Amendment to Amended and Restated Employment Agreement, dated January 6, 2022, by and between BicycleTx Ltd. and Michael Skynner, Ph.D

Exhibit 10.11

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Dr Michael Skynner
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January 5, 2022

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Dear Michael,

Amendment to your service agreement with BicycleTX Limited (the “Company”) dated 26 September 2019 (the “Service Agreement”)

Following our recent discussions regarding a move from the Chief Operating Officer role to the new Chief Technology Officer role, I am happy to write to you to confirm this agreed move and to confirm the applicable amendments to the terms set out in your Service Agreement.

With effect from 3 January 2022:

Your salary will be £405,100 per annum paid monthly in arrears on or about the last working day of each month (less statutory and voluntary deductions) (“Salary”). Your Salary will be reviewed annually in accordance with the Company's practices from time to time (which is expected to be by the end of the first quarter of each year). You will be notified in writing of any changes to your Salary or benefits.

The remaining terms of your employment shall continue to apply without change.

Please sign a copy of this letter where indicated below to acknowledge receipt and your agreement to the terms of this letter.

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If you have any questions regarding the information in this letter, please let me know.

Yours sincerely

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/s/ Kevin Lee

Kevin Lee, CEO
For and on behalf of the Company

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Signed:/s/ Michael Skynner​ ​

Name:Michael Skynner

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Date:January 6, 2022​ ​