AMENDMENT

EX-10.1(IV) 2 ex10-1iv.htm EXHIBIT 10.1(IV) ex10-1iv.htm

EXHIBIT 10.1(iv)

AMENDMENT

This Amendment is made as of this 24th day of January 2011, by and between YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., of Hi Tech Park, Edmond J. Safra Campus, Givat Ram, Jerusalem 91390, Israel (“Yissum”); and

BIOCANCELL THERAPEUTICS ISRAEL LTD. of Beit Beck, Har Hotzvim, Jerusalem, Israel (the “Company"), of the second part;

WHEREAS, the Company and Yissum executed an amended and restated license agreement on November 14, 2005, as supplemented and amended (the “License Agreement”), pursuant to which the Company obtained an exclusive license to certain patents owned by Yissum; and

WHEREAS the Parties wish to amend the License Agreement to add new patents and patent applications to the list of Patents exclusively licensed to the Company as part of the Licensed Technology.

NOW THEREFORE, in consideration of the mutual promises and covenants set forth herein, the parties hereby agree, as follows:

1.	All capitalized terms not defined herein shall have the meaning ascribed to them in the License Agreement.

2.	Appendix 1 of the License Agreement shall be amended to add the following patents and patent applications:

NUCLEIC ACID CONSTRUCTS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING SAME FOR TREATING CANCER (H19 + Tnf Alpha), Yissum Ref# 2989

NUCLEIC ACID AGENTS FOR DOWNREGULATING H19, AND METHODS OF USING SAME, Yissum Ref# 3025

NUCLEIC ACID CONSTRUCTS AND METHODS FOR SPECIFIC SILENCING OF H19 (siRNA H19 - cancer + stem cells) Yissum Ref# 3309

H19 SILENCING NUCLEIC ACID AGENTS FOR TREATING RHEUMATOID ARTHRITIS (siRNA - RA), Yissum Ref# 3310

CONSTRUCTS CONTAINING MULTIPLE EXPRESSION CASSETTES FOR CANCER THERAPY, Yissum Ref# 3423

A new Appendix 1 to the License Agreement, including Yissum Reference Numbers, is annexed to this Amendment.

3.	All other provisions of the License Agreement, including, without limitation, all terms of the Amendment to License Agreement dated September 11, 2007 which shall apply to the terms hereof, shall continue to have the same force and effect as they had prior to this Addendum.

IN WITNESS WHEREOF, the parties have executed this Agreement as a deed and delivered on the date first above written.

YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD		BIOCANCELL THERAPEUTICS ISRAEL, LTD.
By: /s/ Shoshi Keynan Shoshi Keynan	/s/ Yaakov Michlin Yaakov Michlin	By: /s/ Uri Danon Uri Danon	/s/ Ira Weinstein Ira Weinstein
Title: VP Licensing, Pharmaceuticals	President & CEO	Title: CEO	CFO
Date: 30/1/2011	30/1/2011	Date: 24/1/11	24/1/11

APPENDIX 1 – THE PATENTS

Family:

2148

Title:

Sensitive Cancer Assay

Inventor

Faculty/Department

Ariel Ilana

Hadassah

Hochberg Avraham

HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences

Application

Publication

Patent

Patent ID

Status

Country

Date

Number

Date

Number

Date

Number

2148-00

Granted

Israel

7/3/1994

108879

31/08/2000

108879

2148-01

Published

PCT

6/3/1995

PCT/EP95/00823

4/9/1995

WO95/24503

2148-03

Granted

6/9/1996

08/704,786

21/09/1999

5,955,273

2148-04

Granted

Europe

6/3/1995

95927570

29/05/2002

759092

Family:

2324

Title:

