
Examination
Europe
16/01/2008
8702653
28/10/2009
2111450
   
3309-03
Filed
Israel
16/01/2008
199867
       
3309-04
Filed
Canada
16/01/2008
2,675,967
       
3309-05
Published
US
16/01/2008
12/523,298
8/4/2010
US-2010/0086526 A1.
   
3309-06
Filed
India
16/01/2008
5257/DELNP/2009
       
                 
                 
Family:
3310
Title:
H19 SILENCING NUCLEIC ACID AGENTS FOR TREATING RHEUMATOID ARTHRITIS (siRNA - RA)
         
                 
                 
Inventor
Faculty/Department
             
Hochberg Avraham
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
             
                 
                 
 
Application
Publication
Patent
Patent ID
Status
Country
Date
Number
Date
Number
Date
Number
3310-00
Expired
US
16/01/2007
60/880,430
       
3310-01
Exhausted
PCT
16/01/2008
PCT/IL2008/000071
24/07/2008
WO 2008/087641 A2
   
3310-02
Examination
Europe
16/01/2008
8702652
28/10/2009
2111449
   
3310-03
Filed
Canada
16/01/2008
2,675,964
       
3310-04
Allowed
US
16/01/2008
12/523,288
29/04/2010
US- 2010/0105759 A1
   
3310-05
Filed
Israel
16/01/2008
199866
       
3310-06
Filed
India
16/01/2008
5271/DELNP/2009
       
                 
                 
Family:
3423
Title:
CONSTRUCTS CONTAINING MULTIPLE EXPRESSION CASSETTES FOR CANCER THERAPY
         
                 
                 
Inventor
Faculty/Department
             
Amit Doron
 HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
             
Hochberg Avraham
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
             
                 
                 
 
Application
Publication
Patent
Patent ID
Status
Country
Date
Number
Date
Number
Date
Number
3423-00
Expired
US
25/10/2007
60/982,442
       
3423-01
Exhausted
PCT
23/10/2008
PCT/IL2008/001405
30/04/2009
WO 2009/053982
   
3423-02
Filed
Russian Federation
23/10/2008
2.01E+09
       
3423-03
Published
US
23/10/2010
12/738,620
7/10/2010
US 2010/0256225 A1
   
3423-04
Filed
Canada
23/10/2008
2,703,774
       
3423-05
Filed
Brazil
23/10/2008
PI 0818937-4
       
3423-06
Filed
India
23/10/2008
2846/DELNP/2010
       
3423-07
Pre-Filing
Korea
           
3423-08
Filed
China
23/10/2008
2.009E+11
       
3423-09
Examination
Europe
23/10/2008
8842129.2
7/7/2010
2203187
   
3423-10
Filed
Israel
23/10/2008
205048
       
3423-11
Filed
Australia
23/10/2008
2.008E+09
       
3423-12
Filed
Japan
23/10/2008
2010-530628