Methods and Compositions for Inducing Tumor-Specific Cytotoxicity

Inventor

Faculty/Department

Ayesh Suhail

HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences

Hochberg Avraham

HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences

Application

Publication

Patent

Patent ID

Status

Country

Date

Number

Date

Number

Date

Number

2324-00

Abandoned

3/10/1997

08/943,608

2324-01

Exhausted

PCT

4/10/1998

PCT/IL98/00486

8/12/1999

WO 99/18195

2324-02

Exhausted

PCT

22/10/2002

PCT/IL02/00843

1/5/2003

WO 03/035883

2324-03

Granted

1/10/1998

09/165,240

11/7/2000

6,087,164

2324-04

Granted

China

4/10/1998

98811834

30/11/2005

ZL 98811833.5

2324-05

Granted

Europe

4/10/1998

98947759

1019499

10/9/2008

1019499

2324-06

Filed

Hungary

4/10/1998

P0003745

2324-07

Granted

Israel

4/10/1998

135430

19/08/2007

Pat & Designs J. 6/2007

20/11/2007

135430

2324-08

Granted

Korea

4/10/1998

2000 ###-###-####

20/10/2005

524262

2324-09

Filed

Mexico

4/10/1998

2000-003843

2324-10

Abandoned

New Zealand

4/10/1998

503843

2324-11

Allowed

Norway

4/10/1998

20001684

2324-12

Abandoned

Poland

4/10/1998

P339949

2324-13

Granted

Russian Federation

4/10/1998

2E+09

2214280

20/10/2003

2214280

2324-14

Granted

10/5/2000

09/568,059

23/10/2001

6,306,833

2324-15

Granted

22/10/2001

10/012,131

29/04/2004

US-2004-0082529

9/5/2006

7,041,654

2324-16

Granted

Australia

4/10/1998

94571/98

19/12/2002

755774

2324-17

Examination

Japan

4/10/1998

2000-514993

2324-18

Granted

Canada

4/10/1998

2,308,124

8/7/2008

2,308,124

2324-19

Granted

Singapore

4/10/1998

200001824-2

4/6/2002

72207

2324-20

Granted

Czech Republic

4/10/1998

PV2000-1201

16/02/2005

294694

2324-21

Abandoned

Europe

22/10/2002

2779859.4

21/07/2004

1438412

2324-22

Abandoned

China

22/10/2002

2825940.8

2324-23

Abandoned

Japan

22/10/2002

2003-538383

2324-24

Abandoned

Israel

22/10/2002

161553

2324-25

Abandoned

Canada

22/10/2002

2,464,394

2324-26

Abandoned

Australia

22/10/2002

2.002E+09

2324-27

Abandoned

Mexico

22/10/2002

PAa2004/003732

2324-28

Granted

Czech Republic

18/06/2004

PV 2004-741

14/02/2005

294941

2324-29

Allowed

Brazil

4/10/1998

PI9812717-9

2324-30

Examination

Japan

24/05/2006

2006-144648

9/11/2006

2006-304801

2324-31

Granted

Mexico

4/10/1998

PA/a/2000/03251

10/4/2007

244867

2324-32

Examination

Japan

24/05/2006

2007-270777

19/06/2008

2008-136480

2324-33

Filed

Norway

20093194

Family:

2989

Title:

Nucleic Acid Constructs, Pharmaceutical Compositions and Methods of Using Same for Treating Cancer (H19 + Tnf Alpha)

Inventor

Faculty/Department

Hochberg Avraham

HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences

Application

Publication

Patent

Patent ID

Status

Country

Date

Number

Date

Number

Date

Number

2989-00

Expired

22/09/2005

60/719,178

2989-01

Exhausted

PCT

21/09/2006

PCT/IL2006/001110

29/03/2007

WO 2007/034487

2989-02

Examination

21/09/2006

12/067,410

2989-03

Examination

Israel

21/09/2006

190311

2989-04

Published

Japan

21/09/2006

2008-531883

5/3/2009

2009-508516

2989-05

Granted

Europe

21/09/2006

6780498.9

4/6/2008

1926814

28/04/2010

1926814

Family:

3025

Title:

NUCLEIC ACID AGENTS FOR DOWNREGULATING H19, AND METHODS OF USING SAME

Inventor

Faculty/Department

Matouk Imad

HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences

Hochberg Avraham

HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences

Application

Publication

Patent

Patent ID

Status

Country

Date

Number

Date

Number

Date

Number

3025-00

Expired

7/7/2005

60/696,795

3025-01

Exhausted

PCT

6/7/2006

PCT/IL2006/000785

18/01/2007

WO 2007/007317

3025-02

Examination

16/01/2008

12/015,325

3025-03

Published

Japan

6/7/2006

2008-520061

11/12/2008

2008-545011

3025-04

Examination

6/7/2006

11/994,810

4/6/2009

US- 2009/0143321 A1

3025-05

Filed

Canada

6/7/2006

2,614,531

3025-06

Exhausted

Australia

6/7/2006

2.006E+09

3025-07

Examination

Europe

6/7/2006

6766118.1

30/04/2008

1915448

3025-08

Filed

India

6/7/2006

2008/DELNP/758

3025-09

Examination

China

21/05/2006

2.007E+11

3025-10

Examination

Israel

188501

Family:

3309

Title:

NUCLEIC ACID CONSTRUCTS AND METHODS FOR SPECIFIC SILENCING OF H19 (siRNA H19 - cancer + stem cells)

Inventor

Faculty/Department

Hochberg Avraham

HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences

Application

Publication

Patent

Patent ID

Status

Country

Date

Number

Date

Number

Date

Number

3309-00

Expired

16/01/2007

60/880,425

3309-01

Exhausted

PCT

16/01/2008

PCT/IL2008/000072

24/07/2008

WO 2008/087642 A2

3309-02

Examination

Europe

16/01/2008

8702653

28/10/2009

2111450

3309-03

Filed

Israel

16/01/2008

199867

3309-04

Filed

Canada

16/01/2008

2,675,967

3309-05

Published

16/01/2008

12/523,298

8/4/2010

US-2010/0086526 A1.

3309-06

Filed

India

16/01/2008

5257/DELNP/2009

Family:

3310

Title:

H19 SILENCING NUCLEIC ACID AGENTS FOR TREATING RHEUMATOID ARTHRITIS (siRNA - RA)

Inventor

Faculty/Department

Hochberg Avraham

HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences

Application

Publication

Patent

Patent ID

Status

Country

Date

Number

Date

Number

Date

Number

3310-00

Expired

16/01/2007

60/880,430

3310-01

Exhausted

PCT

16/01/2008

PCT/IL2008/000071

24/07/2008

WO 2008/087641 A2

3310-02

Examination

Europe

16/01/2008

8702652

28/10/2009

2111449

3310-03

Filed

Canada

16/01/2008

2,675,964

3310-04

Allowed

16/01/2008

12/523,288

29/04/2010

US- 2010/0105759 A1

3310-05

Filed

Israel

16/01/2008

199866

3310-06

Filed

India

16/01/2008

5271/DELNP/2009

Family:

3423

Title:

CONSTRUCTS CONTAINING MULTIPLE EXPRESSION CASSETTES FOR CANCER THERAPY

Inventor

Faculty/Department

Amit Doron

HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences

Hochberg Avraham

HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences

Application

Publication

Patent

Patent ID

Status

Country

Date

Number

Date

Number

Date

Number

3423-00

Expired

25/10/2007

60/982,442

3423-01

Exhausted

PCT

23/10/2008

PCT/IL2008/001405

30/04/2009

WO 2009/053982

3423-02

Filed

Russian Federation

23/10/2008

2.01E+09

3423-03

Published

23/10/2010

12/738,620

7/10/2010

US 2010/0256225 A1

3423-04

Filed

Canada

23/10/2008

2,703,774

3423-05

Filed

Brazil

23/10/2008

PI 0818937-4

3423-06

Filed

India

23/10/2008

2846/DELNP/2010

3423-07

Pre-Filing

Korea

3423-08

Filed

China

23/10/2008

2.009E+11

3423-09

Examination

Europe

23/10/2008

8842129.2

7/7/2010

2203187

3423-10

Filed

Israel

23/10/2008

205048

3423-11

Filed

Australia

23/10/2008

2.008E+09

3423-12

Filed

Japan

23/10/2008

2010-530628